Q9BQ70 (TCF25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor 25
Short name=TCF-25

Alternative name(s):
Nuclear localized protein 1

Gene names

Name:	TCF25
Synonyms:	KIAA1049, NULP1
ORF Names:	FKSG26

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	676 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development. Ref.1
Subunit structure	Interacts with XIAP By similarity.
Subcellular location	Nucleus. Note: Some staining in the cytosol. Ref.1 Ref.5
Tissue specificity	In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart. Ref.1
Domain	The C-terminal region mediates transcriptional repression. Ref.1
Sequence similarities	Belongs to the TCF25 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Repressor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	heart development Non-traceable author statement Ref.1. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay Ref.1. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from direct assay. Source: HPA nucleolus Inferred from direct assay. Source: HPA
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SAT1	P21673	3	EBI-745182,EBI-711613

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 676	676	Transcription factor 25		PRO_0000087265
Amino acid modifications
	Modified residue	602	1	Phosphoserine Ref.6 Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Q9BQ70 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 6ECF8A1C78141296	FASTA	676	76,667
	10 20 30 40 50 60 MSRRALRRLR GEQRGQEPLG PGALHFDLRD DDDAEEEGPK RELGVRRPGG AGKEGVRVNN 70 80 90 100 110 120 RFELINIDDL EDDPVVNGER SGCALTDAVA PGNKGRGQRG NTESKTDGDD TETVPSEQSH 130 140 150 160 170 180 ASGKLRKKKK KQKNKKSSTG EASENGLEDI DRILERIEDS TGLNRPGPAP LSSRKHVLYV 190 200 210 220 230 240 EHRHLNPDTE LKRYFGARAI LGEQRPRQRQ RVYPKCTWLT TPKSTWPRYS KPGLSMRLLE 250 260 270 280 290 300 SKKGLSFFAF EHSEEYQQAQ HKFLVAVESM EPNNIVVLLQ TSPYHVDSLL QLSDACRFQE 310 320 330 340 350 360 DQEMARDLVE RALYSMECAF HPLFSLTSGA CRLDYRRPEN RSFYLALYKQ MSFLEKRGCP 370 380 390 400 410 420 RTALEYCKLI LSLEPDEDPL CMLLLIDHLA LRARNYEYLI RLFQEWEAHR NLSQLPNFAF 430 440 450 460 470 480 SVPLAYFLLS QQTDLPECEQ SSARQKASLL IQQALTMFPG VLLPLLESCS VRPDASVSSH 490 500 510 520 530 540 RFFGPNAEIS QPPALSQLVN LYLGRSHFLW KEPATMSWLE ENVHEVLQAV DAGDPAVEAC 550 560 570 580 590 600 ENRRKVLYQR APRNIHRHVI LSEIKEAVAA LPPDVTTQSV MGFDPLPPSD TIYSYVRPER 610 620 630 640 650 660 LSPISHGNTI ALFFRSLLPN YTMEGERPEE GVAGGLNRNQ GLNRLMLAVR DMMANFHLND 670 LEAPHEDDAE GEGEWD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"hnulp1, a basic helix-loop-helix protein with a novel transcriptional repressive domain, inhibits transcriptional activity of serum response factor." Cai Z., Wang Y., Yu W., Xiao J., Li Y., Liu L., Zhu C., Tan K., Deng Y., Yuan W., Liu M., Wu X. Biochem. Biophys. Res. Commun. 343:973-981(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DOMAIN.
[2]	"Characterization of FKSG26, a novel gene located on human chromosome 16q24.3." Wang Y.-G., Gong L. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Lymph and Muscle.
[4]	"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-676. Tissue: Brain.
[5]	"Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein." Steen H., Lindholm D. Biochem. Biophys. Res. Commun. 366:432-437(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-602, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-602, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ321703 mRNA. Translation: ABC55265.1. AF322111 mRNA. Translation: AAG50276.1. BC000959 mRNA. Translation: AAH00959.1. BC009349 mRNA. Translation: AAH09349.1. BC011884 mRNA. Translation: AAH11884.1. AB028972 mRNA. Translation: BAA83001.1.
IPI	IPI00007320.
RefSeq	NP_055787.1. NM_014972.2.
UniGene	Hs.415342.
3D structure databases
ProteinModelPortal	Q9BQ70.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BQ70. 3 interactions.
STRING	9606.ENSP00000263346.
PTM databases
PhosphoSite	Q9BQ70.
Polymorphism databases
DMDM	23396596.
Proteomic databases
PaxDb	Q9BQ70.
PRIDE	Q9BQ70.
Protocols and materials databases
DNASU	22980.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263346; ENSP00000263346; ENSG00000141002.
GeneID	22980.
KEGG	hsa:22980.
UCSC	uc002fpb.2. human.
Organism-specific databases
CTD	22980.
GeneCards	GC16P089939.
HGNC	HGNC:29181. TCF25.
HPA	HPA041699. HPA041786.
MIM	612326. gene.
neXtProt	NX_Q9BQ70.
PharmGKB	PA145007492.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG284902.
HOGENOM	HOG000047644.
HOVERGEN	HBG070024.
InParanoid	Q9BQ70.
OMA	GEQRPRQ.
OrthoDB	EOG46143F.
PhylomeDB	Q9BQ70.
Gene expression databases
ArrayExpress	Q9BQ70.
Bgee	Q9BQ70.
CleanEx	HS_TCF25.
Genevestigator	Q9BQ70.
GermOnline	ENSG00000141002. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.10. 1 hit.
InterPro	IPR006994. TCF25. IPR011990. TPR-like_helical. [Graphical view]
PANTHER	PTHR22684. PTHR22684. 1 hit.
Pfam	PF04910. Tcf25. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TCF25. human.
GenomeRNAi	22980.
NextBio	43803.
SOURCE	Search...

Entry information

Entry name

TCF25_HUMAN

Accession

Primary (citable) accession number: Q9BQ70
Secondary accession number(s): Q2MK75, Q9UPV3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.