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Protein

RNA-binding protein 4B

Gene

RBM4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri160 – 177CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionActivator, RNA-binding
Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 4B
Alternative name(s):
RNA-binding motif protein 30
RNA-binding motif protein 4B
RNA-binding protein 30
Gene namesi
Name:RBM4B
Synonyms:RBM30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28842. RBM4B.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173914.
PharmGKBiPA134977404.

Polymorphism and mutation databases

DMDMi62511129.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817871 – 359RNA-binding protein 4BAdd BLAST359

Proteomic databases

EPDiQ9BQ04.
MaxQBiQ9BQ04.
PaxDbiQ9BQ04.
PeptideAtlasiQ9BQ04.
PRIDEiQ9BQ04.

2D gel databases

SWISS-2DPAGEiQ9BQ04.

PTM databases

iPTMnetiQ9BQ04.
PhosphoSitePlusiQ9BQ04.

Expressioni

Tissue specificityi

Expressed in liver and kidney (at protein level). Ubiquitously expressed.2 Publications

Gene expression databases

BgeeiENSG00000173914.
CleanExiHS_RBM4B.
ExpressionAtlasiQ9BQ04. baseline and differential.
GenevisibleiQ9BQ04. HS.

Organism-specific databases

HPAiHPA042174.
HPA047849.

Interactioni

Subunit structurei

Interacts with TNPO3, which may mediate nuclear import of the protein.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123760. 62 interactors.
IntActiQ9BQ04. 16 interactors.
MINTiMINT-1379498.
STRINGi9606.ENSP00000310471.

Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi76 – 84Combined sources9
Helixi91 – 99Combined sources9
Beta strandi106 – 109Combined sources4
Beta strandi111 – 119Combined sources9
Helixi121 – 131Combined sources11
Beta strandi134 – 136Combined sources3
Beta strandi139 – 147Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DGTNMR-A75-153[»]
ProteinModelPortaliQ9BQ04.
SMRiQ9BQ04.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BQ04.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 72RRM 1PROSITE-ProRule annotationAdd BLAST71
Domaini78 – 148RRM 2PROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni196 – 359Interaction with TNPO3By similarityAdd BLAST164

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi231 – 240Poly-Ala10
Compositional biasi286 – 293Poly-Ala8

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri160 – 177CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0109. Eukaryota.
ENOG41105PP. LUCA.
GeneTreeiENSGT00390000020883.
HOGENOMiHOG000026790.
HOVERGENiHBG062217.
InParanoidiQ9BQ04.
KOiK13187.
OMAiVYYNDAY.
OrthoDBiEOG091G08PZ.
PhylomeDBiQ9BQ04.
TreeFamiTF320661.

Family and domain databases

CDDicd12606. RRM1_RBM4. 1 hit.
cd12607. RRM2_RBM4. 1 hit.
Gene3Di4.10.60.10. 1 hit.
InterProiView protein in InterPro
IPR034897. RBM4_RRM1.
IPR034898. RBM4_RRM2.
IPR000504. RRM_dom.
IPR001878. Znf_CCHC.
PfamiView protein in Pfam
PF00076. RRM_1. 2 hits.
PF00098. zf-CCHC. 1 hit.
SMARTiView protein in SMART
SM00360. RRM. 2 hits.
SM00343. ZnF_C2HC. 1 hit.
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiView protein in PROSITE
PS50102. RRM. 2 hits.
PS50158. ZF_CCHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BQ04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLFIGNLP REATEQEIRS LFEQYGKVLE CDIIKNYGFV HIEDKTAAED
60 70 80 90 100
AIRNLHHYKL HGVNINVEAS KNKSKASTKL HVGNISPTCT NQELRAKFEE
110 120 130 140 150
YGPVIECDIV KDYAFVHMER AEDAVEAIRG LDNTEFQGKR MHVQLSTSRL
160 170 180 190 200
RTAPGMGDQS GCYRCGKEGH WSKECPVDRT GRVADFTEQY NEQYGAVRTP
210 220 230 240 250
YTMGYGESMY YNDAYGALDY YKRYRVRSYE AVAAAAAASA YNYAEQTMSH
260 270 280 290 300
LPQVQSTTVT SHLNSTSVDP YDRHLLPNSG AAATSAAMAA AAATTSSYYG
310 320 330 340 350
RDRSPLRRAA AMLPTVGEGY GYGPESELSQ ASAATRNSLY DMARYEREQY

VDRARYSAF
Length:359
Mass (Da):40,150
Last modified:June 1, 2001 - v1
Checksum:iC336DF80460BD474
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06476693E → V1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095158 mRNA. Translation: BAG52995.1.
CH471076 Genomic DNA. Translation: EAW74558.1.
BC003503 mRNA. Translation: AAH03503.1.
BC004951 mRNA. Translation: AAH04951.1.
CCDSiCCDS8149.1.
RefSeqiNP_001273064.1. NM_001286135.1.
NP_113680.1. NM_031492.3.
XP_011543599.1. XM_011545297.2.
XP_016873891.1. XM_017018402.1.
UniGeneiHs.618713.

Genome annotation databases

EnsembliENST00000310046; ENSP00000310471; ENSG00000173914.
ENST00000525754; ENSP00000433071; ENSG00000173914.
GeneIDi83759.
KEGGihsa:83759.
UCSCiuc001oja.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRBM4B_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ04
Secondary accession number(s): B3KT83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: August 30, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references