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Protein

F-box-like/WD repeat-containing protein TBL1Y

Gene

TBL1Y

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ9BQ87

Names & Taxonomyi

Protein namesi
Recommended name:
F-box-like/WD repeat-containing protein TBL1Y
Alternative name(s):
Transducin beta-like protein 1Y
Transducin-beta-like protein 1, Y-linked
Gene namesi
Name:TBL1Y
Synonyms:TBL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

EuPathDBiHostDB:ENSG00000092377.13
HGNCiHGNC:18502 TBL1Y
MIMi400033 gene
neXtProtiNX_Q9BQ87

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi90665
OpenTargetsiENSG00000092377
PharmGKBiPA38564

Polymorphism and mutation databases

BioMutaiTBL1Y
DMDMi23396873

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512641 – 522F-box-like/WD repeat-containing protein TBL1YAdd BLAST522

Proteomic databases

EPDiQ9BQ87
MaxQBiQ9BQ87
PaxDbiQ9BQ87
PeptideAtlasiQ9BQ87
PRIDEiQ9BQ87

PTM databases

iPTMnetiQ9BQ87
PhosphoSitePlusiQ9BQ87

Expressioni

Tissue specificityi

Fetal brain and prostate.1 Publication

Gene expression databases

BgeeiENSG00000092377
CleanExiHS_TBL1Y
ExpressionAtlasiQ9BQ87 baseline and differential
GenevisibleiQ9BQ87 HS

Organism-specific databases

HPAiHPA060073

Interactioni

Subunit structurei

Probable component of the N-Cor repressor complex and some E3 ubiquitin ligase complex.By similarity

Protein-protein interaction databases

BioGridi12475130 interactors.
CORUMiQ9BQ87
IntActiQ9BQ87 2 interactors.
MINTiQ9BQ87
STRINGi9606.ENSP00000328879

Structurei

3D structure databases

ProteinModelPortaliQ9BQ87
SMRiQ9BQ87
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 36LisHPROSITE-ProRule annotationAdd BLAST33
Domaini41 – 86F-box-likeAdd BLAST46
Repeati177 – 216WD 1Add BLAST40
Repeati233 – 272WD 2Add BLAST40
Repeati274 – 313WD 3Add BLAST40
Repeati316 – 354WD 4Add BLAST39
Repeati357 – 396WD 5Add BLAST40
Repeati399 – 447WD 6Add BLAST49
Repeati450 – 489WD 7Add BLAST40
Repeati491 – 521WD 8Add BLAST31

Domaini

The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.By similarity

Sequence similaritiesi

Belongs to the WD repeat EBI family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0273 Eukaryota
ENOG410XRSY LUCA
GeneTreeiENSGT00890000139430
HOGENOMiHOG000220902
HOVERGENiHBG050240
InParanoidiQ9BQ87
KOiK04508
OMAiENGAHEI
OrthoDBiEOG091G04MW
PhylomeDBiQ9BQ87
TreeFamiTF323190

Family and domain databases

Gene3Di2.130.10.101 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR006594 LisH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08513 LisH, 1 hit
PF00400 WD40, 6 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00667 LisH, 1 hit
SM00320 WD40, 8 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit
PS00678 WD_REPEATS_1, 4 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BQ87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPSALI
60 70 80 90 100
SILQKGLQYV EAEISINKDG TVFDSRPIES LSLIVAVIPD VVQMRQQAFG
110 120 130 140 150
EKLTQQQASA AATEASAMAK AATMTPAAIS QQNPPKNREA TVNGEENGAH
160 170 180 190 200
EINNHSKPME IDGDVEIPPN KATVLRGHES EVFICAWNPV SDLLASGSGD
210 220 230 240 250
STARIWNLNE NSNGGSTQLV LRHCIREGGH DVPSNKDVTS LDWNSDGTLL
260 270 280 290 300
AMGSYDGFAR IWTENGNLAS TLGQHKGPIF ALKWNKKGNY VLSAGVDKTT
310 320 330 340 350
IIWDAHTGEA KQQFPFHSAP ALDVDWQNNM TFASCSTDMC IHVCRLGCDH
360 370 380 390 400
PVKTFQGHTN EVNAIKWDPS GMLLASCSDD MTLKIWSMKQ DACVHDLQAH
410 420 430 440 450
SKEIYTIKWS PTGPATSNPN SSIMLASASF DSTVRLWDVE QGVCTHTLMK
460 470 480 490 500
HQEPVYSVAF SPDGKYLASG SFDKYVHIWN TQSGSLVHSY QGTGGIFEVC
510 520
WNARGDKVGA SASDGSVCVL DL
Length:522
Mass (Da):56,688
Last modified:June 1, 2001 - v1
Checksum:i4E020216422442D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332220 mRNA Translation: AAK13472.1
AF332221 mRNA Translation: AAK13473.1
AF332222 mRNA Translation: AAK13474.1
CH471163 Genomic DNA Translation: EAW59126.1
BC130471 mRNA Translation: AAI30472.1
BC130473 mRNA Translation: AAI30474.1
CCDSiCCDS14779.1
RefSeqiNP_150600.1, NM_033284.1
NP_599020.1, NM_134258.1
NP_599021.1, NM_134259.1
UniGeneiHs.664560

Genome annotation databases

EnsembliENST00000346432; ENSP00000328879; ENSG00000092377
ENST00000355162; ENSP00000347289; ENSG00000092377
ENST00000383032; ENSP00000372499; ENSG00000092377
GeneIDi90665
KEGGihsa:90665
UCSCiuc004frb.3 human

Similar proteinsi

Entry informationi

Entry nameiTBL1Y_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ87
Secondary accession number(s): A1L4B3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome