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Protein

Potassium voltage-gated channel subfamily S member 3

Gene

KCNS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:10484328). Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity).By similarity1 Publication

GO - Molecular functioni

  • delayed rectifier potassium channel activity Source: ProtInc
  • potassium channel regulator activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-HSA-1296072 Voltage gated Potassium channels
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

Protein family/group databases

TCDBi1.A.1.2.15 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily S member 3
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 3
Voltage-gated potassium channel subunit Kv9.3
Gene namesi
Name:KCNS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000170745.11
HGNCiHGNC:6302 KCNS3
MIMi603888 gene
neXtProtiNX_Q9BQ31

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 182CytoplasmicBy similarityAdd BLAST182
Transmembranei183 – 204Helical; Name=Segment S1By similarityAdd BLAST22
Topological domaini205 – 220ExtracellularBy similarityAdd BLAST16
Transmembranei221 – 243Helical; Name=Segment S2By similarityAdd BLAST23
Topological domaini244 – 254CytoplasmicBy similarityAdd BLAST11
Transmembranei255 – 275Helical; Name=Segment S3By similarityAdd BLAST21
Topological domaini276 – 285ExtracellularBy similarity10
Transmembranei286 – 306Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST21
Topological domaini307 – 321CytoplasmicBy similarityAdd BLAST15
Transmembranei322 – 343Helical; Name=Segment S5By similarityAdd BLAST22
Topological domaini344 – 357ExtracellularBy similarityAdd BLAST14
Intramembranei358 – 369Helical; Name=Pore helixBy similarityAdd BLAST12
Intramembranei370 – 377By similarity8
Topological domaini378 – 384ExtracellularBy similarity7
Transmembranei385 – 413Helical; Name=Segment S6By similarityAdd BLAST29
Topological domaini414 – 491CytoplasmicBy similarityAdd BLAST78

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3790
OpenTargetsiENSG00000170745
PharmGKBiPA30080

Chemistry databases

ChEMBLiCHEMBL2362996

Polymorphism and mutation databases

BioMutaiKCNS3
DMDMi311033434

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540871 – 491Potassium voltage-gated channel subfamily S member 3Add BLAST491

Proteomic databases

PaxDbiQ9BQ31
PeptideAtlasiQ9BQ31
PRIDEiQ9BQ31

Expressioni

Tissue specificityi

Detected in whole normal term placental and placental chorionic plate arteries and veins. Detected in syncytiotrophoblast and in blood vessel endothelium within intermediate villi and chorionic plate (at protein level) (PubMed:22943705). Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung (PubMed:10484328).2 Publications

Gene expression databases

BgeeiENSG00000170745
CleanExiHS_KCNS3
ExpressionAtlasiQ9BQ31 baseline and differential
GenevisibleiQ9BQ31 HS

Organism-specific databases

HPAiHPA014864

Interactioni

Subunit structurei

Heterotetramer with KCNB1 (PubMed:10484328). Does not form homomultimers (PubMed:10484328).1 Publication

Protein-protein interaction databases

BioGridi109991, 36 interactors
IntActiQ9BQ31, 1 interactor
STRINGi9606.ENSP00000305824

Structurei

3D structure databases

ProteinModelPortaliQ9BQ31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi370 – 375Selectivity filterBy similarity6

Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118981
HOGENOMiHOG000231016
HOVERGENiHBG052230
InParanoidiQ9BQ31
KOiK04933
OMAiWDQKSND
OrthoDBiEOG091G0FP3
PhylomeDBiQ9BQ31
TreeFamiTF313103

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003971 K_chnl_volt-dep_Kv9
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01494 KV9CHANNEL
PR01491 KVCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BQ31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFGEFFHRP GQDEELVNLN VGGFKQSVDQ STLLRFPHTR LGKLLTCHSE
60 70 80 90 100
EAILELCDDY SVADKEYYFD RNPSLFRYVL NFYYTGKLHV MEELCVFSFC
110 120 130 140 150
QEIEYWGINE LFIDSCCSNR YQERKEENHE KDWDQKSHDV STDSSFEESS
160 170 180 190 200
LFEKELEKFD TLRFGQLRKK IWIRMENPAY CLSAKLIAIS SLSVVLASIV
210 220 230 240 250
AMCVHSMSEF QNEDGEVDDP VLEGVEIACI AWFTGELAVR LAAAPCQKKF
260 270 280 290 300
WKNPLNIIDF VSIIPFYATL AVDTKEEESE DIENMGKVVQ ILRLMRIFRI
310 320 330 340 350
LKLARHSVGL RSLGATLRHS YHEVGLLLLF LSVGISIFSV LIYSVEKDDH
360 370 380 390 400
TSSLTSIPIC WWWATISMTT VGYGDTHPVT LAGKLIASTC IICGILVVAL
410 420 430 440 450
PITIIFNKFS KYYQKQKDID VDQCSEDAPE KCHELPYFNI RDIYAQRMHT
460 470 480 490
FITSLSSVGI VVSDPDSTDA SSIEDNEDIC NTTSLENCTA K
Length:491
Mass (Da):56,001
Last modified:November 2, 2010 - v3
Checksum:iFFE02CA3DCA50185
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27S → Y in AAH15947 (PubMed:15815621).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036986225V → L1 PublicationCorresponds to variant dbSNP:rs17856097Ensembl.1
Natural variantiVAR_014200450T → A3 PublicationsCorresponds to variant dbSNP:rs4832524Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043472 mRNA Translation: AAC13164.1
AK314451 mRNA Translation: BAG37059.1
AC093731 Genomic DNA Translation: AAX88969.1
CH471053 Genomic DNA Translation: EAX00861.1
CH471053 Genomic DNA Translation: EAX00862.1
BC004148 mRNA Translation: AAH04148.1
BC004987 mRNA Translation: AAH04987.1
BC015947 mRNA Translation: AAH15947.1
CCDSiCCDS1692.1
RefSeqiNP_001269357.1, NM_001282428.1
NP_002243.3, NM_002252.4
XP_011531127.1, XM_011532825.1
XP_016859548.1, XM_017004059.1
UniGeneiHs.414489

Genome annotation databases

EnsembliENST00000304101; ENSP00000305824; ENSG00000170745
ENST00000403915; ENSP00000385968; ENSG00000170745
GeneIDi3790
KEGGihsa:3790
UCSCiuc002rcv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKCNS3_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ31
Secondary accession number(s): D6W520
, O43651, Q4ZFY1, Q96B56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: November 2, 2010
Last modified: April 25, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health