Reviewed, UniProtKB/Swiss-Prot Q9BQ87 (TBL1Y_HUMAN)

Names and origin

Protein names

Recommended name:
    F-box-like/WD repeat-containing protein TBL1Y
Alternative name(s):
    Transducin beta-like protein 1Y
    Transducin-beta-like protein 1, Y-linked

Gene names

Name:	TBL1Y
Synonyms:	TBL1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	522 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange By similarity.
Subunit structure	Probable component of the N-Cor repressor complex and some E3 ubiquitin ligase complex By similarity.
Subcellular location	Nucleus By similarity.
Tissue specificity	Fetal brain and prostate. Ref.1
Domain	The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes By similarity.
Sequence similarities	Belongs to the WD repeat EBI family. Contains 1 F-box-like domain. Contains 1 LisH domain. Contains 8 WD repeats.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Ubl conjugation pathway
Cellular component	Nucleus
Domain	Repeat WD repeat
Molecular function	Activator
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 522	522	F-box-like/WD repeat-containing protein TBL1Y		PRO_0000051264
Regions
	Domain	4 – 36	33	LisH
	Domain	41 – 86	46	F-box-like
	Repeat	177 – 216	40	WD 1
	Repeat	233 – 272	40	WD 2
	Repeat	274 – 313	40	WD 3
	Repeat	316 – 354	39	WD 4
	Repeat	357 – 396	40	WD 5
	Repeat	399 – 447	49	WD 6
	Repeat	450 – 489	40	WD 7
	Repeat	491 – 521	31	WD 8

Sequences

	Sequence		Length	Mass (Da)
	Q9BQ87-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 4E020216422442D8	FASTA	522	56,688
	10 20 30 40 50 60 MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPSALI SILQKGLQYV 70 80 90 100 110 120 EAEISINKDG TVFDSRPIES LSLIVAVIPD VVQMRQQAFG EKLTQQQASA AATEASAMAK 130 140 150 160 170 180 AATMTPAAIS QQNPPKNREA TVNGEENGAH EINNHSKPME IDGDVEIPPN KATVLRGHES 190 200 210 220 230 240 EVFICAWNPV SDLLASGSGD STARIWNLNE NSNGGSTQLV LRHCIREGGH DVPSNKDVTS 250 260 270 280 290 300 LDWNSDGTLL AMGSYDGFAR IWTENGNLAS TLGQHKGPIF ALKWNKKGNY VLSAGVDKTT 310 320 330 340 350 360 IIWDAHTGEA KQQFPFHSAP ALDVDWQNNM TFASCSTDMC IHVCRLGCDH PVKTFQGHTN 370 380 390 400 410 420 EVNAIKWDPS GMLLASCSDD MTLKIWSMKQ DACVHDLQAH SKEIYTIKWS PTGPATSNPN 430 440 450 460 470 480 SSIMLASASF DSTVRLWDVE QGVCTHTLMK HQEPVYSVAF SPDGKYLASG SFDKYVHIWN 490 500 510 520 TQSGSLVHSY QGTGGIFEVC WNARGDKVGA SASDGSVCVL DL

References

[1]

"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C. Nature 423:825-837(2003) [PubMed: 12815422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF332220 mRNA. Translation: AAK13472.1. AF332221 mRNA. Translation: AAK13473.1. AF332222 mRNA. Translation: AAK13474.1.
IPI	IPI00020873.
RefSeq	NP_150600.1. NP_599020.1. NP_599021.1.
UniGene	Hs.664560
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BQ87.
Proteomic databases
PRIDE	Q9BQ87.
Genome annotation databases
Ensembl	ENST00000346432; ENSP00000328879; ENSG00000092377; Homo sapiens. [Genome view] ENST00000355162; ENSP00000347289; ENSG00000092377; Homo sapiens. [Genome view] ENST00000383032; ENSP00000372499; ENSG00000092377; Homo sapiens. [Genome view]
GeneID	90665.
KEGG	hsa:90665.
UCSC	uc004frb.1. human.
Organism-specific databases
CTD	90665.
GeneCards	GC0YP006822.
HGNC	HGNC:18502. TBL1Y.
MIM	400033. gene.
PharmGKB	PA38564.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9BQ87.
HOVERGEN	Q9BQ87.
OMA	ENGAHEI
OrthoDB	EOG998XKH
Gene expression databases
ArrayExpress	Q9BQ87.
Bgee	Q9BQ87.
CleanEx	HS_TBL1Y.
Genevestigator	Q9BQ87.
GermOnline	ENSG00000092377. Homo sapiens.
Family and domain databases
InterPro	IPR020472. G-protein_beta_WD-40_rep_reg. IPR006594. LisH_dimerisation. IPR013720. LisH_dimerisation_sub. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019782. WD40_repeat_2. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 2 hits.
Pfam	PF08513. LisH. 1 hit. PF00400. WD40. 7 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00667. LisH. 1 hit. SM00320. WD40. 8 hits. [Graphical view]
PROSITE	PS50896. LISH. 1 hit. PS00678. WD_REPEATS_1. 4 hits. PS50082. WD_REPEATS_2. 6 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	76909.
SOURCE	Search...

Entry information

Entry name

TBL1Y_HUMAN

Accession

Primary (citable) accession number: Q9BQ87

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	June 1, 2001
Last modified:	November 24, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.