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Protein

Transcription factor 25

Gene

TCF25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development.1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. heart development Source: UniProtKB
  2. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 25
Short name:
TCF-25
Alternative name(s):
Nuclear localized protein 1
Gene namesi
Name:TCF25
Synonyms:KIAA1049, NULP1
ORF Names:FKSG26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29181. TCF25.

Subcellular locationi

Nucleus 2 Publications
Note: Some staining in the cytosol.

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145007492.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 676676Transcription factor 25PRO_0000087265Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei602 – 6021Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BQ70.
PaxDbiQ9BQ70.
PRIDEiQ9BQ70.

PTM databases

PhosphoSiteiQ9BQ70.

Expressioni

Tissue specificityi

In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart.1 Publication

Gene expression databases

BgeeiQ9BQ70.
CleanExiHS_TCF25.
ExpressionAtlasiQ9BQ70. baseline and differential.
GenevestigatoriQ9BQ70.

Organism-specific databases

HPAiHPA041699.
HPA041786.

Interactioni

Subunit structurei

Interacts with XIAP.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SAT1P216734EBI-745182,EBI-711613

Protein-protein interaction databases

BioGridi116629. 17 interactions.
IntActiQ9BQ70. 7 interactions.
MINTiMINT-3060374.
STRINGi9606.ENSP00000263346.

Structurei

3D structure databases

ProteinModelPortaliQ9BQ70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The C-terminal region mediates transcriptional repression.1 Publication

Sequence similaritiesi

Belongs to the TCF25 family.Curated

Phylogenomic databases

eggNOGiNOG284902.
GeneTreeiENSGT00390000005563.
HOGENOMiHOG000047644.
HOVERGENiHBG070024.
InParanoidiQ9BQ70.
OMAiMPLLDHC.
OrthoDBiEOG7VMP5V.
PhylomeDBiQ9BQ70.
TreeFamiTF106155.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006994. TCF25.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR22684. PTHR22684. 1 hit.
PfamiPF04910. Tcf25. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BQ70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRALRRLR GEQRGQEPLG PGALHFDLRD DDDAEEEGPK RELGVRRPGG
60 70 80 90 100
AGKEGVRVNN RFELINIDDL EDDPVVNGER SGCALTDAVA PGNKGRGQRG
110 120 130 140 150
NTESKTDGDD TETVPSEQSH ASGKLRKKKK KQKNKKSSTG EASENGLEDI
160 170 180 190 200
DRILERIEDS TGLNRPGPAP LSSRKHVLYV EHRHLNPDTE LKRYFGARAI
210 220 230 240 250
LGEQRPRQRQ RVYPKCTWLT TPKSTWPRYS KPGLSMRLLE SKKGLSFFAF
260 270 280 290 300
EHSEEYQQAQ HKFLVAVESM EPNNIVVLLQ TSPYHVDSLL QLSDACRFQE
310 320 330 340 350
DQEMARDLVE RALYSMECAF HPLFSLTSGA CRLDYRRPEN RSFYLALYKQ
360 370 380 390 400
MSFLEKRGCP RTALEYCKLI LSLEPDEDPL CMLLLIDHLA LRARNYEYLI
410 420 430 440 450
RLFQEWEAHR NLSQLPNFAF SVPLAYFLLS QQTDLPECEQ SSARQKASLL
460 470 480 490 500
IQQALTMFPG VLLPLLESCS VRPDASVSSH RFFGPNAEIS QPPALSQLVN
510 520 530 540 550
LYLGRSHFLW KEPATMSWLE ENVHEVLQAV DAGDPAVEAC ENRRKVLYQR
560 570 580 590 600
APRNIHRHVI LSEIKEAVAA LPPDVTTQSV MGFDPLPPSD TIYSYVRPER
610 620 630 640 650
LSPISHGNTI ALFFRSLLPN YTMEGERPEE GVAGGLNRNQ GLNRLMLAVR
660 670
DMMANFHLND LEAPHEDDAE GEGEWD
Length:676
Mass (Da):76,667
Last modified:June 1, 2001 - v1
Checksum:i6ECF8A1C78141296
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ321703 mRNA. Translation: ABC55265.1.
AF322111 mRNA. Translation: AAG50276.1.
BC000959 mRNA. Translation: AAH00959.1.
BC009349 mRNA. Translation: AAH09349.1.
BC011884 mRNA. Translation: AAH11884.1.
AB028972 mRNA. Translation: BAA83001.1.
CCDSiCCDS10987.1.
RefSeqiNP_055787.1. NM_014972.2.
UniGeneiHs.415342.

Genome annotation databases

EnsembliENST00000263346; ENSP00000263346; ENSG00000141002.
GeneIDi22980.
KEGGihsa:22980.
UCSCiuc002fpb.2. human.

Polymorphism databases

DMDMi23396596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ321703 mRNA. Translation: ABC55265.1.
AF322111 mRNA. Translation: AAG50276.1.
BC000959 mRNA. Translation: AAH00959.1.
BC009349 mRNA. Translation: AAH09349.1.
BC011884 mRNA. Translation: AAH11884.1.
AB028972 mRNA. Translation: BAA83001.1.
CCDSiCCDS10987.1.
RefSeqiNP_055787.1. NM_014972.2.
UniGeneiHs.415342.

3D structure databases

ProteinModelPortaliQ9BQ70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116629. 17 interactions.
IntActiQ9BQ70. 7 interactions.
MINTiMINT-3060374.
STRINGi9606.ENSP00000263346.

PTM databases

PhosphoSiteiQ9BQ70.

Polymorphism databases

DMDMi23396596.

Proteomic databases

MaxQBiQ9BQ70.
PaxDbiQ9BQ70.
PRIDEiQ9BQ70.

Protocols and materials databases

DNASUi22980.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263346; ENSP00000263346; ENSG00000141002.
GeneIDi22980.
KEGGihsa:22980.
UCSCiuc002fpb.2. human.

Organism-specific databases

CTDi22980.
GeneCardsiGC16P089939.
HGNCiHGNC:29181. TCF25.
HPAiHPA041699.
HPA041786.
MIMi612326. gene.
neXtProtiNX_Q9BQ70.
PharmGKBiPA145007492.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG284902.
GeneTreeiENSGT00390000005563.
HOGENOMiHOG000047644.
HOVERGENiHBG070024.
InParanoidiQ9BQ70.
OMAiMPLLDHC.
OrthoDBiEOG7VMP5V.
PhylomeDBiQ9BQ70.
TreeFamiTF106155.

Miscellaneous databases

ChiTaRSiTCF25. human.
GenomeRNAii22980.
NextBioi43803.
PROiQ9BQ70.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BQ70.
CleanExiHS_TCF25.
ExpressionAtlasiQ9BQ70. baseline and differential.
GenevestigatoriQ9BQ70.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006994. TCF25.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR22684. PTHR22684. 1 hit.
PfamiPF04910. Tcf25. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "hnulp1, a basic helix-loop-helix protein with a novel transcriptional repressive domain, inhibits transcriptional activity of serum response factor."
    Cai Z., Wang Y., Yu W., Xiao J., Li Y., Liu L., Zhu C., Tan K., Deng Y., Yuan W., Liu M., Wu X.
    Biochem. Biophys. Res. Commun. 343:973-981(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DOMAIN.
  2. "Characterization of FKSG26, a novel gene located on human chromosome 16q24.3."
    Wang Y.-G., Gong L.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Lymph and Muscle.
  4. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-676.
    Tissue: Brain.
  5. "Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein."
    Steen H., Lindholm D.
    Biochem. Biophys. Res. Commun. 366:432-437(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-602, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-602, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTCF25_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ70
Secondary accession number(s): Q2MK75, Q9UPV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: March 4, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.