Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Actin-related protein 2/3 complex subunit 5-like protein

Gene

ARPC5L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 5-like protein
Alternative name(s):
Arp2/3 complex 16 kDa subunit 2
Short name:
ARC16-2
Gene namesi
Name:ARPC5L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23366. ARPC5L.

Subcellular locationi

GO - Cellular componenti

  • Arp2/3 protein complex Source: InterPro
  • cytoplasm Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134991012.

Polymorphism and mutation databases

BioMutaiARPC5L.
DMDMi74752229.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Actin-related protein 2/3 complex subunit 5-like proteinPRO_0000279480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BPX5.
MaxQBiQ9BPX5.
PaxDbiQ9BPX5.
PeptideAtlasiQ9BPX5.
PRIDEiQ9BPX5.
TopDownProteomicsiQ9BPX5.

PTM databases

iPTMnetiQ9BPX5.
PhosphoSiteiQ9BPX5.

Expressioni

Gene expression databases

BgeeiENSG00000136950.
CleanExiHS_ARPC5L.
ExpressionAtlasiQ9BPX5. baseline and differential.
GenevisibleiQ9BPX5. HS.

Organism-specific databases

HPAiHPA022013.

Interactioni

Subunit structurei

May be a component of the Arp2/3 complex in which it may replace ARPC5.

Protein-protein interaction databases

BioGridi123617. 53 interactions.
IntActiQ9BPX5. 37 interactions.
MINTiMINT-5001923.
STRINGi9606.ENSP00000259477.

Structurei

3D structure databases

ProteinModelPortaliQ9BPX5.
SMRiQ9BPX5. Positions 13-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC5 family.Curated

Phylogenomic databases

eggNOGiKOG3380. Eukaryota.
ENOG4111FGV. LUCA.
GeneTreeiENSGT00390000014806.
HOGENOMiHOG000197215.
HOVERGENiHBG050583.
InParanoidiQ9BPX5.
KOiK05754.
OMAiSQDTLMK.
OrthoDBiEOG091G0R2J.
PhylomeDBiQ9BPX5.
TreeFamiTF319716.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiIPR006789. ARPC5.
IPR030075. ARPC5L.
[Graphical view]
PANTHERiPTHR12644. PTHR12644. 1 hit.
PTHR12644:SF2. PTHR12644:SF2. 1 hit.
PfamiPF04699. P16-Arc. 1 hit.
[Graphical view]
PIRSFiPIRSF039096. p16-ARC. 1 hit.
SUPFAMiSSF69103. SSF69103. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BPX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARNTLSSRF RRVDIDEFDE NKFVDEQEEA AAAAAEPGPD PSEVDGLLRQ
60 70 80 90 100
GDMLRAFHAA LRNSPVNTKN QAVKERAQGV VLKVLTNFKS SEIEQAVQSL
110 120 130 140 150
DRNGVDLLMK YIYKGFEKPT ENSSAVLLQW HEKALAVGGL GSIIRVLTAR

KTV
Length:153
Mass (Da):16,941
Last modified:June 1, 2001 - v1
Checksum:iD8E4772404300560
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301Missing in AAP97155 (Ref. 1) Curated
Sequence conflicti36 – 372EP → RT in AAP97155 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087842 mRNA. Translation: AAP97155.1.
AL354928 Genomic DNA. Translation: CAI39641.1.
BC000018 mRNA. Translation: AAH00018.1.
BC000798 mRNA. Translation: AAH00798.1.
BC002418 mRNA. Translation: AAH02418.1.
CCDSiCCDS6859.1.
RefSeqiNP_112240.1. NM_030978.2.
UniGeneiHs.132499.
Hs.743864.

Genome annotation databases

EnsembliENST00000259477; ENSP00000259477; ENSG00000136950.
ENST00000353214; ENSP00000345361; ENSG00000136950.
GeneIDi81873.
KEGGihsa:81873.
UCSCiuc004boz.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087842 mRNA. Translation: AAP97155.1.
AL354928 Genomic DNA. Translation: CAI39641.1.
BC000018 mRNA. Translation: AAH00018.1.
BC000798 mRNA. Translation: AAH00798.1.
BC002418 mRNA. Translation: AAH02418.1.
CCDSiCCDS6859.1.
RefSeqiNP_112240.1. NM_030978.2.
UniGeneiHs.132499.
Hs.743864.

3D structure databases

ProteinModelPortaliQ9BPX5.
SMRiQ9BPX5. Positions 13-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123617. 53 interactions.
IntActiQ9BPX5. 37 interactions.
MINTiMINT-5001923.
STRINGi9606.ENSP00000259477.

PTM databases

iPTMnetiQ9BPX5.
PhosphoSiteiQ9BPX5.

Polymorphism and mutation databases

BioMutaiARPC5L.
DMDMi74752229.

Proteomic databases

EPDiQ9BPX5.
MaxQBiQ9BPX5.
PaxDbiQ9BPX5.
PeptideAtlasiQ9BPX5.
PRIDEiQ9BPX5.
TopDownProteomicsiQ9BPX5.

Protocols and materials databases

DNASUi81873.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259477; ENSP00000259477; ENSG00000136950.
ENST00000353214; ENSP00000345361; ENSG00000136950.
GeneIDi81873.
KEGGihsa:81873.
UCSCiuc004boz.2. human.

Organism-specific databases

CTDi81873.
GeneCardsiARPC5L.
H-InvDBHIX0008377.
HGNCiHGNC:23366. ARPC5L.
HPAiHPA022013.
neXtProtiNX_Q9BPX5.
PharmGKBiPA134991012.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3380. Eukaryota.
ENOG4111FGV. LUCA.
GeneTreeiENSGT00390000014806.
HOGENOMiHOG000197215.
HOVERGENiHBG050583.
InParanoidiQ9BPX5.
KOiK05754.
OMAiSQDTLMK.
OrthoDBiEOG091G0R2J.
PhylomeDBiQ9BPX5.
TreeFamiTF319716.

Miscellaneous databases

GenomeRNAii81873.
PROiQ9BPX5.

Gene expression databases

BgeeiENSG00000136950.
CleanExiHS_ARPC5L.
ExpressionAtlasiQ9BPX5. baseline and differential.
GenevisibleiQ9BPX5. HS.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiIPR006789. ARPC5.
IPR030075. ARPC5L.
[Graphical view]
PANTHERiPTHR12644. PTHR12644. 1 hit.
PTHR12644:SF2. PTHR12644:SF2. 1 hit.
PfamiPF04699. P16-Arc. 1 hit.
[Graphical view]
PIRSFiPIRSF039096. p16-ARC. 1 hit.
SUPFAMiSSF69103. SSF69103. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARP5L_HUMAN
AccessioniPrimary (citable) accession number: Q9BPX5
Secondary accession number(s): Q7Z523
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.