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Protein

Protein NipSnap homolog 1

Gene

NIPSNAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. neurotransmitter binding Source: Ensembl

GO - Biological processi

  1. sensory perception of pain Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NipSnap homolog 1
Short name:
NipSnap1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:7827. NIPSNAP1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Ensembl
  2. mitochondrion Source: UniProtKB
  3. synaptic membrane Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31634.

Polymorphism and mutation databases

BioMutaiNIPSNAP1.
DMDMi17380144.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Protein NipSnap homolog 1PRO_0000221146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei65 – 651N6-acetyllysineBy similarity
Modified residuei66 – 661N6-acetyllysineBy similarity
Modified residuei73 – 731N6-acetyllysineBy similarity
Modified residuei80 – 801N6-acetyllysineBy similarity
Modified residuei129 – 1291Phosphoserine1 Publication
Modified residuei143 – 1431N6-acetyllysineBy similarity
Modified residuei146 – 1461N6-acetyllysine; alternate1 Publication
Modified residuei146 – 1461N6-succinyllysine; alternateBy similarity
Modified residuei191 – 1911N6-acetyllysineBy similarity
Modified residuei193 – 1931N6-acetyllysine; alternateBy similarity
Modified residuei193 – 1931N6-succinyllysine; alternateBy similarity
Modified residuei279 – 2791N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BPW8.
PaxDbiQ9BPW8.
PeptideAtlasiQ9BPW8.
PRIDEiQ9BPW8.

2D gel databases

UCD-2DPAGEQ9BPW8.

PTM databases

PhosphoSiteiQ9BPW8.

Expressioni

Tissue specificityi

Ubiquitous. Highest expression in liver.

Gene expression databases

BgeeiQ9BPW8.
CleanExiHS_NIPSNAP1.
ExpressionAtlasiQ9BPW8. baseline and differential.
GenevestigatoriQ9BPW8.

Organism-specific databases

HPAiHPA059227.

Interactioni

Protein-protein interaction databases

BioGridi114080. 27 interactions.
IntActiQ9BPW8. 17 interactions.
MINTiMINT-1405060.
STRINGi9606.ENSP00000216121.

Structurei

3D structure databases

ProteinModelPortaliQ9BPW8.
SMRiQ9BPW8. Positions 185-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NipSnap family.Curated

Phylogenomic databases

eggNOGiNOG09022.
GeneTreeiENSGT00730000110910.
HOGENOMiHOG000194298.
HOVERGENiHBG052627.
InParanoidiQ9BPW8.
OMAiAFSYWPQ.
OrthoDBiEOG769ZM2.
PhylomeDBiQ9BPW8.
TreeFamiTF314501.

Family and domain databases

InterProiIPR011008. Dimeric_a/b-barrel.
IPR012577. NIPSNAP.
[Graphical view]
PfamiPF07978. NIPSNAP. 1 hit.
[Graphical view]
SUPFAMiSSF54909. SSF54909. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9BPW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRLCSISV TARRLLGGPG PRAGDVASAA AARFYSKDNE GSWFRSLFVH
60 70 80 90 100
KVDPRKDAHS TLLSKKETSN LYKIQFHNVK PEYLDAYNSL TEAVLPKLHL
110 120 130 140 150
DEDYPCSLVG NWNTWYGEQD QAVHLWRFSG GYPALMDCMN KLKNNKEYLE
160 170 180 190 200
FRRERSQMLL SRRNQLLLEF SFWNEPQPRM GPNIYELRTY KLKPGTMIEW
210 220 230 240 250
GNNWARAIKY RQENQEAVGG FFSQIGELYV VHHLWAYKDL QSREETRNAA
260 270 280
WRKRGWDENV YYTVPLVRHM ESRIMIPLKI SPLQ
Length:284
Mass (Da):33,310
Last modified:June 1, 2001 - v1
Checksum:iE0B3E60082C2CACA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561S → T in CAA04632 (PubMed:9661659).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti245 – 2451E → K.
Corresponds to variant rs1058646 [ dbSNP | Ensembl ].
VAR_011630

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001258 mRNA. Translation: CAA04632.1.
AK314407 mRNA. Translation: BAG37030.1.
CH471095 Genomic DNA. Translation: EAW59813.1.
BC006473 mRNA. Translation: AAH06473.1.
BC002371 mRNA. Translation: AAH02371.1.
CCDSiCCDS13860.1.
RefSeqiNP_001189431.1. NM_001202502.1.
NP_003625.2. NM_003634.3.
UniGeneiHs.173878.

Genome annotation databases

EnsembliENST00000216121; ENSP00000216121; ENSG00000184117.
GeneIDi8508.
KEGGihsa:8508.
UCSCiuc003afx.4. human.

Polymorphism and mutation databases

BioMutaiNIPSNAP1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001258 mRNA. Translation: CAA04632.1.
AK314407 mRNA. Translation: BAG37030.1.
CH471095 Genomic DNA. Translation: EAW59813.1.
BC006473 mRNA. Translation: AAH06473.1.
BC002371 mRNA. Translation: AAH02371.1.
CCDSiCCDS13860.1.
RefSeqiNP_001189431.1. NM_001202502.1.
NP_003625.2. NM_003634.3.
UniGeneiHs.173878.

3D structure databases

ProteinModelPortaliQ9BPW8.
SMRiQ9BPW8. Positions 185-283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114080. 27 interactions.
IntActiQ9BPW8. 17 interactions.
MINTiMINT-1405060.
STRINGi9606.ENSP00000216121.

PTM databases

PhosphoSiteiQ9BPW8.

Polymorphism and mutation databases

BioMutaiNIPSNAP1.
DMDMi17380144.

2D gel databases

UCD-2DPAGEQ9BPW8.

Proteomic databases

MaxQBiQ9BPW8.
PaxDbiQ9BPW8.
PeptideAtlasiQ9BPW8.
PRIDEiQ9BPW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216121; ENSP00000216121; ENSG00000184117.
GeneIDi8508.
KEGGihsa:8508.
UCSCiuc003afx.4. human.

Organism-specific databases

CTDi8508.
GeneCardsiGC22M029952.
HGNCiHGNC:7827. NIPSNAP1.
HPAiHPA059227.
MIMi603249. gene.
neXtProtiNX_Q9BPW8.
PharmGKBiPA31634.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG09022.
GeneTreeiENSGT00730000110910.
HOGENOMiHOG000194298.
HOVERGENiHBG052627.
InParanoidiQ9BPW8.
OMAiAFSYWPQ.
OrthoDBiEOG769ZM2.
PhylomeDBiQ9BPW8.
TreeFamiTF314501.

Miscellaneous databases

ChiTaRSiNIPSNAP1. human.
GenomeRNAii8508.
NextBioi31843.
PROiQ9BPW8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BPW8.
CleanExiHS_NIPSNAP1.
ExpressionAtlasiQ9BPW8. baseline and differential.
GenevestigatoriQ9BPW8.

Family and domain databases

InterProiIPR011008. Dimeric_a/b-barrel.
IPR012577. NIPSNAP.
[Graphical view]
PfamiPF07978. NIPSNAP. 1 hit.
[Graphical view]
SUPFAMiSSF54909. SSF54909. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family."
    Seroussi E., Pan H.Q., Kedra D., Roe B.A., Dumanski J.P.
    Gene 212:13-20(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiNIPS1_HUMAN
AccessioniPrimary (citable) accession number: Q9BPW8
Secondary accession number(s): B2RAY3, O43800
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: April 29, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.