Q9BQ87 (TBL1Y_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
F-box-like/WD repeat-containing protein TBL1Y

Alternative name(s):
Transducin beta-like protein 1Y
Transducin-beta-like protein 1, Y-linked

Gene names

Name:	TBL1Y
Synonyms:	TBL1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	522 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange By similarity.
Subunit structure	Probable component of the N-Cor repressor complex and some E3 ubiquitin ligase complex By similarity.
Subcellular location	Nucleus By similarity.
Tissue specificity	Fetal brain and prostate. Ref.1
Domain	The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes By similarity.
Sequence similarities	Belongs to the WD repeat EBI family. Contains 1 F-box-like domain. Contains 1 LisH domain. Contains 8 WD repeats.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Ubl conjugation pathway
Cellular component	Nucleus
Domain	Repeat WD repeat
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 522	522	F-box-like/WD repeat-containing protein TBL1Y		PRO_0000051264
Regions
	Domain	4 – 36	33	LisH
	Domain	41 – 86	46	F-box-like
	Repeat	177 – 216	40	WD 1
	Repeat	233 – 272	40	WD 2
	Repeat	274 – 313	40	WD 3
	Repeat	316 – 354	39	WD 4
	Repeat	357 – 396	40	WD 5
	Repeat	399 – 447	49	WD 6
	Repeat	450 – 489	40	WD 7
	Repeat	491 – 521	31	WD 8

Sequences

	Sequence		Length	Mass (Da)
	Q9BQ87 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 4E020216422442D8	FASTA	522	56,688
	10 20 30 40 50 60 MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPSALI SILQKGLQYV 70 80 90 100 110 120 EAEISINKDG TVFDSRPIES LSLIVAVIPD VVQMRQQAFG EKLTQQQASA AATEASAMAK 130 140 150 160 170 180 AATMTPAAIS QQNPPKNREA TVNGEENGAH EINNHSKPME IDGDVEIPPN KATVLRGHES 190 200 210 220 230 240 EVFICAWNPV SDLLASGSGD STARIWNLNE NSNGGSTQLV LRHCIREGGH DVPSNKDVTS 250 260 270 280 290 300 LDWNSDGTLL AMGSYDGFAR IWTENGNLAS TLGQHKGPIF ALKWNKKGNY VLSAGVDKTT 310 320 330 340 350 360 IIWDAHTGEA KQQFPFHSAP ALDVDWQNNM TFASCSTDMC IHVCRLGCDH PVKTFQGHTN 370 380 390 400 410 420 EVNAIKWDPS GMLLASCSDD MTLKIWSMKQ DACVHDLQAH SKEIYTIKWS PTGPATSNPN 430 440 450 460 470 480 SSIMLASASF DSTVRLWDVE QGVCTHTLMK HQEPVYSVAF SPDGKYLASG SFDKYVHIWN 490 500 510 520 TQSGSLVHSY QGTGGIFEVC WNARGDKVGA SASDGSVCVL DL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C. Nature 423:825-837(2003) [PubMed: 12815422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF332220 mRNA. Translation: AAK13472.1. AF332221 mRNA. Translation: AAK13473.1. AF332222 mRNA. Translation: AAK13474.1. CH471163 Genomic DNA. Translation: EAW59126.1. BC130471 mRNA. Translation: AAI30472.1. BC130473 mRNA. Translation: AAI30474.1.
IPI	IPI00020873.
RefSeq	NP_150600.1. NM_033284.1. NP_599020.1. NM_134258.1. NP_599021.1. NM_134259.1.
UniGene	Hs.664560.
3D structure databases
ProteinModelPortal	Q9BQ87.
SMR	Q9BQ87. Positions 2-65, 172-522.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BQ87.
PTM databases
PhosphoSite	Q9BQ87.
Polymorphism databases
DMDM	23396873.
Proteomic databases
PRIDE	Q9BQ87.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000346432; ENSP00000328879; ENSG00000092377. ENST00000355162; ENSP00000347289; ENSG00000092377. ENST00000383032; ENSP00000372499; ENSG00000092377.
GeneID	90665.
KEGG	hsa:90665.
UCSC	uc004frb.1. human.
Organism-specific databases
CTD	90665.
GeneCards	GC0YP006778.
HGNC	HGNC:18502. TBL1Y.
MIM	400033. gene.
neXtProt	NX_Q9BQ87.
PharmGKB	PA38564.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00550000074625.
HOGENOM	HBG717050.
HOVERGEN	HBG050240.
InParanoid	Q9BQ87.
OMA	ENGAHEI.
OrthoDB	EOG412M5M.
PhylomeDB	Q9BQ87.
Gene expression databases
ArrayExpress	Q9BQ87.
Bgee	Q9BQ87.
CleanEx	HS_TBL1Y.
Genevestigator	Q9BQ87.
GermOnline	ENSG00000092377. Homo sapiens.
Family and domain databases
InterPro	IPR020472. G-protein_beta_WD-40_rep. IPR006594. LisH_dimerisation. IPR013720. LisH_dimerisation_subgr. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 2 hits.
KO	K04508.
Pfam	PF08513. LisH. 1 hit. PF00400. WD40. 7 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00667. LisH. 1 hit. SM00320. WD40. 8 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS50896. LISH. 1 hit. PS00678. WD_REPEATS_1. 4 hits. PS50082. WD_REPEATS_2. 6 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	76909.
SOURCE	Search...

Entry information

Entry name

TBL1Y_HUMAN

Accession

Primary (citable) accession number: Q9BQ87
Secondary accession number(s): A1L4B3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.