Q9BQ16 (TICN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Testican-3

Alternative name(s):
SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3

Gene names

Name:	SPOCK3
Synonyms:	TICN3
ORF Names:	UNQ409/PRO771

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Tissue specificity	Expressed in brain.
Post-translational modification	Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides By similarity.
Sequence similarities	Contains 1 Kazal-like domain. Contains 1 thyroglobulin type-1 domain.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Ligand	Calcium
Molecular function	Metalloenzyme inhibitor Metalloprotease inhibitor Protease inhibitor
PTM	Disulfide bond Glycoprotein Heparan sulfate Proteoglycan
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Inferred from electronic annotation. Source: Compara signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular matrix Inferred from direct assay Ref.2. Source: UniProtKB extracellular space Inferred from direct assay Ref.2. Source: UniProtKB proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro glycosaminoglycan binding Inferred from electronic annotation. Source: Compara metalloendopeptidase inhibitor activity Inferred from direct assay Ref.2. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 3 (identifier: Q9BQ16-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q9BQ16-1)

The sequence of this isoform differs from the canonical sequence as follows:
     64-66: Missing.

Isoform 2 (identifier: Q9BQ16-2)

Also known as: N-tes;

The sequence of this isoform differs from the canonical sequence as follows:
     314-316: DPP → GKR
     317-436: Missing.

Isoform 4 (identifier: Q9BQ16-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: MLKVSAVLCV...QWNKFRDEVE → MITQDHIHMSSGLSQ

Note: No experimental confirmation available.

Isoform 5 (identifier: Q9BQ16-5)

The sequence of this isoform differs from the canonical sequence as follows:
     64-161: Missing.

Isoform 6 (identifier: Q9BQ16-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MLKVSAVLCVCAAAWCSQSLAAAA → MINNGSPQSLSMTRKSDSGTNSET
     25-120: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 436	415	Testican-3		PRO_0000026703
Regions
	Domain	133 – 185	53	Kazal-like
	Domain	314 – 380	67	Thyroglobulin type-1
	Compositional bias	394 – 436	43	Asp-rich
Amino acid modifications
	Glycosylation	387	1	O-linked (Xyl...) (glycosaminoglycan) Potential
	Glycosylation	392	1	O-linked (Xyl...) (glycosaminoglycan) Potential
	Disulfide bond	90 ↔ 101		By similarity
	Disulfide bond	95 ↔ 111		By similarity
	Disulfide bond	139 ↔ 169		By similarity
	Disulfide bond	142 ↔ 162		By similarity
	Disulfide bond	151 ↔ 183		By similarity
	Disulfide bond	317 ↔ 341		By similarity
	Disulfide bond	352 ↔ 359		By similarity
	Disulfide bond	361 ↔ 380		By similarity
Natural variations
	Alternative sequence	1 – 66	66	MLKVS…RDEVE → MITQDHIHMSSGLSQ in isoform 4.		VSP_043681
	Alternative sequence	1 – 24	24	MLKVS…LAAAA → MINNGSPQSLSMTRKSDSGT NSET in isoform 6.		VSP_045899
	Alternative sequence	25 – 120	96	Missing in isoform 6.		VSP_045900
	Alternative sequence	64 – 161	98	Missing in isoform 5.		VSP_045104
	Alternative sequence	64 – 66	3	Missing in isoform 1.		VSP_013598
	Alternative sequence	314 – 316	3	DPP → GKR in isoform 2.		VSP_005334
	Alternative sequence	317 – 436	120	Missing in isoform 2.		VSP_005335
	Natural variant	112	1	I → V. Corresponds to variant rs9685645 [ dbSNP | Ensembl ].		VAR_051562
Experimental info
	Sequence conflict	348	1	K → M in CAA04775. Ref.1
	Sequence conflict	405	1	E → G in BAG58265. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3 [UniParc]. Last modified May 10, 2005. Version 2. Checksum: AAEDD1998C656FC0	FASTA	436	49,429
	10 20 30 40 50 60 MLKVSAVLCV CAAAWCSQSL AAAAAVAAAG GRSDGGNFLD DKQWLTTISQ YDKEVGQWNK 70 80 90 100 110 120 FRDEVEDDYF RTWSPGKPFD QALDPAKDPC LKMKCSRHKV CIAQDSQTAV CISHRRLTHR 130 140 150 160 170 180 MKEAGVDHRQ WRGPILSTCK QCPVVYPSPV CGSDGHTYSF QCKLEYQACV LGKQISVKCE 190 200 210 220 230 240 GHCPCPSDKP TSTSRNVKRA CSDLEFREVA NRLRDWFKAL HESGSQNKKT KTLLRPERSR 250 260 270 280 290 300 FDTSILPICK DSLGWMFNRL DTNYDLLLDQ SELRSIYLDK NEQCTKAFFN SCDTYKDSLI 310 320 330 340 350 360 SNNEWCYCFQ RQQDPPCQTE LSNIQKRQGV KKLLGQYIPL CDEDGYYKPT QCHGSVGQCW 370 380 390 400 410 420 CVDRYGNEVM GSRINGVADC AIDFEISGDF ASGDFHEWTD DEDDEDDIMN DEDEIEDDDE 430 DEGDDDDGGD DHDVYI
	Isoform 1 [UniParc]. Checksum: B697CDE58F7028AF	FASTA	433	49,072
	10 20 30 40 50 60 MLKVSAVLCV CAAAWCSQSL AAAAAVAAAG GRSDGGNFLD DKQWLTTISQ YDKEVGQWNK 70 80 90 100 110 120 FRDDDYFRTW SPGKPFDQAL DPAKDPCLKM KCSRHKVCIA QDSQTAVCIS HRRLTHRMKE 130 140 150 160 170 180 AGVDHRQWRG PILSTCKQCP VVYPSPVCGS DGHTYSFQCK LEYQACVLGK QISVKCEGHC 190 200 210 220 230 240 PCPSDKPTST SRNVKRACSD LEFREVANRL RDWFKALHES GSQNKKTKTL LRPERSRFDT 250 260 270 280 290 300 SILPICKDSL GWMFNRLDTN YDLLLDQSEL RSIYLDKNEQ CTKAFFNSCD TYKDSLISNN 310 320 330 340 350 360 EWCYCFQRQQ DPPCQTELSN IQKRQGVKKL LGQYIPLCDE DGYYKPTQCH GSVGQCWCVD 370 380 390 400 410 420 RYGNEVMGSR INGVADCAID FEISGDFASG DFHEWTDDED DEDDIMNDED EIEDDDEDEG 430 DDDDGGDDHD VYI
	Isoform 2 (N-tes) [UniParc]. Checksum: 6607E14FC72D4F44	FASTA	316	35,950
	10 20 30 40 50 60 MLKVSAVLCV CAAAWCSQSL AAAAAVAAAG GRSDGGNFLD DKQWLTTISQ YDKEVGQWNK 70 80 90 100 110 120 FRDEVEDDYF RTWSPGKPFD QALDPAKDPC LKMKCSRHKV CIAQDSQTAV CISHRRLTHR 130 140 150 160 170 180 MKEAGVDHRQ WRGPILSTCK QCPVVYPSPV CGSDGHTYSF QCKLEYQACV LGKQISVKCE 190 200 210 220 230 240 GHCPCPSDKP TSTSRNVKRA CSDLEFREVA NRLRDWFKAL HESGSQNKKT KTLLRPERSR 250 260 270 280 290 300 FDTSILPICK DSLGWMFNRL DTNYDLLLDQ SELRSIYLDK NEQCTKAFFN SCDTYKDSLI 310 SNNEWCYCFQ RQQGKR
	Isoform 4 [UniParc]. Checksum: 00E0842D266E4A83	FASTA	385	44,061
	10 20 30 40 50 60 MITQDHIHMS SGLSQDDYFR TWSPGKPFDQ ALDPAKDPCL KMKCSRHKVC IAQDSQTAVC 70 80 90 100 110 120 ISHRRLTHRM KEAGVDHRQW RGPILSTCKQ CPVVYPSPVC GSDGHTYSFQ CKLEYQACVL 130 140 150 160 170 180 GKQISVKCEG HCPCPSDKPT STSRNVKRAC SDLEFREVAN RLRDWFKALH ESGSQNKKTK 190 200 210 220 230 240 TLLRPERSRF DTSILPICKD SLGWMFNRLD TNYDLLLDQS ELRSIYLDKN EQCTKAFFNS 250 260 270 280 290 300 CDTYKDSLIS NNEWCYCFQR QQDPPCQTEL SNIQKRQGVK KLLGQYIPLC DEDGYYKPTQ 310 320 330 340 350 360 CHGSVGQCWC VDRYGNEVMG SRINGVADCA IDFEISGDFA SGDFHEWTDD EDDEDDIMND 370 380 EDEIEDDDED EGDDDDGGDD HDVYI
	Isoform 5 [UniParc]. Checksum: 2259AE11269F6627	FASTA	338	38,282
	10 20 30 40 50 60 MLKVSAVLCV CAAAWCSQSL AAAAAVAAAG GRSDGGNFLD DKQWLTTISQ YDKEVGQWNK 70 80 90 100 110 120 FRDCKLEYQA CVLGKQISVK CEGHCPCPSD KPTSTSRNVK RACSDLEFRE VANRLRDWFK 130 140 150 160 170 180 ALHESGSQNK KTKTLLRPER SRFDTSILPI CKDSLGWMFN RLDTNYDLLL DQSELRSIYL 190 200 210 220 230 240 DKNEQCTKAF FNSCDTYKDS LISNNEWCYC FQRQQDPPCQ TELSNIQKRQ GVKKLLGQYI 250 260 270 280 290 300 PLCDEDGYYK PTQCHGSVGQ CWCVDRYGNE VMGSRINGVA DCAIDFEISG DFASGDFHEW 310 320 330 TDDEDDEDDI MNDEDEIEDD DEDEGDDDDG GDDHDVYI
	Isoform 6 [UniParc]. Checksum: 46149953687E2F86	FASTA	340	38,678
	10 20 30 40 50 60 MINNGSPQSL SMTRKSDSGT NSETMKEAGV DHRQWRGPIL STCKQCPVVY PSPVCGSDGH 70 80 90 100 110 120 TYSFQCKLEY QACVLGKQIS VKCEGHCPCP SDKPTSTSRN VKRACSDLEF REVANRLRDW 130 140 150 160 170 180 FKALHESGSQ NKKTKTLLRP ERSRFDTSIL PICKDSLGWM FNRLDTNYDL LLDQSELRSI 190 200 210 220 230 240 YLDKNEQCTK AFFNSCDTYK DSLISNNEWC YCFQRQQDPP CQTELSNIQK RQGVKKLLGQ 250 260 270 280 290 300 YIPLCDEDGY YKPTQCHGSV GQCWCVDRYG NEVMGSRING VADCAIDFEI SGDFASGDFH 310 320 330 340 EWTDDEDDED DIMNDEDEIE DDDEDEGDDD DGGDDHDVYI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of testican-3, a novel member of brain-specific, calcium-binding proteoglycans." Vannahme C., Hartmann U., Goesling S., Kohfeldt E., Timpl R., Paulsson M., Maurer P. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Brain.
[2]	"Suppression of membrane-type 1 matrix metalloproteinase (MMP)-mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product, N-Tes." Nakada M., Yamada A., Takino T., Miyamori H., Takahashi T., Yamashita J., Sato H. Cancer Res. 61:8896-8902(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHARACTERIZATION. Tissue: Fetal kidney.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4; 5 AND 6). Tissue: Brain, Caudate nucleus and Corpus callosum.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung and Muscle.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ001454 mRNA. Translation: CAA04775.1. AB056866 mRNA. Translation: BAB64908.1. AY358973 mRNA. Translation: AAQ89332.1. AK091078 mRNA. Translation: BAG52279.1. AK295281 mRNA. Translation: BAG58265.1. AK294637 mRNA. Translation: BAG57816.1. AK295015 mRNA. Translation: BAG58075.1. AK313042 mRNA. Translation: BAG35874.1. AC010103 Genomic DNA. No translation available. AC020599 Genomic DNA. No translation available. AC023492 Genomic DNA. No translation available. AC107210 Genomic DNA. No translation available. CH471056 Genomic DNA. Translation: EAX04811.1. BC000460 mRNA. Translation: AAH00460.1. BC003017 mRNA. Translation: AAH03017.1. BC013983 mRNA. Translation: AAH13983.1.
IPI	IPI00419590. IPI00478890. IPI00555693. IPI00974268. IPI00978156.
RefSeq	NP_001035249.1. NM_001040159.1. NP_001191281.1. NM_001204352.1. NP_001191283.1. NM_001204354.1. NP_001191284.1. NM_001204355.1. NP_001191287.1. NM_001204358.1. NP_001238896.1. NM_001251967.1. NP_058646.2. NM_016950.2.
UniGene	Hs.481133.
3D structure databases
ProteinModelPortal	Q9BQ16.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4830490.
STRING	9606.ENSP00000350153.
Protein family/group databases
MEROPS	I31.007.
PTM databases
PhosphoSite	Q9BQ16.
Polymorphism databases
DMDM	67473703.
Proteomic databases
PaxDb	Q9BQ16.
PRIDE	Q9BQ16.
Protocols and materials databases
DNASU	50859.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357154; ENSP00000349677; ENSG00000196104. ENST00000357545; ENSP00000350153; ENSG00000196104. ENST00000421836; ENSP00000411344; ENSG00000196104. ENST00000502330; ENSP00000423606; ENSG00000196104. ENST00000504953; ENSP00000425570; ENSG00000196104. ENST00000506886; ENSP00000420920; ENSG00000196104. ENST00000511269; ENSP00000425502; ENSG00000196104. ENST00000511531; ENSP00000423421; ENSG00000196104. ENST00000512648; ENSP00000426177; ENSG00000196104. ENST00000512681; ENSP00000426318; ENSG00000196104. ENST00000534949; ENSP00000438142; ENSG00000196104. ENST00000541637; ENSP00000445430; ENSG00000196104.
GeneID	50859.
KEGG	hsa:50859.
UCSC	uc003iri.1. human. uc003irj.1. human.
Organism-specific databases
CTD	50859.
GeneCards	GC04M167654.
HGNC	HGNC:13565. SPOCK3.
MIM	607989. gene.
neXtProt	NX_Q9BQ16.
PharmGKB	PA134977377.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG244822.
HOGENOM	HOG000293295.
HOVERGEN	HBG026595.
InParanoid	Q9BQ16.
KO	K08136.
OMA	HEWTDDE.
OrthoDB	EOG44MXSB.
PhylomeDB	Q9BQ16.
Gene expression databases
ArrayExpress	Q9BQ16.
Bgee	Q9BQ16.
CleanEx	HS_SPOCK3.
Genevestigator	Q9BQ16.
GermOnline	ENSG00000196104. Homo sapiens.
Family and domain databases
Gene3D	1.10.238.10. 1 hit. 4.10.800.10. 1 hit.
InterPro	IPR011992. EF-hand-like_dom. IPR002350. Kazal_dom. IPR019577. SPARC/Testican_Ca-bd-dom. IPR000716. Thyroglobulin_1. [Graphical view]
Pfam	PF07648. Kazal_2. 1 hit. PF10591. SPARC_Ca_bdg. 1 hit. PF00086. Thyroglobulin_1. 1 hit. [Graphical view]
SMART	SM00280. KAZAL. 1 hit. SM00211. TY. 1 hit. [Graphical view]
SUPFAM	SSF57610. Thyroglobulin_1. 1 hit.
PROSITE	PS51465. KAZAL_2. 1 hit. PS00484. THYROGLOBULIN_1_1. 1 hit. PS51162. THYROGLOBULIN_1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SPOCK3. human.
GenomeRNAi	50859.
NextBio	53356.
SOURCE	Search...

Entry information

Entry name

TICN3_HUMAN

Accession

Primary (citable) accession number: Q9BQ16
Secondary accession number(s): B2R7M7 , B3KR67, B4DGK5, B4DHB4, B4DHV3, F5H099, O75705, Q6UW53, Q96Q26

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	May 10, 2005
Last modified:	May 1, 2013
This is version 117 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.