SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9BQ70

- TCF25_HUMAN

UniProt

Q9BQ70 - TCF25_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Transcription factor 25
Gene
TCF25, KIAA1049, NULP1, FKSG26
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development.1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. heart development Source: UniProtKB
  2. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 25
Short name:
TCF-25
Alternative name(s):
Nuclear localized protein 1
Gene namesi
Name:TCF25
Synonyms:KIAA1049, NULP1
ORF Names:FKSG26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:29181. TCF25.

Subcellular locationi

Nucleus
Note: Some staining in the cytosol.2 Publications

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145007492.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 676676Transcription factor 25
PRO_0000087265Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei602 – 6021Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BQ70.
PaxDbiQ9BQ70.
PRIDEiQ9BQ70.

PTM databases

PhosphoSiteiQ9BQ70.

Expressioni

Tissue specificityi

In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart.1 Publication

Gene expression databases

ArrayExpressiQ9BQ70.
BgeeiQ9BQ70.
CleanExiHS_TCF25.
GenevestigatoriQ9BQ70.

Organism-specific databases

HPAiHPA041699.
HPA041786.

Interactioni

Subunit structurei

Interacts with XIAP By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
SAT1P216734EBI-745182,EBI-711613

Protein-protein interaction databases

BioGridi116629. 10 interactions.
IntActiQ9BQ70. 5 interactions.
MINTiMINT-3060374.
STRINGi9606.ENSP00000263346.

Structurei

3D structure databases

ProteinModelPortaliQ9BQ70.

Family & Domainsi

Domaini

The C-terminal region mediates transcriptional repression.1 Publication

Sequence similaritiesi

Belongs to the TCF25 family.

Phylogenomic databases

eggNOGiNOG284902.
HOGENOMiHOG000047644.
HOVERGENiHBG070024.
InParanoidiQ9BQ70.
OMAiMPLLDHC.
OrthoDBiEOG7VMP5V.
PhylomeDBiQ9BQ70.
TreeFamiTF106155.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006994. TCF25.
IPR011990. TPR-like_helical.
[Graphical view]
PANTHERiPTHR22684. PTHR22684. 1 hit.
PfamiPF04910. Tcf25. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BQ70-1 [UniParc]FASTAAdd to Basket

« Hide

MSRRALRRLR GEQRGQEPLG PGALHFDLRD DDDAEEEGPK RELGVRRPGG    50
AGKEGVRVNN RFELINIDDL EDDPVVNGER SGCALTDAVA PGNKGRGQRG 100
NTESKTDGDD TETVPSEQSH ASGKLRKKKK KQKNKKSSTG EASENGLEDI 150
DRILERIEDS TGLNRPGPAP LSSRKHVLYV EHRHLNPDTE LKRYFGARAI 200
LGEQRPRQRQ RVYPKCTWLT TPKSTWPRYS KPGLSMRLLE SKKGLSFFAF 250
EHSEEYQQAQ HKFLVAVESM EPNNIVVLLQ TSPYHVDSLL QLSDACRFQE 300
DQEMARDLVE RALYSMECAF HPLFSLTSGA CRLDYRRPEN RSFYLALYKQ 350
MSFLEKRGCP RTALEYCKLI LSLEPDEDPL CMLLLIDHLA LRARNYEYLI 400
RLFQEWEAHR NLSQLPNFAF SVPLAYFLLS QQTDLPECEQ SSARQKASLL 450
IQQALTMFPG VLLPLLESCS VRPDASVSSH RFFGPNAEIS QPPALSQLVN 500
LYLGRSHFLW KEPATMSWLE ENVHEVLQAV DAGDPAVEAC ENRRKVLYQR 550
APRNIHRHVI LSEIKEAVAA LPPDVTTQSV MGFDPLPPSD TIYSYVRPER 600
LSPISHGNTI ALFFRSLLPN YTMEGERPEE GVAGGLNRNQ GLNRLMLAVR 650
DMMANFHLND LEAPHEDDAE GEGEWD 676
Length:676
Mass (Da):76,667
Last modified:June 1, 2001 - v1
Checksum:i6ECF8A1C78141296
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ321703 mRNA. Translation: ABC55265.1.
AF322111 mRNA. Translation: AAG50276.1.
BC000959 mRNA. Translation: AAH00959.1.
BC009349 mRNA. Translation: AAH09349.1.
BC011884 mRNA. Translation: AAH11884.1.
AB028972 mRNA. Translation: BAA83001.1.
CCDSiCCDS10987.1.
RefSeqiNP_055787.1. NM_014972.2.
UniGeneiHs.415342.

Genome annotation databases

EnsembliENST00000263346; ENSP00000263346; ENSG00000141002.
GeneIDi22980.
KEGGihsa:22980.
UCSCiuc002fpb.2. human.

Polymorphism databases

DMDMi23396596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ321703 mRNA. Translation: ABC55265.1 .
AF322111 mRNA. Translation: AAG50276.1 .
BC000959 mRNA. Translation: AAH00959.1 .
BC009349 mRNA. Translation: AAH09349.1 .
BC011884 mRNA. Translation: AAH11884.1 .
AB028972 mRNA. Translation: BAA83001.1 .
CCDSi CCDS10987.1.
RefSeqi NP_055787.1. NM_014972.2.
UniGenei Hs.415342.

3D structure databases

ProteinModelPortali Q9BQ70.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116629. 10 interactions.
IntActi Q9BQ70. 5 interactions.
MINTi MINT-3060374.
STRINGi 9606.ENSP00000263346.

PTM databases

PhosphoSitei Q9BQ70.

Polymorphism databases

DMDMi 23396596.

Proteomic databases

MaxQBi Q9BQ70.
PaxDbi Q9BQ70.
PRIDEi Q9BQ70.

Protocols and materials databases

DNASUi 22980.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263346 ; ENSP00000263346 ; ENSG00000141002 .
GeneIDi 22980.
KEGGi hsa:22980.
UCSCi uc002fpb.2. human.

Organism-specific databases

CTDi 22980.
GeneCardsi GC16P089939.
HGNCi HGNC:29181. TCF25.
HPAi HPA041699.
HPA041786.
MIMi 612326. gene.
neXtProti NX_Q9BQ70.
PharmGKBi PA145007492.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284902.
HOGENOMi HOG000047644.
HOVERGENi HBG070024.
InParanoidi Q9BQ70.
OMAi MPLLDHC.
OrthoDBi EOG7VMP5V.
PhylomeDBi Q9BQ70.
TreeFami TF106155.

Miscellaneous databases

ChiTaRSi TCF25. human.
GenomeRNAii 22980.
NextBioi 43803.
PROi Q9BQ70.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BQ70.
Bgeei Q9BQ70.
CleanExi HS_TCF25.
Genevestigatori Q9BQ70.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR006994. TCF25.
IPR011990. TPR-like_helical.
[Graphical view ]
PANTHERi PTHR22684. PTHR22684. 1 hit.
Pfami PF04910. Tcf25. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "hnulp1, a basic helix-loop-helix protein with a novel transcriptional repressive domain, inhibits transcriptional activity of serum response factor."
    Cai Z., Wang Y., Yu W., Xiao J., Li Y., Liu L., Zhu C., Tan K., Deng Y., Yuan W., Liu M., Wu X.
    Biochem. Biophys. Res. Commun. 343:973-981(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DOMAIN.
  2. "Characterization of FKSG26, a novel gene located on human chromosome 16q24.3."
    Wang Y.-G., Gong L.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Lymph and Muscle.
  4. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-676.
    Tissue: Brain.
  5. "Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein."
    Steen H., Lindholm D.
    Biochem. Biophys. Res. Commun. 366:432-437(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-602, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-602, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTCF25_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ70
Secondary accession number(s): Q2MK75, Q9UPV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi