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Protein

Small integral membrane protein 7

Gene

SMIM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Small integral membrane protein 7
Gene namesi
Name:SMIM7
Synonyms:C19orf42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000214046.8.
HGNCiHGNC:28419. SMIM7.
neXtProtiNX_Q9BQ49.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 53ExtracellularSequence analysisAdd BLAST36
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Topological domaini75CytoplasmicSequence analysis1

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000214046.
PharmGKBiPA144596475.

Polymorphism and mutation databases

BioMutaiSMIM7.
DMDMi193806332.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000028404718 – 75Small integral membrane protein 7Add BLAST58

Proteomic databases

EPDiQ9BQ49.
MaxQBiQ9BQ49.
PaxDbiQ9BQ49.
PeptideAtlasiQ9BQ49.
PRIDEiQ9BQ49.
TopDownProteomicsiQ9BQ49.

PTM databases

iPTMnetiQ9BQ49.
PhosphoSitePlusiQ9BQ49.

Expressioni

Gene expression databases

BgeeiENSG00000214046.
CleanExiHS_C19orf42.
ExpressionAtlasiQ9BQ49. baseline and differential.
GenevisibleiQ9BQ49. HS.

Organism-specific databases

HPAiHPA043127.

Interactioni

Protein-protein interaction databases

BioGridi122534. 1 interactor.
STRINGi9606.ENSP00000417147.

Structurei

3D structure databases

ProteinModelPortaliQ9BQ49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SMIM7 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J12F. Eukaryota.
ENOG4111VAP. LUCA.
GeneTreeiENSGT00390000014626.
HOGENOMiHOG000015376.
HOVERGENiHBG060869.
InParanoidiQ9BQ49.
PhylomeDBiQ9BQ49.
TreeFamiTF332999.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BQ49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGDILLFGT LLMNAGAVLN FKLKKKDTQG FGEESREPST GDNIREFLLS
60 70
LRYFRIFIAL WNIFMMFCMI VLFGS
Length:75
Mass (Da):8,631
Last modified:July 1, 2008 - v2
Checksum:i5CF77700933970D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025602 mRNA. No translation available.
AC024075 Genomic DNA. No translation available.
BC001680 mRNA. No translation available.
BC001948 mRNA. No translation available.
CCDSiCCDS12348.2.
RefSeqiNP_077009.2. NM_024104.3.
UniGeneiHs.356467.

Genome annotation databases

EnsembliENST00000481671; ENSP00000433833; ENSG00000214046.
ENST00000487416; ENSP00000417147; ENSG00000214046.
ENST00000593404; ENSP00000471355; ENSG00000214046.
ENST00000593409; ENSP00000469962; ENSG00000214046.
ENST00000597781; ENSP00000469440; ENSG00000214046.
ENST00000599310; ENSP00000469918; ENSG00000214046.
GeneIDi79086.
KEGGihsa:79086.
UCSCiuc002ner.4. human.

Similar proteinsi

Entry informationi

Entry nameiSMIM7_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ49
Secondary accession number(s): A8MX44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 1, 2008
Last modified: September 27, 2017
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries