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Protein

Protein CMSS1

Gene

CMSS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CMSS1
Alternative name(s):
Cms1 ribosomal small subunit homolog
Gene namesi
Name:CMSS1
Synonyms:C3orf26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28666. CMSS1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672387.

Polymorphism and mutation databases

BioMutaiCMSS1.
DMDMi215274008.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Protein CMSS1PRO_0000239014Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191PhosphoserineBy similarity
Modified residuei24 – 241PhosphoserineBy similarity
Modified residuei212 – 2121PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BQ75.
MaxQBiQ9BQ75.
PaxDbiQ9BQ75.
PRIDEiQ9BQ75.

PTM databases

iPTMnetiQ9BQ75.
PhosphoSiteiQ9BQ75.

Expressioni

Gene expression databases

BgeeiQ9BQ75.
CleanExiHS_C3orf26.
ExpressionAtlasiQ9BQ75. baseline and differential.
GenevisibleiQ9BQ75. HS.

Organism-specific databases

HPAiHPA042820.

Interactioni

Protein-protein interaction databases

BioGridi124045. 20 interactions.
IntActiQ9BQ75. 13 interactions.
MINTiMINT-4786845.
STRINGi9606.ENSP00000410396.

Structurei

3D structure databases

ProteinModelPortaliQ9BQ75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CMS1 family.Curated

Phylogenomic databases

eggNOGiKOG3089. Eukaryota.
ENOG410XPW6. LUCA.
GeneTreeiENSGT00390000006574.
HOGENOMiHOG000261668.
HOVERGENiHBG081007.
InParanoidiQ9BQ75.
OMAiCFLIQPK.
OrthoDBiEOG7VHT0S.
PhylomeDBiQ9BQ75.
TreeFamiTF329710.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR032704. Cms1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24030. PTHR24030. 1 hit.
PfamiPF14617. CMS1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BQ75-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADDLGDEWW ENQPTGAGSS PEASDGEGEG DTEVMQQETV PVPVPSEKTK
60 70 80 90 100
QPKECFLIQP KERKENTTKT RKRRKKKITD VLAKSEPKPG LPEDLQKLMK
110 120 130 140 150
DYYSSRRLVI ELEELNLPDS CFLKANDLTH SLSSYLKEIC PKWVKLRKNH
160 170 180 190 200
SEKKSVLMLI ICSSAVRALE LIRSMTAFRG DGKVIKLFAK HIKVQAQVKL
210 220 230 240 250
LEKRVVHLGV GTPGRIKELV KQGGLNLSPL KFLVFDWNWR DQKLRRMMDI
260 270
PEIRKEVFEL LEMGVLSLCK SESLKLGLF
Length:279
Mass (Da):31,884
Last modified:November 25, 2008 - v2
Checksum:iB0FE22D1A88CF1C9
GO
Isoform 2 (identifier: Q9BQ75-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MADDLGDEWWENQPTGAGSSP → MHG

Show »
Length:261
Mass (Da):29,964
Checksum:i0260020D28874C39
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751K → E in BAG62383 (PubMed:14702039).Curated
Sequence conflicti249 – 2502DI → GV in BAG62383 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti138 – 1381E → G.1 Publication
Corresponds to variant rs11537817 [ dbSNP | Ensembl ].
VAR_047645
Natural varianti166 – 1661V → I.
Corresponds to variant rs11537816 [ dbSNP | Ensembl ].
VAR_033658

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2121MADDL…AGSSP → MHG in isoform 2. 1 PublicationVSP_046688Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291392 mRNA. Translation: BAF84081.1.
AK300704 mRNA. Translation: BAG62383.1.
AK312483 mRNA. Translation: BAG35386.1.
AC024938 Genomic DNA. No translation available.
AC069222 Genomic DNA. No translation available.
AC117419 Genomic DNA. No translation available.
AC129803 Genomic DNA. No translation available.
AC130887 Genomic DNA. No translation available.
BC006475 mRNA. Translation: AAH06475.1.
BC006512 mRNA. Translation: AAH06512.1.
CCDSiCCDS2935.1. [Q9BQ75-1]
CCDS54618.1. [Q9BQ75-2]
RefSeqiNP_001161396.1. NM_001167924.1. [Q9BQ75-2]
NP_115735.2. NM_032359.3. [Q9BQ75-1]
UniGeneiHs.581320.

Genome annotation databases

EnsembliENST00000421999; ENSP00000410396; ENSG00000184220. [Q9BQ75-1]
ENST00000489081; ENSP00000419161; ENSG00000184220. [Q9BQ75-2]
GeneIDi84319.
KEGGihsa:84319.
UCSCiuc003dtl.4. human. [Q9BQ75-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291392 mRNA. Translation: BAF84081.1.
AK300704 mRNA. Translation: BAG62383.1.
AK312483 mRNA. Translation: BAG35386.1.
AC024938 Genomic DNA. No translation available.
AC069222 Genomic DNA. No translation available.
AC117419 Genomic DNA. No translation available.
AC129803 Genomic DNA. No translation available.
AC130887 Genomic DNA. No translation available.
BC006475 mRNA. Translation: AAH06475.1.
BC006512 mRNA. Translation: AAH06512.1.
CCDSiCCDS2935.1. [Q9BQ75-1]
CCDS54618.1. [Q9BQ75-2]
RefSeqiNP_001161396.1. NM_001167924.1. [Q9BQ75-2]
NP_115735.2. NM_032359.3. [Q9BQ75-1]
UniGeneiHs.581320.

3D structure databases

ProteinModelPortaliQ9BQ75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124045. 20 interactions.
IntActiQ9BQ75. 13 interactions.
MINTiMINT-4786845.
STRINGi9606.ENSP00000410396.

PTM databases

iPTMnetiQ9BQ75.
PhosphoSiteiQ9BQ75.

Polymorphism and mutation databases

BioMutaiCMSS1.
DMDMi215274008.

Proteomic databases

EPDiQ9BQ75.
MaxQBiQ9BQ75.
PaxDbiQ9BQ75.
PRIDEiQ9BQ75.

Protocols and materials databases

DNASUi84319.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000421999; ENSP00000410396; ENSG00000184220. [Q9BQ75-1]
ENST00000489081; ENSP00000419161; ENSG00000184220. [Q9BQ75-2]
GeneIDi84319.
KEGGihsa:84319.
UCSCiuc003dtl.4. human. [Q9BQ75-1]

Organism-specific databases

CTDi84319.
GeneCardsiCMSS1.
H-InvDBHIX0003504.
HGNCiHGNC:28666. CMSS1.
HPAiHPA042820.
neXtProtiNX_Q9BQ75.
PharmGKBiPA142672387.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3089. Eukaryota.
ENOG410XPW6. LUCA.
GeneTreeiENSGT00390000006574.
HOGENOMiHOG000261668.
HOVERGENiHBG081007.
InParanoidiQ9BQ75.
OMAiCFLIQPK.
OrthoDBiEOG7VHT0S.
PhylomeDBiQ9BQ75.
TreeFamiTF329710.

Miscellaneous databases

GenomeRNAii84319.
PROiQ9BQ75.

Gene expression databases

BgeeiQ9BQ75.
CleanExiHS_C3orf26.
ExpressionAtlasiQ9BQ75. baseline and differential.
GenevisibleiQ9BQ75. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR032704. Cms1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24030. PTHR24030. 1 hit.
PfamiPF14617. CMS1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Hippocampus and Skeletal muscle.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-138.
    Tissue: Lung.
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-212, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCMS1_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ75
Secondary accession number(s): A8K5S7, B4DUM1, E9PHS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 25, 2008
Last modified: June 8, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.