Q9BPX5 (ARP5L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Actin-related protein 2/3 complex subunit 5-like protein

Alternative name(s):
Arp2/3 complex 16 kDa subunit 2
Short name=ARC16-2

Gene names

Name:

ARPC5L

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	153 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subunit structure	May be a component of the Arp2/3 complex in which it may replace ARPC5.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Sequence similarities	Belongs to the ARPC5 family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	Actin-binding
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	regulation of actin filament polymerization Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	actin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 153	152	Actin-related protein 2/3 complex subunit 5-like protein		PRO_0000279480
Amino acid modifications
	Modified residue	64	1	Phosphoserine Ref.5
Experimental info
	Sequence conflict	30	1	Missing in AAP97155. Ref.1
	Sequence conflict	36 – 37	2	EP → RT in AAP97155. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BPX5 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: D8E4772404300560	FASTA	153	16,941
	10 20 30 40 50 60 MARNTLSSRF RRVDIDEFDE NKFVDEQEEA AAAAAEPGPD PSEVDGLLRQ GDMLRAFHAA 70 80 90 100 110 120 LRNSPVNTKN QAVKERAQGV VLKVLTNFKS SEIEQAVQSL DRNGVDLLMK YIYKGFEKPT 130 140 150 ENSSAVLLQW HEKALAVGGL GSIIRVLTAR KTV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a novel human cDNA homologous to human Arp2/3 complex 16kDa subunit (ARC16) mRNA." Zhang M., Yu L., Zhou Y., Hu P.R., Xin Y.R., Zhao S.Y. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Placenta.
[4]	Lubec G., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 12-49; 90-110 AND 115-145, MASS SPECTROMETRY. Tissue: Fetal brain cortex.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF087842 mRNA. Translation: AAP97155.1. AL354928 Genomic DNA. Translation: CAI39641.1. BC000018 mRNA. Translation: AAH00018.1. BC000798 mRNA. Translation: AAH00798.1. BC002418 mRNA. Translation: AAH02418.1.
IPI	IPI00414554.
RefSeq	NP_112240.1. NM_030978.1.
UniGene	Hs.132499.
3D structure databases
ProteinModelPortal	Q9BPX5.
SMR	Q9BPX5. Positions 8-152.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BPX5. 3 interactions.
MINT	MINT-5001923.
STRING	Q9BPX5.
PTM databases
PhosphoSite	Q9BPX5.
Polymorphism databases
DMDM	74752229.
Proteomic databases
PeptideAtlas	Q9BPX5.
PRIDE	Q9BPX5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000259477; ENSP00000259477; ENSG00000136950. ENST00000353214; ENSP00000345361; ENSG00000136950.
GeneID	81873.
KEGG	hsa:81873.
UCSC	uc004bpa.2. human.
Organism-specific databases
CTD	81873.
GeneCards	GC09P127624.
H-InvDB	HIX0008377.
HGNC	HGNC:23366. ARPC5L.
HPA	HPA022013.
neXtProt	NX_Q9BPX5.
PharmGKB	PA134991012.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20910.
GeneTree	ENSGT00390000014806.
HOGENOM	HBG377673.
HOVERGEN	HBG050583.
InParanoid	Q9BPX5.
OMA	WDMLRAF.
OrthoDB	EOG49KFRW.
PhylomeDB	Q9BPX5.
Gene expression databases
ArrayExpress	Q9BPX5.
Bgee	Q9BPX5.
CleanEx	HS_ARPC5L.
Genevestigator	Q9BPX5.
Family and domain databases
InterPro	IPR006789. ARP2/3_p16_Arc. [Graphical view]
Gene3D	G3DSA:1.25.40.190. p16_Arc. 1 hit.
KO	K05754.
PANTHER	PTHR12644. p16_Arc. 1 hit.
Pfam	PF04699. P16-Arc. 1 hit. [Graphical view]
SUPFAM	SSF69103. p16_Arc. 1 hit.
ProtoNet	Search...
Other
NextBio	72214.

Entry information

Entry name

ARP5L_HUMAN

Accession

Primary (citable) accession number: Q9BPX5
Secondary accession number(s): Q7Z523

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.