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Q9BQ31

- KCNS3_HUMAN

UniProt

Q9BQ31 - KCNS3_HUMAN

Protein

Potassium voltage-gated channel subfamily S member 3

Gene

KCNS3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 3 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Potassium channel subunit. Modulates channel activity and reduces the ion flow By similarity.By similarity

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: ProtInc
    2. potassium channel regulator activity Source: ProtInc

    GO - Biological processi

    1. energy reserve metabolic process Source: Reactome
    2. potassium ion transport Source: ProtInc
    3. protein homooligomerization Source: InterPro
    4. regulation of insulin secretion Source: Reactome
    5. small molecule metabolic process Source: Reactome
    6. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_75770. Voltage gated Potassium channels.

    Protein family/group databases

    TCDBi1.A.1.2.15. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily S member 3
    Alternative name(s):
    Delayed-rectifier K(+) channel alpha subunit 3
    Voltage-gated potassium channel subunit Kv9.3
    Gene namesi
    Name:KCNS3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:6302. KCNS3.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein
    Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. Golgi apparatus Source: HPA
    3. plasma membrane Source: HPA
    4. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30080.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Potassium voltage-gated channel subfamily S member 3PRO_0000054087Add
    BLAST

    Proteomic databases

    PaxDbiQ9BQ31.
    PRIDEiQ9BQ31.

    Expressioni

    Tissue specificityi

    Detected in whole normal term placental and placental chorionic plate arteries and veins. Detected in syncytiotrophoblast and in blood vessel endothelium within intermediate villi and chorionic plate (at protein level). Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung.1 Publication

    Gene expression databases

    ArrayExpressiQ9BQ31.
    BgeeiQ9BQ31.
    CleanExiHS_KCNS3.
    GenevestigatoriQ9BQ31.

    Organism-specific databases

    HPAiHPA014864.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins By similarity.By similarity

    Protein-protein interaction databases

    BioGridi109991. 2 interactions.
    IntActiQ9BQ31. 1 interaction.
    STRINGi9606.ENSP00000305824.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BQ31.
    SMRiQ9BQ31. Positions 14-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 185185CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini207 – 21812ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini240 – 25314CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini275 – 28713ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini309 – 32315CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini345 – 35713ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini379 – 3857ExtracellularSequence Analysis
    Topological domaini407 – 49185CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei358 – 37821Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei186 – 20621Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei219 – 23921Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei254 – 27421Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821Helical; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei324 – 34421Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei386 – 40621Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni358 – 37821Segment H5 (pore-forming)Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi370 – 3756Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231016.
    HOVERGENiHBG052230.
    InParanoidiQ9BQ31.
    KOiK04933.
    OMAiWDQKSND.
    OrthoDBiEOG7CRTPP.
    PhylomeDBiQ9BQ31.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9BQ31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVFGEFFHRP GQDEELVNLN VGGFKQSVDQ STLLRFPHTR LGKLLTCHSE    50
    EAILELCDDY SVADKEYYFD RNPSLFRYVL NFYYTGKLHV MEELCVFSFC 100
    QEIEYWGINE LFIDSCCSNR YQERKEENHE KDWDQKSHDV STDSSFEESS 150
    LFEKELEKFD TLRFGQLRKK IWIRMENPAY CLSAKLIAIS SLSVVLASIV 200
    AMCVHSMSEF QNEDGEVDDP VLEGVEIACI AWFTGELAVR LAAAPCQKKF 250
    WKNPLNIIDF VSIIPFYATL AVDTKEEESE DIENMGKVVQ ILRLMRIFRI 300
    LKLARHSVGL RSLGATLRHS YHEVGLLLLF LSVGISIFSV LIYSVEKDDH 350
    TSSLTSIPIC WWWATISMTT VGYGDTHPVT LAGKLIASTC IICGILVVAL 400
    PITIIFNKFS KYYQKQKDID VDQCSEDAPE KCHELPYFNI RDIYAQRMHT 450
    FITSLSSVGI VVSDPDSTDA SSIEDNEDIC NTTSLENCTA K 491
    Length:491
    Mass (Da):56,001
    Last modified:November 2, 2010 - v3
    Checksum:iFFE02CA3DCA50185
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271S → Y in AAH15947. (PubMed:15815621)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti225 – 2251V → L.1 Publication
    Corresponds to variant rs17856097 [ dbSNP | Ensembl ].
    VAR_036986
    Natural varianti450 – 4501T → A.3 Publications
    Corresponds to variant rs4832524 [ dbSNP | Ensembl ].
    VAR_014200

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043472 mRNA. Translation: AAC13164.1.
    AK314451 mRNA. Translation: BAG37059.1.
    AC093731 Genomic DNA. Translation: AAX88969.1.
    CH471053 Genomic DNA. Translation: EAX00861.1.
    CH471053 Genomic DNA. Translation: EAX00862.1.
    BC004148 mRNA. Translation: AAH04148.1.
    BC004987 mRNA. Translation: AAH04987.1.
    BC015947 mRNA. Translation: AAH15947.1.
    CCDSiCCDS1692.1.
    RefSeqiNP_001269357.1. NM_001282428.1.
    NP_002243.3. NM_002252.4.
    UniGeneiHs.414489.

    Genome annotation databases

    EnsembliENST00000304101; ENSP00000305824; ENSG00000170745.
    ENST00000403915; ENSP00000385968; ENSG00000170745.
    GeneIDi3790.
    KEGGihsa:3790.
    UCSCiuc002rcv.3. human.

    Polymorphism databases

    DMDMi311033434.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043472 mRNA. Translation: AAC13164.1 .
    AK314451 mRNA. Translation: BAG37059.1 .
    AC093731 Genomic DNA. Translation: AAX88969.1 .
    CH471053 Genomic DNA. Translation: EAX00861.1 .
    CH471053 Genomic DNA. Translation: EAX00862.1 .
    BC004148 mRNA. Translation: AAH04148.1 .
    BC004987 mRNA. Translation: AAH04987.1 .
    BC015947 mRNA. Translation: AAH15947.1 .
    CCDSi CCDS1692.1.
    RefSeqi NP_001269357.1. NM_001282428.1.
    NP_002243.3. NM_002252.4.
    UniGenei Hs.414489.

    3D structure databases

    ProteinModelPortali Q9BQ31.
    SMRi Q9BQ31. Positions 14-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109991. 2 interactions.
    IntActi Q9BQ31. 1 interaction.
    STRINGi 9606.ENSP00000305824.

    Chemistry

    ChEMBLi CHEMBL2362996.

    Protein family/group databases

    TCDBi 1.A.1.2.15. the voltage-gated ion channel (vic) superfamily.

    Polymorphism databases

    DMDMi 311033434.

    Proteomic databases

    PaxDbi Q9BQ31.
    PRIDEi Q9BQ31.

    Protocols and materials databases

    DNASUi 3790.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304101 ; ENSP00000305824 ; ENSG00000170745 .
    ENST00000403915 ; ENSP00000385968 ; ENSG00000170745 .
    GeneIDi 3790.
    KEGGi hsa:3790.
    UCSCi uc002rcv.3. human.

    Organism-specific databases

    CTDi 3790.
    GeneCardsi GC02P018059.
    H-InvDB HIX0001848.
    HGNCi HGNC:6302. KCNS3.
    HPAi HPA014864.
    MIMi 603888. gene.
    neXtProti NX_Q9BQ31.
    PharmGKBi PA30080.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231016.
    HOVERGENi HBG052230.
    InParanoidi Q9BQ31.
    KOi K04933.
    OMAi WDQKSND.
    OrthoDBi EOG7CRTPP.
    PhylomeDBi Q9BQ31.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNS3.
    GenomeRNAii 3790.
    NextBioi 14883.
    PROi Q9BQ31.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BQ31.
    Bgeei Q9BQ31.
    CleanExi HS_KCNS3.
    Genevestigatori Q9BQ31.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Electrically silent potassium channel subunits from human lens epithelium."
      Shepard A.R., Rae J.L.
      Am. J. Physiol. 277:C412-C424(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-450.
      Tissue: Lens epithelium.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-450.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-225 AND ALA-450.
      Tissue: Kidney and Skin.
    6. "Expression of an electrically silent voltage-gated potassium channel in the human placenta."
      Fyfe G.K., Panicker S., Jones R.L., Wareing M.
      J. Obstet. Gynaecol. 32:624-629(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiKCNS3_HUMAN
    AccessioniPrimary (citable) accession number: Q9BQ31
    Secondary accession number(s): D6W520
    , O43651, Q4ZFY1, Q96B56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 119 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3