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Q9BQ31 (KCNS3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily S member 3
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 3
Voltage-gated potassium channel subunit Kv9.3
Gene names
Name:KCNS3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potassium channel subunit. Modulates channel activity and reduces the ion flow By similarity.

Subunit structure

Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.

Tissue specificity

Detected in whole normal term placental and placental chorionic plate arteries and veins. Detected in syncytiotrophoblast and in blood vessel endothelium within intermediate villi and chorionic plate (at protein level). Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung. Ref.6

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Potassium voltage-gated channel subfamily S member 3
PRO_0000054087

Regions

Topological domain1 – 185185Cytoplasmic Potential
Transmembrane186 – 20621Helical; Name=Segment S1; Potential
Topological domain207 – 21812Extracellular Potential
Transmembrane219 – 23921Helical; Name=Segment S2; Potential
Topological domain240 – 25314Cytoplasmic Potential
Transmembrane254 – 27421Helical; Name=Segment S3; Potential
Topological domain275 – 28713Extracellular Potential
Transmembrane288 – 30821Helical; Name=Segment S4; Potential
Topological domain309 – 32315Cytoplasmic Potential
Transmembrane324 – 34421Helical; Name=Segment S5; Potential
Topological domain345 – 35713Extracellular Potential
Intramembrane358 – 37821Pore-forming; Name=Segment H5; Potential
Topological domain379 – 3857Extracellular Potential
Transmembrane386 – 40621Helical; Name=Segment S6; Potential
Topological domain407 – 49185Cytoplasmic Potential
Region358 – 37821Segment H5 (pore-forming) Potential
Motif370 – 3756Selectivity filter By similarity

Natural variations

Natural variant2251V → L. Ref.5
Corresponds to variant rs17856097 [ dbSNP | Ensembl ].
VAR_036986
Natural variant4501T → A. Ref.1 Ref.4 Ref.5
Corresponds to variant rs4832524 [ dbSNP | Ensembl ].
VAR_014200

Experimental info

Sequence conflict271S → Y in AAH15947. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9BQ31 [UniParc].

Last modified November 2, 2010. Version 3.
Checksum: FFE02CA3DCA50185

FASTA49156,001
        10         20         30         40         50         60 
MVFGEFFHRP GQDEELVNLN VGGFKQSVDQ STLLRFPHTR LGKLLTCHSE EAILELCDDY 

        70         80         90        100        110        120 
SVADKEYYFD RNPSLFRYVL NFYYTGKLHV MEELCVFSFC QEIEYWGINE LFIDSCCSNR 

       130        140        150        160        170        180 
YQERKEENHE KDWDQKSHDV STDSSFEESS LFEKELEKFD TLRFGQLRKK IWIRMENPAY 

       190        200        210        220        230        240 
CLSAKLIAIS SLSVVLASIV AMCVHSMSEF QNEDGEVDDP VLEGVEIACI AWFTGELAVR 

       250        260        270        280        290        300 
LAAAPCQKKF WKNPLNIIDF VSIIPFYATL AVDTKEEESE DIENMGKVVQ ILRLMRIFRI 

       310        320        330        340        350        360 
LKLARHSVGL RSLGATLRHS YHEVGLLLLF LSVGISIFSV LIYSVEKDDH TSSLTSIPIC 

       370        380        390        400        410        420 
WWWATISMTT VGYGDTHPVT LAGKLIASTC IICGILVVAL PITIIFNKFS KYYQKQKDID 

       430        440        450        460        470        480 
VDQCSEDAPE KCHELPYFNI RDIYAQRMHT FITSLSSVGI VVSDPDSTDA SSIEDNEDIC 

       490 
NTTSLENCTA K 

« Hide

References

« Hide 'large scale' references
[1]"Electrically silent potassium channel subunits from human lens epithelium."
Shepard A.R., Rae J.L.
Am. J. Physiol. 277:C412-C424(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-450.
Tissue: Lens epithelium.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-450.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-225 AND ALA-450.
Tissue: Kidney and Skin.
[6]"Expression of an electrically silent voltage-gated potassium channel in the human placenta."
Fyfe G.K., Panicker S., Jones R.L., Wareing M.
J. Obstet. Gynaecol. 32:624-629(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF043472 mRNA. Translation: AAC13164.1.
AK314451 mRNA. Translation: BAG37059.1.
AC093731 Genomic DNA. Translation: AAX88969.1.
CH471053 Genomic DNA. Translation: EAX00861.1.
CH471053 Genomic DNA. Translation: EAX00862.1.
BC004148 mRNA. Translation: AAH04148.1.
BC004987 mRNA. Translation: AAH04987.1.
BC015947 mRNA. Translation: AAH15947.1.
CCDSCCDS1692.1.
RefSeqNP_001269357.1. NM_001282428.1.
NP_002243.3. NM_002252.4.
UniGeneHs.414489.

3D structure databases

ProteinModelPortalQ9BQ31.
SMRQ9BQ31. Positions 14-416.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109991. 2 interactions.
IntActQ9BQ31. 1 interaction.
STRING9606.ENSP00000305824.

Chemistry

ChEMBLCHEMBL2362996.

Protein family/group databases

TCDB1.A.1.2.15. the voltage-gated ion channel (vic) superfamily.

Polymorphism databases

DMDM311033434.

Proteomic databases

PaxDbQ9BQ31.
PRIDEQ9BQ31.

Protocols and materials databases

DNASU3790.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304101; ENSP00000305824; ENSG00000170745.
ENST00000403915; ENSP00000385968; ENSG00000170745.
GeneID3790.
KEGGhsa:3790.
UCSCuc002rcv.3. human.

Organism-specific databases

CTD3790.
GeneCardsGC02P018059.
H-InvDBHIX0001848.
HGNCHGNC:6302. KCNS3.
HPAHPA014864.
MIM603888. gene.
neXtProtNX_Q9BQ31.
PharmGKBPA30080.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1226.
HOGENOMHOG000231016.
HOVERGENHBG052230.
InParanoidQ9BQ31.
KOK04933.
OMAWDQKSND.
OrthoDBEOG7CRTPP.
PhylomeDBQ9BQ31.
TreeFamTF313103.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_13685. Neuronal System.

Gene expression databases

ArrayExpressQ9BQ31.
BgeeQ9BQ31.
CleanExHS_KCNS3.
GenevestigatorQ9BQ31.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

GeneWikiKCNS3.
GenomeRNAi3790.
NextBio14883.
PROQ9BQ31.
SOURCESearch...

Entry information

Entry nameKCNS3_HUMAN
AccessionPrimary (citable) accession number: Q9BQ31
Secondary accession number(s): D6W520 expand/collapse secondary AC list , O43651, Q4ZFY1, Q96B56
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM