Reviewed,
UniProtKB/Swiss-Prot Q9BQ70 (TCF25_HUMAN)
Last modified
November 24, 2009.
Version 59.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Transcription factor 25 Alternative name(s): Nuclear localized protein 1 | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 676 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development. Ref.1 |
| Subunit structure | Interacts with XIAP By similarity. |
| Subcellular location | |
| Tissue specificity | In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart. Ref.1 |
| Domain | The C-terminal region mediates transcriptional repression. Ref.1 |
| Sequence similarities | Belongs to the TCF25 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Ligand | DNA-binding |
| Molecular function | Repressor |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | heart development Ref.1 Non-traceable author statement. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Ref.1Inferred from direct assay. Source: UniProtKB transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Ref.1 Inferred from direct assay. Source: UniProtKB |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct transcription factor activity Ref.1Inferred from direct assay. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "hnulp1, a basic helix-loop-helix protein with a novel transcriptional repressive domain, inhibits transcriptional activity of serum response factor." Cai Z., Wang Y., Yu W., Xiao J., Li Y., Liu L., Zhu C., Tan K., Deng Y., Yuan W., Liu M., Wu X. Biochem. Biophys. Res. Commun. 343:973-981(2006) [PubMed: 16574069] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DOMAIN. |
| [2] | "Characterization of FKSG26, a novel gene located on human chromosome 16q24.3." Wang Y.-G., Gong L. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Lymph and Muscle. |
| [4] | "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed: 10470851] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-676. Tissue: Brain. |
| [5] | "Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein." Steen H., Lindholm D. Biochem. Biophys. Res. Commun. 366:432-437(2008) [PubMed: 18068114] [Abstract] Cited for: SUBCELLULAR LOCATION. |
| [6] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-602, MASS SPECTROMETRY. |
| [7] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| DQ321703 mRNA. Translation: ABC55265.1. AF322111 mRNA. Translation: AAG50276.1. BC000959 mRNA. Translation: AAH00959.1. BC009349 mRNA. Translation: AAH09349.1. BC011884 mRNA. Translation: AAH11884.1. AB028972 mRNA. Translation: BAA83001.1. | |
| IPI | IPI00007320. |
| RefSeq | NP_055787.1. |
| UniGene | Hs.415342 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9BQ70. 2 interactions. |
| STRING | Q9BQ70. |
PTM databases | |
| PhosphoSite | Q9BQ70. |
Proteomic databases | |
| PRIDE | Q9BQ70. |
Genome annotation databases | |
| Ensembl | ENST00000263346; ENSP00000263346; ENSG00000141002; Homo sapiens. [Genome view] |
| GeneID | 22980. |
| KEGG | hsa:22980. |
| UCSC | uc002fpb.1. human. |
Organism-specific databases | |
| CTD | 22980. |
| GeneCards | GC16P088469. |
| HGNC | HGNC:29181. TCF25. |
| MIM | 612326. gene. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9BQ70. |
| HOVERGEN | Q9BQ70. |
| OMA | LGEQRPR |
| OrthoDB | EOG9N5ZH0 |
Gene expression databases | |
| ArrayExpress | Q9BQ70. |
| Bgee | Q9BQ70. |
| CleanEx | HS_TCF25. |
| Genevestigator | Q9BQ70. |
| GermOnline | ENSG00000141002. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR006994. bHLH_Nulp1. [Graphical view] |
| PANTHER | PTHR22684. bHLH_Nulp1. 1 hit. |
| Pfam | PF04910. DUF654. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 43803. |
| SOURCE | Search... |
Entry information
| Entry name | TCF25_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9BQ70 Secondary accession number(s): Q2MK75, Q9UPV3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


