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Q9BQ70 (TCF25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor 25

Short name=TCF-25
Alternative name(s):
Nuclear localized protein 1
Gene names
Name:TCF25
Synonyms:KIAA1049, NULP1
ORF Names:FKSG26
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length676 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development. Ref.1

Subunit structure

Interacts with XIAP By similarity.

Subcellular location

Nucleus. Note: Some staining in the cytosol. Ref.1 Ref.5

Tissue specificity

In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart. Ref.1

Domain

The C-terminal region mediates transcriptional repression. Ref.1

Sequence similarities

Belongs to the TCF25 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SAT1P216734EBI-745182,EBI-711613

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 676676Transcription factor 25
PRO_0000087265

Amino acid modifications

Modified residue6021Phosphoserine Ref.6 Ref.7

Sequences

Sequence LengthMass (Da)Tools
Q9BQ70 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 6ECF8A1C78141296

FASTA67676,667
        10         20         30         40         50         60 
MSRRALRRLR GEQRGQEPLG PGALHFDLRD DDDAEEEGPK RELGVRRPGG AGKEGVRVNN 

        70         80         90        100        110        120 
RFELINIDDL EDDPVVNGER SGCALTDAVA PGNKGRGQRG NTESKTDGDD TETVPSEQSH 

       130        140        150        160        170        180 
ASGKLRKKKK KQKNKKSSTG EASENGLEDI DRILERIEDS TGLNRPGPAP LSSRKHVLYV 

       190        200        210        220        230        240 
EHRHLNPDTE LKRYFGARAI LGEQRPRQRQ RVYPKCTWLT TPKSTWPRYS KPGLSMRLLE 

       250        260        270        280        290        300 
SKKGLSFFAF EHSEEYQQAQ HKFLVAVESM EPNNIVVLLQ TSPYHVDSLL QLSDACRFQE 

       310        320        330        340        350        360 
DQEMARDLVE RALYSMECAF HPLFSLTSGA CRLDYRRPEN RSFYLALYKQ MSFLEKRGCP 

       370        380        390        400        410        420 
RTALEYCKLI LSLEPDEDPL CMLLLIDHLA LRARNYEYLI RLFQEWEAHR NLSQLPNFAF 

       430        440        450        460        470        480 
SVPLAYFLLS QQTDLPECEQ SSARQKASLL IQQALTMFPG VLLPLLESCS VRPDASVSSH 

       490        500        510        520        530        540 
RFFGPNAEIS QPPALSQLVN LYLGRSHFLW KEPATMSWLE ENVHEVLQAV DAGDPAVEAC 

       550        560        570        580        590        600 
ENRRKVLYQR APRNIHRHVI LSEIKEAVAA LPPDVTTQSV MGFDPLPPSD TIYSYVRPER 

       610        620        630        640        650        660 
LSPISHGNTI ALFFRSLLPN YTMEGERPEE GVAGGLNRNQ GLNRLMLAVR DMMANFHLND 

       670 
LEAPHEDDAE GEGEWD 

« Hide

References

« Hide 'large scale' references
[1]"hnulp1, a basic helix-loop-helix protein with a novel transcriptional repressive domain, inhibits transcriptional activity of serum response factor."
Cai Z., Wang Y., Yu W., Xiao J., Li Y., Liu L., Zhu C., Tan K., Deng Y., Yuan W., Liu M., Wu X.
Biochem. Biophys. Res. Commun. 343:973-981(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DOMAIN.
[2]"Characterization of FKSG26, a novel gene located on human chromosome 16q24.3."
Wang Y.-G., Gong L.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Lymph and Muscle.
[4]"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-676.
Tissue: Brain.
[5]"Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein."
Steen H., Lindholm D.
Biochem. Biophys. Res. Commun. 366:432-437(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-602, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-602, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ321703 mRNA. Translation: ABC55265.1.
AF322111 mRNA. Translation: AAG50276.1.
BC000959 mRNA. Translation: AAH00959.1.
BC009349 mRNA. Translation: AAH09349.1.
BC011884 mRNA. Translation: AAH11884.1.
AB028972 mRNA. Translation: BAA83001.1.
CCDSCCDS10987.1.
RefSeqNP_055787.1. NM_014972.2.
UniGeneHs.415342.

3D structure databases

ProteinModelPortalQ9BQ70.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116629. 8 interactions.
IntActQ9BQ70. 5 interactions.
MINTMINT-3060374.
STRING9606.ENSP00000263346.

PTM databases

PhosphoSiteQ9BQ70.

Polymorphism databases

DMDM23396596.

Proteomic databases

MaxQBQ9BQ70.
PaxDbQ9BQ70.
PRIDEQ9BQ70.

Protocols and materials databases

DNASU22980.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263346; ENSP00000263346; ENSG00000141002.
GeneID22980.
KEGGhsa:22980.
UCSCuc002fpb.2. human.

Organism-specific databases

CTD22980.
GeneCardsGC16P089939.
HGNCHGNC:29181. TCF25.
HPAHPA041699.
HPA041786.
MIM612326. gene.
neXtProtNX_Q9BQ70.
PharmGKBPA145007492.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG284902.
HOGENOMHOG000047644.
HOVERGENHBG070024.
InParanoidQ9BQ70.
OMAMPLLDHC.
OrthoDBEOG7VMP5V.
PhylomeDBQ9BQ70.
TreeFamTF106155.

Gene expression databases

ArrayExpressQ9BQ70.
BgeeQ9BQ70.
CleanExHS_TCF25.
GenevestigatorQ9BQ70.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
InterProIPR006994. TCF25.
IPR011990. TPR-like_helical.
[Graphical view]
PANTHERPTHR22684. PTHR22684. 1 hit.
PfamPF04910. Tcf25. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTCF25. human.
GenomeRNAi22980.
NextBio43803.
PROQ9BQ70.
SOURCESearch...

Entry information

Entry nameTCF25_HUMAN
AccessionPrimary (citable) accession number: Q9BQ70
Secondary accession number(s): Q2MK75, Q9UPV3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM