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Protein

Protein NipSnap homolog 1

Gene

NIPSNAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NipSnap homolog 1
Short name:
NipSnap1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000184117.11
HGNCiHGNC:7827 NIPSNAP1
MIMi603249 gene
neXtProtiNX_Q9BPW8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi8508
OpenTargetsiENSG00000184117
PharmGKBiPA31634

Polymorphism and mutation databases

BioMutaiNIPSNAP1
DMDMi17380144

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211461 – 284Protein NipSnap homolog 1Add BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65N6-acetyllysineBy similarity1
Modified residuei66N6-acetyllysineBy similarity1
Modified residuei73N6-acetyllysineBy similarity1
Modified residuei80N6-acetyllysineBy similarity1
Modified residuei129PhosphoserineCombined sources1
Modified residuei143N6-acetyllysineBy similarity1
Modified residuei146N6-acetyllysine; alternateCombined sources1
Modified residuei146N6-succinyllysine; alternateBy similarity1
Modified residuei191N6-acetyllysineBy similarity1
Modified residuei193N6-acetyllysine; alternateBy similarity1
Modified residuei193N6-succinyllysine; alternateBy similarity1
Modified residuei279N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BPW8
MaxQBiQ9BPW8
PaxDbiQ9BPW8
PeptideAtlasiQ9BPW8
PRIDEiQ9BPW8

2D gel databases

UCD-2DPAGEiQ9BPW8

PTM databases

iPTMnetiQ9BPW8
PhosphoSitePlusiQ9BPW8

Expressioni

Tissue specificityi

Ubiquitous. Highest expression in liver.

Gene expression databases

BgeeiENSG00000184117
CleanExiHS_NIPSNAP1
ExpressionAtlasiQ9BPW8 baseline and differential
GenevisibleiQ9BPW8 HS

Organism-specific databases

HPAiHPA059227

Interactioni

Protein-protein interaction databases

BioGridi114080, 73 interactors
IntActiQ9BPW8, 58 interactors
MINTiQ9BPW8
STRINGi9606.ENSP00000216121

Structurei

3D structure databases

ProteinModelPortaliQ9BPW8
SMRiQ9BPW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NipSnap family.Curated

Phylogenomic databases

eggNOGiKOG2883 Eukaryota
ENOG410XSWP LUCA
GeneTreeiENSGT00730000110910
HOGENOMiHOG000194298
HOVERGENiHBG052627
InParanoidiQ9BPW8
OMAiYALHTHN
OrthoDBiEOG091G0G3J
PhylomeDBiQ9BPW8
TreeFamiTF314501

Family and domain databases

InterProiView protein in InterPro
IPR011008 Dimeric_a/b-barrel
IPR012577 NIPSNAP
PfamiView protein in Pfam
PF07978 NIPSNAP, 1 hit
SUPFAMiSSF54909 SSF54909, 2 hits

Sequencei

Sequence statusi: Complete.

Q9BPW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRLCSISV TARRLLGGPG PRAGDVASAA AARFYSKDNE GSWFRSLFVH
60 70 80 90 100
KVDPRKDAHS TLLSKKETSN LYKIQFHNVK PEYLDAYNSL TEAVLPKLHL
110 120 130 140 150
DEDYPCSLVG NWNTWYGEQD QAVHLWRFSG GYPALMDCMN KLKNNKEYLE
160 170 180 190 200
FRRERSQMLL SRRNQLLLEF SFWNEPQPRM GPNIYELRTY KLKPGTMIEW
210 220 230 240 250
GNNWARAIKY RQENQEAVGG FFSQIGELYV VHHLWAYKDL QSREETRNAA
260 270 280
WRKRGWDENV YYTVPLVRHM ESRIMIPLKI SPLQ
Length:284
Mass (Da):33,310
Last modified:June 1, 2001 - v1
Checksum:iE0B3E60082C2CACA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156S → T in CAA04632 (PubMed:9661659).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011630245E → K. Corresponds to variant dbSNP:rs1058646Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001258 mRNA Translation: CAA04632.1
AK314407 mRNA Translation: BAG37030.1
CH471095 Genomic DNA Translation: EAW59813.1
BC006473 mRNA Translation: AAH06473.1
BC002371 mRNA Translation: AAH02371.1
CCDSiCCDS13860.1
RefSeqiNP_001189431.1, NM_001202502.1
NP_003625.2, NM_003634.3
UniGeneiHs.173878

Genome annotation databases

EnsembliENST00000216121; ENSP00000216121; ENSG00000184117
GeneIDi8508
KEGGihsa:8508
UCSCiuc003afx.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNIPS1_HUMAN
AccessioniPrimary (citable) accession number: Q9BPW8
Secondary accession number(s): B2RAY3, O43800
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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