Q9BQ31 (KCNS3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily S member 3

Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 3
Voltage-gated potassium channel subunit Kv9.3

Gene names

Name:

KCNS3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Potassium channel subunit. Modulates channel activity and reduces the ion flow By similarity.
Subunit structure	Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein. Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.
Tissue specificity	Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung.
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similarities	Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	energy reserve metabolic process Traceable author statement. Source: Reactome protein homooligomerization Inferred from electronic annotation. Source: InterPro regulation of insulin secretion Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	Golgi apparatus Inferred from direct assay. Source: HPA plasma membrane Inferred from direct assay. Source: HPA voltage-gated potassium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	delayed rectifier potassium channel activity Traceable author statement Ref.1. Source: ProtInc potassium channel regulator activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 491	491	Potassium voltage-gated channel subfamily S member 3		PRO_0000054087
Regions
	Topological domain	1 – 185	185	Cytoplasmic Potential
	Transmembrane	186 – 206	21	Helical; Name=Segment S1; Potential
	Topological domain	207 – 218	12	Extracellular Potential
	Transmembrane	219 – 239	21	Helical; Name=Segment S2; Potential
	Topological domain	240 – 253	14	Cytoplasmic Potential
	Transmembrane	254 – 274	21	Helical; Name=Segment S3; Potential
	Topological domain	275 – 287	13	Extracellular Potential
	Transmembrane	288 – 308	21	Helical; Name=Segment S4; Potential
	Topological domain	309 – 323	15	Cytoplasmic Potential
	Transmembrane	324 – 344	21	Helical; Name=Segment S5; Potential
	Topological domain	345 – 357	13	Extracellular Potential
	Intramembrane	358 – 378	21	Pore-forming; Name=Segment H5; Potential
	Topological domain	379 – 385	7	Extracellular Potential
	Transmembrane	386 – 406	21	Helical; Name=Segment S6; Potential
	Topological domain	407 – 491	85	Cytoplasmic Potential
	Region	358 – 378	21	Segment H5 (pore-forming) Potential
	Motif	370 – 375	6	Selectivity filter By similarity
Natural variations
	Natural variant	225	1	V → L. Ref.5 Corresponds to variant rs17856097 [ dbSNP | Ensembl ].		VAR_036986
	Natural variant	450	1	T → A. Ref.1 Ref.4 Ref.5 Corresponds to variant rs4832524 [ dbSNP | Ensembl ].		VAR_014200
Experimental info
	Sequence conflict	27	1	S → Y in AAH15947. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9BQ31 [UniParc]. Last modified November 2, 2010. Version 3. Checksum: FFE02CA3DCA50185	FASTA	491	56,001
	10 20 30 40 50 60 MVFGEFFHRP GQDEELVNLN VGGFKQSVDQ STLLRFPHTR LGKLLTCHSE EAILELCDDY 70 80 90 100 110 120 SVADKEYYFD RNPSLFRYVL NFYYTGKLHV MEELCVFSFC QEIEYWGINE LFIDSCCSNR 130 140 150 160 170 180 YQERKEENHE KDWDQKSHDV STDSSFEESS LFEKELEKFD TLRFGQLRKK IWIRMENPAY 190 200 210 220 230 240 CLSAKLIAIS SLSVVLASIV AMCVHSMSEF QNEDGEVDDP VLEGVEIACI AWFTGELAVR 250 260 270 280 290 300 LAAAPCQKKF WKNPLNIIDF VSIIPFYATL AVDTKEEESE DIENMGKVVQ ILRLMRIFRI 310 320 330 340 350 360 LKLARHSVGL RSLGATLRHS YHEVGLLLLF LSVGISIFSV LIYSVEKDDH TSSLTSIPIC 370 380 390 400 410 420 WWWATISMTT VGYGDTHPVT LAGKLIASTC IICGILVVAL PITIIFNKFS KYYQKQKDID 430 440 450 460 470 480 VDQCSEDAPE KCHELPYFNI RDIYAQRMHT FITSLSSVGI VVSDPDSTDA SSIEDNEDIC 490 NTTSLENCTA K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Electrically silent potassium channel subunits from human lens epithelium." Shepard A.R., Rae J.L. Am. J. Physiol. 277:C412-C424(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-450. Tissue: Lens epithelium.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-450.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-225 AND ALA-450. Tissue: Kidney and Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF043472 mRNA. Translation: AAC13164.1. AK314451 mRNA. Translation: BAG37059.1. AC093731 Genomic DNA. Translation: AAX88969.1. CH471053 Genomic DNA. Translation: EAX00861.1. CH471053 Genomic DNA. Translation: EAX00862.1. BC004148 mRNA. Translation: AAH04148.1. BC004987 mRNA. Translation: AAH04987.1. BC015947 mRNA. Translation: AAH15947.1.
IPI	IPI00304363.
RefSeq	NP_002243.3. NM_002252.3.
UniGene	Hs.414489.
3D structure databases
ProteinModelPortal	Q9BQ31.
SMR	Q9BQ31. Positions 14-416.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BQ31. 1 interaction.
STRING	9606.ENSP00000305824.
Polymorphism databases
DMDM	311033434.
Proteomic databases
PaxDb	Q9BQ31.
PRIDE	Q9BQ31.
Protocols and materials databases
DNASU	3790.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304101; ENSP00000305824; ENSG00000170745. ENST00000403915; ENSP00000385968; ENSG00000170745.
GeneID	3790.
KEGG	hsa:3790.
UCSC	uc002rcv.3. human.
Organism-specific databases
CTD	3790.
GeneCards	GC02P018059.
H-InvDB	HIX0001848.
HGNC	HGNC:6302. KCNS3.
HPA	HPA014864.
MIM	603888. gene.
neXtProt	NX_Q9BQ31.
PharmGKB	PA30080.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1226.
HOGENOM	HOG000231016.
HOVERGEN	HBG052230.
InParanoid	Q9BQ31.
KO	K04933.
OMA	PSQKKFW.
OrthoDB	EOG4PVNZS.
PhylomeDB	Q9BQ31.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_13685. Neuronal System.
Gene expression databases
ArrayExpress	Q9BQ31.
Bgee	Q9BQ31.
CleanEx	HS_KCNS3.
Genevestigator	Q9BQ31.
GermOnline	ENSG00000170745. Homo sapiens.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003971. K_chnl_volt-dep_Kv9. IPR003131. T1-type_BTB. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01494. KV9CHANNEL. PR01491. KVCHANNEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	3790.
NextBio	14883.
SOURCE	Search...

Entry information

Entry name

KCNS3_HUMAN

Accession

Primary (citable) accession number: Q9BQ31
Secondary accession number(s): D6W520 , O43651, Q4ZFY1, Q96B56

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2002
Last sequence update:	November 2, 2010
Last modified:	May 1, 2013
This is version 105 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.