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Protein

SOSS complex subunit B1

Gene

NABP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi22 – 92OBAdd BLAST71

GO - Molecular functioni

  • DNA polymerase binding Source: BHF-UCL
  • G-rich strand telomeric DNA binding Source: BHF-UCL
  • single-stranded DNA binding Source: UniProtKB

GO - Biological processi

  • cellular response to DNA damage stimulus Source: UniProtKB
  • DNA repair Source: UniProtKB
  • double-strand break repair via homologous recombination Source: UniProtKB
  • establishment of protein localization to telomere Source: BHF-UCL
  • mitotic cell cycle checkpoint Source: UniProtKB
  • positive regulation of telomere capping Source: BHF-UCL
  • response to ionizing radiation Source: UniProtKB
  • snRNA transcription by RNA polymerase II Source: Reactome

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
SOSS complex subunit B1
Alternative name(s):
Nucleic acid-binding protein 2
Oligonucleotide/oligosaccharide-binding fold-containing protein 2B
Sensor of single-strand DNA complex subunit B1
Sensor of ssDNA subunit B1
Short name:
SOSS-B1
Single-stranded DNA-binding protein 1
Short name:
hSSB1
Gene namesi
Name:NABP2
Synonyms:OBFC2B, SSB1
ORF Names:LP3587
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139579.12
HGNCiHGNC:28412 NABP2
MIMi612104 gene
neXtProtiNX_Q9BQ15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi117T → A: Loss of phosphorylation by ATM. 1 Publication1
Mutagenesisi117T → E: Enhances ATM-dependent signaling. 1 Publication1

Organism-specific databases

DisGeNETi79035
OpenTargetsiENSG00000139579
PharmGKBiPA143485567

Polymorphism and mutation databases

BioMutaiNABP2
DMDMi74761196

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003339581 – 211SOSS complex subunit B1Add BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117Phosphothreonine; by ATM1 Publication1

Post-translational modificationi

Phosphorylated by ATM in response to DNA damage. Phosphorylation prevents degradation by the proteasome, hence stabilization of the protein and accumulation within cells.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BQ15
MaxQBiQ9BQ15
PaxDbiQ9BQ15
PeptideAtlasiQ9BQ15
PRIDEiQ9BQ15

PTM databases

iPTMnetiQ9BQ15
PhosphoSitePlusiQ9BQ15

Expressioni

Gene expression databases

BgeeiENSG00000139579
CleanExiHS_OBFC2B
ExpressionAtlasiQ9BQ15 baseline and differential
GenevisibleiQ9BQ15 HS

Organism-specific databases

HPAiHPA044615
HPA057213

Interactioni

Subunit structurei

Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Directly interacts with ATM, SOSS-A/INTS3 and RAD51. Interacts with INTS7.4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • DNA polymerase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi12250050 interactors.
IntActiQ9BQ15 20 interactors.
STRINGi9606.ENSP00000267023

Structurei

Secondary structure

1211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 9Combined sources3
Beta strandi20 – 26Combined sources7
Beta strandi33 – 35Combined sources3
Beta strandi40 – 45Combined sources6
Beta strandi48 – 53Combined sources6
Helixi56 – 61Combined sources6
Beta strandi66 – 69Combined sources4
Beta strandi93 – 98Combined sources6
Beta strandi100 – 104Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OWTX-ray2.00B1-211[»]
4OWWX-ray2.30B1-211[»]
4OWXX-ray2.30B1-211[»]
5D8EX-ray3.00A/B/C/D1-109[»]
5D8FX-ray2.35A/B1-109[»]
DisProtiDP00864
ProteinModelPortaliQ9BQ15
SMRiQ9BQ15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi158 – 198Pro-richAdd BLAST41

Sequence similaritiesi

Belongs to the SOSS-B family. SOSS-B1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG3416 Eukaryota
ENOG4111MBP LUCA
GeneTreeiENSGT00390000001913
HOGENOMiHOG000006622
InParanoidiQ9BQ15
OMAiPNHTAAG
OrthoDBiEOG091G0YHH
PhylomeDBiQ9BQ15
TreeFamiTF313902

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PfamiView protein in Pfam
PF01336 tRNA_anti-codon, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BQ15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTETFVKDI KPGLKNLNLI FIVLETGRVT KTKDGHEVRT CKVADKTGSI
60 70 80 90 100
NISVWDDVGN LIQPGDIIRL TKGYASVFKG CLTLYTGRGG DLQKIGEFCM
110 120 130 140 150
VYSEVPNFSE PNPEYSTQQA PNKAVQNDSN PSASQPTTGP SAASPASENQ
160 170 180 190 200
NGNGLSAPPG PGGGPHPPHT PSHPPSTRIT RSQPNHTPAG PPGPSSNPVS
210
NGKETRRSSK R
Length:211
Mass (Da):22,338
Last modified:June 1, 2001 - v1
Checksum:iB72014397B7947E2
GO
Isoform 2 (identifier: Q9BQ15-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.

Show »
Length:112
Mass (Da):11,493
Checksum:iB066AA52BECFDC94
GO

Sequence cautioni

The sequence AAP34465 differs from that shown. Reason: Frameshift at position 169.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0336041 – 99Missing in isoform 2. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY203942 mRNA Translation: AAP34465.1 Frameshift.
CH471054 Genomic DNA Translation: EAW96913.1
AC073896 Genomic DNA No translation available.
BC001079 mRNA Translation: AAH01079.1
BC006171 mRNA Translation: AAH06171.1
CCDSiCCDS8911.1 [Q9BQ15-1]
RefSeqiNP_076973.1, NM_024068.3 [Q9BQ15-1]
XP_005269205.1, XM_005269148.4 [Q9BQ15-1]
XP_005269206.1, XM_005269149.4 [Q9BQ15-1]
UniGeneiHs.240170

Genome annotation databases

EnsembliENST00000267023; ENSP00000267023; ENSG00000139579 [Q9BQ15-1]
ENST00000341463; ENSP00000368862; ENSG00000139579 [Q9BQ15-1]
ENST00000380198; ENSP00000369545; ENSG00000139579 [Q9BQ15-1]
GeneIDi79035
KEGGihsa:79035
UCSCiuc001ski.4 human [Q9BQ15-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSOSB1_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ15
Secondary accession number(s): A6NDF8, Q6XYC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome