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Protein

BTB/POZ domain-containing protein KCTD14

Gene

KCTD14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD14
Gene namesi
Name:KCTD14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:23295. KCTD14.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134875104.

Polymorphism and mutation databases

BioMutaiKCTD14.
DMDMi251757290.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255BTB/POZ domain-containing protein KCTD14PRO_0000191299Add
BLAST

Proteomic databases

EPDiQ9BQ13.
MaxQBiQ9BQ13.
PaxDbiQ9BQ13.
PeptideAtlasiQ9BQ13.
PRIDEiQ9BQ13.

PTM databases

iPTMnetiQ9BQ13.
PhosphoSiteiQ9BQ13.

Expressioni

Gene expression databases

BgeeiQ9BQ13.
CleanExiHS_KCTD14.
GenevisibleiQ9BQ13. HS.

Organism-specific databases

HPAiHPA041118.
HPA042181.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
STK16O757163EBI-10189448,EBI-749295
TCF4P158843EBI-10189448,EBI-533224

Protein-protein interaction databases

BioGridi122436. 5 interactions.
IntActiQ9BQ13. 2 interactions.
STRINGi9606.ENSP00000316482.

Structurei

3D structure databases

ProteinModelPortaliQ9BQ13.
SMRiQ9BQ13. Positions 37-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 13098BTBAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00530000063071.
HOGENOMiHOG000113201.
HOVERGENiHBG052220.
InParanoidiQ9BQ13.
OMAiFGPWKAA.
OrthoDBiEOG790G15.
PhylomeDBiQ9BQ13.
TreeFamiTF315332.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BQ13-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWQGCAVERP VGRMTSQTPL PQSPRPRRPT MSTVVELNVG GEFHTTTLGT
60 70 80 90 100
LRKFPGSKLA EMFSSLAKAS TDAEGRFFID RPSTYFRPIL DYLRTGQVPT
110 120 130 140 150
QHIPEVYREA QFYEIKPLVK LLEDMPQIFG EQVSRKQFLL QVPGYSENLE
160 170 180 190 200
LMVRLARAEA ITARKSSVLV CLVETEEQDA YYSEVLCFLQ DKKMFKSVVK
210 220 230 240 250
FGPWKAVLDN SDLMHCLEMD IKAQGYKVFS KFYLTYPTKR NEFHFNIYSF

TFTWW
Length:255
Mass (Da):29,591
Last modified:July 7, 2009 - v2
Checksum:i8CACBE1B28951536
GO
Isoform 2 (identifier: Q9BQ13-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: Missing.

Note: No experimental confirmation available.
Show »
Length:225
Mass (Da):26,188
Checksum:iBA8435C5D6C2476D
GO

Sequence cautioni

The sequence AAH01062.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH01929.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BX359005 differs from that shown. Reason: Frameshift at position 182. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3030Missing in isoform 2. 1 PublicationVSP_054562Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX359005 mRNA. No translation available.
AK313892 mRNA. Translation: BAG36615.1.
AP003032 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW75043.1.
BC001062 mRNA. Translation: AAH01062.1. Different initiation.
BC001929 mRNA. Translation: AAH01929.1. Different initiation.
CCDSiCCDS60908.1. [Q9BQ13-2]
CCDS8255.2. [Q9BQ13-1]
RefSeqiNP_001269335.1. NM_001282406.1. [Q9BQ13-2]
NP_076419.2. NM_023930.3. [Q9BQ13-1]
UniGeneiHs.709780.

Genome annotation databases

EnsembliENST00000353172; ENSP00000316482; ENSG00000151364. [Q9BQ13-1]
ENST00000533144; ENSP00000431155; ENSG00000151364. [Q9BQ13-2]
GeneIDi65987.
KEGGihsa:65987.
UCSCiuc001oyw.5. human. [Q9BQ13-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX359005 mRNA. No translation available.
AK313892 mRNA. Translation: BAG36615.1.
AP003032 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW75043.1.
BC001062 mRNA. Translation: AAH01062.1. Different initiation.
BC001929 mRNA. Translation: AAH01929.1. Different initiation.
CCDSiCCDS60908.1. [Q9BQ13-2]
CCDS8255.2. [Q9BQ13-1]
RefSeqiNP_001269335.1. NM_001282406.1. [Q9BQ13-2]
NP_076419.2. NM_023930.3. [Q9BQ13-1]
UniGeneiHs.709780.

3D structure databases

ProteinModelPortaliQ9BQ13.
SMRiQ9BQ13. Positions 37-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122436. 5 interactions.
IntActiQ9BQ13. 2 interactions.
STRINGi9606.ENSP00000316482.

PTM databases

iPTMnetiQ9BQ13.
PhosphoSiteiQ9BQ13.

Polymorphism and mutation databases

BioMutaiKCTD14.
DMDMi251757290.

Proteomic databases

EPDiQ9BQ13.
MaxQBiQ9BQ13.
PaxDbiQ9BQ13.
PeptideAtlasiQ9BQ13.
PRIDEiQ9BQ13.

Protocols and materials databases

DNASUi65987.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353172; ENSP00000316482; ENSG00000151364. [Q9BQ13-1]
ENST00000533144; ENSP00000431155; ENSG00000151364. [Q9BQ13-2]
GeneIDi65987.
KEGGihsa:65987.
UCSCiuc001oyw.5. human. [Q9BQ13-1]

Organism-specific databases

CTDi65987.
GeneCardsiKCTD14.
HGNCiHGNC:23295. KCTD14.
HPAiHPA041118.
HPA042181.
neXtProtiNX_Q9BQ13.
PharmGKBiPA134875104.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00530000063071.
HOGENOMiHOG000113201.
HOVERGENiHBG052220.
InParanoidiQ9BQ13.
OMAiFGPWKAA.
OrthoDBiEOG790G15.
PhylomeDBiQ9BQ13.
TreeFamiTF315332.

Miscellaneous databases

ChiTaRSiKCTD14. human.
GenomeRNAii65987.
PROiQ9BQ13.

Gene expression databases

BgeeiQ9BQ13.
CleanExiHS_KCTD14.
GenevisibleiQ9BQ13. HS.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-255 (ISOFORM 1).
    Tissue: Lung.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKCD14_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ13
Secondary accession number(s): B2R9R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 7, 2009
Last modified: July 6, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.