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Protein

F-box-like/WD repeat-containing protein TBL1Y

Gene

TBL1Y

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ9BQ87.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box-like/WD repeat-containing protein TBL1Y
Alternative name(s):
Transducin beta-like protein 1Y
Transducin-beta-like protein 1, Y-linked
Gene namesi
Name:TBL1Y
Synonyms:TBL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

HGNCiHGNC:18502. TBL1Y.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38564.

Polymorphism and mutation databases

BioMutaiTBL1Y.
DMDMi23396873.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 522521F-box-like/WD repeat-containing protein TBL1YPRO_0000051264Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei130 – 1301PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BQ87.
MaxQBiQ9BQ87.
PaxDbiQ9BQ87.
PeptideAtlasiQ9BQ87.
PRIDEiQ9BQ87.

PTM databases

iPTMnetiQ9BQ87.
PhosphoSiteiQ9BQ87.

Expressioni

Tissue specificityi

Fetal brain and prostate.1 Publication

Gene expression databases

BgeeiQ9BQ87.
CleanExiHS_TBL1Y.
ExpressionAtlasiQ9BQ87. baseline and differential.
GenevisibleiQ9BQ87. HS.

Organism-specific databases

HPAiHPA060073.

Interactioni

Subunit structurei

Probable component of the N-Cor repressor complex and some E3 ubiquitin ligase complex.By similarity

Protein-protein interaction databases

BioGridi124751. 28 interactions.
IntActiQ9BQ87. 2 interactions.
STRINGi9606.ENSP00000328879.

Structurei

3D structure databases

ProteinModelPortaliQ9BQ87.
SMRiQ9BQ87. Positions 2-65, 162-522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 3633LisHPROSITE-ProRule annotationAdd
BLAST
Domaini41 – 8646F-box-likeAdd
BLAST
Repeati177 – 21640WD 1Add
BLAST
Repeati233 – 27240WD 2Add
BLAST
Repeati274 – 31340WD 3Add
BLAST
Repeati316 – 35439WD 4Add
BLAST
Repeati357 – 39640WD 5Add
BLAST
Repeati399 – 44749WD 6Add
BLAST
Repeati450 – 48940WD 7Add
BLAST
Repeati491 – 52131WD 8Add
BLAST

Domaini

The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.By similarity

Sequence similaritiesi

Belongs to the WD repeat EBI family.Curated
Contains 1 F-box-like domain.Curated
Contains 1 LisH domain.PROSITE-ProRule annotation
Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0273. Eukaryota.
ENOG410XRSY. LUCA.
GeneTreeiENSGT00750000117536.
HOGENOMiHOG000220902.
HOVERGENiHBG050240.
InParanoidiQ9BQ87.
KOiK04508.
OMAiENGAHEI.
OrthoDBiEOG79CXZ3.
PhylomeDBiQ9BQ87.
TreeFamiTF323190.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08513. LisH. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00667. LisH. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BQ87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPSALI
60 70 80 90 100
SILQKGLQYV EAEISINKDG TVFDSRPIES LSLIVAVIPD VVQMRQQAFG
110 120 130 140 150
EKLTQQQASA AATEASAMAK AATMTPAAIS QQNPPKNREA TVNGEENGAH
160 170 180 190 200
EINNHSKPME IDGDVEIPPN KATVLRGHES EVFICAWNPV SDLLASGSGD
210 220 230 240 250
STARIWNLNE NSNGGSTQLV LRHCIREGGH DVPSNKDVTS LDWNSDGTLL
260 270 280 290 300
AMGSYDGFAR IWTENGNLAS TLGQHKGPIF ALKWNKKGNY VLSAGVDKTT
310 320 330 340 350
IIWDAHTGEA KQQFPFHSAP ALDVDWQNNM TFASCSTDMC IHVCRLGCDH
360 370 380 390 400
PVKTFQGHTN EVNAIKWDPS GMLLASCSDD MTLKIWSMKQ DACVHDLQAH
410 420 430 440 450
SKEIYTIKWS PTGPATSNPN SSIMLASASF DSTVRLWDVE QGVCTHTLMK
460 470 480 490 500
HQEPVYSVAF SPDGKYLASG SFDKYVHIWN TQSGSLVHSY QGTGGIFEVC
510 520
WNARGDKVGA SASDGSVCVL DL
Length:522
Mass (Da):56,688
Last modified:June 1, 2001 - v1
Checksum:i4E020216422442D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332220 mRNA. Translation: AAK13472.1.
AF332221 mRNA. Translation: AAK13473.1.
AF332222 mRNA. Translation: AAK13474.1.
CH471163 Genomic DNA. Translation: EAW59126.1.
BC130471 mRNA. Translation: AAI30472.1.
BC130473 mRNA. Translation: AAI30474.1.
CCDSiCCDS14779.1.
RefSeqiNP_150600.1. NM_033284.1.
NP_599020.1. NM_134258.1.
NP_599021.1. NM_134259.1.
UniGeneiHs.664560.

Genome annotation databases

EnsembliENST00000346432; ENSP00000328879; ENSG00000092377.
ENST00000355162; ENSP00000347289; ENSG00000092377.
ENST00000383032; ENSP00000372499; ENSG00000092377.
GeneIDi90665.
KEGGihsa:90665.
UCSCiuc004frb.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332220 mRNA. Translation: AAK13472.1.
AF332221 mRNA. Translation: AAK13473.1.
AF332222 mRNA. Translation: AAK13474.1.
CH471163 Genomic DNA. Translation: EAW59126.1.
BC130471 mRNA. Translation: AAI30472.1.
BC130473 mRNA. Translation: AAI30474.1.
CCDSiCCDS14779.1.
RefSeqiNP_150600.1. NM_033284.1.
NP_599020.1. NM_134258.1.
NP_599021.1. NM_134259.1.
UniGeneiHs.664560.

3D structure databases

ProteinModelPortaliQ9BQ87.
SMRiQ9BQ87. Positions 2-65, 162-522.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124751. 28 interactions.
IntActiQ9BQ87. 2 interactions.
STRINGi9606.ENSP00000328879.

PTM databases

iPTMnetiQ9BQ87.
PhosphoSiteiQ9BQ87.

Polymorphism and mutation databases

BioMutaiTBL1Y.
DMDMi23396873.

Proteomic databases

EPDiQ9BQ87.
MaxQBiQ9BQ87.
PaxDbiQ9BQ87.
PeptideAtlasiQ9BQ87.
PRIDEiQ9BQ87.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346432; ENSP00000328879; ENSG00000092377.
ENST00000355162; ENSP00000347289; ENSG00000092377.
ENST00000383032; ENSP00000372499; ENSG00000092377.
GeneIDi90665.
KEGGihsa:90665.
UCSCiuc004frb.3. human.

Organism-specific databases

CTDi90665.
GeneCardsiTBL1Y.
HGNCiHGNC:18502. TBL1Y.
HPAiHPA060073.
MIMi400033. gene.
neXtProtiNX_Q9BQ87.
PharmGKBiPA38564.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0273. Eukaryota.
ENOG410XRSY. LUCA.
GeneTreeiENSGT00750000117536.
HOGENOMiHOG000220902.
HOVERGENiHBG050240.
InParanoidiQ9BQ87.
KOiK04508.
OMAiENGAHEI.
OrthoDBiEOG79CXZ3.
PhylomeDBiQ9BQ87.
TreeFamiTF323190.

Enzyme and pathway databases

SignaLinkiQ9BQ87.

Miscellaneous databases

ChiTaRSiTBL1Y. human.
GenomeRNAii90665.
PROiQ9BQ87.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BQ87.
CleanExiHS_TBL1Y.
ExpressionAtlasiQ9BQ87. baseline and differential.
GenevisibleiQ9BQ87. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08513. LisH. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00667. LisH. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTBL1Y_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ87
Secondary accession number(s): A1L4B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.