Reviewed, UniProtKB/Swiss-Prot Q9BPY8 (HOP_HUMAN)

Names and origin

Protein names

Recommended name:
    Homeodomain-only protein
Alternative name(s):
    Lung cancer-associated Y protein
    Odd homeobox protein 1
    Not expressed in choriocarcinoma protein 1

Gene names

Name:	HOPX
Synonyms:	HOD, HOP, LAGY, NECC1, OB1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	73 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy By similarity. May act as a tumor suppressor.
Subunit structure	Interacts with serum response factor (SRF). Component of a large complex containing histone deacetylases such as HDAC2 By similarity.
Subcellular location	Nucleus By similarity.
Tissue specificity	Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Ref.2 Ref.3
Involvement in disease	Defects in HOPX may be a cause of various types of cancer, such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma.
Sequence similarities	Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Disease	Proto-oncogene
Domain	Homeobox
Molecular function	Developmental protein Repressor
Gene Ontology (GO)
Biological process	negative regulation of cell differentiation Inferred from direct assay. Source: MGI transcription Inferred from electronic annotation. Source: UniProtKB-KW trophectodermal cell differentiation Inferred from direct assay. Source: MGI
Cellular component	nucleus Inferred from direct assay. Source: MGI
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BPY8-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BPY8-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     49-72: KWFKQRLAKWRRSEGLPSECRSVT → GSDLISRSKIWHPESSPQREGYPHSLLCLAFDYFSLLPPQCKEMV

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 73	73	Homeodomain-only protein		PRO_0000049129
Regions
	DNA binding	3 – 62	60	Homeobox; atypical
Natural variations
	Alternative sequence	49 – 72	24	KWFKQ…CRSVT → GSDLISRSKIWHPESSPQRE GYPHSLLCLAFDYFSLLPPQ CKEMV in isoform 2.		VSP_012659
Experimental info
	Sequence conflict	72	1	T → I in AAH14225. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) [UniParc]. Last modified June 1, 2001. Version 1. Checksum: CE65E4D2A8972022	FASTA	73	8,260
	10 20 30 40 50 60 MSAETASGPT EDQVEILEYN FNKVDKHPDS TTLCLIAAEA GLSEEETQKW FKQRLAKWRR 70 SEGLPSECRS VTD
	Isoform 2 (B). Checksum: 5CCB1DE706D502A6	FASTA	94	10,475
	10 20 30 40 50 60 MSAETASGPT EDQVEILEYN FNKVDKHPDS TTLCLIAAEA GLSEEETQGS DLISRSKIWH 70 80 90 PESSPQREGY PHSLLCLAFD YFSLLPPQCK EMVD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development." Adu J., Leong F.T., Smith N.R., Leek J.P., Markham A.F., Robinson P.A., Mighell A.J. Mech. Dev. 119:S43-S47(2002) [PubMed: 14516659] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Heart.
[2]	"NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif." Asanoma K., Matsuda T., Kondo H., Kato K., Kishino T., Niikawa N., Wake N., Kato H. Genomics 81:15-25(2003) [PubMed: 12573257] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, POSSIBLE INVOLVEMENT IN CHORIOCARCINOMA.
[3]	"Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancer." Chen Y., Petersen S., Pacyna-Gengelbach M., Pietas A., Petersen I. Oncology 64:450-458(2003) [PubMed: 12759545] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, POSSIBLE INVOLVEMENT IN LUNG CANCER.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: B-cell.
[6]	"Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma." Lemaire F., Millon R., Muller D., Rabouel Y., Bracco L., Abecassis J., Wasylyk B. Br. J. Cancer 91:258-261(2004) [PubMed: 15213722] [Abstract] Cited for: INVOLVEMENT IN HEAD AND NECK SQUAMOUS CELL CARCINOMA.
[7]	"Association between gene expression profile and tumor invasion in oral squamous cell carcinoma." Toruner G.A., Ulger C., Alkan M., Galante A.T., Rinaggio J., Wilk R., Tian B., Soteropoulos P., Hameed M.R., Schwalb M.N., Dermody J.J. Cancer Genet. Cytogenet. 154:27-35(2004) [PubMed: 15381369] [Abstract] Cited for: INVOLVEMENT IN ORAL SQUAMOUS CELL CARCINOMA.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF492675 mRNA. Translation: AAM46827.1. AF492676 mRNA. Translation: AAM46828.1. AF492677 mRNA. Translation: AAM46829.1. AF492678 mRNA. Translation: AAM46830.1. AF492679 mRNA. Translation: AAM46831.1. AF492680 mRNA. Translation: AAM46832.1. AF492681 mRNA. Translation: AAM46833.1. AB059408 mRNA. Translation: BAB40926.1. AB059409 mRNA. Translation: BAB40927.1. AB059410 mRNA. Translation: BAB40928.1. AF454763 mRNA. Translation: AAL56613.1. AK289707 mRNA. Translation: BAF82396.1. BC014225 mRNA. Translation: AAH14225.1.
IPI	IPI00386436. IPI00876964.
RefSeq	NP_001138931.1. NP_001138932.1. NP_115884.4. NP_631957.1. NP_631958.1.
UniGene	Hs.654864
3D structure databases
SMR	Q9BPY8. Positions 1-73.
ModBase	Search...
Proteomic databases
PRIDE	Q9BPY8.
Genome annotation databases
Ensembl	ENSG00000171476. Homo sapiens. [Contig view]
GeneID	84525.
KEGG	hsa:84525.
Organism-specific databases
GeneCards	GC04M057210.
H-InvDB	HIX0004237.
HGNC	HGNC:24961. HOPX.
MIM	607275. gene.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9BPY8.
HOVERGEN	Q9BPY8.
Gene expression databases
ArrayExpress	Q9BPY8.
Bgee	Q9BPY8.
CleanEx	HS_HOPX.
GermOnline	ENSG00000171476. Homo sapiens.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. False negative. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	74351.
SOURCE	Search...

Entry information

Entry name

HOP_HUMAN

Accession

Primary (citable) accession number: Q9BPY8
Secondary accession number(s): A8K0Z2, Q8N0V6, Q96CI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)