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Q9BPW8

- NIPS1_HUMAN

UniProt

Q9BPW8 - NIPS1_HUMAN

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Protein

Protein NipSnap homolog 1

Gene

NIPSNAP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. neurotransmitter binding Source: Ensembl

GO - Biological processi

  1. sensory perception of pain Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NipSnap homolog 1
Short name:
NipSnap1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:7827. NIPSNAP1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Ensembl
  2. mitochondrion Source: UniProtKB
  3. synaptic membrane Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31634.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Protein NipSnap homolog 1PRO_0000221146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei65 – 651N6-acetyllysineBy similarity
Modified residuei66 – 661N6-acetyllysineBy similarity
Modified residuei73 – 731N6-acetyllysineBy similarity
Modified residuei80 – 801N6-acetyllysineBy similarity
Modified residuei143 – 1431N6-acetyllysineBy similarity
Modified residuei146 – 1461N6-acetyllysine; alternate1 Publication
Modified residuei146 – 1461N6-succinyllysine; alternateBy similarity
Modified residuei191 – 1911N6-acetyllysineBy similarity
Modified residuei193 – 1931N6-acetyllysine; alternateBy similarity
Modified residuei193 – 1931N6-succinyllysine; alternateBy similarity
Modified residuei279 – 2791N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9BPW8.
PaxDbiQ9BPW8.
PeptideAtlasiQ9BPW8.
PRIDEiQ9BPW8.

2D gel databases

UCD-2DPAGEQ9BPW8.

PTM databases

PhosphoSiteiQ9BPW8.

Expressioni

Tissue specificityi

Ubiquitous. Highest expression in liver.

Gene expression databases

BgeeiQ9BPW8.
CleanExiHS_NIPSNAP1.
ExpressionAtlasiQ9BPW8. baseline and differential.
GenevestigatoriQ9BPW8.

Organism-specific databases

HPAiHPA059227.

Interactioni

Protein-protein interaction databases

BioGridi114080. 20 interactions.
IntActiQ9BPW8. 17 interactions.
MINTiMINT-1405060.
STRINGi9606.ENSP00000216121.

Structurei

3D structure databases

ProteinModelPortaliQ9BPW8.
SMRiQ9BPW8. Positions 185-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NipSnap family.Curated

Phylogenomic databases

eggNOGiNOG09022.
GeneTreeiENSGT00730000110910.
HOGENOMiHOG000194298.
HOVERGENiHBG052627.
InParanoidiQ9BPW8.
OMAiAFSYWPQ.
OrthoDBiEOG769ZM2.
PhylomeDBiQ9BPW8.
TreeFamiTF314501.

Family and domain databases

InterProiIPR011008. Dimeric_a/b-barrel.
IPR012577. NIPSNAP.
[Graphical view]
PfamiPF07978. NIPSNAP. 1 hit.
[Graphical view]
SUPFAMiSSF54909. SSF54909. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9BPW8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPRLCSISV TARRLLGGPG PRAGDVASAA AARFYSKDNE GSWFRSLFVH
60 70 80 90 100
KVDPRKDAHS TLLSKKETSN LYKIQFHNVK PEYLDAYNSL TEAVLPKLHL
110 120 130 140 150
DEDYPCSLVG NWNTWYGEQD QAVHLWRFSG GYPALMDCMN KLKNNKEYLE
160 170 180 190 200
FRRERSQMLL SRRNQLLLEF SFWNEPQPRM GPNIYELRTY KLKPGTMIEW
210 220 230 240 250
GNNWARAIKY RQENQEAVGG FFSQIGELYV VHHLWAYKDL QSREETRNAA
260 270 280
WRKRGWDENV YYTVPLVRHM ESRIMIPLKI SPLQ
Length:284
Mass (Da):33,310
Last modified:June 1, 2001 - v1
Checksum:iE0B3E60082C2CACA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561S → T in CAA04632. (PubMed:9661659)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti245 – 2451E → K.
Corresponds to variant rs1058646 [ dbSNP | Ensembl ].
VAR_011630

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001258 mRNA. Translation: CAA04632.1.
AK314407 mRNA. Translation: BAG37030.1.
CH471095 Genomic DNA. Translation: EAW59813.1.
BC006473 mRNA. Translation: AAH06473.1.
BC002371 mRNA. Translation: AAH02371.1.
CCDSiCCDS13860.1.
RefSeqiNP_001189431.1. NM_001202502.1.
NP_003625.2. NM_003634.3.
UniGeneiHs.173878.

Genome annotation databases

EnsembliENST00000216121; ENSP00000216121; ENSG00000184117.
GeneIDi8508.
KEGGihsa:8508.
UCSCiuc003afx.4. human.

Polymorphism databases

DMDMi17380144.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001258 mRNA. Translation: CAA04632.1 .
AK314407 mRNA. Translation: BAG37030.1 .
CH471095 Genomic DNA. Translation: EAW59813.1 .
BC006473 mRNA. Translation: AAH06473.1 .
BC002371 mRNA. Translation: AAH02371.1 .
CCDSi CCDS13860.1.
RefSeqi NP_001189431.1. NM_001202502.1.
NP_003625.2. NM_003634.3.
UniGenei Hs.173878.

3D structure databases

ProteinModelPortali Q9BPW8.
SMRi Q9BPW8. Positions 185-283.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114080. 20 interactions.
IntActi Q9BPW8. 17 interactions.
MINTi MINT-1405060.
STRINGi 9606.ENSP00000216121.

PTM databases

PhosphoSitei Q9BPW8.

Polymorphism databases

DMDMi 17380144.

2D gel databases

UCD-2DPAGE Q9BPW8.

Proteomic databases

MaxQBi Q9BPW8.
PaxDbi Q9BPW8.
PeptideAtlasi Q9BPW8.
PRIDEi Q9BPW8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000216121 ; ENSP00000216121 ; ENSG00000184117 .
GeneIDi 8508.
KEGGi hsa:8508.
UCSCi uc003afx.4. human.

Organism-specific databases

CTDi 8508.
GeneCardsi GC22M029952.
HGNCi HGNC:7827. NIPSNAP1.
HPAi HPA059227.
MIMi 603249. gene.
neXtProti NX_Q9BPW8.
PharmGKBi PA31634.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG09022.
GeneTreei ENSGT00730000110910.
HOGENOMi HOG000194298.
HOVERGENi HBG052627.
InParanoidi Q9BPW8.
OMAi AFSYWPQ.
OrthoDBi EOG769ZM2.
PhylomeDBi Q9BPW8.
TreeFami TF314501.

Miscellaneous databases

ChiTaRSi NIPSNAP1. human.
GenomeRNAii 8508.
NextBioi 31843.
PROi Q9BPW8.
SOURCEi Search...

Gene expression databases

Bgeei Q9BPW8.
CleanExi HS_NIPSNAP1.
ExpressionAtlasi Q9BPW8. baseline and differential.
Genevestigatori Q9BPW8.

Family and domain databases

InterProi IPR011008. Dimeric_a/b-barrel.
IPR012577. NIPSNAP.
[Graphical view ]
Pfami PF07978. NIPSNAP. 1 hit.
[Graphical view ]
SUPFAMi SSF54909. SSF54909. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family."
    Seroussi E., Pan H.Q., Kedra D., Roe B.A., Dumanski J.P.
    Gene 212:13-20(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNIPS1_HUMAN
AccessioniPrimary (citable) accession number: Q9BPW8
Secondary accession number(s): B2RAY3, O43800
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3