ID   TICN3_HUMAN             Reviewed;         436 AA.
AC   Q9BQ16; B2R7M7; B3KR67; B4DGK5; B4DHB4; B4DHV3; B4DI46; B4DJY3; E7EP61;
AC   F5H099; O75705; Q6UW53; Q96Q26;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 2.
DT   27-MAR-2024, entry version 192.
DE   RecName: Full=Testican-3;
DE   AltName: Full=SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3;
DE   Flags: Precursor;
GN   Name=SPOCK3; Synonyms=TICN3; ORFNames=UNQ409/PRO771;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RC   TISSUE=Brain;
RA   Vannahme C., Hartmann U., Goesling S., Kohfeldt E., Timpl R., Paulsson M.,
RA   Maurer P.;
RT   "Cloning and expression of testican-3, a novel member of brain-specific,
RT   calcium-binding proteoglycans.";
RL   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND CHARACTERIZATION.
RC   TISSUE=Fetal kidney;
RX   PubMed=11751414;
RA   Nakada M., Yamada A., Takino T., Miyamori H., Takahashi T., Yamashita J.,
RA   Sato H.;
RT   "Suppression of membrane-type 1 matrix metalloproteinase (MMP)-mediated
RT   MMP-2 activation and tumor invasion by testican 3 and its splicing variant
RT   gene product, N-Tes.";
RL   Cancer Res. 61:8896-8902(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4; 5; 6 AND 7), AND
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-356 (ISOFORM 8).
RC   TISSUE=Brain, Caudate nucleus, Corpus callosum, and Thalamus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Lung, and Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May participate in diverse steps of neurogenesis. Inhibits
CC       the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and
CC       MT3-MMP. May interfere with tumor invasion.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=9;
CC       Name=3;
CC         IsoId=Q9BQ16-3; Sequence=Displayed;
CC       Name=1;
CC         IsoId=Q9BQ16-1; Sequence=VSP_013598;
CC       Name=2; Synonyms=N-tes;
CC         IsoId=Q9BQ16-2; Sequence=VSP_005334, VSP_005335;
CC       Name=4;
CC         IsoId=Q9BQ16-4; Sequence=VSP_043681;
CC       Name=5;
CC         IsoId=Q9BQ16-5; Sequence=VSP_045104;
CC       Name=6;
CC         IsoId=Q9BQ16-6; Sequence=VSP_045899, VSP_045900;
CC       Name=7;
CC         IsoId=Q9BQ16-7; Sequence=VSP_046686;
CC       Name=8;
CC         IsoId=Q9BQ16-8; Sequence=VSP_013598, VSP_046687;
CC       Name=9;
CC         IsoId=Q9BQ16-9; Sequence=VSP_013598, VSP_005334, VSP_005335;
CC   -!- TISSUE SPECIFICITY: Expressed in brain.
CC   -!- PTM: Contains chondroitin sulfate and heparan sulfate O-linked
CC       oligosaccharides. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAG58995.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AJ001454; CAA04775.1; -; mRNA.
DR   EMBL; AB056866; BAB64908.1; -; mRNA.
DR   EMBL; AY358973; AAQ89332.1; -; mRNA.
DR   EMBL; AK091078; BAG52279.1; -; mRNA.
DR   EMBL; AK295281; BAG58265.1; -; mRNA.
DR   EMBL; AK295407; BAG58358.1; -; mRNA.
DR   EMBL; AK294637; BAG57816.1; -; mRNA.
DR   EMBL; AK295015; BAG58075.1; -; mRNA.
DR   EMBL; AK296291; BAG58995.1; ALT_INIT; mRNA.
DR   EMBL; AK313042; BAG35874.1; -; mRNA.
DR   EMBL; AC010103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC020599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC023492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC107210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471056; EAX04811.1; -; Genomic_DNA.
DR   EMBL; BC000460; AAH00460.1; -; mRNA.
DR   EMBL; BC003017; AAH03017.1; -; mRNA.
DR   EMBL; BC013983; AAH13983.1; -; mRNA.
DR   CCDS; CCDS34095.1; -. [Q9BQ16-1]
DR   CCDS; CCDS54817.1; -. [Q9BQ16-3]
DR   CCDS; CCDS56343.1; -. [Q9BQ16-7]
DR   CCDS; CCDS56344.1; -. [Q9BQ16-4]
DR   CCDS; CCDS56346.1; -. [Q9BQ16-8]
DR   CCDS; CCDS56347.1; -. [Q9BQ16-9]
DR   CCDS; CCDS58931.1; -. [Q9BQ16-5]
DR   RefSeq; NP_001035249.1; NM_001040159.1. [Q9BQ16-1]
DR   RefSeq; NP_001191281.1; NM_001204352.1. [Q9BQ16-4]
DR   RefSeq; NP_001191282.1; NM_001204353.1. [Q9BQ16-7]
DR   RefSeq; NP_001191283.1; NM_001204354.1.
DR   RefSeq; NP_001191284.1; NM_001204355.1. [Q9BQ16-6]
DR   RefSeq; NP_001191285.1; NM_001204356.1. [Q9BQ16-8]
DR   RefSeq; NP_001191287.1; NM_001204358.1. [Q9BQ16-9]
DR   RefSeq; NP_001238896.1; NM_001251967.1. [Q9BQ16-5]
DR   RefSeq; NP_058646.2; NM_016950.2. [Q9BQ16-3]
DR   RefSeq; XP_011530320.1; XM_011532018.1. [Q9BQ16-3]
DR   RefSeq; XP_016863747.1; XM_017008258.1. [Q9BQ16-1]
DR   AlphaFoldDB; Q9BQ16; -.
DR   SMR; Q9BQ16; -.
DR   BioGRID; 119160; 7.
DR   IntAct; Q9BQ16; 4.
DR   MINT; Q9BQ16; -.
DR   STRING; 9606.ENSP00000349677; -.
DR   MEROPS; I01.980; -.
DR   MEROPS; I31.007; -.
DR   GlyCosmos; Q9BQ16; 2 sites, No reported glycans.
DR   GlyGen; Q9BQ16; 3 sites, 1 O-linked glycan (1 site).
DR   iPTMnet; Q9BQ16; -.
DR   PhosphoSitePlus; Q9BQ16; -.
DR   BioMuta; SPOCK3; -.
DR   DMDM; 67473703; -.
DR   jPOST; Q9BQ16; -.
DR   MassIVE; Q9BQ16; -.
DR   MaxQB; Q9BQ16; -.
DR   PaxDb; 9606-ENSP00000349677; -.
DR   PeptideAtlas; Q9BQ16; -.
DR   ProteomicsDB; 17290; -.
DR   ProteomicsDB; 25277; -.
DR   ProteomicsDB; 4139; -.
DR   ProteomicsDB; 4275; -.
DR   ProteomicsDB; 4419; -.
DR   ProteomicsDB; 78611; -. [Q9BQ16-3]
DR   ProteomicsDB; 78612; -. [Q9BQ16-1]
DR   ProteomicsDB; 78613; -. [Q9BQ16-2]
DR   ProteomicsDB; 78614; -. [Q9BQ16-4]
DR   TopDownProteomics; Q9BQ16-2; -. [Q9BQ16-2]
DR   TopDownProteomics; Q9BQ16-3; -. [Q9BQ16-3]
DR   TopDownProteomics; Q9BQ16-5; -. [Q9BQ16-5]
DR   Antibodypedia; 28345; 156 antibodies from 19 providers.
DR   DNASU; 50859; -.
DR   Ensembl; ENST00000357154.7; ENSP00000349677.3; ENSG00000196104.11. [Q9BQ16-3]
DR   Ensembl; ENST00000357545.9; ENSP00000350153.4; ENSG00000196104.11. [Q9BQ16-1]
DR   Ensembl; ENST00000421836.6; ENSP00000411344.2; ENSG00000196104.11. [Q9BQ16-4]
DR   Ensembl; ENST00000502330.5; ENSP00000423606.1; ENSG00000196104.11. [Q9BQ16-3]
DR   Ensembl; ENST00000504953.5; ENSP00000425570.1; ENSG00000196104.11. [Q9BQ16-1]
DR   Ensembl; ENST00000506886.5; ENSP00000420920.1; ENSG00000196104.11. [Q9BQ16-3]
DR   Ensembl; ENST00000510741.5; ENSP00000426716.1; ENSG00000196104.11. [Q9BQ16-8]
DR   Ensembl; ENST00000511269.5; ENSP00000425502.1; ENSG00000196104.11. [Q9BQ16-1]
DR   Ensembl; ENST00000511531.5; ENSP00000423421.1; ENSG00000196104.11. [Q9BQ16-3]
DR   Ensembl; ENST00000512648.5; ENSP00000426177.1; ENSG00000196104.11. [Q9BQ16-9]
DR   Ensembl; ENST00000512681.5; ENSP00000426318.1; ENSG00000196104.11. [Q9BQ16-5]
DR   Ensembl; ENST00000541354.5; ENSP00000444789.1; ENSG00000196104.11. [Q9BQ16-7]
DR   GeneID; 50859; -.
DR   KEGG; hsa:50859; -.
DR   MANE-Select; ENST00000357545.9; ENSP00000350153.4; NM_001040159.2; NP_001035249.1. [Q9BQ16-1]
DR   UCSC; uc003iri.2; human. [Q9BQ16-3]
DR   AGR; HGNC:13565; -.
DR   CTD; 50859; -.
DR   DisGeNET; 50859; -.
DR   GeneCards; SPOCK3; -.
DR   HGNC; HGNC:13565; SPOCK3.
DR   HPA; ENSG00000196104; Tissue enhanced (brain, parathyroid gland, prostate).
DR   MIM; 607989; gene.
DR   neXtProt; NX_Q9BQ16; -.
DR   OpenTargets; ENSG00000196104; -.
DR   PharmGKB; PA134977377; -.
DR   VEuPathDB; HostDB:ENSG00000196104; -.
DR   eggNOG; KOG3555; Eukaryota.
DR   GeneTree; ENSGT00940000157828; -.
DR   HOGENOM; CLU_037217_1_0_1; -.
DR   InParanoid; Q9BQ16; -.
DR   OMA; PQTAVCI; -.
DR   OrthoDB; 4174283at2759; -.
DR   PhylomeDB; Q9BQ16; -.
DR   TreeFam; TF317779; -.
DR   PathwayCommons; Q9BQ16; -.
DR   Reactome; R-HSA-1592389; Activation of Matrix Metalloproteinases.
DR   SignaLink; Q9BQ16; -.
DR   BioGRID-ORCS; 50859; 14 hits in 1138 CRISPR screens.
DR   ChiTaRS; SPOCK3; human.
DR   GenomeRNAi; 50859; -.
DR   Pharos; Q9BQ16; Tbio.
DR   PRO; PR:Q9BQ16; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q9BQ16; Protein.
DR   Bgee; ENSG00000196104; Expressed in lateral globus pallidus and 157 other cell types or tissues.
DR   ExpressionAtlas; Q9BQ16; baseline and differential.
DR   GO; GO:0031012; C:extracellular matrix; IDA:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005539; F:glycosaminoglycan binding; IEA:Ensembl.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IDA:UniProtKB.
DR   GO; GO:2000146; P:negative regulation of cell motility; TAS:ParkinsonsUK-UCL.
DR   GO; GO:0010951; P:negative regulation of endopeptidase activity; IDA:UniProtKB.
DR   CDD; cd16239; EFh_SPARC_TICN3; 1.
DR   CDD; cd00104; KAZAL_FS; 1.
DR   CDD; cd00191; TY; 1.
DR   Gene3D; 3.30.60.30; -; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   InterPro; IPR019577; SPARC/Testican_Ca-bd-dom.
DR   InterPro; IPR000716; Thyroglobulin_1.
DR   InterPro; IPR036857; Thyroglobulin_1_sf.
DR   PANTHER; PTHR13866; SPARC OSTEONECTIN; 1.
DR   PANTHER; PTHR13866:SF21; TESTICAN-3; 1.
DR   Pfam; PF07648; Kazal_2; 1.
DR   Pfam; PF10591; SPARC_Ca_bdg; 1.
DR   Pfam; PF00086; Thyroglobulin_1; 1.
DR   SMART; SM00280; KAZAL; 1.
DR   SMART; SM00211; TY; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR   SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
DR   PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR   PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
DR   Genevisible; Q9BQ16; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Calcium; Disulfide bond; Extracellular matrix;
KW   Glycoprotein; Heparan sulfate; Metalloenzyme inhibitor;
KW   Metalloprotease inhibitor; Protease inhibitor; Proteoglycan;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..436
FT                   /note="Testican-3"
FT                   /id="PRO_0000026703"
FT   DOMAIN          133..185
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DOMAIN          314..380
FT                   /note="Thyroglobulin type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00500"
FT   REGION          393..436
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..436
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        387
FT                   /note="O-linked (Xyl...) (glycosaminoglycan) serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        392
FT                   /note="O-linked (Xyl...) (glycosaminoglycan) serine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        90..101
FT                   /evidence="ECO:0000250"
FT   DISULFID        95..111
FT                   /evidence="ECO:0000250"
FT   DISULFID        139..169
FT                   /evidence="ECO:0000250"
FT   DISULFID        142..162
FT                   /evidence="ECO:0000250"
FT   DISULFID        151..183
FT                   /evidence="ECO:0000250"
FT   DISULFID        317..341
FT                   /evidence="ECO:0000250"
FT   DISULFID        352..359
FT                   /evidence="ECO:0000250"
FT   DISULFID        361..380
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         1..120
FT                   /note="Missing (in isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_046686"
FT   VAR_SEQ         1..66
FT                   /note="MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQWLTTISQYD
FT                   KEVGQWNKFRDEVE -> MITQDHIHMSSGLSQ (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_043681"
FT   VAR_SEQ         1..24
FT                   /note="MLKVSAVLCVCAAAWCSQSLAAAA -> MINNGSPQSLSMTRKSDSGTNSET
FT                   (in isoform 6)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_045899"
FT   VAR_SEQ         25..120
FT                   /note="Missing (in isoform 6)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_045900"
FT   VAR_SEQ         64..161
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_045104"
FT   VAR_SEQ         64..66
FT                   /note="Missing (in isoform 1, isoform 8 and isoform 9)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_013598"
FT   VAR_SEQ         200..240
FT                   /note="ACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSR -> G (in
FT                   isoform 8)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_046687"
FT   VAR_SEQ         314..316
FT                   /note="DPP -> GKR (in isoform 2 and isoform 9)"
FT                   /evidence="ECO:0000303|PubMed:11751414"
FT                   /id="VSP_005334"
FT   VAR_SEQ         317..436
FT                   /note="Missing (in isoform 2 and isoform 9)"
FT                   /evidence="ECO:0000303|PubMed:11751414"
FT                   /id="VSP_005335"
FT   VARIANT         112
FT                   /note="I -> V (in dbSNP:rs9685645)"
FT                   /id="VAR_051562"
FT   CONFLICT        348
FT                   /note="K -> M (in Ref. 1; CAA04775)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        405
FT                   /note="E -> G (in Ref. 4; BAG58265)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   436 AA;  49429 MW;  AAEDD1998C656FC0 CRC64;
     MLKVSAVLCV CAAAWCSQSL AAAAAVAAAG GRSDGGNFLD DKQWLTTISQ YDKEVGQWNK
     FRDEVEDDYF RTWSPGKPFD QALDPAKDPC LKMKCSRHKV CIAQDSQTAV CISHRRLTHR
     MKEAGVDHRQ WRGPILSTCK QCPVVYPSPV CGSDGHTYSF QCKLEYQACV LGKQISVKCE
     GHCPCPSDKP TSTSRNVKRA CSDLEFREVA NRLRDWFKAL HESGSQNKKT KTLLRPERSR
     FDTSILPICK DSLGWMFNRL DTNYDLLLDQ SELRSIYLDK NEQCTKAFFN SCDTYKDSLI
     SNNEWCYCFQ RQQDPPCQTE LSNIQKRQGV KKLLGQYIPL CDEDGYYKPT QCHGSVGQCW
     CVDRYGNEVM GSRINGVADC AIDFEISGDF ASGDFHEWTD DEDDEDDIMN DEDEIEDDDE
     DEGDDDDGGD DHDVYI
//