Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor 25

Gene

TCF25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • heart development Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 25
Short name:
TCF-25
Alternative name(s):
Nuclear localized protein 1
Gene namesi
Name:TCF25
Synonyms:KIAA1049, NULP1
ORF Names:FKSG26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29181. TCF25.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22980.
OpenTargetsiENSG00000141002.
PharmGKBiPA145007492.

Polymorphism and mutation databases

BioMutaiTCF25.
DMDMi23396596.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000872651 – 676Transcription factor 25Add BLAST676

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei602PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BQ70.
MaxQBiQ9BQ70.
PaxDbiQ9BQ70.
PeptideAtlasiQ9BQ70.
PRIDEiQ9BQ70.

PTM databases

iPTMnetiQ9BQ70.
PhosphoSitePlusiQ9BQ70.

Expressioni

Tissue specificityi

In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart.1 Publication

Gene expression databases

BgeeiENSG00000141002.
CleanExiHS_TCF25.
ExpressionAtlasiQ9BQ70. baseline and differential.
GenevisibleiQ9BQ70. HS.

Organism-specific databases

HPAiHPA041699.
HPA041786.

Interactioni

Subunit structurei

Interacts with XIAP.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116629. 27 interactors.
IntActiQ9BQ70. 24 interactors.
MINTiMINT-3060374.
STRINGi9606.ENSP00000263346.

Structurei

3D structure databases

ProteinModelPortaliQ9BQ70.
SMRiQ9BQ70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The C-terminal region mediates transcriptional repression.1 Publication

Sequence similaritiesi

Belongs to the TCF25 family.Curated

Phylogenomic databases

eggNOGiKOG2422. Eukaryota.
ENOG410XQ1Q. LUCA.
GeneTreeiENSGT00390000005563.
HOGENOMiHOG000047644.
HOVERGENiHBG070024.
InParanoidiQ9BQ70.
OMAiLMFPGVL.
OrthoDBiEOG091G0HZK.
PhylomeDBiQ9BQ70.
TreeFamiTF106155.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR006994. TCF25.
IPR011990. TPR-like_helical_dom.
PANTHERiPTHR22684. PTHR22684. 1 hit.
PfamiView protein in Pfam
PF04910. Tcf25. 1 hit.
SUPFAMiSSF48452. SSF48452. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BQ70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRALRRLR GEQRGQEPLG PGALHFDLRD DDDAEEEGPK RELGVRRPGG
60 70 80 90 100
AGKEGVRVNN RFELINIDDL EDDPVVNGER SGCALTDAVA PGNKGRGQRG
110 120 130 140 150
NTESKTDGDD TETVPSEQSH ASGKLRKKKK KQKNKKSSTG EASENGLEDI
160 170 180 190 200
DRILERIEDS TGLNRPGPAP LSSRKHVLYV EHRHLNPDTE LKRYFGARAI
210 220 230 240 250
LGEQRPRQRQ RVYPKCTWLT TPKSTWPRYS KPGLSMRLLE SKKGLSFFAF
260 270 280 290 300
EHSEEYQQAQ HKFLVAVESM EPNNIVVLLQ TSPYHVDSLL QLSDACRFQE
310 320 330 340 350
DQEMARDLVE RALYSMECAF HPLFSLTSGA CRLDYRRPEN RSFYLALYKQ
360 370 380 390 400
MSFLEKRGCP RTALEYCKLI LSLEPDEDPL CMLLLIDHLA LRARNYEYLI
410 420 430 440 450
RLFQEWEAHR NLSQLPNFAF SVPLAYFLLS QQTDLPECEQ SSARQKASLL
460 470 480 490 500
IQQALTMFPG VLLPLLESCS VRPDASVSSH RFFGPNAEIS QPPALSQLVN
510 520 530 540 550
LYLGRSHFLW KEPATMSWLE ENVHEVLQAV DAGDPAVEAC ENRRKVLYQR
560 570 580 590 600
APRNIHRHVI LSEIKEAVAA LPPDVTTQSV MGFDPLPPSD TIYSYVRPER
610 620 630 640 650
LSPISHGNTI ALFFRSLLPN YTMEGERPEE GVAGGLNRNQ GLNRLMLAVR
660 670
DMMANFHLND LEAPHEDDAE GEGEWD
Length:676
Mass (Da):76,667
Last modified:June 1, 2001 - v1
Checksum:i6ECF8A1C78141296
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ321703 mRNA. Translation: ABC55265.1.
AF322111 mRNA. Translation: AAG50276.1.
BC000959 mRNA. Translation: AAH00959.1.
BC009349 mRNA. Translation: AAH09349.1.
BC011884 mRNA. Translation: AAH11884.1.
AB028972 mRNA. Translation: BAA83001.1.
CCDSiCCDS10987.1.
RefSeqiNP_055787.1. NM_014972.2.
UniGeneiHs.415342.

Genome annotation databases

EnsembliENST00000263346; ENSP00000263346; ENSG00000141002.
ENST00000640279; ENSP00000491638; ENSG00000141002.
GeneIDi22980.
KEGGihsa:22980.
UCSCiuc002fpb.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ321703 mRNA. Translation: ABC55265.1.
AF322111 mRNA. Translation: AAG50276.1.
BC000959 mRNA. Translation: AAH00959.1.
BC009349 mRNA. Translation: AAH09349.1.
BC011884 mRNA. Translation: AAH11884.1.
AB028972 mRNA. Translation: BAA83001.1.
CCDSiCCDS10987.1.
RefSeqiNP_055787.1. NM_014972.2.
UniGeneiHs.415342.

3D structure databases

ProteinModelPortaliQ9BQ70.
SMRiQ9BQ70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116629. 27 interactors.
IntActiQ9BQ70. 24 interactors.
MINTiMINT-3060374.
STRINGi9606.ENSP00000263346.

PTM databases

iPTMnetiQ9BQ70.
PhosphoSitePlusiQ9BQ70.

Polymorphism and mutation databases

BioMutaiTCF25.
DMDMi23396596.

Proteomic databases

EPDiQ9BQ70.
MaxQBiQ9BQ70.
PaxDbiQ9BQ70.
PeptideAtlasiQ9BQ70.
PRIDEiQ9BQ70.

Protocols and materials databases

DNASUi22980.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263346; ENSP00000263346; ENSG00000141002.
ENST00000640279; ENSP00000491638; ENSG00000141002.
GeneIDi22980.
KEGGihsa:22980.
UCSCiuc002fpb.3. human.

Organism-specific databases

CTDi22980.
DisGeNETi22980.
GeneCardsiTCF25.
HGNCiHGNC:29181. TCF25.
HPAiHPA041699.
HPA041786.
MIMi612326. gene.
neXtProtiNX_Q9BQ70.
OpenTargetsiENSG00000141002.
PharmGKBiPA145007492.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2422. Eukaryota.
ENOG410XQ1Q. LUCA.
GeneTreeiENSGT00390000005563.
HOGENOMiHOG000047644.
HOVERGENiHBG070024.
InParanoidiQ9BQ70.
OMAiLMFPGVL.
OrthoDBiEOG091G0HZK.
PhylomeDBiQ9BQ70.
TreeFamiTF106155.

Miscellaneous databases

ChiTaRSiTCF25. human.
GenomeRNAii22980.
PROiPR:Q9BQ70.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141002.
CleanExiHS_TCF25.
ExpressionAtlasiQ9BQ70. baseline and differential.
GenevisibleiQ9BQ70. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR006994. TCF25.
IPR011990. TPR-like_helical_dom.
PANTHERiPTHR22684. PTHR22684. 1 hit.
PfamiView protein in Pfam
PF04910. Tcf25. 1 hit.
SUPFAMiSSF48452. SSF48452. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTCF25_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ70
Secondary accession number(s): Q2MK75, Q9UPV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: June 7, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.