ID   CG025_HUMAN             Reviewed;         421 AA.
AC   Q9BPX7; A4D1V2; J3KR36; Q9H779;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   27-MAR-2024, entry version 143.
DE   RecName: Full=UPF0415 protein C7orf25;
GN   Name=C7orf25;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA   Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA   Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA   Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA   Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA   Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA   Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA   Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA   Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA   Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA   Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA   Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA   Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT   networks.";
RL   Cell 127:635-648(2006).
CC   -!- INTERACTION:
CC       Q9BPX7; O00178: GTPBP1; NbExp=3; IntAct=EBI-718586, EBI-4403245;
CC       Q9BPX7; P49792: RANBP2; NbExp=3; IntAct=EBI-718586, EBI-973138;
CC       Q9BPX7; P26639: TARS1; NbExp=3; IntAct=EBI-718586, EBI-1042683;
CC       Q9BPX7; B2RDX5; NbExp=3; IntAct=EBI-718586, EBI-10173104;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9BPX7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9BPX7-2; Sequence=VSP_047243;
CC   -!- SIMILARITY: Belongs to the UPF0415 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK024820; BAB15019.1; -; mRNA.
DR   EMBL; AC010132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH236951; EAL24004.1; -; Genomic_DNA.
DR   EMBL; BC000769; AAH00769.1; -; mRNA.
DR   EMBL; BC001845; AAH01845.1; -; mRNA.
DR   CCDS; CCDS5466.1; -. [Q9BPX7-1]
DR   RefSeq; NP_001093328.1; NM_001099858.1. [Q9BPX7-1]
DR   RefSeq; NP_076959.2; NM_024054.2. [Q9BPX7-1]
DR   RefSeq; XP_005249901.1; XM_005249844.3.
DR   RefSeq; XP_016868086.1; XM_017012597.1.
DR   AlphaFoldDB; Q9BPX7; -.
DR   SMR; Q9BPX7; -.
DR   BioGRID; 122489; 22.
DR   IntAct; Q9BPX7; 26.
DR   MINT; Q9BPX7; -.
DR   STRING; 9606.ENSP00000413029; -.
DR   CarbonylDB; Q9BPX7; -.
DR   GlyGen; Q9BPX7; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q9BPX7; -.
DR   PhosphoSitePlus; Q9BPX7; -.
DR   BioMuta; C7orf25; -.
DR   DMDM; 74732797; -.
DR   EPD; Q9BPX7; -.
DR   jPOST; Q9BPX7; -.
DR   MassIVE; Q9BPX7; -.
DR   MaxQB; Q9BPX7; -.
DR   PaxDb; 9606-ENSP00000413029; -.
DR   PeptideAtlas; Q9BPX7; -.
DR   ProteomicsDB; 78593; -. [Q9BPX7-1]
DR   Pumba; Q9BPX7; -.
DR   Antibodypedia; 13143; 81 antibodies from 13 providers.
DR   DNASU; 79020; -.
DR   Ensembl; ENST00000350427.5; ENSP00000343364.4; ENSG00000136197.14. [Q9BPX7-1]
DR   Ensembl; ENST00000438029.1; ENSP00000396597.1; ENSG00000136197.14. [Q9BPX7-1]
DR   Ensembl; ENST00000447342.5; ENSP00000413029.2; ENSG00000136197.14. [Q9BPX7-2]
DR   GeneID; 79020; -.
DR   KEGG; hsa:79020; -.
DR   MANE-Select; ENST00000350427.5; ENSP00000343364.4; NM_001099858.2; NP_001093328.2.
DR   UCSC; uc003thx.5; human. [Q9BPX7-1]
DR   AGR; HGNC:21703; -.
DR   CTD; 79020; -.
DR   GeneCards; C7orf25; -.
DR   HGNC; HGNC:21703; C7orf25.
DR   HPA; ENSG00000136197; Low tissue specificity.
DR   neXtProt; NX_Q9BPX7; -.
DR   PharmGKB; PA134976499; -.
DR   VEuPathDB; HostDB:ENSG00000136197; -.
DR   VEuPathDB; HostDB:ENSG00000256646; -.
DR   eggNOG; KOG4529; Eukaryota.
DR   GeneTree; ENSGT00390000014722; -.
DR   HOGENOM; CLU_054053_0_0_1; -.
DR   InParanoid; Q9BPX7; -.
DR   OMA; HFCMFQR; -.
DR   OrthoDB; 3680584at2759; -.
DR   PhylomeDB; Q9BPX7; -.
DR   TreeFam; TF105980; -.
DR   PathwayCommons; Q9BPX7; -.
DR   SignaLink; Q9BPX7; -.
DR   BioGRID-ORCS; 79020; 19 hits in 1142 CRISPR screens.
DR   ChiTaRS; C7orf25; human.
DR   GenomeRNAi; 79020; -.
DR   Pharos; Q9BPX7; Tdark.
DR   PRO; PR:Q9BPX7; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q9BPX7; Protein.
DR   Bgee; ENSG00000136197; Expressed in primordial germ cell in gonad and 99 other cell types or tissues.
DR   ExpressionAtlas; Q9BPX7; baseline and differential.
DR   InterPro; IPR010733; DUF1308.
DR   InterPro; IPR041076; DUF5614.
DR   PANTHER; PTHR13379; UNCHARACTERIZED DUF1308; 1.
DR   PANTHER; PTHR13379:SF0; UPF0415 PROTEIN C7ORF25; 1.
DR   Pfam; PF07000; DUF1308; 1.
DR   Pfam; PF18474; DUF5614; 1.
DR   Genevisible; Q9BPX7; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..421
FT                   /note="UPF0415 protein C7orf25"
FT                   /id="PRO_0000279529"
FT   VAR_SEQ         1
FT                   /note="M -> MQEVPEAAGLARVEPPRRSSGVGAARLRFPGGSRPLRARACVLALAV
FT                   LALPERNNADSM (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_047243"
FT   VARIANT         265
FT                   /note="G -> E (in dbSNP:rs3735471)"
FT                   /id="VAR_053848"
FT   CONFLICT        131
FT                   /note="W -> R (in Ref. 1; BAB15019)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   421 AA;  46451 MW;  D7C421DC4CA80E9C CRC64;
     MSAHSMLCER IAIAKELIKR AESLSRSRKG GIEGGAKLCS KLKAELKFLQ KVEAGKVAIK
     ESHLQSTNLT HLRAIVESAE NLEEVVSVLH VFGYTDTLGE KQTLVVDVVA NGGHTWVKAI
     GRKAEALHNI WLGRGQYGDK SIIEQAEDFL QASHQQPVQY SNPHIIFAFY NSVSSPMAEK
     LKEMGISVRG DIVAVNALLD HPEELQPSES ESDDEGPELL QVTRVDRENI LASVAFPTEI
     KVDVCKRVNL DITTLITYVS ALSYGGCHFI FKEKVLTEQA EQERKEQVLP QLEAFMKDKE
     LFACESAVKD FQSILDTLGG PGERERATVL IKRINVVPDQ PSERALRLVA SSKINSRSLT
     IFGTGDTLKA ITMTANSGFV RAANNQGVKF SVFIHQPRAL TESKEALATP LPKDYTTDSE
     H
//