Q9BPY3 (F118B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM118B

Gene names

Name:

FAM118B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the FAM118 family.

Ontologies

Keywords
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.4
	Chain	2 – 351	350	Protein FAM118B		PRO_0000295103
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.4 Ref.6
	Modified residue	9	1	Phosphoserine Ref.4
Experimental info
	Sequence conflict	133	1	D → G in BAB14987. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BPY3 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: D298067C1D17E339	FASTA	351	39,499
	10 20 30 40 50 60 MASTGSQASD IDEIFGFFND GEPPTKKPRK LLPSLKTKKP RELVLVIGTG ISAAVAPQVP 70 80 90 100 110 120 ALKSWKGLIQ ALLDAAIDFD LLEDEESKKF QKCLHEDKNL VHVAHDLIQK LSPRTSNVRS 130 140 150 160 170 180 TFFKDCLYEV FDDLESKMED SGKQLLQSVL HLMENGALVL TTNFDNLLEL YAADQGKQLE 190 200 210 220 230 240 SLDLTDEKKV LEWAQEKRKL SVLHIHGVYT NPSGIVLHPA GYQNVLRNTE VMREIQKLYE 250 260 270 280 290 300 NKSFLFLGCG WTVDDTTFQA LFLEAVKHKS DLEHFMLVRR GDVDEFKKLR ENMLDKGIKV 310 320 330 340 350 ISYGDDYADL PEYFKRLTCE ISTRGTSAGM VREGQLNGSS AAHSEIRGCS T

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix and Lung.
[4]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, MASS SPECTROMETRY, CLEAVAGE OF INITIATOR METHIONINE. Tissue: Cervix carcinoma.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK024756 mRNA. Translation: BAB14987.1. CR457334 mRNA. Translation: CAG33615.1. BC001340 mRNA. Translation: AAH01340.1. BC001647 mRNA. Translation: AAH01647.1.
IPI	IPI00002240.
RefSeq	NP_078832.1. NM_024556.3.
UniGene	Hs.276315.
3D structure databases
ProteinModelPortal	Q9BPY3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BPY3. 1 interaction.
MINT	MINT-1425805.
PTM databases
PhosphoSite	Q9BPY3.
Polymorphism databases
DMDM	74732801.
Proteomic databases
PaxDb	Q9BPY3.
PeptideAtlas	Q9BPY3.
PRIDE	Q9BPY3.
Protocols and materials databases
DNASU	79607.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000533050; ENSP00000433343; ENSG00000197798.
GeneID	79607.
KEGG	hsa:79607.
UCSC	uc001qdf.3. human.
Organism-specific databases
CTD	79607.
GeneCards	GC11P126081.
H-InvDB	HIX0010251.
HGNC	HGNC:26110. FAM118B.
HPA	HPA041644. HPA042100.
neXtProt	NX_Q9BPY3.
PharmGKB	PA145008413.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46711.
HOGENOM	HOG000072713.
HOVERGEN	HBG055230.
InParanoid	Q9BPY3.
OMA	LYETKSF.
OrthoDB	EOG4BZN2V.
PhylomeDB	Q9BPY3.
Gene expression databases
ArrayExpress	Q9BPY3.
Bgee	Q9BPY3.
CleanEx	HS_FAM118B.
Genevestigator	Q9BPY3.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	79607.
NextBio	68646.

Entry information

Entry name

F118B_HUMAN

Accession

Primary (citable) accession number: Q9BPY3
Secondary accession number(s): Q9H7B0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.