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Q9BQ51 (PD1L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Programmed cell death 1 ligand 2

Short name=PD-1 ligand 2
Short name=PD-L2
Short name=PDCD1 ligand 2
Short name=Programmed death ligand 2
Alternative name(s):
Butyrophilin B7-DC
Short name=B7-DC
CD_antigen=CD273
Gene names
Name:PDCD1LG2
Synonyms:B7DC, CD273, PDCD1L2, PDL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production By similarity.

Subunit structure

Interacts with PDCD1 By similarity.

Subcellular location

Isoform 3: Secreted Probable Ref.3.

Isoform 2: Endomembrane system; Single-pass type I membrane protein Ref.3.

Isoform 1: Cell membrane; Single-pass type I membrane protein Ref.3.

Tissue specificity

Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus. Ref.2

Induction

Up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL4/interleukin-4. Ref.1 Ref.2

Sequence similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BQ51-1)

Also known as: PD-L2I; Type I;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BQ51-2)

Also known as: PD-L2II; Type II;

The sequence of this isoform differs from the canonical sequence as follows:
     121-211: ASYRKINTHI...LTLASIDLQS → G
Isoform 3 (identifier: Q9BQ51-3)

Also known as: PD-L2III; Type III;

The sequence of this isoform differs from the canonical sequence as follows:
     121-182: ASYRKINTHI...LYQVTSVLRL → DGTQDPSNLA...NKEGSEQCYL
     183-273: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.6
Chain20 – 273254Programmed cell death 1 ligand 2
PRO_0000014555

Regions

Topological domain20 – 220201Extracellular Potential
Transmembrane221 – 24121Helical; Potential
Topological domain242 – 27332Cytoplasmic Potential
Domain21 – 11898Ig-like V-type
Domain122 – 20382Ig-like C2-type

Amino acid modifications

Glycosylation371N-linked (GlcNAc...) Potential
Glycosylation641N-linked (GlcNAc...) Potential
Glycosylation1571N-linked (GlcNAc...) Potential
Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation1891N-linked (GlcNAc...) Potential
Disulfide bond42 ↔ 102 By similarity
Disulfide bond143 ↔ 192 By similarity

Natural variations

Alternative sequence121 – 21191ASYRK…IDLQS → G in isoform 2.
VSP_013740
Alternative sequence121 – 18262ASYRK…SVLRL → DGTQDPSNLAASHFHPLLHH CFHFHSHSDSPKKTTLSKAV FFKRHNKKTCHHNKEGSEQC YL in isoform 3.
VSP_013738
Alternative sequence183 – 27391Missing in isoform 3.
VSP_013739
Natural variant581S → T.
Corresponds to variant rs12339171 [ dbSNP | Ensembl ].
VAR_049842
Natural variant2291F → S. Ref.1 Ref.2 Ref.3 Ref.5
Corresponds to variant rs7854303 [ dbSNP | Ensembl ].
VAR_022449
Natural variant2411I → T.
Corresponds to variant rs7854413 [ dbSNP | Ensembl ].
VAR_049843

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (PD-L2I) (Type I) [UniParc].

Last modified May 10, 2005. Version 2.
Checksum: 8B7E963C9BA26ED9

FASTA27330,957
        10         20         30         40         50         60 
MIFLLLMLSL ELQLHQIAAL FTVTVPKELY IIEHGSNVTL ECNFDTGSHV NLGAITASLQ 

        70         80         90        100        110        120 
KVENDTSPHR ERATLLEEQL PLGKASFHIP QVQVRDEGQY QCIIIYGVAW DYKYLTLKVK 

       130        140        150        160        170        180 
ASYRKINTHI LKVPETDEVE LTCQATGYPL AEVSWPNVSV PANTSHSRTP EGLYQVTSVL 

       190        200        210        220        230        240 
RLKPPPGRNF SCVFWNTHVR ELTLASIDLQ SQMEPRTHPT WLLHIFIPFC IIAFIFIATV 

       250        260        270 
IALRKQLCQK LYSSKDTTKR PVTTTKREVN SAI 

« Hide

Isoform 2 (PD-L2II) (Type II) [UniParc].

Checksum: ADFCD2E70205B137
Show »

FASTA18320,867
Isoform 3 (PD-L2III) (Type III) [UniParc].

Checksum: 357E9952F65BCADC
Show »

FASTA18220,745

References

« Hide 'large scale' references
[1]"B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells."
Tseng S.-Y., Otsuji M., Gorski K., Huang X., Slansky J.E., Pai S.I., Shalabi A., Shin T., Pardoll D.M., Tsuchiya H.
J. Exp. Med. 193:839-846(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, VARIANT SER-229.
[2]"PD-L2 is a second ligand for PD-1 and inhibits T cell activation."
Latchman Y., Wood C.R., Chernova T., Chaudhary D., Borde M., Chernova I., Iwai Y., Long A.J., Brown J.A., Nunes R., Greenfield E.A., Bourque K., Boussiotis V.A., Carter L.L., Carreno B.M., Malenkovich N., Nishimura H., Okazaki T. expand/collapse author list , Honjo T., Sharpe A.H., Freeman G.J.
Nat. Immunol. 2:261-268(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION, VARIANT SER-229.
[3]"Cloning and identification of two novel splice variants of human PD-L2."
He X.-H., Liu Y., Xu L.-H., Zeng Y.-Y.
Acta Biochim. Biophys. Sin. 36:284-289(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), SUBCELLULAR LOCATION, VARIANT SER-229.
[4]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-229.
Tissue: Brain and Lung.
[6]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-34.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF329193 mRNA. Translation: AAK31105.1.
AF344424 mRNA. Translation: AAK15370.1.
AY254343 mRNA. Translation: AAP13471.1.
AY271901 mRNA. Translation: AAP49000.1.
AY271902 mRNA. Translation: AAP49001.1.
AL162253 Genomic DNA. Translation: CAI15984.1.
BC074766 mRNA. Translation: AAH74766.1.
BC113678 mRNA. Translation: AAI13679.1.
BC113680 mRNA. Translation: AAI13681.1.
RefSeqNP_079515.2. NM_025239.3.
UniGeneHs.532279.
Hs.617872.

3D structure databases

ProteinModelPortalQ9BQ51.
SMRQ9BQ51. Positions 20-208.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123259. 1 interaction.
STRING9606.ENSP00000380855.

Protein family/group databases

MEROPSI43.001.

PTM databases

PhosphoSiteQ9BQ51.

Polymorphism databases

DMDM73917618.

Proteomic databases

PaxDbQ9BQ51.
PRIDEQ9BQ51.

Protocols and materials databases

DNASU80380.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000397745; ENSP00000380853; ENSG00000197646. [Q9BQ51-2]
ENST00000397747; ENSP00000380855; ENSG00000197646. [Q9BQ51-1]
GeneID80380.
KEGGhsa:80380.
UCSCuc003zjg.4. human. [Q9BQ51-1]
uc010mho.1. human. [Q9BQ51-2]
uc010mhp.1. human. [Q9BQ51-3]

Organism-specific databases

CTD80380.
GeneCardsGC09P005500.
H-InvDBHIX0007901.
HGNCHGNC:18731. PDCD1LG2.
HPAHPA013411.
MIM605723. gene.
neXtProtNX_Q9BQ51.
PharmGKBPA134891547.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39387.
HOGENOMHOG000059625.
HOVERGENHBG082112.
InParanoidQ9BQ51.
KOK06708.
OMAVAWDYKY.
OrthoDBEOG7T7GTP.
PhylomeDBQ9BQ51.
TreeFamTF331083.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeQ9BQ51.
CleanExHS_PDCD1LG2.
GenevestigatorQ9BQ51.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPDCD1LG2.
GenomeRNAi80380.
NextBio70976.
PROQ9BQ51.
SOURCESearch...

Entry information

Entry namePD1L2_HUMAN
AccessionPrimary (citable) accession number: Q9BQ51
Secondary accession number(s): Q14CN8 expand/collapse secondary AC list , Q5T7Z6, Q6JXL8, Q6JXL9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: March 19, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries