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Protein

Ras-like protein family member 11B

Gene

RASL11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 47GTPBy similarity8
Nucleotide bindingi87 – 94GTPBy similarity8
Nucleotide bindingi152 – 155GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128045-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-like protein family member 11B
Gene namesi
Name:RASL11BImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:23804. RASL11B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi65997.
OpenTargetsiENSG00000128045.
PharmGKBiPA134872992.

Polymorphism and mutation databases

BioMutaiRASL11B.
DMDMi74732795.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003083651 – 248Ras-like protein family member 11BAdd BLAST248

Proteomic databases

PaxDbiQ9BPW5.
PeptideAtlasiQ9BPW5.
PRIDEiQ9BPW5.

PTM databases

iPTMnetiQ9BPW5.
PhosphoSitePlusiQ9BPW5.

Expressioni

Tissue specificityi

Widely expressed with highest levels in placenta and primary macrophages.1 Publication

Developmental stagei

Up-regulated during development of primary monocytes into macrophages.1 Publication

Inductioni

By TGFB1.1 Publication

Gene expression databases

BgeeiENSG00000128045.
CleanExiHS_RASL11B.
GenevisibleiQ9BPW5. HS.

Organism-specific databases

HPAiHPA057803.

Interactioni

Protein-protein interaction databases

BioGridi122444. 7 interactors.
IntActiQ9BPW5. 2 interactors.
MINTiMINT-1456556.
STRINGi9606.ENSP00000248706.

Structurei

3D structure databases

ProteinModelPortaliQ9BPW5.
SMRiQ9BPW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 246Small GTPase-likeAdd BLAST218

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133696.
HOGENOMiHOG000233973.
HOVERGENiHBG108422.
InParanoidiQ9BPW5.
KOiK07853.
OMAiLHVKQVD.
OrthoDBiEOG091G0M6D.
PhylomeDBiQ9BPW5.
TreeFamiTF318030.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BPW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLIQNMCTI AEYPAPGNAA ASDCCVGAAG RRLVKIAVVG ASGVGKTALV
60 70 80 90 100
VRFLTKRFIG DYERNAGNLY TRQVQIEGET LALQVQDTPG IQVHENSLSC
110 120 130 140 150
SEQLNRCIRW ADAVVIVFSI TDYKSYELIS QLHQHVQQLH LGTRLPVVVV
160 170 180 190 200
ANKADLLHIK QVDPQLGLQL ASMLGCSFYE VSVSENYNDV YSAFHVLCKE
210 220 230 240
VSHKQQPSST PEKRRTSLIP RPKSPNMQDL KRRFKQALSA KVRTVTSV
Length:248
Mass (Da):27,508
Last modified:June 1, 2001 - v1
Checksum:iE45301814B6C2ABC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3L → H in BAB55008 (PubMed:14702039).Curated1
Sequence conflicti50V → L in BAB55008 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY839725 mRNA. Translation: AAX46798.1.
AK027267 mRNA. Translation: BAB55008.1.
AK314942 mRNA. Translation: BAG37448.1.
CH471057 Genomic DNA. Translation: EAX05441.1.
BC001087 mRNA. Translation: AAH01087.1.
BC001846 mRNA. Translation: AAH01846.1.
BC025694 mRNA. Translation: AAH25694.1.
BK001672 mRNA. Translation: DAA02135.1.
CCDSiCCDS3490.1.
RefSeqiNP_076429.1. NM_023940.2.
UniGeneiHs.8035.

Genome annotation databases

EnsembliENST00000248706; ENSP00000248706; ENSG00000128045.
GeneIDi65997.
KEGGihsa:65997.
UCSCiuc003gzt.4. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY839725 mRNA. Translation: AAX46798.1.
AK027267 mRNA. Translation: BAB55008.1.
AK314942 mRNA. Translation: BAG37448.1.
CH471057 Genomic DNA. Translation: EAX05441.1.
BC001087 mRNA. Translation: AAH01087.1.
BC001846 mRNA. Translation: AAH01846.1.
BC025694 mRNA. Translation: AAH25694.1.
BK001672 mRNA. Translation: DAA02135.1.
CCDSiCCDS3490.1.
RefSeqiNP_076429.1. NM_023940.2.
UniGeneiHs.8035.

3D structure databases

ProteinModelPortaliQ9BPW5.
SMRiQ9BPW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122444. 7 interactors.
IntActiQ9BPW5. 2 interactors.
MINTiMINT-1456556.
STRINGi9606.ENSP00000248706.

PTM databases

iPTMnetiQ9BPW5.
PhosphoSitePlusiQ9BPW5.

Polymorphism and mutation databases

BioMutaiRASL11B.
DMDMi74732795.

Proteomic databases

PaxDbiQ9BPW5.
PeptideAtlasiQ9BPW5.
PRIDEiQ9BPW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248706; ENSP00000248706; ENSG00000128045.
GeneIDi65997.
KEGGihsa:65997.
UCSCiuc003gzt.4. human.

Organism-specific databases

CTDi65997.
DisGeNETi65997.
GeneCardsiRASL11B.
H-InvDBHIX0004215.
HGNCiHGNC:23804. RASL11B.
HPAiHPA057803.
MIMi612404. gene.
neXtProtiNX_Q9BPW5.
OpenTargetsiENSG00000128045.
PharmGKBiPA134872992.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133696.
HOGENOMiHOG000233973.
HOVERGENiHBG108422.
InParanoidiQ9BPW5.
KOiK07853.
OMAiLHVKQVD.
OrthoDBiEOG091G0M6D.
PhylomeDBiQ9BPW5.
TreeFamiTF318030.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128045-MONOMER.

Miscellaneous databases

ChiTaRSiRASL11B. human.
GeneWikiiRASL11B.
GenomeRNAii65997.
PROiQ9BPW5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128045.
CleanExiHS_RASL11B.
GenevisibleiQ9BPW5. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRSLBB_HUMAN
AccessioniPrimary (citable) accession number: Q9BPW5
Secondary accession number(s): B2RC51, Q96KC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.