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Protein

Actin-related protein 2/3 complex subunit 5-like protein

Gene

ARPC5L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 5-like protein
Alternative name(s):
Arp2/3 complex 16 kDa subunit 2
Short name:
ARC16-2
Gene namesi
Name:ARPC5L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23366. ARPC5L.

Subcellular locationi

GO - Cellular componenti

  • Arp2/3 protein complex Source: GO_Central
  • cytoplasm Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi81873.
OpenTargetsiENSG00000136950.
PharmGKBiPA134991012.

Polymorphism and mutation databases

BioMutaiARPC5L.
DMDMi74752229.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794801 – 153Actin-related protein 2/3 complex subunit 5-like proteinAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BPX5.
MaxQBiQ9BPX5.
PaxDbiQ9BPX5.
PeptideAtlasiQ9BPX5.
PRIDEiQ9BPX5.
TopDownProteomicsiQ9BPX5.

PTM databases

iPTMnetiQ9BPX5.
PhosphoSitePlusiQ9BPX5.

Expressioni

Gene expression databases

BgeeiENSG00000136950.
CleanExiHS_ARPC5L.
ExpressionAtlasiQ9BPX5. baseline and differential.
GenevisibleiQ9BPX5. HS.

Organism-specific databases

HPAiHPA022013.

Interactioni

Subunit structurei

May be a component of the Arp2/3 complex in which it may replace ARPC5.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123617. 53 interactors.
DIPiDIP-50399N.
IntActiQ9BPX5. 38 interactors.
MINTiMINT-5001923.
STRINGi9606.ENSP00000259477.

Structurei

3D structure databases

ProteinModelPortaliQ9BPX5.
SMRiQ9BPX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC5 family.Curated

Phylogenomic databases

eggNOGiKOG3380. Eukaryota.
ENOG4111FGV. LUCA.
GeneTreeiENSGT00390000014806.
HOGENOMiHOG000197215.
HOVERGENiHBG050583.
InParanoidiQ9BPX5.
KOiK05754.
OMAiCKSANWL.
OrthoDBiEOG091G0R2J.
PhylomeDBiQ9BPX5.
TreeFamiTF319716.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiView protein in InterPro
IPR006789. ARPC5.
IPR030075. ARPC5L.
PANTHERiPTHR12644. PTHR12644. 1 hit.
PTHR12644:SF6. PTHR12644:SF6. 1 hit.
PfamiView protein in Pfam
PF04699. P16-Arc. 1 hit.
PIRSFiPIRSF039096. p16-ARC. 1 hit.
SUPFAMiSSF69103. SSF69103. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BPX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARNTLSSRF RRVDIDEFDE NKFVDEQEEA AAAAAEPGPD PSEVDGLLRQ
60 70 80 90 100
GDMLRAFHAA LRNSPVNTKN QAVKERAQGV VLKVLTNFKS SEIEQAVQSL
110 120 130 140 150
DRNGVDLLMK YIYKGFEKPT ENSSAVLLQW HEKALAVGGL GSIIRVLTAR

KTV
Length:153
Mass (Da):16,941
Last modified:June 1, 2001 - v1
Checksum:iD8E4772404300560
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30Missing in AAP97155 (Ref. 1) Curated1
Sequence conflicti36 – 37EP → RT in AAP97155 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087842 mRNA. Translation: AAP97155.1.
AL354928 Genomic DNA. No translation available.
BC000018 mRNA. Translation: AAH00018.1.
BC000798 mRNA. Translation: AAH00798.1.
BC002418 mRNA. Translation: AAH02418.1.
CCDSiCCDS6859.1.
RefSeqiNP_112240.1. NM_030978.2.
UniGeneiHs.132499.
Hs.743864.

Genome annotation databases

EnsembliENST00000259477; ENSP00000259477; ENSG00000136950.
ENST00000353214; ENSP00000345361; ENSG00000136950.
GeneIDi81873.
KEGGihsa:81873.
UCSCiuc004boz.2. human.

Similar proteinsi

Entry informationi

Entry nameiARP5L_HUMAN
AccessioniPrimary (citable) accession number: Q9BPX5
Secondary accession number(s): Q7Z523
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: June 1, 2001
Last modified: August 30, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families