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Protein

Transcription factor 25

Gene

TCF25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  • heart development Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 25
Short name:
TCF-25
Alternative name(s):
Nuclear localized protein 1
Gene namesi
Name:TCF25
Synonyms:KIAA1049, NULP1
ORF Names:FKSG26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000141002.18
HGNCiHGNC:29181 TCF25
MIMi612326 gene
neXtProtiNX_Q9BQ70

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22980
OpenTargetsiENSG00000141002
PharmGKBiPA145007492

Polymorphism and mutation databases

BioMutaiTCF25
DMDMi23396596

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000872651 – 676Transcription factor 25Add BLAST676

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei602PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BQ70
MaxQBiQ9BQ70
PaxDbiQ9BQ70
PeptideAtlasiQ9BQ70
PRIDEiQ9BQ70

PTM databases

iPTMnetiQ9BQ70
PhosphoSitePlusiQ9BQ70

Expressioni

Tissue specificityi

In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart.1 Publication

Gene expression databases

BgeeiENSG00000141002
CleanExiHS_TCF25
ExpressionAtlasiQ9BQ70 baseline and differential
GenevisibleiQ9BQ70 HS

Organism-specific databases

HPAiHPA041699
HPA041786

Interactioni

Subunit structurei

Interacts with XIAP.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116629, 31 interactors
IntActiQ9BQ70, 22 interactors
MINTiQ9BQ70
STRINGi9606.ENSP00000263346

Structurei

3D structure databases

ProteinModelPortaliQ9BQ70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The C-terminal region mediates transcriptional repression.1 Publication

Sequence similaritiesi

Belongs to the TCF25 family.Curated

Phylogenomic databases

eggNOGiKOG2422 Eukaryota
ENOG410XQ1Q LUCA
GeneTreeiENSGT00390000005563
HOGENOMiHOG000047644
HOVERGENiHBG070024
InParanoidiQ9BQ70
OMAiRSKQFGW
OrthoDBiEOG091G0HZK
PhylomeDBiQ9BQ70
TreeFamiTF106155

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR006994 TCF25
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR22684 PTHR22684, 1 hit
PfamiView protein in Pfam
PF04910 Tcf25, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BQ70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRALRRLR GEQRGQEPLG PGALHFDLRD DDDAEEEGPK RELGVRRPGG
60 70 80 90 100
AGKEGVRVNN RFELINIDDL EDDPVVNGER SGCALTDAVA PGNKGRGQRG
110 120 130 140 150
NTESKTDGDD TETVPSEQSH ASGKLRKKKK KQKNKKSSTG EASENGLEDI
160 170 180 190 200
DRILERIEDS TGLNRPGPAP LSSRKHVLYV EHRHLNPDTE LKRYFGARAI
210 220 230 240 250
LGEQRPRQRQ RVYPKCTWLT TPKSTWPRYS KPGLSMRLLE SKKGLSFFAF
260 270 280 290 300
EHSEEYQQAQ HKFLVAVESM EPNNIVVLLQ TSPYHVDSLL QLSDACRFQE
310 320 330 340 350
DQEMARDLVE RALYSMECAF HPLFSLTSGA CRLDYRRPEN RSFYLALYKQ
360 370 380 390 400
MSFLEKRGCP RTALEYCKLI LSLEPDEDPL CMLLLIDHLA LRARNYEYLI
410 420 430 440 450
RLFQEWEAHR NLSQLPNFAF SVPLAYFLLS QQTDLPECEQ SSARQKASLL
460 470 480 490 500
IQQALTMFPG VLLPLLESCS VRPDASVSSH RFFGPNAEIS QPPALSQLVN
510 520 530 540 550
LYLGRSHFLW KEPATMSWLE ENVHEVLQAV DAGDPAVEAC ENRRKVLYQR
560 570 580 590 600
APRNIHRHVI LSEIKEAVAA LPPDVTTQSV MGFDPLPPSD TIYSYVRPER
610 620 630 640 650
LSPISHGNTI ALFFRSLLPN YTMEGERPEE GVAGGLNRNQ GLNRLMLAVR
660 670
DMMANFHLND LEAPHEDDAE GEGEWD
Length:676
Mass (Da):76,667
Last modified:June 1, 2001 - v1
Checksum:i6ECF8A1C78141296
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ321703 mRNA Translation: ABC55265.1
AF322111 mRNA Translation: AAG50276.1
BC000959 mRNA Translation: AAH00959.1
BC009349 mRNA Translation: AAH09349.1
BC011884 mRNA Translation: AAH11884.1
AB028972 mRNA Translation: BAA83001.1
CCDSiCCDS10987.1
RefSeqiNP_055787.1, NM_014972.2
UniGeneiHs.415342

Genome annotation databases

EnsembliENST00000263346; ENSP00000263346; ENSG00000141002
ENST00000640279; ENSP00000491638; ENSG00000141002
GeneIDi22980
KEGGihsa:22980
UCSCiuc002fpb.3 human

Similar proteinsi

Entry informationi

Entry nameiTCF25_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ70
Secondary accession number(s): Q2MK75, Q9UPV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health