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Protein

39S ribosomal protein L34, mitochondrial

Gene

MRPL34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. mitochondrial translation Source: Reactome
  2. mitochondrial translational elongation Source: Reactome
  3. mitochondrial translational initiation Source: Reactome
  4. mitochondrial translational termination Source: Reactome
  5. organelle organization Source: Reactome
  6. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L34, mitochondrial
Short name:
L34mt
Short name:
MRP-L34
Gene namesi
Name:MRPL34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:14488. MRPL34.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Reactome
  2. mitochondrial ribosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30965.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 9239S ribosomal protein L34, mitochondrialPRO_0000030520
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

MaxQBiQ9BQ48.
PaxDbiQ9BQ48.
PRIDEiQ9BQ48.

PTM databases

PhosphoSiteiQ9BQ48.

Expressioni

Gene expression databases

BgeeiQ9BQ48.
CleanExiHS_MRPL34.
ExpressionAtlasiQ9BQ48. baseline and differential.
GenevestigatoriQ9BQ48.

Organism-specific databases

HPAiHPA049276.

Interactioni

Protein-protein interaction databases

BioGridi122367. 11 interactions.
STRINGi9606.ENSP00000252602.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4021-92[»]
ProteinModelPortaliQ9BQ48.
SMRiQ9BQ48. Positions 50-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L34P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG273530.
GeneTreeiENSGT00390000012240.
HOGENOMiHOG000111573.
HOVERGENiHBG018253.
InParanoidiQ9BQ48.
KOiK02914.
PhylomeDBiQ9BQ48.
TreeFamiTF324478.

Family and domain databases

InterProiIPR000271. Ribosomal_L34.
[Graphical view]
PANTHERiPTHR14503. PTHR14503. 1 hit.
PfamiPF00468. Ribosomal_L34. 1 hit.
[Graphical view]
ProDomiPD003101. Ribosomal_L34. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR01030. rpmH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BQ48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLAGSLLG PTSRSAALLG GRWLQPRAWL GFPDAWGLPT PQQARGKARG
60 70 80 90
NEYQPSNIKR KNKHGWVRRL STPAGVQVIL RRMLKGRKSL SH
Length:92
Mass (Da):10,165
Last modified:June 1, 2001 - v1
Checksum:i923C87BAFA01054C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049652 mRNA. Translation: BAB40857.1.
BC000071 mRNA. Translation: AAH00071.1.
BC021801 mRNA. Translation: AAH21801.1.
CCDSiCCDS12356.1.
RefSeqiNP_076426.1. NM_023937.3.
UniGeneiHs.515242.

Genome annotation databases

EnsembliENST00000252602; ENSP00000252602; ENSG00000130312.
ENST00000594999; ENSP00000471820; ENSG00000130312.
ENST00000600434; ENSP00000469581; ENSG00000130312.
GeneIDi64981.
KEGGihsa:64981.
UCSCiuc002ngc.1. human.

Polymorphism databases

DMDMi20139691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049652 mRNA. Translation: BAB40857.1.
BC000071 mRNA. Translation: AAH00071.1.
BC021801 mRNA. Translation: AAH21801.1.
CCDSiCCDS12356.1.
RefSeqiNP_076426.1. NM_023937.3.
UniGeneiHs.515242.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4021-92[»]
ProteinModelPortaliQ9BQ48.
SMRiQ9BQ48. Positions 50-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122367. 11 interactions.
STRINGi9606.ENSP00000252602.

PTM databases

PhosphoSiteiQ9BQ48.

Polymorphism databases

DMDMi20139691.

Proteomic databases

MaxQBiQ9BQ48.
PaxDbiQ9BQ48.
PRIDEiQ9BQ48.

Protocols and materials databases

DNASUi64981.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252602; ENSP00000252602; ENSG00000130312.
ENST00000594999; ENSP00000471820; ENSG00000130312.
ENST00000600434; ENSP00000469581; ENSG00000130312.
GeneIDi64981.
KEGGihsa:64981.
UCSCiuc002ngc.1. human.

Organism-specific databases

CTDi64981.
GeneCardsiGC19P017902.
HGNCiHGNC:14488. MRPL34.
HPAiHPA049276.
MIMi611840. gene.
neXtProtiNX_Q9BQ48.
PharmGKBiPA30965.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG273530.
GeneTreeiENSGT00390000012240.
HOGENOMiHOG000111573.
HOVERGENiHBG018253.
InParanoidiQ9BQ48.
KOiK02914.
PhylomeDBiQ9BQ48.
TreeFamiTF324478.

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Miscellaneous databases

ChiTaRSiMRPL34. human.
GenomeRNAii64981.
NextBioi67172.
PROiQ9BQ48.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BQ48.
CleanExiHS_MRPL34.
ExpressionAtlasiQ9BQ48. baseline and differential.
GenevestigatoriQ9BQ48.

Family and domain databases

InterProiIPR000271. Ribosomal_L34.
[Graphical view]
PANTHERiPTHR14503. PTHR14503. 1 hit.
PfamiPF00468. Ribosomal_L34. 1 hit.
[Graphical view]
ProDomiPD003101. Ribosomal_L34. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR01030. rpmH_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Placenta.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM34_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: June 1, 2001
Last modified: March 4, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.