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Q9BQ65

- USB1_HUMAN

UniProt

Q9BQ65 - USB1_HUMAN

Protein

U6 snRNA phosphodiesterase

Gene

USB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.2 PublicationsUniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei120 – 1201Proton donor/acceptor1 Publication
    Active sitei208 – 2081Proton donor/acceptor1 Publication

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: UniProtKB

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. RNA phosphodiester bond hydrolysis, exonucleolytic Source: GOC
    3. RNA splicing Source: UniProtKB
    4. U6 snRNA 3'-end processing Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Nuclease

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U6 snRNA phosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
    Short name:
    hUsb1
    Gene namesi
    Name:USB1UniRule annotation
    Synonyms:C16orf57
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:25792. USB1.

    Subcellular locationi

    Nucleus 1 PublicationUniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Poikiloderma with neutropenia (PN) [MIM:604173]: A genodermatosis characterized by poikiloderma, pachyonychia and chronic neutropenia. The disorder starts as a papular erythematous rash on the limbs during the first year of life. It gradually spreads centripetally and, as the papular rash resolves, hypo- and hyperpigmentation result, with development of telangiectasias. Another skin manifestation is pachyonychia, but alopecia and leukoplakia are distinctively absent. Patients have recurrent pneumonias that usually result in reactive airway disease and/or chronic cough. One of the most important extracutaneous symptoms is an increased susceptibility to infections, mainly affecting the respiratory system, primarily due to a chronic neutropenia and to neutrophil functional defects. Bone marrow abnormalities account for neutropenia and may evolve into myelodysplasia associated with the risk of leukemic transformation. Poikiloderma with neutropenia shows phenotypic overlap with Rothmund-Thomson syndrome.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi120 – 1201H → A: Abolishes exoribonuclease activity. 1 Publication
    Mutagenesisi208 – 2081H → A: Abolishes exoribonuclease activity. No rescue of the molecular phenotype caused by USB1 depletion. 2 Publications

    Organism-specific databases

    MIMi604173. phenotype.
    Orphaneti1775. Dyskeratosis congenita.
    221046. Poikiloderma with neutropenia.
    PharmGKBiPA143485394.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265U6 snRNA phosphodiesterasePRO_0000274391Add
    BLAST

    Proteomic databases

    MaxQBiQ9BQ65.
    PaxDbiQ9BQ65.
    PRIDEiQ9BQ65.

    PTM databases

    PhosphoSiteiQ9BQ65.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BQ65.
    BgeeiQ9BQ65.
    CleanExiHS_C16orf57.
    GenevestigatoriQ9BQ65.

    Organism-specific databases

    HPAiHPA041791.

    Interactioni

    Protein-protein interaction databases

    BioGridi122778. 7 interactions.
    IntActiQ9BQ65. 2 interactions.
    MINTiMINT-1184765.
    STRINGi9606.ENSP00000219281.

    Structurei

    Secondary structure

    1
    265
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi80 – 8910
    Helixi93 – 10715
    Beta strandi117 – 1226
    Beta strandi127 – 1304
    Helixi131 – 1333
    Helixi134 – 14512
    Beta strandi155 – 1628
    Beta strandi166 – 17510
    Helixi179 – 19517
    Beta strandi208 – 2169
    Helixi219 – 2224
    Helixi225 – 23511
    Helixi241 – 2444
    Beta strandi250 – 2556
    Beta strandi258 – 2636

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4H7WX-ray1.10A73-265[»]
    ProteinModelPortaliQ9BQ65.
    SMRiQ9BQ65. Positions 79-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the USB1 family.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG251744.
    HOGENOMiHOG000213585.
    HOVERGENiHBG081315.
    InParanoidiQ9BQ65.
    OMAiHHWIQPF.
    PhylomeDBiQ9BQ65.
    TreeFamiTF324364.

    Family and domain databases

    HAMAPiMF_03040. USB1.
    InterProiIPR027521. Usb1.
    [Graphical view]
    PANTHERiPTHR13522. PTHR13522. 1 hit.
    PfamiPF09749. HVSL. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BQ65-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSAAPLVGYS SSGSEDESED GMRTRPGDGS HRRGQSPLPR QRFPVPDSVL    50
    NMFPGTEEGP EDDSTKHGGR VRTFPHERGN WATHVYVPYE AKEEFLDLLD 100
    VLLPHAQTYV PRLVRMKVFH LSLSQSVVLR HHWILPFVQA LKARMTSFHR 150
    FFFTANQVKI YTNQEKTRTF IGLEVTSGHA QFLDLVSEVD RVMEEFNLTT 200
    FYQDPSFHLS LAWCVGDARL QLEGQCLQEL QAIVDGFEDA EVLLRVHTEQ 250
    VRCKSGNKFF SMPLK 265
    Length:265
    Mass (Da):30,268
    Last modified:June 1, 2001 - v1
    Checksum:i75D8BF51DF8D353D
    GO
    Isoform 2 (identifier: Q9BQ65-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         150-167: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:247
    Mass (Da):28,051
    Checksum:iE2A5B443D8385DF4
    GO
    Isoform 3 (identifier: Q9BQ65-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         150-265: RFFFTANQVK...GNKFFSMPLK → SPHPGPHCLI...LRQEPGSQTR

    Note: No experimental confirmation available.

    Show »
    Length:186
    Mass (Da):20,802
    Checksum:iB319207B0717EF30
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti89 – 891Y → C in AAH10099. (PubMed:15489334)Curated
    Sequence conflicti209 – 2091L → P in BAB14469. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti115 – 1151R → K.
    Corresponds to variant rs35025252 [ dbSNP | Ensembl ].
    VAR_053822
    Natural varianti250 – 2501Q → E.
    Corresponds to variant rs16959641 [ dbSNP | Ensembl ].
    VAR_030277

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei150 – 265116RFFFT…SMPLK → SPHPGPHCLIGTKDAPVTQE IPKDLGALRQEPGSQTR in isoform 3. 1 PublicationVSP_042936Add
    BLAST
    Alternative sequencei150 – 16718Missing in isoform 2. 1 PublicationVSP_042878Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023216 mRNA. Translation: BAB14469.1.
    AK301494 mRNA. Translation: BAG63005.1.
    AK303121 mRNA. Translation: BAG64227.1.
    AC010543 Genomic DNA. No translation available.
    AC012182 Genomic DNA. No translation available.
    BC004415 mRNA. Translation: AAH04415.1.
    BC006291 mRNA. Translation: AAH06291.1.
    BC007774 mRNA. Translation: AAH07774.1.
    BC010099 mRNA. Translation: AAH10099.1.
    BC021554 mRNA. Translation: AAH21554.1.
    CCDSiCCDS10791.1. [Q9BQ65-1]
    CCDS55997.1. [Q9BQ65-3]
    CCDS55998.1. [Q9BQ65-2]
    RefSeqiNP_001182231.1. NM_001195302.1. [Q9BQ65-2]
    NP_001191840.1. NM_001204911.1. [Q9BQ65-3]
    NP_078874.2. NM_024598.3. [Q9BQ65-1]
    UniGeneiHs.408702.

    Genome annotation databases

    EnsembliENST00000219281; ENSP00000219281; ENSG00000103005. [Q9BQ65-1]
    ENST00000423271; ENSP00000409792; ENSG00000103005. [Q9BQ65-3]
    ENST00000539737; ENSP00000446143; ENSG00000103005. [Q9BQ65-2]
    GeneIDi79650.
    KEGGihsa:79650.
    UCSCiuc002emz.3. human. [Q9BQ65-1]
    uc010via.2. human. [Q9BQ65-3]
    uc010vib.2. human. [Q9BQ65-2]

    Polymorphism databases

    DMDMi74732815.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023216 mRNA. Translation: BAB14469.1 .
    AK301494 mRNA. Translation: BAG63005.1 .
    AK303121 mRNA. Translation: BAG64227.1 .
    AC010543 Genomic DNA. No translation available.
    AC012182 Genomic DNA. No translation available.
    BC004415 mRNA. Translation: AAH04415.1 .
    BC006291 mRNA. Translation: AAH06291.1 .
    BC007774 mRNA. Translation: AAH07774.1 .
    BC010099 mRNA. Translation: AAH10099.1 .
    BC021554 mRNA. Translation: AAH21554.1 .
    CCDSi CCDS10791.1. [Q9BQ65-1 ]
    CCDS55997.1. [Q9BQ65-3 ]
    CCDS55998.1. [Q9BQ65-2 ]
    RefSeqi NP_001182231.1. NM_001195302.1. [Q9BQ65-2 ]
    NP_001191840.1. NM_001204911.1. [Q9BQ65-3 ]
    NP_078874.2. NM_024598.3. [Q9BQ65-1 ]
    UniGenei Hs.408702.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4H7W X-ray 1.10 A 73-265 [» ]
    ProteinModelPortali Q9BQ65.
    SMRi Q9BQ65. Positions 79-265.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122778. 7 interactions.
    IntActi Q9BQ65. 2 interactions.
    MINTi MINT-1184765.
    STRINGi 9606.ENSP00000219281.

    PTM databases

    PhosphoSitei Q9BQ65.

    Polymorphism databases

    DMDMi 74732815.

    Proteomic databases

    MaxQBi Q9BQ65.
    PaxDbi Q9BQ65.
    PRIDEi Q9BQ65.

    Protocols and materials databases

    DNASUi 79650.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000219281 ; ENSP00000219281 ; ENSG00000103005 . [Q9BQ65-1 ]
    ENST00000423271 ; ENSP00000409792 ; ENSG00000103005 . [Q9BQ65-3 ]
    ENST00000539737 ; ENSP00000446143 ; ENSG00000103005 . [Q9BQ65-2 ]
    GeneIDi 79650.
    KEGGi hsa:79650.
    UCSCi uc002emz.3. human. [Q9BQ65-1 ]
    uc010via.2. human. [Q9BQ65-3 ]
    uc010vib.2. human. [Q9BQ65-2 ]

    Organism-specific databases

    CTDi 79650.
    GeneCardsi GC16P058033.
    H-InvDB HIX0019615.
    HGNCi HGNC:25792. USB1.
    HPAi HPA041791.
    MIMi 604173. phenotype.
    613276. gene.
    neXtProti NX_Q9BQ65.
    Orphaneti 1775. Dyskeratosis congenita.
    221046. Poikiloderma with neutropenia.
    PharmGKBi PA143485394.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG251744.
    HOGENOMi HOG000213585.
    HOVERGENi HBG081315.
    InParanoidi Q9BQ65.
    OMAi HHWIQPF.
    PhylomeDBi Q9BQ65.
    TreeFami TF324364.

    Miscellaneous databases

    ChiTaRSi C16orf57. human.
    GenomeRNAii 79650.
    NextBioi 68808.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BQ65.
    Bgeei Q9BQ65.
    CleanExi HS_C16orf57.
    Genevestigatori Q9BQ65.

    Family and domain databases

    HAMAPi MF_03040. USB1.
    InterProi IPR027521. Usb1.
    [Graphical view ]
    PANTHERi PTHR13522. PTHR13522. 1 hit.
    Pfami PF09749. HVSL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Synovium and Thymus.
    2. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney, Pancreas, Placenta, Skin and Uterus.
    4. "Targeted next-generation sequencing appoints c16orf57 as clericuzio-type poikiloderma with neutropenia gene."
      Volpi L., Roversi G., Colombo E.A., Leijsten N., Concolino D., Calabria A., Mencarelli M.A., Fimiani M., Macciardi F., Pfundt R., Schoenmakers E.F., Larizza L.
      Am. J. Hum. Genet. 86:72-76(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN PN.
    5. "Identification of a homozygous deletion mutation in C16orf57 in a family with Clericuzio-type poikiloderma with neutropenia."
      Tanaka A., Morice-Picard F., Lacombe D., Nagy N., Hide M., Taieb A., McGrath J.
      Am. J. Med. Genet. A 152:1347-1348(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN PN.
    6. "C16orf57, a gene mutated in poikiloderma with neutropenia, encodes a putative phosphodiesterase responsible for the U6 snRNA 3' end modification."
      Mroczek S., Krwawicz J., Kutner J., Lazniewski M., Kucinski I., Ginalski K., Dziembowski A.
      Genes Dev. 26:1911-1925(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, FUNCTION, MUTAGENESIS OF HIS-208.
    7. "Aberrant 3' oligoadenylation of spliceosomal U6 small nuclear RNA in poikiloderma with neutropenia."
      Hilcenko C., Simpson P.J., Finch A.J., Bowler F.R., Churcher M.J., Jin L., Packman L.C., Shlien A., Campbell P., Kirwan M., Dokal I., Warren A.J.
      Blood 121:1028-1038(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.1 ANGSTROMS) OF 73-265, CATALYTIC ACTIVITY, FUNCTION, ACTIVE SITE, MUTAGENESIS OF HIS-120 AND HIS-208.

    Entry informationi

    Entry nameiUSB1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BQ65
    Secondary accession number(s): B4DWE3
    , B4DZW5, Q96FZ9, Q9H8X8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3