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Protein

Telomerase RNA component interacting RNase

Gene

TRIR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to all four unpaired RNA nucleotides from 5' end or 3' end with higher efficiency for purine bases (PubMed:28322335).1 Publication

Enzyme regulationi

Zn2+ inhibits the RNase activity while Mg2+, Ca2+, Mn2+, K+, Na+, EDTA and EGTA show little effect on the exoribonuclease activity (PubMed:28322335).1 Publication

pH dependencei

Optimum pH is 6.5-12.1 Publication

Temperature dependencei

Optimum temperature is 37-75 degrees Celsius.1 Publication

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Telomerase RNA component interacting RNase1 Publication (EC:3.1.13.-1 Publication)
Alternative name(s):
Exoribonuclease TRIRCurated
Gene namesi
Name:TRIR1 Publication
Synonyms:C19orf43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000123144.10.
HGNCiHGNC:28424. C19orf43.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000123144.
PharmGKBiPA144596476.

Polymorphism and mutation databases

BioMutaiC19orf43.
DMDMi74732813.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002807621 – 176Telomerase RNA component interacting RNaseAdd BLAST176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei146N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BQ61.
MaxQBiQ9BQ61.
PaxDbiQ9BQ61.
PeptideAtlasiQ9BQ61.
PRIDEiQ9BQ61.
TopDownProteomicsiQ9BQ61.

PTM databases

iPTMnetiQ9BQ61.
PhosphoSitePlusiQ9BQ61.

Expressioni

Gene expression databases

BgeeiENSG00000123144.
CleanExiHS_C19orf43.
ExpressionAtlasiQ9BQ61. baseline and differential.
GenevisibleiQ9BQ61. HS.

Organism-specific databases

HPAiHPA059965.

Interactioni

Subunit structurei

Part of the telomerase RNA 3' end complex which contains about 488 proteins (PubMed:28322335).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SNRPAP090124EBI-744881,EBI-607085

Protein-protein interaction databases

BioGridi122473. 13 interactors.
CORUMiQ9BQ61.
IntActiQ9BQ61. 12 interactors.
MINTiMINT-3060318.
STRINGi9606.ENSP00000242784.

Structurei

3D structure databases

ProteinModelPortaliQ9BQ61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi20 – 25Poly-Gly6

Domaini

The C-terminus contains a key domain which is responsible for the RNA digestion activity (PubMed:28322335).1 Publication

Phylogenomic databases

eggNOGiENOG410J165. Eukaryota.
ENOG4111WVB. LUCA.
GeneTreeiENSGT00390000012267.
HOGENOMiHOG000111989.
HOVERGENiHBG081358.
InParanoidiQ9BQ61.
OMAiTGMVAKK.
OrthoDBiEOG091G0UIB.
PhylomeDBiQ9BQ61.
TreeFamiTF323808.

Sequencei

Sequence statusi: Complete.

Q9BQ61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARGRRAEP QGREAPGPAG GGGGGSRWAE SGSGTSPESG DEEVSGAGSS
60 70 80 90 100
PVSGGVNLFA NDGSFLELFK RKMEEEQRQR QEEPPPGPQR PDQSAAAAGP
110 120 130 140 150
GDPKRKGGPG STLSFVGKRR GGNKLALKTG IVAKKQKTED EVLTSKGDAW
160 170
AKYMAEVKKY KAHQCGDDDK TRPLVK
Length:176
Mass (Da):18,419
Last modified:June 1, 2001 - v1
Checksum:i7A96B523F5C05CB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000216 mRNA. Translation: AAH00216.1.
BC004533 mRNA. Translation: AAH04533.1.
BC015347 mRNA. Translation: AAH15347.1.
CCDSiCCDS12279.1.
RefSeqiNP_001316667.1. NM_001329738.1.
NP_076943.1. NM_024038.3.
UniGeneiHs.515155.

Genome annotation databases

EnsembliENST00000242784; ENSP00000242784; ENSG00000123144.
GeneIDi79002.
KEGGihsa:79002.
UCSCiuc002muu.4. human.

Similar proteinsi

Entry informationi

Entry nameiTRIR_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2001
Last modified: November 22, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM