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Q9BPW8 (NIPS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein NipSnap homolog 1

Short name=NipSnap1
Gene names
Name:NIPSNAP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Ubiquitous. Highest expression in liver.

Sequence similarities

Belongs to the NipSnap family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284Protein NipSnap homolog 1
PRO_0000221146

Amino acid modifications

Modified residue651N6-acetyllysine By similarity
Modified residue661N6-acetyllysine By similarity
Modified residue731N6-acetyllysine By similarity
Modified residue801N6-acetyllysine By similarity
Modified residue1431N6-acetyllysine By similarity
Modified residue1461N6-acetyllysine; alternate Ref.5
Modified residue1461N6-succinyllysine; alternate By similarity
Modified residue1911N6-acetyllysine By similarity
Modified residue1931N6-acetyllysine; alternate By similarity
Modified residue1931N6-succinyllysine; alternate By similarity
Modified residue2791N6-acetyllysine By similarity

Natural variations

Natural variant2451E → K.
Corresponds to variant rs1058646 [ dbSNP | Ensembl ].
VAR_011630

Experimental info

Sequence conflict1561S → T in CAA04632. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9BPW8 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: E0B3E60082C2CACA

FASTA28433,310
        10         20         30         40         50         60 
MAPRLCSISV TARRLLGGPG PRAGDVASAA AARFYSKDNE GSWFRSLFVH KVDPRKDAHS 

        70         80         90        100        110        120 
TLLSKKETSN LYKIQFHNVK PEYLDAYNSL TEAVLPKLHL DEDYPCSLVG NWNTWYGEQD 

       130        140        150        160        170        180 
QAVHLWRFSG GYPALMDCMN KLKNNKEYLE FRRERSQMLL SRRNQLLLEF SFWNEPQPRM 

       190        200        210        220        230        240 
GPNIYELRTY KLKPGTMIEW GNNWARAIKY RQENQEAVGG FFSQIGELYV VHHLWAYKDL 

       250        260        270        280 
QSREETRNAA WRKRGWDENV YYTVPLVRHM ESRIMIPLKI SPLQ 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family."
Seroussi E., Pan H.Q., Kedra D., Roe B.A., Dumanski J.P.
Gene 212:13-20(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ001258 mRNA. Translation: CAA04632.1.
AK314407 mRNA. Translation: BAG37030.1.
CH471095 Genomic DNA. Translation: EAW59813.1.
BC006473 mRNA. Translation: AAH06473.1.
BC002371 mRNA. Translation: AAH02371.1.
CCDSCCDS13860.1.
RefSeqNP_001189431.1. NM_001202502.1.
NP_003625.2. NM_003634.3.
UniGeneHs.173878.

3D structure databases

ProteinModelPortalQ9BPW8.
SMRQ9BPW8. Positions 185-283.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114080. 18 interactions.
IntActQ9BPW8. 17 interactions.
MINTMINT-1405060.
STRING9606.ENSP00000216121.

PTM databases

PhosphoSiteQ9BPW8.

Polymorphism databases

DMDM17380144.

2D gel databases

UCD-2DPAGEQ9BPW8.

Proteomic databases

MaxQBQ9BPW8.
PaxDbQ9BPW8.
PeptideAtlasQ9BPW8.
PRIDEQ9BPW8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000216121; ENSP00000216121; ENSG00000184117.
GeneID8508.
KEGGhsa:8508.
UCSCuc003afx.4. human.

Organism-specific databases

CTD8508.
GeneCardsGC22M029952.
HGNCHGNC:7827. NIPSNAP1.
HPAHPA059227.
MIM603249. gene.
neXtProtNX_Q9BPW8.
PharmGKBPA31634.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG09022.
HOGENOMHOG000194298.
HOVERGENHBG052627.
InParanoidQ9BPW8.
OMAAFSYWPQ.
OrthoDBEOG769ZM2.
PhylomeDBQ9BPW8.
TreeFamTF314501.

Gene expression databases

ArrayExpressQ9BPW8.
BgeeQ9BPW8.
CleanExHS_NIPSNAP1.
GenevestigatorQ9BPW8.

Family and domain databases

InterProIPR011008. Dimeric_a/b-barrel.
IPR012577. NIPSNAP.
[Graphical view]
PfamPF07978. NIPSNAP. 1 hit.
[Graphical view]
SUPFAMSSF54909. SSF54909. 2 hits.
ProtoNetSearch...

Other

ChiTaRSNIPSNAP1. human.
GenomeRNAi8508.
NextBio31843.
PROQ9BPW8.
SOURCESearch...

Entry information

Entry nameNIPS1_HUMAN
AccessionPrimary (citable) accession number: Q9BPW8
Secondary accession number(s): B2RAY3, O43800
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM