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Q9BQ70

- TCF25_HUMAN

UniProt

Q9BQ70 - TCF25_HUMAN

Protein

Transcription factor 25

Gene

TCF25

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development.1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. heart development Source: UniProtKB
    2. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor 25
    Short name:
    TCF-25
    Alternative name(s):
    Nuclear localized protein 1
    Gene namesi
    Name:TCF25
    Synonyms:KIAA1049, NULP1
    ORF Names:FKSG26
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:29181. TCF25.

    Subcellular locationi

    Nucleus 2 Publications
    Note: Some staining in the cytosol.

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145007492.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 676676Transcription factor 25PRO_0000087265Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei602 – 6021Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BQ70.
    PaxDbiQ9BQ70.
    PRIDEiQ9BQ70.

    PTM databases

    PhosphoSiteiQ9BQ70.

    Expressioni

    Tissue specificityi

    In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart.1 Publication

    Gene expression databases

    ArrayExpressiQ9BQ70.
    BgeeiQ9BQ70.
    CleanExiHS_TCF25.
    GenevestigatoriQ9BQ70.

    Organism-specific databases

    HPAiHPA041699.
    HPA041786.

    Interactioni

    Subunit structurei

    Interacts with XIAP.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SAT1P216734EBI-745182,EBI-711613

    Protein-protein interaction databases

    BioGridi116629. 10 interactions.
    IntActiQ9BQ70. 7 interactions.
    MINTiMINT-3060374.
    STRINGi9606.ENSP00000263346.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BQ70.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The C-terminal region mediates transcriptional repression.1 Publication

    Sequence similaritiesi

    Belongs to the TCF25 family.Curated

    Phylogenomic databases

    eggNOGiNOG284902.
    HOGENOMiHOG000047644.
    HOVERGENiHBG070024.
    InParanoidiQ9BQ70.
    OMAiMPLLDHC.
    OrthoDBiEOG7VMP5V.
    PhylomeDBiQ9BQ70.
    TreeFamiTF106155.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR006994. TCF25.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PANTHERiPTHR22684. PTHR22684. 1 hit.
    PfamiPF04910. Tcf25. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BQ70-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRRALRRLR GEQRGQEPLG PGALHFDLRD DDDAEEEGPK RELGVRRPGG    50
    AGKEGVRVNN RFELINIDDL EDDPVVNGER SGCALTDAVA PGNKGRGQRG 100
    NTESKTDGDD TETVPSEQSH ASGKLRKKKK KQKNKKSSTG EASENGLEDI 150
    DRILERIEDS TGLNRPGPAP LSSRKHVLYV EHRHLNPDTE LKRYFGARAI 200
    LGEQRPRQRQ RVYPKCTWLT TPKSTWPRYS KPGLSMRLLE SKKGLSFFAF 250
    EHSEEYQQAQ HKFLVAVESM EPNNIVVLLQ TSPYHVDSLL QLSDACRFQE 300
    DQEMARDLVE RALYSMECAF HPLFSLTSGA CRLDYRRPEN RSFYLALYKQ 350
    MSFLEKRGCP RTALEYCKLI LSLEPDEDPL CMLLLIDHLA LRARNYEYLI 400
    RLFQEWEAHR NLSQLPNFAF SVPLAYFLLS QQTDLPECEQ SSARQKASLL 450
    IQQALTMFPG VLLPLLESCS VRPDASVSSH RFFGPNAEIS QPPALSQLVN 500
    LYLGRSHFLW KEPATMSWLE ENVHEVLQAV DAGDPAVEAC ENRRKVLYQR 550
    APRNIHRHVI LSEIKEAVAA LPPDVTTQSV MGFDPLPPSD TIYSYVRPER 600
    LSPISHGNTI ALFFRSLLPN YTMEGERPEE GVAGGLNRNQ GLNRLMLAVR 650
    DMMANFHLND LEAPHEDDAE GEGEWD 676
    Length:676
    Mass (Da):76,667
    Last modified:June 1, 2001 - v1
    Checksum:i6ECF8A1C78141296
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ321703 mRNA. Translation: ABC55265.1.
    AF322111 mRNA. Translation: AAG50276.1.
    BC000959 mRNA. Translation: AAH00959.1.
    BC009349 mRNA. Translation: AAH09349.1.
    BC011884 mRNA. Translation: AAH11884.1.
    AB028972 mRNA. Translation: BAA83001.1.
    CCDSiCCDS10987.1.
    RefSeqiNP_055787.1. NM_014972.2.
    UniGeneiHs.415342.

    Genome annotation databases

    EnsembliENST00000263346; ENSP00000263346; ENSG00000141002.
    GeneIDi22980.
    KEGGihsa:22980.
    UCSCiuc002fpb.2. human.

    Polymorphism databases

    DMDMi23396596.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ321703 mRNA. Translation: ABC55265.1 .
    AF322111 mRNA. Translation: AAG50276.1 .
    BC000959 mRNA. Translation: AAH00959.1 .
    BC009349 mRNA. Translation: AAH09349.1 .
    BC011884 mRNA. Translation: AAH11884.1 .
    AB028972 mRNA. Translation: BAA83001.1 .
    CCDSi CCDS10987.1.
    RefSeqi NP_055787.1. NM_014972.2.
    UniGenei Hs.415342.

    3D structure databases

    ProteinModelPortali Q9BQ70.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116629. 10 interactions.
    IntActi Q9BQ70. 7 interactions.
    MINTi MINT-3060374.
    STRINGi 9606.ENSP00000263346.

    PTM databases

    PhosphoSitei Q9BQ70.

    Polymorphism databases

    DMDMi 23396596.

    Proteomic databases

    MaxQBi Q9BQ70.
    PaxDbi Q9BQ70.
    PRIDEi Q9BQ70.

    Protocols and materials databases

    DNASUi 22980.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263346 ; ENSP00000263346 ; ENSG00000141002 .
    GeneIDi 22980.
    KEGGi hsa:22980.
    UCSCi uc002fpb.2. human.

    Organism-specific databases

    CTDi 22980.
    GeneCardsi GC16P089939.
    HGNCi HGNC:29181. TCF25.
    HPAi HPA041699.
    HPA041786.
    MIMi 612326. gene.
    neXtProti NX_Q9BQ70.
    PharmGKBi PA145007492.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284902.
    HOGENOMi HOG000047644.
    HOVERGENi HBG070024.
    InParanoidi Q9BQ70.
    OMAi MPLLDHC.
    OrthoDBi EOG7VMP5V.
    PhylomeDBi Q9BQ70.
    TreeFami TF106155.

    Miscellaneous databases

    ChiTaRSi TCF25. human.
    GenomeRNAii 22980.
    NextBioi 43803.
    PROi Q9BQ70.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BQ70.
    Bgeei Q9BQ70.
    CleanExi HS_TCF25.
    Genevestigatori Q9BQ70.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR006994. TCF25.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    PANTHERi PTHR22684. PTHR22684. 1 hit.
    Pfami PF04910. Tcf25. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "hnulp1, a basic helix-loop-helix protein with a novel transcriptional repressive domain, inhibits transcriptional activity of serum response factor."
      Cai Z., Wang Y., Yu W., Xiao J., Li Y., Liu L., Zhu C., Tan K., Deng Y., Yuan W., Liu M., Wu X.
      Biochem. Biophys. Res. Commun. 343:973-981(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DOMAIN.
    2. "Characterization of FKSG26, a novel gene located on human chromosome 16q24.3."
      Wang Y.-G., Gong L.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Lymph and Muscle.
    4. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-676.
      Tissue: Brain.
    5. "Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein."
      Steen H., Lindholm D.
      Biochem. Biophys. Res. Commun. 366:432-437(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-602, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-602, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTCF25_HUMAN
    AccessioniPrimary (citable) accession number: Q9BQ70
    Secondary accession number(s): Q2MK75, Q9UPV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3