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Protein

Glutamate-rich WD repeat-containing protein 1

Gene

GRWD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725).1 Publication

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • DNA replication origin binding Source: UniProtKB
  • histone binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • DNA replication Source: UniProtKB
  • nucleosome assembly Source: UniProtKB
  • nucleosome disassembly Source: UniProtKB

Keywordsi

Biological processDNA replication

Enzyme and pathway databases

SignaLinkiQ9BQ67

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-rich WD repeat-containing protein 1
Gene namesi
Name:GRWD1
Synonyms:GRWD, KIAA1942, WDR28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105447.12
HGNCiHGNC:21270 GRWD1
MIMi610597 gene
neXtProtiNX_Q9BQ67

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105447
PharmGKBiPA134897548

Polymorphism and mutation databases

BioMutaiGRWD1
DMDMi18202731

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510111 – 446Glutamate-rich WD repeat-containing protein 1Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphothreonineCombined sources1
Modified residuei119PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BQ67
MaxQBiQ9BQ67
PaxDbiQ9BQ67
PeptideAtlasiQ9BQ67
PRIDEiQ9BQ67

2D gel databases

SWISS-2DPAGEiQ9BQ67

PTM databases

iPTMnetiQ9BQ67
PhosphoSitePlusiQ9BQ67
SwissPalmiQ9BQ67

Expressioni

Inductioni

Induced by E2F transcription factors (PubMed:14990995).1 Publication

Gene expression databases

BgeeiENSG00000105447
CleanExiHS_GRWD1
ExpressionAtlasiQ9BQ67 baseline and differential
GenevisibleiQ9BQ67 HS

Organism-specific databases

HPAiHPA042643
HPA055680

Interactioni

Subunit structurei

Interacts with METTL18 (PubMed:23349634). Interacts with CDT1; origin binding of GRWD1 is dependent on CDT1 (PubMed:25990725). Interacts with CDC6; origin binding of GRWD1 is dependent on CDC6 (PubMed:25990725). Binds to histone H2A-H2B and H3-H4 complexes (PubMed:25990725).2 Publications

GO - Molecular functioni

  • histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi12375144 interactors.
CORUMiQ9BQ67
IntActiQ9BQ67 20 interactors.
MINTiQ9BQ67
STRINGi9606.ENSP00000253237

Structurei

3D structure databases

ProteinModelPortaliQ9BQ67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati54 – 110WD 1Add BLAST57
Repeati163 – 204WD 2Add BLAST42
Repeati205 – 250WD 3Add BLAST46
Repeati251 – 297WD 4Add BLAST47
Repeati298 – 343WD 5Add BLAST46
Repeati344 – 405WD 6Add BLAST62
Repeati406 – 442WD 7Add BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi123 – 136Asp/Glu-rich (acidic)Add BLAST14

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0302 Eukaryota
ENOG410XPDB LUCA
GeneTreeiENSGT00550000075124
HOGENOMiHOG000036730
HOVERGENiHBG051847
InParanoidiQ9BQ67
KOiK14848
OMAiCLSFDII
OrthoDBiEOG091G07FI
PhylomeDBiQ9BQ67
TreeFamiTF312982

Family and domain databases

Gene3Di2.130.10.101 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR022052 Histone-bd_RBBP4_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12265 CAF1C_H4-bd, 1 hit
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BQ67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARKGRRRT CETGEPMEAE SGDTSSEGPA QVYLPGRGPP LREGEELVMD
60 70 80 90 100
EEAYVLYHRA QTGAPCLSFD IVRDHLGDNR TELPLTLYLC AGTQAESAQS
110 120 130 140 150
NRLMMLRMHN LHGTKPPPSE GSDEEEEEED EEDEEERKPQ LELAMVPHYG
160 170 180 190 200
GINRVRVSWL GEEPVAGVWS EKGQVEVFAL RRLLQVVEEP QALAAFLRDE
210 220 230 240 250
QAQMKPIFSF AGHMGEGFAL DWSPRVTGRL LTGDCQKNIH LWTPTDGGSW
260 270 280 290 300
HVDQRPFVGH TRSVEDLQWS PTENTVFASC SADASIRIWD IRAAPSKACM
310 320 330 340 350
LTTATAHDGD VNVISWSRRE PFLLSGGDDG ALKIWDLRQF KSGSPVATFK
360 370 380 390 400
QHVAPVTSVE WHPQDSGVFA ASGADHQITQ WDLAVERDPE AGDVEADPGL
410 420 430 440
ADLPQQLLFV HQGETELKEL HWHPQCPGLL VSTALSGFTI FRTISV
Length:446
Mass (Da):49,419
Last modified:June 1, 2001 - v1
Checksum:i748CA005313FF8A8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046334319R → Q1 PublicationCorresponds to variant dbSNP:rs2302951Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337808 mRNA Translation: AAK17998.1
EF011614 mRNA Translation: ABK41104.1
AC008403 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52347.1
BC002440 mRNA Translation: AAH02440.1
AB075822 mRNA Translation: BAB85528.1
CCDSiCCDS12720.1
RefSeqiNP_113673.3, NM_031485.3
UniGeneiHs.400625

Genome annotation databases

EnsembliENST00000253237; ENSP00000253237; ENSG00000105447
GeneIDi83743
KEGGihsa:83743
UCSCiuc002pjd.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGRWD1_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ67
Secondary accession number(s): A0MNN5, Q8TF59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome