Q9BPW8 (NIPS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein NipSnap homolog 1
Short name=NipSnap1

Gene names

Name:

NIPSNAP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Ubiquitous. Highest expression in liver.
Sequence similarities	Belongs to the NipSnap family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sensory perception of pain Inferred from electronic annotation. Source: Compara
Cellular_component	mitochondrial inner membrane Inferred from electronic annotation. Source: Compara mitochondrion Inferred from sequence or structural similarity. Source: UniProtKB synaptic membrane Inferred from electronic annotation. Source: Compara
Molecular_function	neurotransmitter binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Protein NipSnap homolog 1		PRO_0000221146
Amino acid modifications
	Modified residue	146	1	N6-acetyllysine Ref.5
Natural variations
	Natural variant	245	1	E → K. Corresponds to variant rs1058646 [ dbSNP | Ensembl ].		VAR_011630
Experimental info
	Sequence conflict	156	1	S → T in CAA04632. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BPW8 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: E0B3E60082C2CACA	FASTA	284	33,310
	10 20 30 40 50 60 MAPRLCSISV TARRLLGGPG PRAGDVASAA AARFYSKDNE GSWFRSLFVH KVDPRKDAHS 70 80 90 100 110 120 TLLSKKETSN LYKIQFHNVK PEYLDAYNSL TEAVLPKLHL DEDYPCSLVG NWNTWYGEQD 130 140 150 160 170 180 QAVHLWRFSG GYPALMDCMN KLKNNKEYLE FRRERSQMLL SRRNQLLLEF SFWNEPQPRM 190 200 210 220 230 240 GPNIYELRTY KLKPGTMIEW GNNWARAIKY RQENQEAVGG FFSQIGELYV VHHLWAYKDL 250 260 270 280 QSREETRNAA WRKRGWDENV YYTVPLVRHM ESRIMIPLKI SPLQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family." Seroussi E., Pan H.Q., Kedra D., Roe B.A., Dumanski J.P. Gene 212:13-20(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[5]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-146, MASS SPECTROMETRY.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ001258 mRNA. Translation: CAA04632.1. AK314407 mRNA. Translation: BAG37030.1. CH471095 Genomic DNA. Translation: EAW59813.1. BC006473 mRNA. Translation: AAH06473.1. BC002371 mRNA. Translation: AAH02371.1.
IPI	IPI00304435.
RefSeq	NP_001189431.1. NM_001202502.1. NP_003625.2. NM_003634.3.
UniGene	Hs.173878.
3D structure databases
ProteinModelPortal	Q9BPW8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BPW8. 13 interactions.
MINT	MINT-1405060.
STRING	9606.ENSP00000216121.
PTM databases
PhosphoSite	Q9BPW8.
Polymorphism databases
DMDM	17380144.
2D gel databases
UCD-2DPAGE	Q9BPW8.
Proteomic databases
PaxDb	Q9BPW8.
PeptideAtlas	Q9BPW8.
PRIDE	Q9BPW8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000216121; ENSP00000216121; ENSG00000184117.
GeneID	8508.
KEGG	hsa:8508.
UCSC	uc003afx.4. human.
Organism-specific databases
CTD	8508.
GeneCards	GC22M029952.
HGNC	HGNC:7827. NIPSNAP1.
MIM	603249. gene.
neXtProt	NX_Q9BPW8.
PharmGKB	PA31634.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG09022.
HOGENOM	HOG000194298.
HOVERGEN	HBG052627.
InParanoid	Q9BPW8.
OMA	VRKIEPT.
OrthoDB	EOG4QFWF5.
Gene expression databases
ArrayExpress	Q9BPW8.
Bgee	Q9BPW8.
CleanEx	HS_NIPSNAP1.
Genevestigator	Q9BPW8.
GermOnline	ENSG00000184117. Homo sapiens.
Family and domain databases
InterPro	IPR011008. Dimeric_a/b-barrel. IPR012577. NIPSNAP. [Graphical view]
Pfam	PF07978. NIPSNAP. 1 hit. [Graphical view]
SUPFAM	SSF54909. Dimer_A_B_barrel. 2 hits.
ProtoNet	Search...
Other
ChiTaRS	NIPSNAP1. human.
GenomeRNAi	8508.
NextBio	31843.
SOURCE	Search...

Entry information

Entry name

NIPS1_HUMAN

Accession

Primary (citable) accession number: Q9BPW8
Secondary accession number(s): B2RAY3, O43800

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.