Q9BPZ2 (SPI2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Spindlin-2B

Alternative name(s):
Spindlin-like protein 2B
Short name=SPIN-2
Short name=SPIN-2B

Gene names

Name:	SPIN2B
Synonyms:	SPIN2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors. Ref.1
Subcellular location	Nucleus Ref.1.
Tissue specificity	Detected in all the examined tissues with highest expression in liver, followed by heart, stomach, kidney, skeletal muscle, placenta, and pancreas.
Miscellaneous	Overexpression in murine myeloid cell line 32Dcl3 causes G2/M arrest.
Sequence similarities	Belongs to the SPIN/STSY family.

Ontologies

Keywords
Biological process	Apoptosis Cell cycle
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW gamete generation Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	Spindlin-2B		PRO_0000181369

Sequences

	Sequence		Length	Mass (Da)
	Q9BPZ2 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: CAD74289970B4BCD	FASTA	258	29,158
	10 20 30 40 50 60 MKTPNAQEAE GQQTRAAAGR ATGSANMTKK KVSQKKQRGR PSSQPRRNIV GCRISHGWKE 70 80 90 100 110 120 GDEPITQWKG TVLDQVPINP SLYLVKYDGI DCVYGLELHR DERVLSLKIL SDRVASSHIS 130 140 150 160 170 180 DANLANTIIG KAVEHMFEGE HGSKDEWRGM VLAQAPIMKA WFYITYEKDP VLYMYQLLDD 190 200 210 220 230 240 YKEGDLRIMP ESSESPPTER EPGGVVDGLI GKHVEYTKED GSKRIGMVIH QVEAKPSVYF 250 IKFDDDFHIY VYDLVKKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression." Fletcher B.S., Dragstedt C., Notterpek L., Nolan G.P. Leukemia 16:1507-1518(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland and Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF356353 mRNA. Translation: AAK37566.1. AL022157 Genomic DNA. Translation: CAI42600.1. BC000044 mRNA. Translation: AAH00044.1. BC071974 mRNA. Translation: AAH71974.1.
IPI	IPI00029084.
RefSeq	NP_001006682.1. NM_001006681.1. NP_001006683.1. NM_001006682.1. NP_001006684.1. NM_001006683.1.
UniGene	Hs.460717.
3D structure databases
ProteinModelPortal	Q9BPZ2.
ModBase	Search...
PTM databases
PhosphoSite	Q9BPZ2.
Polymorphism databases
DMDM	23822181.
Proteomic databases
PaxDb	Q9BPZ2.
PRIDE	Q9BPZ2.
Protocols and materials databases
DNASU	474343.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000275988; ENSP00000275988; ENSG00000186787. ENST00000333933; ENSP00000335008; ENSG00000186787. ENST00000374912; ENSP00000364047; ENSG00000186787.
GeneID	474343.
KEGG	hsa:474343.
UCSC	uc004duy.3. human.
Organism-specific databases
CTD	474343.
GeneCards	GC0XM057163.
HGNC	HGNC:33147. SPIN2B.
HPA	HPA000162.
MIM	300517. gene.
neXtProt	NX_Q9BPZ2.
PharmGKB	PA162404530.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40069.
HOGENOM	HOG000293367.
HOVERGEN	HBG000686.
InParanoid	Q9BPZ2.
OMA	MTKKKAS.
OrthoDB	EOG4RV2S3.
PhylomeDB	Q9BPZ2.
Gene expression databases
ArrayExpress	Q9BPZ2.
Bgee	Q9BPZ2.
CleanEx	HS_SPIN2B.
Genevestigator	Q9BPZ2.
GermOnline	ENSG00000186787. Homo sapiens.
Family and domain databases
InterPro	IPR003671. Spin_Ssty. [Graphical view]
Pfam	PF02513. Spin-Ssty. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	474343.
NextBio	111680.
SOURCE	Search...

Entry information

Entry name

SPI2B_HUMAN

Accession

Primary (citable) accession number: Q9BPZ2
Secondary accession number(s): Q7Z2M0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	June 1, 2001
Last modified:	May 29, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.