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Q9BPZ2

- SPI2B_HUMAN

UniProt

Q9BPZ2 - SPI2B_HUMAN

Protein

Spindlin-2B

Gene

SPIN2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors.1 Publication

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cell cycle Source: UniProtKB-KW
    3. gamete generation Source: InterPro

    Keywords - Biological processi

    Apoptosis, Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Spindlin-2B
    Alternative name(s):
    Spindlin-like protein 2B
    Short name:
    SPIN-2
    Short name:
    SPIN-2B
    Gene namesi
    Name:SPIN2B
    Synonyms:SPIN2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:33147. SPIN2B.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162404530.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 258258Spindlin-2BPRO_0000181369Add
    BLAST

    Proteomic databases

    MaxQBiQ9BPZ2.
    PaxDbiQ9BPZ2.
    PRIDEiQ9BPZ2.

    PTM databases

    PhosphoSiteiQ9BPZ2.

    Expressioni

    Tissue specificityi

    Detected in all the examined tissues with highest expression in liver, followed by heart, stomach, kidney, skeletal muscle, placenta, and pancreas.

    Gene expression databases

    BgeeiQ9BPZ2.
    CleanExiHS_SPIN2B.
    GenevestigatoriQ9BPZ2.

    Organism-specific databases

    HPAiHPA000162.

    Interactioni

    Protein-protein interaction databases

    BioGridi138877. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BPZ2.
    SMRiQ9BPZ2. Positions 46-256.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SPIN/STSY family.Curated

    Phylogenomic databases

    eggNOGiNOG40069.
    HOGENOMiHOG000293367.
    HOVERGENiHBG000686.
    InParanoidiQ9BPZ2.
    OMAiMTKKKAS.
    PhylomeDBiQ9BPZ2.
    TreeFamiTF332665.

    Family and domain databases

    InterProiIPR029564. SPIN-2.
    IPR003671. SPIN/Ssty.
    [Graphical view]
    PANTHERiPTHR10405. PTHR10405. 1 hit.
    PTHR10405:SF17. PTHR10405:SF17. 1 hit.
    PfamiPF02513. Spin-Ssty. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BPZ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTPNAQEAE GQQTRAAAGR ATGSANMTKK KVSQKKQRGR PSSQPRRNIV    50
    GCRISHGWKE GDEPITQWKG TVLDQVPINP SLYLVKYDGI DCVYGLELHR 100
    DERVLSLKIL SDRVASSHIS DANLANTIIG KAVEHMFEGE HGSKDEWRGM 150
    VLAQAPIMKA WFYITYEKDP VLYMYQLLDD YKEGDLRIMP ESSESPPTER 200
    EPGGVVDGLI GKHVEYTKED GSKRIGMVIH QVEAKPSVYF IKFDDDFHIY 250
    VYDLVKKS 258
    Length:258
    Mass (Da):29,158
    Last modified:June 1, 2001 - v1
    Checksum:iCAD74289970B4BCD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF356353 mRNA. Translation: AAK37566.1.
    AL022157 Genomic DNA. Translation: CAI42600.1.
    BC000044 mRNA. Translation: AAH00044.1.
    BC071974 mRNA. Translation: AAH71974.1.
    CCDSiCCDS35311.1.
    RefSeqiNP_001006682.1. NM_001006681.1.
    NP_001006683.1. NM_001006682.1.
    NP_001006684.1. NM_001006683.1.
    XP_005262067.1. XM_005262010.1.
    UniGeneiHs.460717.
    Hs.745094.

    Genome annotation databases

    EnsembliENST00000275988; ENSP00000275988; ENSG00000186787.
    ENST00000333933; ENSP00000335008; ENSG00000186787.
    ENST00000374912; ENSP00000364047; ENSG00000186787.
    GeneIDi474343.
    KEGGihsa:474343.
    UCSCiuc004duy.3. human.

    Polymorphism databases

    DMDMi23822181.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF356353 mRNA. Translation: AAK37566.1 .
    AL022157 Genomic DNA. Translation: CAI42600.1 .
    BC000044 mRNA. Translation: AAH00044.1 .
    BC071974 mRNA. Translation: AAH71974.1 .
    CCDSi CCDS35311.1.
    RefSeqi NP_001006682.1. NM_001006681.1.
    NP_001006683.1. NM_001006682.1.
    NP_001006684.1. NM_001006683.1.
    XP_005262067.1. XM_005262010.1.
    UniGenei Hs.460717.
    Hs.745094.

    3D structure databases

    ProteinModelPortali Q9BPZ2.
    SMRi Q9BPZ2. Positions 46-256.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 138877. 1 interaction.

    PTM databases

    PhosphoSitei Q9BPZ2.

    Polymorphism databases

    DMDMi 23822181.

    Proteomic databases

    MaxQBi Q9BPZ2.
    PaxDbi Q9BPZ2.
    PRIDEi Q9BPZ2.

    Protocols and materials databases

    DNASUi 474343.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000275988 ; ENSP00000275988 ; ENSG00000186787 .
    ENST00000333933 ; ENSP00000335008 ; ENSG00000186787 .
    ENST00000374912 ; ENSP00000364047 ; ENSG00000186787 .
    GeneIDi 474343.
    KEGGi hsa:474343.
    UCSCi uc004duy.3. human.

    Organism-specific databases

    CTDi 474343.
    GeneCardsi GC0XM057163.
    HGNCi HGNC:33147. SPIN2B.
    HPAi HPA000162.
    MIMi 300517. gene.
    neXtProti NX_Q9BPZ2.
    PharmGKBi PA162404530.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40069.
    HOGENOMi HOG000293367.
    HOVERGENi HBG000686.
    InParanoidi Q9BPZ2.
    OMAi MTKKKAS.
    PhylomeDBi Q9BPZ2.
    TreeFami TF332665.

    Miscellaneous databases

    GenomeRNAii 474343.
    NextBioi 111680.
    PROi Q9BPZ2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BPZ2.
    CleanExi HS_SPIN2B.
    Genevestigatori Q9BPZ2.

    Family and domain databases

    InterProi IPR029564. SPIN-2.
    IPR003671. SPIN/Ssty.
    [Graphical view ]
    PANTHERi PTHR10405. PTHR10405. 1 hit.
    PTHR10405:SF17. PTHR10405:SF17. 1 hit.
    Pfami PF02513. Spin-Ssty. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression."
      Fletcher B.S., Dragstedt C., Notterpek L., Nolan G.P.
      Leukemia 16:1507-1518(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland and Placenta.

    Entry informationi

    Entry nameiSPI2B_HUMAN
    AccessioniPrimary (citable) accession number: Q9BPZ2
    Secondary accession number(s): Q7Z2M0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Overexpression in murine myeloid cell line 32Dcl3 causes G2/M arrest.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3