Reviewed,
UniProtKB/Swiss-Prot Q9BPX5 (ARP5L_HUMAN)
Last modified
December 15, 2009.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Actin-related protein 2/3 complex subunit 5-like protein Alternative name(s): Arp2/3 complex 16 kDa subunit 2 Short name=ARC16-2 | ||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 153 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. |
| Subunit structure | May be a component of the Arp2/3 complex in which it may replace ARPC5. |
| Subcellular location | Cytoplasm › cytoskeleton By similarity. |
| Sequence similarities | Belongs to the ARPC5 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Cytoskeleton |
| Ligand | Actin-binding |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | regulation of actin filament polymerization Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeletonInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | actin binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 153 | 152 | Actin-related protein 2/3 complex subunit 5-like protein | PRO_0000279480 | |||||
Amino acid modifications | |||||||||
| Modified residue | 64 | 1 | Phosphoserine Ref.5 | ||||||
Experimental info | |||||||||
| Sequence conflict | 30 | 1 | Missing in AAP97155. Ref.1 | ||||||
| Sequence conflict | 36 – 37 | 2 | EP → RT in AAP97155. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning of a novel human cDNA homologous to human Arp2/3 complex 16kDa subunit (ARC16) mRNA." Zhang M., Yu L., Zhou Y., Hu P.R., Xin Y.R., Zhao S.Y. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. Dunham I.Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Placenta. |
| [4] | Lubec G., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 12-49; 90-110 AND 115-145, MASS SPECTROMETRY. Tissue: Fetal brain cortex. |
| [5] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64, MASS SPECTROMETRY. Tissue: Epithelium. |
| [6] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AF087842 mRNA. Translation: AAP97155.1. AL354928 Genomic DNA. Translation: CAI39641.1. BC000018 mRNA. Translation: AAH00018.1. BC000798 mRNA. Translation: AAH00798.1. BC002418 mRNA. Translation: AAH02418.1. | |
| IPI | IPI00414554. |
| RefSeq | NP_112240.1. |
| UniGene | Hs.132499 |
3D structure databases | |
| SMR | Q9BPX5. Positions 8-152. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9BPX5. 3 interactions. |
| STRING | Q9BPX5. |
Proteomic databases | |
| PeptideAtlas | Q9BPX5. |
| PRIDE | Q9BPX5. |
Genome annotation databases | |
| Ensembl | ENST00000259477; ENSP00000259477; ENSG00000136950; Homo sapiens. [Genome view] ENST00000353214; ENSP00000345361; ENSG00000136950; Homo sapiens. [Genome view] |
| GeneID | 81873. |
| KEGG | hsa:81873. |
| UCSC | uc004bpa.2. human. |
Organism-specific databases | |
| CTD | 81873. |
| GeneCards | GC09P126664. |
| HGNC | HGNC:23366. ARPC5L. |
| HPA | HPA022013. |
| PharmGKB | PA134991012. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG377673. |
| HOVERGEN | Q9BPX5. |
| InParanoid | Q9BPX5. |
| OMA | RNSPINT. |
| OrthoDB | EOG9MPM8R. |
Gene expression databases | |
| ArrayExpress | Q9BPX5. |
| Bgee | Q9BPX5. |
| CleanEx | HS_ARPC5L. |
| Genevestigator | Q9BPX5. |
Family and domain databases | |
| InterPro | IPR006789. ARP2/3_p16_Arc. [Graphical view] |
| Gene3D | G3DSA:1.25.40.190. p16_Arc. 1 hit. |
| PANTHER | PTHR12644. p16_Arc. 1 hit. |
| Pfam | PF04699. P16-Arc. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 72214. |
Entry information
| Entry name | ARP5L_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9BPX5 Secondary accession number(s): Q7Z523 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 9 Human chromosome 9: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with


