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Q9BQ51

- PD1L2_HUMAN

UniProt

Q9BQ51 - PD1L2_HUMAN

Protein

Programmed cell death 1 ligand 2

Gene

PDCD1LG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (10 May 2005)
      Previous versions | rss
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    Functioni

    Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production By similarity.By similarity

    GO - Biological processi

    1. immune response Source: UniProtKB
    2. negative regulation of T cell proliferation Source: Ensembl
    3. positive regulation of T cell proliferation Source: Ensembl
    4. T cell costimulation Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_19324. PD-1 signaling.

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Programmed cell death 1 ligand 2
    Short name:
    PD-1 ligand 2
    Short name:
    PD-L2
    Short name:
    PDCD1 ligand 2
    Short name:
    Programmed death ligand 2
    Alternative name(s):
    Butyrophilin B7-DC
    Short name:
    B7-DC
    CD_antigen: CD273
    Gene namesi
    Name:PDCD1LG2
    Synonyms:B7DC, CD273, PDCD1L2, PDL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:18731. PDCD1LG2.

    Subcellular locationi

    GO - Cellular componenti

    1. endomembrane system Source: UniProtKB-SubCell
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134891547.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19191 PublicationAdd
    BLAST
    Chaini20 – 273254Programmed cell death 1 ligand 2PRO_0000014555Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi42 ↔ 102PROSITE-ProRule annotation
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi143 ↔ 192PROSITE-ProRule annotation
    Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9BQ51.
    PaxDbiQ9BQ51.
    PRIDEiQ9BQ51.

    PTM databases

    PhosphoSiteiQ9BQ51.

    Expressioni

    Tissue specificityi

    Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.1 Publication

    Inductioni

    Up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL4/interleukin-4.2 Publications

    Gene expression databases

    BgeeiQ9BQ51.
    CleanExiHS_PDCD1LG2.
    GenevestigatoriQ9BQ51.

    Organism-specific databases

    HPAiHPA013411.

    Interactioni

    Subunit structurei

    Interacts with PDCD1.By similarity

    Protein-protein interaction databases

    BioGridi123259. 1 interaction.
    STRINGi9606.ENSP00000380855.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BQ51.
    SMRiQ9BQ51. Positions 20-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 220201ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini242 – 27332CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei221 – 24121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 11898Ig-like V-typeAdd
    BLAST
    Domaini122 – 20382Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39387.
    HOGENOMiHOG000059625.
    HOVERGENiHBG082112.
    InParanoidiQ9BQ51.
    KOiK06708.
    OMAiVAWDYKY.
    OrthoDBiEOG7T7GTP.
    PhylomeDBiQ9BQ51.
    TreeFamiTF331083.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BQ51-1) [UniParc]FASTAAdd to Basket

    Also known as: PD-L2I, Type I

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIFLLLMLSL ELQLHQIAAL FTVTVPKELY IIEHGSNVTL ECNFDTGSHV    50
    NLGAITASLQ KVENDTSPHR ERATLLEEQL PLGKASFHIP QVQVRDEGQY 100
    QCIIIYGVAW DYKYLTLKVK ASYRKINTHI LKVPETDEVE LTCQATGYPL 150
    AEVSWPNVSV PANTSHSRTP EGLYQVTSVL RLKPPPGRNF SCVFWNTHVR 200
    ELTLASIDLQ SQMEPRTHPT WLLHIFIPFC IIAFIFIATV IALRKQLCQK 250
    LYSSKDTTKR PVTTTKREVN SAI 273
    Length:273
    Mass (Da):30,957
    Last modified:May 10, 2005 - v2
    Checksum:i8B7E963C9BA26ED9
    GO
    Isoform 2 (identifier: Q9BQ51-2) [UniParc]FASTAAdd to Basket

    Also known as: PD-L2II, Type II

    The sequence of this isoform differs from the canonical sequence as follows:
         121-211: ASYRKINTHI...LTLASIDLQS → G

    Show »
    Length:183
    Mass (Da):20,867
    Checksum:iADFCD2E70205B137
    GO
    Isoform 3 (identifier: Q9BQ51-3) [UniParc]FASTAAdd to Basket

    Also known as: PD-L2III, Type III

    The sequence of this isoform differs from the canonical sequence as follows:
         121-182: ASYRKINTHI...LYQVTSVLRL → DGTQDPSNLA...NKEGSEQCYL
         183-273: Missing.

    Show »
    Length:182
    Mass (Da):20,745
    Checksum:i357E9952F65BCADC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti58 – 581S → T.
    Corresponds to variant rs12339171 [ dbSNP | Ensembl ].
    VAR_049842
    Natural varianti229 – 2291F → S.4 Publications
    Corresponds to variant rs7854303 [ dbSNP | Ensembl ].
    VAR_022449
    Natural varianti241 – 2411I → T.
    Corresponds to variant rs7854413 [ dbSNP | Ensembl ].
    VAR_049843

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei121 – 21191ASYRK…IDLQS → G in isoform 2. 1 PublicationVSP_013740Add
    BLAST
    Alternative sequencei121 – 18262ASYRK…SVLRL → DGTQDPSNLAASHFHPLLHH CFHFHSHSDSPKKTTLSKAV FFKRHNKKTCHHNKEGSEQC YL in isoform 3. 1 PublicationVSP_013738Add
    BLAST
    Alternative sequencei183 – 27391Missing in isoform 3. 1 PublicationVSP_013739Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF329193 mRNA. Translation: AAK31105.1.
    AF344424 mRNA. Translation: AAK15370.1.
    AY254343 mRNA. Translation: AAP13471.1.
    AY271901 mRNA. Translation: AAP49000.1.
    AY271902 mRNA. Translation: AAP49001.1.
    AL162253 Genomic DNA. Translation: CAI15984.1.
    BC074766 mRNA. Translation: AAH74766.1.
    BC113678 mRNA. Translation: AAI13679.1.
    BC113680 mRNA. Translation: AAI13681.1.
    CCDSiCCDS6465.1. [Q9BQ51-1]
    RefSeqiNP_079515.2. NM_025239.3. [Q9BQ51-1]
    UniGeneiHs.532279.
    Hs.617872.

    Genome annotation databases

    EnsembliENST00000397747; ENSP00000380855; ENSG00000197646. [Q9BQ51-1]
    GeneIDi80380.
    KEGGihsa:80380.
    UCSCiuc003zjg.4. human. [Q9BQ51-1]
    uc010mho.1. human. [Q9BQ51-2]
    uc010mhp.1. human. [Q9BQ51-3]

    Polymorphism databases

    DMDMi73917618.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF329193 mRNA. Translation: AAK31105.1 .
    AF344424 mRNA. Translation: AAK15370.1 .
    AY254343 mRNA. Translation: AAP13471.1 .
    AY271901 mRNA. Translation: AAP49000.1 .
    AY271902 mRNA. Translation: AAP49001.1 .
    AL162253 Genomic DNA. Translation: CAI15984.1 .
    BC074766 mRNA. Translation: AAH74766.1 .
    BC113678 mRNA. Translation: AAI13679.1 .
    BC113680 mRNA. Translation: AAI13681.1 .
    CCDSi CCDS6465.1. [Q9BQ51-1 ]
    RefSeqi NP_079515.2. NM_025239.3. [Q9BQ51-1 ]
    UniGenei Hs.532279.
    Hs.617872.

    3D structure databases

    ProteinModelPortali Q9BQ51.
    SMRi Q9BQ51. Positions 20-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123259. 1 interaction.
    STRINGi 9606.ENSP00000380855.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei Q9BQ51.

    Polymorphism databases

    DMDMi 73917618.

    Proteomic databases

    MaxQBi Q9BQ51.
    PaxDbi Q9BQ51.
    PRIDEi Q9BQ51.

    Protocols and materials databases

    DNASUi 80380.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000397747 ; ENSP00000380855 ; ENSG00000197646 . [Q9BQ51-1 ]
    GeneIDi 80380.
    KEGGi hsa:80380.
    UCSCi uc003zjg.4. human. [Q9BQ51-1 ]
    uc010mho.1. human. [Q9BQ51-2 ]
    uc010mhp.1. human. [Q9BQ51-3 ]

    Organism-specific databases

    CTDi 80380.
    GeneCardsi GC09P005500.
    H-InvDB HIX0007901.
    HGNCi HGNC:18731. PDCD1LG2.
    HPAi HPA013411.
    MIMi 605723. gene.
    neXtProti NX_Q9BQ51.
    PharmGKBi PA134891547.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39387.
    HOGENOMi HOG000059625.
    HOVERGENi HBG082112.
    InParanoidi Q9BQ51.
    KOi K06708.
    OMAi VAWDYKY.
    OrthoDBi EOG7T7GTP.
    PhylomeDBi Q9BQ51.
    TreeFami TF331083.

    Enzyme and pathway databases

    Reactomei REACT_19324. PD-1 signaling.

    Miscellaneous databases

    GeneWikii PDCD1LG2.
    GenomeRNAii 80380.
    NextBioi 70976.
    PROi Q9BQ51.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BQ51.
    CleanExi HS_PDCD1LG2.
    Genevestigatori Q9BQ51.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells."
      Tseng S.-Y., Otsuji M., Gorski K., Huang X., Slansky J.E., Pai S.I., Shalabi A., Shin T., Pardoll D.M., Tsuchiya H.
      J. Exp. Med. 193:839-846(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, VARIANT SER-229.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION, VARIANT SER-229.
    3. "Cloning and identification of two novel splice variants of human PD-L2."
      He X.-H., Liu Y., Xu L.-H., Zeng Y.-Y.
      Acta Biochim. Biophys. Sin. 36:284-289(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), SUBCELLULAR LOCATION, VARIANT SER-229.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-229.
      Tissue: Brain and Lung.
    6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-34.

    Entry informationi

    Entry nameiPD1L2_HUMAN
    AccessioniPrimary (citable) accession number: Q9BQ51
    Secondary accession number(s): Q14CN8
    , Q5T7Z6, Q6JXL8, Q6JXL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3