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Q9BQ31

- KCNS3_HUMAN

UniProt

Q9BQ31 - KCNS3_HUMAN

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Protein

Potassium voltage-gated channel subfamily S member 3

Gene

KCNS3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity).By similarity

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: ProtInc
  2. potassium channel regulator activity Source: ProtInc

GO - Biological processi

  1. energy reserve metabolic process Source: Reactome
  2. potassium ion transport Source: ProtInc
  3. protein homooligomerization Source: InterPro
  4. regulation of insulin secretion Source: Reactome
  5. small molecule metabolic process Source: Reactome
  6. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_75770. Voltage gated Potassium channels.

Protein family/group databases

TCDBi1.A.1.2.15. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily S member 3
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 3
Voltage-gated potassium channel subunit Kv9.3
Gene namesi
Name:KCNS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:6302. KCNS3.

Subcellular locationi

Cell membrane; Multi-pass membrane protein
Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 185185CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei186 – 20621Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Topological domaini207 – 21812ExtracellularSequence AnalysisAdd
BLAST
Transmembranei219 – 23921Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Topological domaini240 – 25314CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei254 – 27421Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Topological domaini275 – 28713ExtracellularSequence AnalysisAdd
BLAST
Transmembranei288 – 30821Helical; Name=Segment S4Sequence AnalysisAdd
BLAST
Topological domaini309 – 32315CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei324 – 34421Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Topological domaini345 – 35713ExtracellularSequence AnalysisAdd
BLAST
Intramembranei358 – 37821Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST
Topological domaini379 – 3857ExtracellularSequence Analysis
Transmembranei386 – 40621Helical; Name=Segment S6Sequence AnalysisAdd
BLAST
Topological domaini407 – 49185CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. Golgi apparatus Source: HPA
  3. plasma membrane Source: HPA
  4. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30080.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Potassium voltage-gated channel subfamily S member 3PRO_0000054087Add
BLAST

Proteomic databases

PaxDbiQ9BQ31.
PRIDEiQ9BQ31.

Expressioni

Tissue specificityi

Detected in whole normal term placental and placental chorionic plate arteries and veins. Detected in syncytiotrophoblast and in blood vessel endothelium within intermediate villi and chorionic plate (at protein level). Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung.1 Publication

Gene expression databases

BgeeiQ9BQ31.
CleanExiHS_KCNS3.
ExpressionAtlasiQ9BQ31. baseline and differential.
GenevestigatoriQ9BQ31.

Organism-specific databases

HPAiHPA014864.

Interactioni

Subunit structurei

Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins (By similarity).By similarity

Protein-protein interaction databases

BioGridi109991. 2 interactions.
IntActiQ9BQ31. 1 interaction.
STRINGi9606.ENSP00000305824.

Structurei

3D structure databases

ProteinModelPortaliQ9BQ31.
SMRiQ9BQ31. Positions 14-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni358 – 37821Segment H5 (pore-forming)Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi370 – 3756Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ9BQ31.
KOiK04933.
OMAiWDQKSND.
OrthoDBiEOG7CRTPP.
PhylomeDBiQ9BQ31.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BQ31-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVFGEFFHRP GQDEELVNLN VGGFKQSVDQ STLLRFPHTR LGKLLTCHSE
60 70 80 90 100
EAILELCDDY SVADKEYYFD RNPSLFRYVL NFYYTGKLHV MEELCVFSFC
110 120 130 140 150
QEIEYWGINE LFIDSCCSNR YQERKEENHE KDWDQKSHDV STDSSFEESS
160 170 180 190 200
LFEKELEKFD TLRFGQLRKK IWIRMENPAY CLSAKLIAIS SLSVVLASIV
210 220 230 240 250
AMCVHSMSEF QNEDGEVDDP VLEGVEIACI AWFTGELAVR LAAAPCQKKF
260 270 280 290 300
WKNPLNIIDF VSIIPFYATL AVDTKEEESE DIENMGKVVQ ILRLMRIFRI
310 320 330 340 350
LKLARHSVGL RSLGATLRHS YHEVGLLLLF LSVGISIFSV LIYSVEKDDH
360 370 380 390 400
TSSLTSIPIC WWWATISMTT VGYGDTHPVT LAGKLIASTC IICGILVVAL
410 420 430 440 450
PITIIFNKFS KYYQKQKDID VDQCSEDAPE KCHELPYFNI RDIYAQRMHT
460 470 480 490
FITSLSSVGI VVSDPDSTDA SSIEDNEDIC NTTSLENCTA K
Length:491
Mass (Da):56,001
Last modified:November 2, 2010 - v3
Checksum:iFFE02CA3DCA50185
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271S → Y in AAH15947. (PubMed:15815621)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti225 – 2251V → L.1 Publication
Corresponds to variant rs17856097 [ dbSNP | Ensembl ].
VAR_036986
Natural varianti450 – 4501T → A.3 Publications
Corresponds to variant rs4832524 [ dbSNP | Ensembl ].
VAR_014200

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043472 mRNA. Translation: AAC13164.1.
AK314451 mRNA. Translation: BAG37059.1.
AC093731 Genomic DNA. Translation: AAX88969.1.
CH471053 Genomic DNA. Translation: EAX00861.1.
CH471053 Genomic DNA. Translation: EAX00862.1.
BC004148 mRNA. Translation: AAH04148.1.
BC004987 mRNA. Translation: AAH04987.1.
BC015947 mRNA. Translation: AAH15947.1.
CCDSiCCDS1692.1.
RefSeqiNP_001269357.1. NM_001282428.1.
NP_002243.3. NM_002252.4.
UniGeneiHs.414489.

Genome annotation databases

EnsembliENST00000304101; ENSP00000305824; ENSG00000170745.
ENST00000403915; ENSP00000385968; ENSG00000170745.
GeneIDi3790.
KEGGihsa:3790.
UCSCiuc002rcv.3. human.

Polymorphism databases

DMDMi311033434.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043472 mRNA. Translation: AAC13164.1 .
AK314451 mRNA. Translation: BAG37059.1 .
AC093731 Genomic DNA. Translation: AAX88969.1 .
CH471053 Genomic DNA. Translation: EAX00861.1 .
CH471053 Genomic DNA. Translation: EAX00862.1 .
BC004148 mRNA. Translation: AAH04148.1 .
BC004987 mRNA. Translation: AAH04987.1 .
BC015947 mRNA. Translation: AAH15947.1 .
CCDSi CCDS1692.1.
RefSeqi NP_001269357.1. NM_001282428.1.
NP_002243.3. NM_002252.4.
UniGenei Hs.414489.

3D structure databases

ProteinModelPortali Q9BQ31.
SMRi Q9BQ31. Positions 14-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109991. 2 interactions.
IntActi Q9BQ31. 1 interaction.
STRINGi 9606.ENSP00000305824.

Chemistry

ChEMBLi CHEMBL2362996.

Protein family/group databases

TCDBi 1.A.1.2.15. the voltage-gated ion channel (vic) superfamily.

Polymorphism databases

DMDMi 311033434.

Proteomic databases

PaxDbi Q9BQ31.
PRIDEi Q9BQ31.

Protocols and materials databases

DNASUi 3790.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304101 ; ENSP00000305824 ; ENSG00000170745 .
ENST00000403915 ; ENSP00000385968 ; ENSG00000170745 .
GeneIDi 3790.
KEGGi hsa:3790.
UCSCi uc002rcv.3. human.

Organism-specific databases

CTDi 3790.
GeneCardsi GC02P018059.
H-InvDB HIX0001848.
HGNCi HGNC:6302. KCNS3.
HPAi HPA014864.
MIMi 603888. gene.
neXtProti NX_Q9BQ31.
PharmGKBi PA30080.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000118981.
HOGENOMi HOG000231016.
HOVERGENi HBG052230.
InParanoidi Q9BQ31.
KOi K04933.
OMAi WDQKSND.
OrthoDBi EOG7CRTPP.
PhylomeDBi Q9BQ31.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikii KCNS3.
GenomeRNAii 3790.
NextBioi 14883.
PROi Q9BQ31.
SOURCEi Search...

Gene expression databases

Bgeei Q9BQ31.
CleanExi HS_KCNS3.
ExpressionAtlasi Q9BQ31. baseline and differential.
Genevestigatori Q9BQ31.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Electrically silent potassium channel subunits from human lens epithelium."
    Shepard A.R., Rae J.L.
    Am. J. Physiol. 277:C412-C424(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-450.
    Tissue: Lens epithelium.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-450.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-225 AND ALA-450.
    Tissue: Kidney and Skin.
  6. "Expression of an electrically silent voltage-gated potassium channel in the human placenta."
    Fyfe G.K., Panicker S., Jones R.L., Wareing M.
    J. Obstet. Gynaecol. 32:624-629(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiKCNS3_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ31
Secondary accession number(s): D6W520
, O43651, Q4ZFY1, Q96B56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3