Reviewed,
UniProtKB/Swiss-Prot Q9BQ87 (TBL1Y_HUMAN)
Last modified
November 24, 2009.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: F-box-like/WD repeat-containing protein TBL1Y Alternative name(s): Transducin beta-like protein 1Y Transducin-beta-like protein 1, Y-linked | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 522 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange By similarity. |
| Subunit structure | Probable component of the N-Cor repressor complex and some E3 ubiquitin ligase complex By similarity. |
| Subcellular location | Nucleus By similarity. |
| Tissue specificity | Fetal brain and prostate. Ref.1 |
| Domain | The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes By similarity. |
| Sequence similarities | Belongs to the WD repeat EBI family. Contains 1 F-box-like domain. Contains 1 LisH domain. Contains 8 WD repeats. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation Ubl conjugation pathway |
| Cellular component | Nucleus |
| Domain | Repeat WD repeat |
| Molecular function | Activator |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcriptionInferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 522 | 522 | F-box-like/WD repeat-containing protein TBL1Y | PRO_0000051264 | |||||
Regions | |||||||||
| Domain | 4 – 36 | 33 | LisH | ||||||
| Domain | 41 – 86 | 46 | F-box-like | ||||||
| Repeat | 177 – 216 | 40 | WD 1 | ||||||
| Repeat | 233 – 272 | 40 | WD 2 | ||||||
| Repeat | 274 – 313 | 40 | WD 3 | ||||||
| Repeat | 316 – 354 | 39 | WD 4 | ||||||
| Repeat | 357 – 396 | 40 | WD 5 | ||||||
| Repeat | 399 – 447 | 49 | WD 6 | ||||||
| Repeat | 450 – 489 | 40 | WD 7 | ||||||
| Repeat | 491 – 521 | 31 | WD 8 | ||||||
Sequences
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References
| [1] | "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. Page D.C.Nature 423:825-837(2003) [PubMed: 12815422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF332220 mRNA. Translation: AAK13472.1. AF332221 mRNA. Translation: AAK13473.1. AF332222 mRNA. Translation: AAK13474.1. | |
| IPI | IPI00020873. |
| RefSeq | NP_150600.1. NP_599020.1. NP_599021.1. |
| UniGene | Hs.664560 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9BQ87. |
Proteomic databases | |
| PRIDE | Q9BQ87. |
Genome annotation databases | |
| Ensembl | ENST00000346432; ENSP00000328879; ENSG00000092377; Homo sapiens. [Genome view] ENST00000355162; ENSP00000347289; ENSG00000092377; Homo sapiens. [Genome view] ENST00000383032; ENSP00000372499; ENSG00000092377; Homo sapiens. [Genome view] |
| GeneID | 90665. |
| KEGG | hsa:90665. |
| UCSC | uc004frb.1. human. |
Organism-specific databases | |
| CTD | 90665. |
| GeneCards | GC0YP006822. |
| HGNC | HGNC:18502. TBL1Y. |
| MIM | 400033. gene. |
| PharmGKB | PA38564. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9BQ87. |
| HOVERGEN | Q9BQ87. |
| OMA | ENGAHEI |
| OrthoDB | EOG998XKH |
Gene expression databases | |
| ArrayExpress | Q9BQ87. |
| Bgee | Q9BQ87. |
| CleanEx | HS_TBL1Y. |
| Genevestigator | Q9BQ87. |
| GermOnline | ENSG00000092377. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR020472. G-protein_beta_WD-40_rep_reg. IPR006594. LisH_dimerisation. IPR013720. LisH_dimerisation_sub. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019782. WD40_repeat_2. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. IPR019781. WD40_repeat_sg. [Graphical view] |
| Gene3D | G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 2 hits. |
| Pfam | PF08513. LisH. 1 hit. PF00400. WD40. 7 hits. [Graphical view] |
| PRINTS | PR00320. GPROTEINBRPT. |
| SMART | SM00667. LisH. 1 hit. SM00320. WD40. 8 hits. [Graphical view] |
| PROSITE | PS50896. LISH. 1 hit. PS00678. WD_REPEATS_1. 4 hits. PS50082. WD_REPEATS_2. 6 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 76909. |
| SOURCE | Search... |
Entry information
| Entry name | TBL1Y_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9BQ87 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome Y Human chromosome Y: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


