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Protein

17-beta-hydroxysteroid dehydrogenase 14

Gene

HSD17B14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei141 – 1411SubstrateBy similarity
Active sitei154 – 1541Proton acceptorPROSITE-ProRule annotation
Binding sitei158 – 1581NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 4028NADBy similarityAdd
BLAST

GO - Molecular functioni

  • estradiol 17-beta-dehydrogenase activity Source: HGNC
  • testosterone 17-beta-dehydrogenase (NADP+) activity Source: HGNC

GO - Biological processi

  • estrogen biosynthetic process Source: Reactome
  • steroid catabolic process Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid metabolism, Steroid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.1.1.62. 2681.
ReactomeiR-HSA-193144. Estrogen biosynthesis.

Chemistry

SwissLipidsiSLP:000001216.

Names & Taxonomyi

Protein namesi
Recommended name:
17-beta-hydroxysteroid dehydrogenase 14 (EC:1.1.1.-)
Short name:
17-beta-HSD 14
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase DHRS10
Dehydrogenase/reductase SDR family member 10
Retinal short-chain dehydrogenase/reductase retSDR3
Short chain dehydrogenase/reductase family 47C member 1
Gene namesi
Name:HSD17B14
Synonyms:DHRS10, SDR3, SDR47C1
ORF Names:UNQ502/PRO474
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23238. HSD17B14.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162391674.

Polymorphism and mutation databases

BioMutaiHSD17B14.
DMDMi74752228.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27027017-beta-hydroxysteroid dehydrogenase 14PRO_0000054654Add
BLAST

Proteomic databases

EPDiQ9BPX1.
PaxDbiQ9BPX1.
PeptideAtlasiQ9BPX1.
PRIDEiQ9BPX1.

PTM databases

iPTMnetiQ9BPX1.
PhosphoSiteiQ9BPX1.

Expressioni

Tissue specificityi

Highly expressed in brain, placenta, liver and kidney.2 Publications

Gene expression databases

BgeeiENSG00000087076.
CleanExiHS_HSD17B14.
ExpressionAtlasiQ9BPX1. baseline and differential.
GenevisibleiQ9BPX1. HS.

Organism-specific databases

HPAiHPA021467.

Interactioni

Subunit structurei

Homotetramer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-742664,EBI-742664
CA8P352195EBI-742664,EBI-718700
CDKN2DP552735EBI-742664,EBI-745859
DDIT3P356383EBI-742664,EBI-742651
DDIT3P35638-23EBI-742664,EBI-10173632
MGC4677Q53S703EBI-742664,EBI-10242717
MPGP293723EBI-742664,EBI-1043398
NEK6Q9HC983EBI-742664,EBI-740364
NUDT18Q6ZVK83EBI-742664,EBI-740486
PHF1O431893EBI-742664,EBI-530034
SNAPC3Q929663EBI-742664,EBI-1760638
SNRPCQ5TAL43EBI-742664,EBI-10246938
SREK1IP1Q8N9Q23EBI-742664,EBI-10268630
TBC1D22BQ9NU193EBI-742664,EBI-8787464
tmp_locus_54Q53NU33EBI-742664,EBI-10242677
WDYHV1Q96HA88EBI-742664,EBI-741158

Protein-protein interaction databases

BioGridi119350. 20 interactions.
IntActiQ9BPX1. 19 interactions.
MINTiMINT-1434384.
STRINGi9606.ENSP00000263278.

Structurei

Secondary structure

1
270
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni6 – 94Combined sources
Beta strandi11 – 155Combined sources
Helixi20 – 3112Combined sources
Beta strandi35 – 417Combined sources
Helixi43 – 5210Combined sources
Beta strandi56 – 605Combined sources
Helixi66 – 8015Combined sources
Beta strandi85 – 884Combined sources
Helixi99 – 1013Combined sources
Helixi104 – 11411Combined sources
Helixi116 – 13217Combined sources
Beta strandi135 – 1395Combined sources
Helixi142 – 1465Combined sources
Helixi152 – 17221Combined sources
Helixi173 – 1753Combined sources
Beta strandi178 – 1847Combined sources
Helixi190 – 1967Combined sources
Beta strandi199 – 2013Combined sources
Helixi202 – 21110Combined sources
Helixi221 – 23414Combined sources
Beta strandi242 – 2465Combined sources
Turni247 – 2504Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YDEX-ray2.40A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-270[»]
ProteinModelPortaliQ9BPX1.
SMRiQ9BPX1. Positions 4-259.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BPX1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG105555.
InParanoidiQ9BPX1.
OMAiGITHPAR.
OrthoDBiEOG091G0GO6.
PhylomeDBiQ9BPX1.
TreeFamiTF354307.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BPX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGTRYAGK VVVVTGGGRG IGAGIVRAFV NSGARVVICD KDESGGRALE
60 70 80 90 100
QELPGAVFIL CDVTQEDDVK TLVSETIRRF GRLDCVVNNA GHHPPPQRPE
110 120 130 140 150
ETSAQGFRQL LELNLLGTYT LTKLALPYLR KSQGNVINIS SLVGAIGQAQ
160 170 180 190 200
AVPYVATKGA VTAMTKALAL DESPYGVRVN CISPGNIWTP LWEELAALMP
210 220 230 240 250
DPRATIREGM LAQPLGRMGQ PAEVGAAAVF LASEANFCTG IELLVTGGAE
260 270
LGYGCKASRS TPVDAPDIPS
Length:270
Mass (Da):28,317
Last modified:June 1, 2001 - v1
Checksum:iDAB68FB8CA422ABC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti205 – 2051T → S in AAF06940 (PubMed:10800688).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311N → D.
Corresponds to variant rs8110220 [ dbSNP | Ensembl ].
VAR_052307
Natural varianti130 – 1301R → W.
Corresponds to variant rs35299026 [ dbSNP | Ensembl ].
VAR_052308

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126781 mRNA. Translation: AAF06940.1.
AY358430 mRNA. Translation: AAQ88796.1.
BC006294 mRNA. Translation: AAH06294.1.
BC006283 mRNA. Translation: AAH06283.1.
CCDSiCCDS12736.1.
RefSeqiNP_057330.2. NM_016246.2.
UniGeneiHs.18788.

Genome annotation databases

EnsembliENST00000263278; ENSP00000263278; ENSG00000087076.
GeneIDi51171.
KEGGihsa:51171.
UCSCiuc002pkv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126781 mRNA. Translation: AAF06940.1.
AY358430 mRNA. Translation: AAQ88796.1.
BC006294 mRNA. Translation: AAH06294.1.
BC006283 mRNA. Translation: AAH06283.1.
CCDSiCCDS12736.1.
RefSeqiNP_057330.2. NM_016246.2.
UniGeneiHs.18788.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YDEX-ray2.40A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-270[»]
ProteinModelPortaliQ9BPX1.
SMRiQ9BPX1. Positions 4-259.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119350. 20 interactions.
IntActiQ9BPX1. 19 interactions.
MINTiMINT-1434384.
STRINGi9606.ENSP00000263278.

Chemistry

SwissLipidsiSLP:000001216.

PTM databases

iPTMnetiQ9BPX1.
PhosphoSiteiQ9BPX1.

Polymorphism and mutation databases

BioMutaiHSD17B14.
DMDMi74752228.

Proteomic databases

EPDiQ9BPX1.
PaxDbiQ9BPX1.
PeptideAtlasiQ9BPX1.
PRIDEiQ9BPX1.

Protocols and materials databases

DNASUi51171.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263278; ENSP00000263278; ENSG00000087076.
GeneIDi51171.
KEGGihsa:51171.
UCSCiuc002pkv.2. human.

Organism-specific databases

CTDi51171.
GeneCardsiHSD17B14.
HGNCiHGNC:23238. HSD17B14.
HPAiHPA021467.
MIMi612832. gene.
neXtProtiNX_Q9BPX1.
PharmGKBiPA162391674.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG105555.
InParanoidiQ9BPX1.
OMAiGITHPAR.
OrthoDBiEOG091G0GO6.
PhylomeDBiQ9BPX1.
TreeFamiTF354307.

Enzyme and pathway databases

BRENDAi1.1.1.62. 2681.
ReactomeiR-HSA-193144. Estrogen biosynthesis.

Miscellaneous databases

EvolutionaryTraceiQ9BPX1.
GenomeRNAii51171.
PROiQ9BPX1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000087076.
CleanExiHS_HSD17B14.
ExpressionAtlasiQ9BPX1. baseline and differential.
GenevisibleiQ9BPX1. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHB14_HUMAN
AccessioniPrimary (citable) accession number: Q9BPX1
Secondary accession number(s): Q9UKU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.