Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9BQ87 (TBL1Y_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-box-like/WD repeat-containing protein TBL1Y
Alternative name(s):
Transducin beta-like protein 1Y
Transducin-beta-like protein 1, Y-linked
Gene names
Name:TBL1Y
Synonyms:TBL1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange By similarity.

Subunit structure

Probable component of the N-Cor repressor complex and some E3 ubiquitin ligase complex By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Fetal brain and prostate. Ref.1

Domain

The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes By similarity.

Sequence similarities

Belongs to the WD repeat EBI family.

Contains 1 F-box-like domain.

Contains 1 LisH domain.

Contains 8 WD repeats.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
Ubl conjugation pathway
   Cellular componentNucleus
   DomainRepeat
WD repeat
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processregulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 522522F-box-like/WD repeat-containing protein TBL1Y
PRO_0000051264

Regions

Domain4 – 3633LisH
Domain41 – 8646F-box-like
Repeat177 – 21640WD 1
Repeat233 – 27240WD 2
Repeat274 – 31340WD 3
Repeat316 – 35439WD 4
Repeat357 – 39640WD 5
Repeat399 – 44749WD 6
Repeat450 – 48940WD 7
Repeat491 – 52131WD 8

Sequences

Sequence LengthMass (Da)Tools
Q9BQ87 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 4E020216422442D8

FASTA52256,688
        10         20         30         40         50         60 
MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPSALI SILQKGLQYV 

        70         80         90        100        110        120 
EAEISINKDG TVFDSRPIES LSLIVAVIPD VVQMRQQAFG EKLTQQQASA AATEASAMAK 

       130        140        150        160        170        180 
AATMTPAAIS QQNPPKNREA TVNGEENGAH EINNHSKPME IDGDVEIPPN KATVLRGHES 

       190        200        210        220        230        240 
EVFICAWNPV SDLLASGSGD STARIWNLNE NSNGGSTQLV LRHCIREGGH DVPSNKDVTS 

       250        260        270        280        290        300 
LDWNSDGTLL AMGSYDGFAR IWTENGNLAS TLGQHKGPIF ALKWNKKGNY VLSAGVDKTT 

       310        320        330        340        350        360 
IIWDAHTGEA KQQFPFHSAP ALDVDWQNNM TFASCSTDMC IHVCRLGCDH PVKTFQGHTN 

       370        380        390        400        410        420 
EVNAIKWDPS GMLLASCSDD MTLKIWSMKQ DACVHDLQAH SKEIYTIKWS PTGPATSNPN 

       430        440        450        460        470        480 
SSIMLASASF DSTVRLWDVE QGVCTHTLMK HQEPVYSVAF SPDGKYLASG SFDKYVHIWN 

       490        500        510        520 
TQSGSLVHSY QGTGGIFEVC WNARGDKVGA SASDGSVCVL DL 

« Hide

References

« Hide 'large scale' references
[1]"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes."
Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. expand/collapse author list , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C.
Nature 423:825-837(2003) [PubMed: 12815422] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF332220 mRNA. Translation: AAK13472.1.
AF332221 mRNA. Translation: AAK13473.1.
AF332222 mRNA. Translation: AAK13474.1.
CH471163 Genomic DNA. Translation: EAW59126.1.
BC130471 mRNA. Translation: AAI30472.1.
BC130473 mRNA. Translation: AAI30474.1.
IPIIPI00020873.
RefSeqNP_150600.1. NM_033284.1.
NP_599020.1. NM_134258.1.
NP_599021.1. NM_134259.1.
UniGeneHs.664560.

3D structure databases

ProteinModelPortalQ9BQ87.
SMRQ9BQ87. Positions 2-65, 172-522.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9BQ87.

PTM databases

PhosphoSiteQ9BQ87.

Polymorphism databases

DMDM23396873.

Proteomic databases

PRIDEQ9BQ87.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000346432; ENSP00000328879; ENSG00000092377.
ENST00000355162; ENSP00000347289; ENSG00000092377.
ENST00000383032; ENSP00000372499; ENSG00000092377.
GeneID90665.
KEGGhsa:90665.
UCSCuc004frb.1. human.

Organism-specific databases

CTD90665.
GeneCardsGC0YP006778.
HGNCHGNC:18502. TBL1Y.
MIM400033. gene.
neXtProtNX_Q9BQ87.
PharmGKBPA38564.
GenAtlasSearch...

Phylogenomic databases

GeneTreeENSGT00550000074625.
HOGENOMHBG717050.
HOVERGENHBG050240.
InParanoidQ9BQ87.
OMAENGAHEI.
OrthoDBEOG412M5M.
PhylomeDBQ9BQ87.

Gene expression databases

ArrayExpressQ9BQ87.
BgeeQ9BQ87.
CleanExHS_TBL1Y.
GenevestigatorQ9BQ87.
GermOnlineENSG00000092377. Homo sapiens.

Family and domain databases

InterProIPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH_dimerisation.
IPR013720. LisH_dimerisation_subgr.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR011046. WD40_repeat-like_dom.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 2 hits.
KOK04508.
PfamPF08513. LisH. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSPR00320. GPROTEINBRPT.
SMARTSM00667. LisH. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMSSF50978. WD40_like. 1 hit.
PROSITEPS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio76909.
SOURCESearch...

Entry information

Entry nameTBL1Y_HUMAN
AccessionPrimary (citable) accession number: Q9BQ87
Secondary accession number(s): A1L4B3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome Y

Human chromosome Y: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families