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Protein

Telomerase RNA component interacting RNase

Gene

TRIR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to all four unpaired RNA nucleotides from 5' end or 3' end with higher efficiency for purine bases (PubMed:28322335).1 Publication

Enzyme regulationi

Zn2+ inhibits the RNase activity while Mg2+, Ca2+, Mn2+, K+, Na+, EDTA and EGTA show little effect on the exoribonuclease activity (PubMed:28322335).1 Publication

pH dependencei

Optimum pH is 6.5-12.1 Publication

Temperature dependencei

Optimum temperature is 37-75 degrees Celsius.1 Publication

GO - Molecular functioni

  • 3'-5' exonuclease activity Source: UniProtKB
  • 5'-3' exonuclease activity Source: UniProtKB
  • RNA binding Source: UniProtKB-KW

GO - Biological processi

  • RNA phosphodiester bond hydrolysis, exonucleolytic Source: UniProtKB
  • rRNA catabolic process Source: UniProtKB

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Telomerase RNA component interacting RNase1 PublicationImported (EC:3.1.13.-1 Publication)
Alternative name(s):
Exoribonuclease TRIRCurated
Gene namesi
Name:TRIR1 PublicationImported
Synonyms:C19orf43Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000123144.10
HGNCiHGNC:28424 TRIR
neXtProtiNX_Q9BQ61

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000123144
PharmGKBiPA144596476

Polymorphism and mutation databases

BioMutaiC19orf43
DMDMi74732813

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002807621 – 176Telomerase RNA component interacting RNaseAdd BLAST176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei146N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BQ61
MaxQBiQ9BQ61
PaxDbiQ9BQ61
PeptideAtlasiQ9BQ61
PRIDEiQ9BQ61
TopDownProteomicsiQ9BQ61

PTM databases

iPTMnetiQ9BQ61
PhosphoSitePlusiQ9BQ61

Expressioni

Gene expression databases

BgeeiENSG00000123144
CleanExiHS_C19orf43
ExpressionAtlasiQ9BQ61 baseline and differential
GenevisibleiQ9BQ61 HS

Organism-specific databases

HPAiHPA059965

Interactioni

Subunit structurei

Part of the telomerase RNA 3' end complex which contains about 488 proteins (PubMed:28322335).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SNRPAP090124EBI-744881,EBI-607085

Protein-protein interaction databases

BioGridi122473, 13 interactors
CORUMiQ9BQ61
IntActiQ9BQ61, 12 interactors
MINTiQ9BQ61
STRINGi9606.ENSP00000242784

Structurei

3D structure databases

ProteinModelPortaliQ9BQ61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi20 – 25Poly-Gly6

Domaini

The C-terminus contains a key domain which is responsible for the RNA digestion activity (PubMed:28322335).1 Publication

Phylogenomic databases

eggNOGiENOG410J165 Eukaryota
ENOG4111WVB LUCA
GeneTreeiENSGT00390000012267
HOGENOMiHOG000111989
HOVERGENiHBG081358
InParanoidiQ9BQ61
OMAiTGMVAKK
OrthoDBiEOG091G0UIB
PhylomeDBiQ9BQ61
TreeFamiTF323808

Sequencei

Sequence statusi: Complete.

Q9BQ61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARGRRAEP QGREAPGPAG GGGGGSRWAE SGSGTSPESG DEEVSGAGSS
60 70 80 90 100
PVSGGVNLFA NDGSFLELFK RKMEEEQRQR QEEPPPGPQR PDQSAAAAGP
110 120 130 140 150
GDPKRKGGPG STLSFVGKRR GGNKLALKTG IVAKKQKTED EVLTSKGDAW
160 170
AKYMAEVKKY KAHQCGDDDK TRPLVK
Length:176
Mass (Da):18,419
Last modified:June 1, 2001 - v1
Checksum:i7A96B523F5C05CB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000216 mRNA Translation: AAH00216.1
BC004533 mRNA Translation: AAH04533.1
BC015347 mRNA Translation: AAH15347.1
CCDSiCCDS12279.1
RefSeqiNP_001316667.1, NM_001329738.1
NP_076943.1, NM_024038.3
UniGeneiHs.515155

Genome annotation databases

EnsembliENST00000242784; ENSP00000242784; ENSG00000123144
GeneIDi79002
KEGGihsa:79002
UCSCiuc002muu.4 human

Entry informationi

Entry nameiTRIR_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM

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