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Q9BPZ2

- SPI2B_HUMAN

UniProt

Q9BPZ2 - SPI2B_HUMAN

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Protein

Spindlin-2B

Gene

SPIN2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors.1 Publication

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cell cycle Source: UniProtKB-KW
  3. gamete generation Source: InterPro
  4. regulation of cell cycle Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Spindlin-2B
Alternative name(s):
Spindlin-like protein 2B
Short name:
SPIN-2
Short name:
SPIN-2B
Gene namesi
Name:SPIN2B
Synonyms:SPIN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:33147. SPIN2B.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162404530.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Spindlin-2BPRO_0000181369Add
BLAST

Proteomic databases

MaxQBiQ9BPZ2.
PaxDbiQ9BPZ2.
PRIDEiQ9BPZ2.

PTM databases

PhosphoSiteiQ9BPZ2.

Expressioni

Tissue specificityi

Detected in all the examined tissues with highest expression in liver, followed by heart, stomach, kidney, skeletal muscle, placenta, and pancreas.

Gene expression databases

BgeeiQ9BPZ2.
CleanExiHS_SPIN2B.
ExpressionAtlasiQ9BPZ2. baseline.
GenevestigatoriQ9BPZ2.

Organism-specific databases

HPAiHPA000162.

Interactioni

Protein-protein interaction databases

BioGridi138877. 24 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9BPZ2.
SMRiQ9BPZ2. Positions 46-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPIN/STSY family.Curated

Phylogenomic databases

eggNOGiNOG40069.
GeneTreeiENSGT00760000119261.
HOGENOMiHOG000293367.
HOVERGENiHBG000686.
InParanoidiQ9BPZ2.
OMAiMTKKKAS.
PhylomeDBiQ9BPZ2.
TreeFamiTF332665.

Family and domain databases

InterProiIPR029564. SPIN-2.
IPR003671. SPIN/Ssty.
[Graphical view]
PANTHERiPTHR10405. PTHR10405. 1 hit.
PTHR10405:SF17. PTHR10405:SF17. 1 hit.
PfamiPF02513. Spin-Ssty. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BPZ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTPNAQEAE GQQTRAAAGR ATGSANMTKK KVSQKKQRGR PSSQPRRNIV
60 70 80 90 100
GCRISHGWKE GDEPITQWKG TVLDQVPINP SLYLVKYDGI DCVYGLELHR
110 120 130 140 150
DERVLSLKIL SDRVASSHIS DANLANTIIG KAVEHMFEGE HGSKDEWRGM
160 170 180 190 200
VLAQAPIMKA WFYITYEKDP VLYMYQLLDD YKEGDLRIMP ESSESPPTER
210 220 230 240 250
EPGGVVDGLI GKHVEYTKED GSKRIGMVIH QVEAKPSVYF IKFDDDFHIY

VYDLVKKS
Length:258
Mass (Da):29,158
Last modified:June 1, 2001 - v1
Checksum:iCAD74289970B4BCD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF356353 mRNA. Translation: AAK37566.1.
AL022157 Genomic DNA. Translation: CAI42600.1.
BC000044 mRNA. Translation: AAH00044.1.
BC071974 mRNA. Translation: AAH71974.1.
CCDSiCCDS35311.1.
RefSeqiNP_001006682.1. NM_001006681.1.
NP_001006683.1. NM_001006682.1.
NP_001006684.1. NM_001006683.1.
XP_005262067.1. XM_005262010.1.
UniGeneiHs.460717.
Hs.745094.

Genome annotation databases

EnsembliENST00000275988; ENSP00000275988; ENSG00000186787.
ENST00000333933; ENSP00000335008; ENSG00000186787.
ENST00000374912; ENSP00000364047; ENSG00000186787.
GeneIDi474343.
KEGGihsa:474343.
UCSCiuc004duy.3. human.

Polymorphism databases

DMDMi23822181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF356353 mRNA. Translation: AAK37566.1 .
AL022157 Genomic DNA. Translation: CAI42600.1 .
BC000044 mRNA. Translation: AAH00044.1 .
BC071974 mRNA. Translation: AAH71974.1 .
CCDSi CCDS35311.1.
RefSeqi NP_001006682.1. NM_001006681.1.
NP_001006683.1. NM_001006682.1.
NP_001006684.1. NM_001006683.1.
XP_005262067.1. XM_005262010.1.
UniGenei Hs.460717.
Hs.745094.

3D structure databases

ProteinModelPortali Q9BPZ2.
SMRi Q9BPZ2. Positions 46-256.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 138877. 24 interactions.

PTM databases

PhosphoSitei Q9BPZ2.

Polymorphism databases

DMDMi 23822181.

Proteomic databases

MaxQBi Q9BPZ2.
PaxDbi Q9BPZ2.
PRIDEi Q9BPZ2.

Protocols and materials databases

DNASUi 474343.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000275988 ; ENSP00000275988 ; ENSG00000186787 .
ENST00000333933 ; ENSP00000335008 ; ENSG00000186787 .
ENST00000374912 ; ENSP00000364047 ; ENSG00000186787 .
GeneIDi 474343.
KEGGi hsa:474343.
UCSCi uc004duy.3. human.

Organism-specific databases

CTDi 474343.
GeneCardsi GC0XM057163.
HGNCi HGNC:33147. SPIN2B.
HPAi HPA000162.
MIMi 300517. gene.
neXtProti NX_Q9BPZ2.
PharmGKBi PA162404530.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40069.
GeneTreei ENSGT00760000119261.
HOGENOMi HOG000293367.
HOVERGENi HBG000686.
InParanoidi Q9BPZ2.
OMAi MTKKKAS.
PhylomeDBi Q9BPZ2.
TreeFami TF332665.

Miscellaneous databases

GenomeRNAii 474343.
NextBioi 111680.
PROi Q9BPZ2.
SOURCEi Search...

Gene expression databases

Bgeei Q9BPZ2.
CleanExi HS_SPIN2B.
ExpressionAtlasi Q9BPZ2. baseline.
Genevestigatori Q9BPZ2.

Family and domain databases

InterProi IPR029564. SPIN-2.
IPR003671. SPIN/Ssty.
[Graphical view ]
PANTHERi PTHR10405. PTHR10405. 1 hit.
PTHR10405:SF17. PTHR10405:SF17. 1 hit.
Pfami PF02513. Spin-Ssty. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression."
    Fletcher B.S., Dragstedt C., Notterpek L., Nolan G.P.
    Leukemia 16:1507-1518(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland and Placenta.

Entry informationi

Entry nameiSPI2B_HUMAN
AccessioniPrimary (citable) accession number: Q9BPZ2
Secondary accession number(s): Q7Z2M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Overexpression in murine myeloid cell line 32Dcl3 causes G2/M arrest.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3