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Protein

Resistin-like beta

Gene

RETNLB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable hormone.

GO - Biological processi

  • cell proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Resistin-like beta
Alternative name(s):
Colon and small intestine-specific cysteine-rich protein
Colon carcinoma-related gene protein
Cysteine-rich secreted protein A12-alpha-like 1
Cysteine-rich secreted protein FIZZ2
RELMbeta
Gene namesi
Name:RETNLB
Synonyms:CCRG, FIZZ2, HXCP2, RETNL2
ORF Names:UNQ408/PRO770
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:20388. RETNLB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134906814.

Polymorphism and mutation databases

BioMutaiRETNLB.
DMDMi18202730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 11188Resistin-like betaPRO_0000030345Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 – 25InterchainCurated
Disulfide bondi55 ↔ 108By similarity
Disulfide bondi67 ↔ 107By similarity
Disulfide bondi76 ↔ 93By similarity
Disulfide bondi78 ↔ 95By similarity
Disulfide bondi82 ↔ 97By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9BQ08.
PRIDEiQ9BQ08.

Expressioni

Tissue specificityi

Expressed only in the gastrointestinal tract, particularly the colon.

Gene expression databases

BgeeiQ9BQ08.
CleanExiHS_RETNLB.
GenevisibleiQ9BQ08. HS.

Organism-specific databases

HPAiHPA049152.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

BioGridi124186. 1 interaction.
STRINGi9606.ENSP00000295755.

Structurei

3D structure databases

ProteinModelPortaliQ9BQ08.
SMRiQ9BQ08. Positions 25-110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the resistin/FIZZ family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JDSE. Eukaryota.
ENOG410ZE8R. LUCA.
GeneTreeiENSGT00390000016177.
HOGENOMiHOG000137607.
HOVERGENiHBG018297.
InParanoidiQ9BQ08.
OMAiCHCQCSV.
OrthoDBiEOG7CVQ14.
PhylomeDBiQ9BQ08.
TreeFamiTF337024.

Family and domain databases

InterProiIPR009714. Resistin.
[Graphical view]
PANTHERiPTHR21101. PTHR21101. 1 hit.
PfamiPF06954. Resistin. 1 hit.
[Graphical view]
SUPFAMiSSF111423. SSF111423. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BQ08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPSSCLLLI LIPLLQLINP GSTQCSLDSV MDKKIKDVLN SLEYSPSPIS
60 70 80 90 100
KKLSCASVKS QGRPSSCPAG MAVTGCACGY GCGSWDVQLE TTCHCQCSVV
110
DWTTARCCHL T
Length:111
Mass (Da):11,730
Last modified:June 1, 2001 - v1
Checksum:iBD64233AF302B4C0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201P → L.
Corresponds to variant rs11708527 [ dbSNP | Ensembl ].
VAR_051791

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352731 Genomic DNA. Translation: AAK18622.1.
AF323084 mRNA. Translation: AAG59827.1.
AF290873 mRNA. Translation: AAK83105.1.
AF323921 mRNA. Translation: AAL96378.1.
AY358655 mRNA. Translation: AAQ89018.1.
BC069318 mRNA. Translation: AAH69318.1.
BC113502 mRNA. Translation: AAI13503.1.
BC113528 mRNA. Translation: AAI13529.1.
CCDSiCCDS2953.1.
RefSeqiNP_115968.1. NM_032579.2.
UniGeneiHs.307047.

Genome annotation databases

EnsembliENST00000295755; ENSP00000295755; ENSG00000163515.
GeneIDi84666.
KEGGihsa:84666.
UCSCiuc003dxh.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352731 Genomic DNA. Translation: AAK18622.1.
AF323084 mRNA. Translation: AAG59827.1.
AF290873 mRNA. Translation: AAK83105.1.
AF323921 mRNA. Translation: AAL96378.1.
AY358655 mRNA. Translation: AAQ89018.1.
BC069318 mRNA. Translation: AAH69318.1.
BC113502 mRNA. Translation: AAI13503.1.
BC113528 mRNA. Translation: AAI13529.1.
CCDSiCCDS2953.1.
RefSeqiNP_115968.1. NM_032579.2.
UniGeneiHs.307047.

3D structure databases

ProteinModelPortaliQ9BQ08.
SMRiQ9BQ08. Positions 25-110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124186. 1 interaction.
STRINGi9606.ENSP00000295755.

Polymorphism and mutation databases

BioMutaiRETNLB.
DMDMi18202730.

Proteomic databases

PaxDbiQ9BQ08.
PRIDEiQ9BQ08.

Protocols and materials databases

DNASUi84666.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295755; ENSP00000295755; ENSG00000163515.
GeneIDi84666.
KEGGihsa:84666.
UCSCiuc003dxh.3. human.

Organism-specific databases

CTDi84666.
GeneCardsiRETNLB.
HGNCiHGNC:20388. RETNLB.
HPAiHPA049152.
MIMi605645. gene.
neXtProtiNX_Q9BQ08.
PharmGKBiPA134906814.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JDSE. Eukaryota.
ENOG410ZE8R. LUCA.
GeneTreeiENSGT00390000016177.
HOGENOMiHOG000137607.
HOVERGENiHBG018297.
InParanoidiQ9BQ08.
OMAiCHCQCSV.
OrthoDBiEOG7CVQ14.
PhylomeDBiQ9BQ08.
TreeFamiTF337024.

Miscellaneous databases

GeneWikiiRETNLB.
GenomeRNAii84666.
NextBioi74657.
PROiQ9BQ08.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BQ08.
CleanExiHS_RETNLB.
GenevisibleiQ9BQ08. HS.

Family and domain databases

InterProiIPR009714. Resistin.
[Graphical view]
PANTHERiPTHR21101. PTHR21101. 1 hit.
PfamiPF06954. Resistin. 1 hit.
[Graphical view]
SUPFAMiSSF111423. SSF111423. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Representational difference analysis using myeloid cells from C/EBP epsilon deletional mice."
    Kubota T., Kawano S., Chih D.Y., Hisatake Y., Chumakov A.M., Taguchi H., Koeffler H.P.
    Blood 96:3953-3957(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Identification of a novel cysteine-rich secreted A12-alpha related protein."
    Rajala M.W., Scherer P.E.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Bioinformatics based discovery of a novel factor with apparent specificity to colon cancer."
    De Young M.P., Damania H., Scheurle D., Zylberberg C., Narayanan R.
    In Vivo 16:239-248(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Small intestine.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiRETNB_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ08
Secondary accession number(s): Q14D27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.