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Protein

Condensin complex subunit 3

Gene

NCAPG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.1 Publication

Miscellaneous

Overexpressed in some cancer lines and some tumor cells.

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic chromosome condensation Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, DNA condensation, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2514853 Condensation of Prometaphase Chromosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin complex subunit 3
Alternative name(s):
Chromosome-associated protein G
Condensin subunit CAP-G
Short name:
hCAP-G
Melanoma antigen NY-MEL-3
Non-SMC condensin I complex subunit G
XCAP-G homolog
Gene namesi
Name:NCAPG
Synonyms:CAPG, NYMEL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109805.9
HGNCiHGNC:24304 NCAPG
MIMi606280 gene
neXtProtiNX_Q9BPX3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64151
OpenTargetsiENSG00000109805
PharmGKBiPA162397165

Polymorphism and mutation databases

BioMutaiNCAPG
DMDMi30172941

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000950411 – 1015Condensin complex subunit 3Add BLAST1015

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei390PhosphoserineCombined sources1
Modified residuei674PhosphoserineCombined sources1
Modified residuei931PhosphothreonineCombined sources1
Modified residuei973PhosphoserineCombined sources1
Modified residuei975PhosphoserineCombined sources1
Modified residuei1002PhosphoserineCombined sources1
Modified residuei1015PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPH subunits, activates the condensin complex and is required for chromosome condensation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BPX3
MaxQBiQ9BPX3
PaxDbiQ9BPX3
PeptideAtlasiQ9BPX3
PRIDEiQ9BPX3

PTM databases

iPTMnetiQ9BPX3
PhosphoSitePlusiQ9BPX3

Expressioni

Tissue specificityi

Highly expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000109805
CleanExiHS_CAPG
HS_NCAPG
ExpressionAtlasiQ9BPX3 baseline and differential
GenevisibleiQ9BPX3 HS

Organism-specific databases

HPAiHPA039613

Interactioni

Subunit structurei

Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NCAPHQ150033EBI-970214,EBI-1046410

Protein-protein interaction databases

BioGridi12208959 interactors.
CORUMiQ9BPX3
DIPiDIP-34891N
IntActiQ9BPX3 14 interactors.
MINTiQ9BPX3
STRINGi9606.ENSP00000251496

Structurei

3D structure databases

ProteinModelPortaliQ9BPX3
SMRiQ9BPX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati94 – 131HEAT 1Add BLAST38
Repeati138 – 173HEAT 2Add BLAST36
Repeati174 – 212HEAT 3Add BLAST39
Repeati238 – 275HEAT 4Add BLAST38
Repeati276 – 313HEAT 5Add BLAST38
Repeati399 – 436HEAT 6Add BLAST38
Repeati439 – 478HEAT 7Add BLAST40
Repeati617 – 654HEAT 8Add BLAST38
Repeati687 – 724HEAT 9Add BLAST38
Repeati865 – 907HEAT 10Add BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi88 – 91Poly-Glu4
Compositional biasi912 – 917Poly-Thr6

Sequence similaritiesi

Belongs to the CND3 (condensin subunit 3) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2025 Eukaryota
COG5218 LUCA
GeneTreeiENSGT00390000001577
HOVERGENiHBG039407
InParanoidiQ9BPX3
KOiK06678
OMAiTNQECFE
OrthoDBiEOG091G0K3M
PhylomeDBiQ9BPX3
TreeFamiTF101160

Family and domain databases

Gene3Di1.25.10.101 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR027165 CND3
IPR025977 Cnd3_C
PANTHERiPTHR14418 PTHR14418, 1 hit
PfamiView protein in Pfam
PF12719 Cnd3, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

Sequencei

Sequence statusi: Complete.

Q9BPX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAERRLLSI KEAFRLAQQP HQNQAKLVVA LSRTYRTMDD KTVFHEEFIH
60 70 80 90 100
YLKYVMVVYK REPAVERVIE FAAKFVTSFH QSDMEDDEEE EDGGLLNYLF
110 120 130 140 150
TFLLKSHEAN SNAVRFRVCL LINKLLGSMP ENAQIDDDVF DKINKAMLIR
160 170 180 190 200
LKDKIPNVRI QAVLALSRLQ DPKDDECPVV NAYATLIEND SNPEVRRAVL
210 220 230 240 250
SCIAPSAKTL PKIVGRTKDV KEAVRKLAYQ VLAEKVHMRA MSIAQRVMLL
260 270 280 290 300
QQGLNDRSDA VKQAMQKHLL QGWLRFSEGN ILELLHRLDV ENSSEVAVSV
310 320 330 340 350
LNALFSITPL SELVGLCKNN DGRKLIPVET LTPEIALYWC ALCEYLKSKG
360 370 380 390 400
DEGEEFLEQI LPEPVVYADY LLSYIQSIPV VNEEHRGDFS YIGNLMTKEF
410 420 430 440 450
IGQQLILIIK SLDTSEEGGR KKLLAVLQEI LILPTIPISL VSFLVERLLH
460 470 480 490 500
IIIDDNKRTQ IVTEIISEIR APIVTVGVNN DPADVRKKEL KMAEIKVKLI
510 520 530 540 550
EAKEALENCI TLQDFNRASE LKEEIKALED ARINLLKETE QLEIKEVHIE
560 570 580 590 600
KNDAETLQKC LILCYELLKQ MSISTGLSAT MNGIIESLIL PGIISIHPVV
610 620 630 640 650
RNLAVLCLGC CGLQNQDFAR KHFVLLLQVL QIDDVTIKIS ALKAIFDQLM
660 670 680 690 700
TFGIEPFKTK KIKTLHCEGT EINSDDEQES KEVEETATAK NVLKLLSDFL
710 720 730 740 750
DSEVSELRTG AAEGLAKLMF SGLLVSSRIL SRLILLWYNP VTEEDVQLRH
760 770 780 790 800
CLGVFFPVFA YASRTNQECF EEAFLPTLQT LANAPASSPL AEIDITNVAE
810 820 830 840 850
LLVDLTRPSG LNPQAKTSQD YQALTVHDNL AMKICNEILT SPCSPEIRVY
860 870 880 890 900
TKALSSLELS SHLAKDLLVL LNEILEQVKD RTCLRALEKI KIQLEKGNKE
910 920 930 940 950
FGDQAEAAQD ATLTTTTFQN EDEKNKEVYM TPLRGVKATQ ASKSTQLKTN
960 970 980 990 1000
RGQRKVTVSA RTNRRCQTAE ADSESDHEVP EPESEMKMRL PRRAKTAALE
1010
KSKLNLAQFL NEDLS
Length:1,015
Mass (Da):114,334
Last modified:June 1, 2001 - v1
Checksum:iD9ACC205C48F3AF5
GO

Sequence cautioni

The sequence AAH00827 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14429 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55165 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115R → G in BAB14069 (PubMed:14702039).Curated1
Sequence conflicti276F → V in AAG30732 (PubMed:10910072).Curated1
Sequence conflicti519S → P in BAB55165 (PubMed:14702039).Curated1
Sequence conflicti676D → V in BAB14069 (PubMed:14702039).Curated1
Sequence conflicti681K → R in BAB14069 (PubMed:14702039).Curated1
Sequence conflicti704V → A in BAB14069 (PubMed:14702039).Curated1
Sequence conflicti836N → D in BAB55165 (PubMed:14702039).Curated1
Sequence conflicti1010L → F in AAG30732 (PubMed:10910072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05304164A → P. Corresponds to variant dbSNP:rs35722563Ensembl.1
Natural variantiVAR_036125265M → T in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_053042581M → I1 PublicationCorresponds to variant dbSNP:rs3795243Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF235023 mRNA Translation: AAG30732.1
AF331796 mRNA Translation: AAG49627.1
AB013299 mRNA Translation: BAB21557.1
AK022512 mRNA Translation: BAB14069.1
AK023147 mRNA Translation: BAB14429.1 Different initiation.
AK027511 mRNA Translation: BAB55165.1 Different initiation.
BC000827 mRNA Translation: AAH00827.1 Different initiation.
BC101476 mRNA Translation: AAI01477.1
CCDSiCCDS3424.1
RefSeqiNP_071741.2, NM_022346.4
UniGeneiHs.567567

Genome annotation databases

EnsembliENST00000251496; ENSP00000251496; ENSG00000109805
GeneIDi64151
KEGGihsa:64151
UCSCiuc003gpp.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCND3_HUMAN
AccessioniPrimary (citable) accession number: Q9BPX3
Secondary accession number(s): Q3MJE0
, Q96SV9, Q9BUR3, Q9BVY1, Q9H914, Q9H9Z6, Q9HBI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome