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Protein

Glutamate-rich WD repeat-containing protein 1

Gene

GRWD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9BQ67.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-rich WD repeat-containing protein 1
Gene namesi
Name:GRWD1
Synonyms:GRWD, KIAA1942, WDR28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:21270. GRWD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134897548.

Polymorphism and mutation databases

BioMutaiGRWD1.
DMDMi18202731.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Glutamate-rich WD repeat-containing protein 1PRO_0000051011Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101PhosphothreonineCombined sources
Modified residuei119 – 1191PhosphoserineCombined sources
Modified residuei122 – 1221PhosphoserineCombined sources
Modified residuei344 – 3441PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BQ67.
MaxQBiQ9BQ67.
PaxDbiQ9BQ67.
PeptideAtlasiQ9BQ67.
PRIDEiQ9BQ67.

2D gel databases

SWISS-2DPAGEQ9BQ67.

PTM databases

iPTMnetiQ9BQ67.
PhosphoSiteiQ9BQ67.
SwissPalmiQ9BQ67.

Expressioni

Gene expression databases

BgeeiENSG00000105447.
CleanExiHS_GRWD1.
ExpressionAtlasiQ9BQ67. baseline and differential.
GenevisibleiQ9BQ67. HS.

Organism-specific databases

HPAiHPA042643.
HPA055680.

Interactioni

Subunit structurei

Interacts with METTL18.1 Publication

Protein-protein interaction databases

BioGridi123751. 41 interactions.
IntActiQ9BQ67. 17 interactions.
MINTiMINT-1148872.
STRINGi9606.ENSP00000253237.

Structurei

3D structure databases

ProteinModelPortaliQ9BQ67.
SMRiQ9BQ67. Positions 53-88, 168-434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati54 – 11057WD 1Add
BLAST
Repeati163 – 20442WD 2Add
BLAST
Repeati205 – 25046WD 3Add
BLAST
Repeati251 – 29747WD 4Add
BLAST
Repeati298 – 34346WD 5Add
BLAST
Repeati344 – 40562WD 6Add
BLAST
Repeati406 – 44237WD 7Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi123 – 13614Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0302. Eukaryota.
ENOG410XPDB. LUCA.
GeneTreeiENSGT00550000075124.
HOGENOMiHOG000036730.
HOVERGENiHBG051847.
InParanoidiQ9BQ67.
KOiK14848.
OMAiIEWHPTE.
OrthoDBiEOG091G07FI.
PhylomeDBiQ9BQ67.
TreeFamiTF312982.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR022052. Histone-bd_RBBP4_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12265. CAF1C_H4-bd. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BQ67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARKGRRRT CETGEPMEAE SGDTSSEGPA QVYLPGRGPP LREGEELVMD
60 70 80 90 100
EEAYVLYHRA QTGAPCLSFD IVRDHLGDNR TELPLTLYLC AGTQAESAQS
110 120 130 140 150
NRLMMLRMHN LHGTKPPPSE GSDEEEEEED EEDEEERKPQ LELAMVPHYG
160 170 180 190 200
GINRVRVSWL GEEPVAGVWS EKGQVEVFAL RRLLQVVEEP QALAAFLRDE
210 220 230 240 250
QAQMKPIFSF AGHMGEGFAL DWSPRVTGRL LTGDCQKNIH LWTPTDGGSW
260 270 280 290 300
HVDQRPFVGH TRSVEDLQWS PTENTVFASC SADASIRIWD IRAAPSKACM
310 320 330 340 350
LTTATAHDGD VNVISWSRRE PFLLSGGDDG ALKIWDLRQF KSGSPVATFK
360 370 380 390 400
QHVAPVTSVE WHPQDSGVFA ASGADHQITQ WDLAVERDPE AGDVEADPGL
410 420 430 440
ADLPQQLLFV HQGETELKEL HWHPQCPGLL VSTALSGFTI FRTISV
Length:446
Mass (Da):49,419
Last modified:June 1, 2001 - v1
Checksum:i748CA005313FF8A8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti319 – 3191R → Q.1 Publication
Corresponds to variant rs2302951 [ dbSNP | Ensembl ].
VAR_046334

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337808 mRNA. Translation: AAK17998.1.
BC002440 mRNA. Translation: AAH02440.1.
AB075822 mRNA. Translation: BAB85528.1.
CCDSiCCDS12720.1.
RefSeqiNP_113673.3. NM_031485.3.
UniGeneiHs.400625.

Genome annotation databases

EnsembliENST00000253237; ENSP00000253237; ENSG00000105447.
GeneIDi83743.
KEGGihsa:83743.
UCSCiuc002pjd.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337808 mRNA. Translation: AAK17998.1.
BC002440 mRNA. Translation: AAH02440.1.
AB075822 mRNA. Translation: BAB85528.1.
CCDSiCCDS12720.1.
RefSeqiNP_113673.3. NM_031485.3.
UniGeneiHs.400625.

3D structure databases

ProteinModelPortaliQ9BQ67.
SMRiQ9BQ67. Positions 53-88, 168-434.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123751. 41 interactions.
IntActiQ9BQ67. 17 interactions.
MINTiMINT-1148872.
STRINGi9606.ENSP00000253237.

PTM databases

iPTMnetiQ9BQ67.
PhosphoSiteiQ9BQ67.
SwissPalmiQ9BQ67.

Polymorphism and mutation databases

BioMutaiGRWD1.
DMDMi18202731.

2D gel databases

SWISS-2DPAGEQ9BQ67.

Proteomic databases

EPDiQ9BQ67.
MaxQBiQ9BQ67.
PaxDbiQ9BQ67.
PeptideAtlasiQ9BQ67.
PRIDEiQ9BQ67.

Protocols and materials databases

DNASUi83743.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253237; ENSP00000253237; ENSG00000105447.
GeneIDi83743.
KEGGihsa:83743.
UCSCiuc002pjd.3. human.

Organism-specific databases

CTDi83743.
GeneCardsiGRWD1.
H-InvDBHIX0080107.
HGNCiHGNC:21270. GRWD1.
HPAiHPA042643.
HPA055680.
MIMi610597. gene.
neXtProtiNX_Q9BQ67.
PharmGKBiPA134897548.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0302. Eukaryota.
ENOG410XPDB. LUCA.
GeneTreeiENSGT00550000075124.
HOGENOMiHOG000036730.
HOVERGENiHBG051847.
InParanoidiQ9BQ67.
KOiK14848.
OMAiIEWHPTE.
OrthoDBiEOG091G07FI.
PhylomeDBiQ9BQ67.
TreeFamiTF312982.

Enzyme and pathway databases

SignaLinkiQ9BQ67.

Miscellaneous databases

GeneWikiiGRWD1.
GenomeRNAii83743.
PROiQ9BQ67.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105447.
CleanExiHS_GRWD1.
ExpressionAtlasiQ9BQ67. baseline and differential.
GenevisibleiQ9BQ67. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR022052. Histone-bd_RBBP4_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12265. CAF1C_H4-bd. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRWD1_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ67
Secondary accession number(s): Q8TF59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.