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Q9BQ51

- PD1L2_HUMAN

UniProt

Q9BQ51 - PD1L2_HUMAN

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Protein

Programmed cell death 1 ligand 2

Gene

PDCD1LG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).By similarity

GO - Biological processi

  1. immune response Source: UniProtKB
  2. negative regulation of T cell proliferation Source: Ensembl
  3. positive regulation of T cell proliferation Source: Ensembl
  4. T cell costimulation Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_19324. PD-1 signaling.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death 1 ligand 2
Short name:
PD-1 ligand 2
Short name:
PD-L2
Short name:
PDCD1 ligand 2
Short name:
Programmed death ligand 2
Alternative name(s):
Butyrophilin B7-DC
Short name:
B7-DC
CD_antigen: CD273
Gene namesi
Name:PDCD1LG2
Synonyms:B7DC, CD273, PDCD1L2, PDL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:18731. PDCD1LG2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 220201ExtracellularSequence AnalysisAdd
BLAST
Transmembranei221 – 24121HelicalSequence AnalysisAdd
BLAST
Topological domaini242 – 27332CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134891547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 273254Programmed cell death 1 ligand 2PRO_0000014555Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi42 ↔ 102PROSITE-ProRule annotation
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi143 ↔ 192PROSITE-ProRule annotation
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9BQ51.
PaxDbiQ9BQ51.
PRIDEiQ9BQ51.

PTM databases

PhosphoSiteiQ9BQ51.

Expressioni

Tissue specificityi

Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.1 Publication

Inductioni

Up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL4/interleukin-4.2 Publications

Gene expression databases

BgeeiQ9BQ51.
CleanExiHS_PDCD1LG2.
GenevestigatoriQ9BQ51.

Organism-specific databases

HPAiHPA013411.

Interactioni

Subunit structurei

Interacts with PDCD1.By similarity

Protein-protein interaction databases

BioGridi123259. 1 interaction.
STRINGi9606.ENSP00000380855.

Structurei

3D structure databases

ProteinModelPortaliQ9BQ51.
SMRiQ9BQ51. Positions 20-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 11898Ig-like V-typeAdd
BLAST
Domaini122 – 20382Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39387.
GeneTreeiENSGT00650000093373.
HOGENOMiHOG000059625.
HOVERGENiHBG082112.
InParanoidiQ9BQ51.
KOiK06708.
OMAiVAWDYKY.
OrthoDBiEOG7T7GTP.
PhylomeDBiQ9BQ51.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BQ51-1) [UniParc]FASTAAdd to Basket

Also known as: PD-L2I, Type I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIFLLLMLSL ELQLHQIAAL FTVTVPKELY IIEHGSNVTL ECNFDTGSHV
60 70 80 90 100
NLGAITASLQ KVENDTSPHR ERATLLEEQL PLGKASFHIP QVQVRDEGQY
110 120 130 140 150
QCIIIYGVAW DYKYLTLKVK ASYRKINTHI LKVPETDEVE LTCQATGYPL
160 170 180 190 200
AEVSWPNVSV PANTSHSRTP EGLYQVTSVL RLKPPPGRNF SCVFWNTHVR
210 220 230 240 250
ELTLASIDLQ SQMEPRTHPT WLLHIFIPFC IIAFIFIATV IALRKQLCQK
260 270
LYSSKDTTKR PVTTTKREVN SAI
Length:273
Mass (Da):30,957
Last modified:May 10, 2005 - v2
Checksum:i8B7E963C9BA26ED9
GO
Isoform 2 (identifier: Q9BQ51-2) [UniParc]FASTAAdd to Basket

Also known as: PD-L2II, Type II

The sequence of this isoform differs from the canonical sequence as follows:
     121-211: ASYRKINTHI...LTLASIDLQS → G

Show »
Length:183
Mass (Da):20,867
Checksum:iADFCD2E70205B137
GO
Isoform 3 (identifier: Q9BQ51-3) [UniParc]FASTAAdd to Basket

Also known as: PD-L2III, Type III

The sequence of this isoform differs from the canonical sequence as follows:
     121-182: ASYRKINTHI...LYQVTSVLRL → DGTQDPSNLA...NKEGSEQCYL
     183-273: Missing.

Show »
Length:182
Mass (Da):20,745
Checksum:i357E9952F65BCADC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581S → T.
Corresponds to variant rs12339171 [ dbSNP | Ensembl ].
VAR_049842
Natural varianti229 – 2291F → S.4 Publications
Corresponds to variant rs7854303 [ dbSNP | Ensembl ].
VAR_022449
Natural varianti241 – 2411I → T.
Corresponds to variant rs7854413 [ dbSNP | Ensembl ].
VAR_049843

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei121 – 21191ASYRK…IDLQS → G in isoform 2. 1 PublicationVSP_013740Add
BLAST
Alternative sequencei121 – 18262ASYRK…SVLRL → DGTQDPSNLAASHFHPLLHH CFHFHSHSDSPKKTTLSKAV FFKRHNKKTCHHNKEGSEQC YL in isoform 3. 1 PublicationVSP_013738Add
BLAST
Alternative sequencei183 – 27391Missing in isoform 3. 1 PublicationVSP_013739Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329193 mRNA. Translation: AAK31105.1.
AF344424 mRNA. Translation: AAK15370.1.
AY254343 mRNA. Translation: AAP13471.1.
AY271901 mRNA. Translation: AAP49000.1.
AY271902 mRNA. Translation: AAP49001.1.
AL162253 Genomic DNA. Translation: CAI15984.1.
BC074766 mRNA. Translation: AAH74766.1.
BC113678 mRNA. Translation: AAI13679.1.
BC113680 mRNA. Translation: AAI13681.1.
CCDSiCCDS6465.1. [Q9BQ51-1]
RefSeqiNP_079515.2. NM_025239.3. [Q9BQ51-1]
UniGeneiHs.532279.
Hs.617872.

Genome annotation databases

EnsembliENST00000397747; ENSP00000380855; ENSG00000197646. [Q9BQ51-1]
GeneIDi80380.
KEGGihsa:80380.
UCSCiuc003zjg.4. human. [Q9BQ51-1]
uc010mho.1. human. [Q9BQ51-2]
uc010mhp.1. human. [Q9BQ51-3]

Polymorphism databases

DMDMi73917618.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329193 mRNA. Translation: AAK31105.1 .
AF344424 mRNA. Translation: AAK15370.1 .
AY254343 mRNA. Translation: AAP13471.1 .
AY271901 mRNA. Translation: AAP49000.1 .
AY271902 mRNA. Translation: AAP49001.1 .
AL162253 Genomic DNA. Translation: CAI15984.1 .
BC074766 mRNA. Translation: AAH74766.1 .
BC113678 mRNA. Translation: AAI13679.1 .
BC113680 mRNA. Translation: AAI13681.1 .
CCDSi CCDS6465.1. [Q9BQ51-1 ]
RefSeqi NP_079515.2. NM_025239.3. [Q9BQ51-1 ]
UniGenei Hs.532279.
Hs.617872.

3D structure databases

ProteinModelPortali Q9BQ51.
SMRi Q9BQ51. Positions 20-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123259. 1 interaction.
STRINGi 9606.ENSP00000380855.

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei Q9BQ51.

Polymorphism databases

DMDMi 73917618.

Proteomic databases

MaxQBi Q9BQ51.
PaxDbi Q9BQ51.
PRIDEi Q9BQ51.

Protocols and materials databases

DNASUi 80380.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000397747 ; ENSP00000380855 ; ENSG00000197646 . [Q9BQ51-1 ]
GeneIDi 80380.
KEGGi hsa:80380.
UCSCi uc003zjg.4. human. [Q9BQ51-1 ]
uc010mho.1. human. [Q9BQ51-2 ]
uc010mhp.1. human. [Q9BQ51-3 ]

Organism-specific databases

CTDi 80380.
GeneCardsi GC09P005500.
H-InvDB HIX0007901.
HGNCi HGNC:18731. PDCD1LG2.
HPAi HPA013411.
MIMi 605723. gene.
neXtProti NX_Q9BQ51.
PharmGKBi PA134891547.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39387.
GeneTreei ENSGT00650000093373.
HOGENOMi HOG000059625.
HOVERGENi HBG082112.
InParanoidi Q9BQ51.
KOi K06708.
OMAi VAWDYKY.
OrthoDBi EOG7T7GTP.
PhylomeDBi Q9BQ51.
TreeFami TF331083.

Enzyme and pathway databases

Reactomei REACT_19324. PD-1 signaling.

Miscellaneous databases

GeneWikii PDCD1LG2.
GenomeRNAii 80380.
NextBioi 70976.
PROi Q9BQ51.
SOURCEi Search...

Gene expression databases

Bgeei Q9BQ51.
CleanExi HS_PDCD1LG2.
Genevestigatori Q9BQ51.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells."
    Tseng S.-Y., Otsuji M., Gorski K., Huang X., Slansky J.E., Pai S.I., Shalabi A., Shin T., Pardoll D.M., Tsuchiya H.
    J. Exp. Med. 193:839-846(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, VARIANT SER-229.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION, VARIANT SER-229.
  3. "Cloning and identification of two novel splice variants of human PD-L2."
    He X.-H., Liu Y., Xu L.-H., Zeng Y.-Y.
    Acta Biochim. Biophys. Sin. 36:284-289(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), SUBCELLULAR LOCATION, VARIANT SER-229.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-229.
    Tissue: Brain and Lung.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-34.

Entry informationi

Entry nameiPD1L2_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ51
Secondary accession number(s): Q14CN8
, Q5T7Z6, Q6JXL8, Q6JXL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3