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Protein

Spindlin-2B

Gene

SPIN2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors (PubMed:12145692). Exhibits H3K4me3-binding activity (PubMed:29061846).2 Publications

Miscellaneous

Overexpression in murine myeloid cell line 32Dcl3 causes G2/M arrest.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei169Histone H3K4me3 and H3R8me2aBy similarity1
Binding sitei176Histone H3K4me3 and H3R8me2aBy similarity1
Binding sitei180Histone H3K4me3 and H3R8me2aBy similarity1

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processApoptosis, Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Spindlin-2B
Alternative name(s):
Spindlin-like protein 2B
Short name:
SPIN-2
Short name:
SPIN-2B
Gene namesi
Name:SPIN2B
Synonyms:SPIN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000186787.7
HGNCiHGNC:33147 SPIN2B
MIMi300517 gene
neXtProtiNX_Q9BPZ2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162404530

Polymorphism and mutation databases

BioMutaiSPIN2B
DMDMi23822181

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001813691 – 258Spindlin-2BAdd BLAST258

Proteomic databases

EPDiQ9BPZ2
MaxQBiQ9BPZ2
PaxDbiQ9BPZ2
PRIDEiQ9BPZ2

PTM databases

iPTMnetiQ9BPZ2
PhosphoSitePlusiQ9BPZ2

Expressioni

Tissue specificityi

Detected in all the examined tissues with highest expression in liver, followed by heart, stomach, kidney, skeletal muscle, placenta, and pancreas.

Gene expression databases

BgeeiENSG00000186787
CleanExiHS_SPIN2B
ExpressionAtlasiQ9BPZ2 baseline and differential
GenevisibleiQ9BPZ2 HS

Organism-specific databases

HPAiHPA000162
HPA069835

Interactioni

Subunit structurei

Interacts with C11orf84/SPINDOC (PubMed:29061846).1 Publication

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi138877, 24 interactors
STRINGi9606.ENSP00000275988

Structurei

Secondary structure

1258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi53 – 58Combined sources6
Beta strandi66 – 75Combined sources10
Beta strandi83 – 87Combined sources5
Beta strandi94 – 96Combined sources3
Turni98 – 100Combined sources3
Beta strandi104 – 110Combined sources7
Helixi122 – 128Combined sources7
Beta strandi132 – 138Combined sources7
Beta strandi142 – 154Combined sources13
Beta strandi156 – 158Combined sources3
Beta strandi161 – 166Combined sources6
Beta strandi169 – 175Combined sources7
Helixi177 – 182Combined sources6
Beta strandi186 – 188Combined sources3
Beta strandi213 – 217Combined sources5
Beta strandi221 – 231Combined sources11
Beta strandi238 – 243Combined sources6
Beta strandi250 – 253Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LUGX-ray1.70A/B/C/D44-258[»]
ProteinModelPortaliQ9BPZ2
SMRiQ9BPZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 99Tudor-like domain 1Sequence analysisAdd BLAST50
Regioni129 – 178Tudor-like domain 2Sequence analysisAdd BLAST50
Regioni138Histone H3K4me3 and H3R8me2a bindingBy similarity1
Regioni210 – 255Tudor-like domain 3Sequence analysisAdd BLAST46
Regioni246 – 248Histone H3K4me3 and H3R8me2a bindingBy similarity3

Sequence similaritiesi

Belongs to the SPIN/STSY family.Curated

Phylogenomic databases

eggNOGiENOG410IGUH Eukaryota
ENOG410XQI2 LUCA
GeneTreeiENSGT00760000119261
HOGENOMiHOG000293367
HOVERGENiHBG000686
InParanoidiQ9BPZ2
OMAiNTQEAEG
OrthoDBiEOG091G0EE3
PhylomeDBiQ9BPZ2
TreeFamiTF332665

Family and domain databases

InterProiView protein in InterPro
IPR029564 SPIN-2
IPR003671 SPIN/Ssty
PANTHERiPTHR10405 PTHR10405, 1 hit
PTHR10405:SF28 PTHR10405:SF28, 1 hit
PfamiView protein in Pfam
PF02513 Spin-Ssty, 3 hits

Sequencei

Sequence statusi: Complete.

Q9BPZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTPNAQEAE GQQTRAAAGR ATGSANMTKK KVSQKKQRGR PSSQPRRNIV
60 70 80 90 100
GCRISHGWKE GDEPITQWKG TVLDQVPINP SLYLVKYDGI DCVYGLELHR
110 120 130 140 150
DERVLSLKIL SDRVASSHIS DANLANTIIG KAVEHMFEGE HGSKDEWRGM
160 170 180 190 200
VLAQAPIMKA WFYITYEKDP VLYMYQLLDD YKEGDLRIMP ESSESPPTER
210 220 230 240 250
EPGGVVDGLI GKHVEYTKED GSKRIGMVIH QVEAKPSVYF IKFDDDFHIY

VYDLVKKS
Length:258
Mass (Da):29,158
Last modified:June 1, 2001 - v1
Checksum:iCAD74289970B4BCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356353 mRNA Translation: AAK37566.1
AL022157 Genomic DNA No translation available.
BC000044 mRNA Translation: AAH00044.1
BC071974 mRNA Translation: AAH71974.1
CCDSiCCDS35311.1
RefSeqiNP_001006682.1, NM_001006681.1
NP_001006683.1, NM_001006682.1
NP_001006684.1, NM_001006683.1
XP_005262066.2, XM_005262009.4
XP_005262067.1, XM_005262010.1
XP_011529090.1, XM_011530788.2
XP_016885041.1, XM_017029552.1
UniGeneiHs.460717
Hs.745094

Genome annotation databases

EnsembliENST00000275988; ENSP00000275988; ENSG00000186787
ENST00000333933; ENSP00000335008; ENSG00000186787
GeneIDi474343
KEGGihsa:474343
UCSCiuc004duy.5 human

Similar proteinsi

Entry informationi

Entry nameiSPI2B_HUMAN
AccessioniPrimary (citable) accession number: Q9BPZ2
Secondary accession number(s): Q7Z2M0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health