ID   APOL4_HUMAN             Reviewed;         351 AA.
AC   Q9BPW4; Q9BQ37; Q9BXQ8;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 3.
DT   24-JAN-2024, entry version 144.
DE   RecName: Full=Apolipoprotein L4;
DE   AltName: Full=Apolipoprotein L-IV;
DE            Short=ApoL-IV;
DE   Flags: Precursor;
GN   Name=APOL4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Pancreas;
RX   PubMed=11290834;
RA   Duchateau P.N., Pullinger C.R., Cho M.H., Eng C., Kane J.P.;
RT   "Apolipoprotein L gene family: tissue-specific expression, splicing,
RT   promoter regions; discovery of a new gene.";
RL   J. Lipid Res. 42:620-630(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RC   TISSUE=Placenta;
RX   PubMed=11374903; DOI=10.1006/geno.2001.6534;
RA   Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J.;
RT   "The human apolipoprotein L gene cluster: identification, classification,
RT   and sites of distribution.";
RL   Genomics 74:71-78(2001).
CC   -!- FUNCTION: May play a role in lipid exchange and transport throughout
CC       the body. May participate in reverse cholesterol transport from
CC       peripheral cells to the liver (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=B;
CC         IsoId=Q9BPW4-1; Sequence=Displayed;
CC       Name=2; Synonyms=A;
CC         IsoId=Q9BPW4-2; Sequence=VSP_000295;
CC       Name=3;
CC         IsoId=Q9BPW4-3; Sequence=VSP_000295, VSP_024380;
CC   -!- TISSUE SPECIFICITY: Widely expressed; the highest levels are in spinal
CC       cord, placenta, adrenal gland; also detected in spleen, bone marrow,
CC       uterus, trachea, mammary gland and testis; levels are low in brain,
CC       heart and pancreas.
CC   -!- SIMILARITY: Belongs to the apolipoprotein L family. {ECO:0000305}.
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DR   EMBL; AY014915; AAG50353.1; -; mRNA.
DR   EMBL; AY014913; AAG50350.1; -; Genomic_DNA.
DR   EMBL; AY014909; AAG50350.1; JOINED; Genomic_DNA.
DR   EMBL; AY014911; AAG50350.1; JOINED; Genomic_DNA.
DR   EMBL; AY014912; AAG50350.1; JOINED; Genomic_DNA.
DR   EMBL; AY014914; AAG50352.1; -; mRNA.
DR   EMBL; AY014913; AAG50351.1; -; Genomic_DNA.
DR   EMBL; AY014910; AAG50351.1; JOINED; Genomic_DNA.
DR   EMBL; AY014911; AAG50351.1; JOINED; Genomic_DNA.
DR   EMBL; AY014912; AAG50351.1; JOINED; Genomic_DNA.
DR   EMBL; AF305226; AAK20212.1; -; mRNA.
DR   CCDS; CCDS74851.1; -. [Q9BPW4-2]
DR   CCDS; CCDS74852.1; -. [Q9BPW4-1]
DR   RefSeq; NP_085146.2; NM_030643.4. [Q9BPW4-2]
DR   RefSeq; NP_663693.1; NM_145660.2. [Q9BPW4-1]
DR   AlphaFoldDB; Q9BPW4; -.
DR   SMR; Q9BPW4; -.
DR   BioGRID; 123325; 2.
DR   IntAct; Q9BPW4; 1.
DR   STRING; 9606.ENSP00000338260; -.
DR   iPTMnet; Q9BPW4; -.
DR   PhosphoSitePlus; Q9BPW4; -.
DR   BioMuta; APOL4; -.
DR   DMDM; 143811364; -.
DR   MassIVE; Q9BPW4; -.
DR   PaxDb; 9606-ENSP00000338260; -.
DR   PeptideAtlas; Q9BPW4; -.
DR   ProteomicsDB; 78577; -. [Q9BPW4-1]
DR   ProteomicsDB; 78578; -. [Q9BPW4-2]
DR   ProteomicsDB; 78579; -. [Q9BPW4-3]
DR   Antibodypedia; 25529; 233 antibodies from 34 providers.
DR   DNASU; 80832; -.
DR   Ensembl; ENST00000332987.5; ENSP00000333229.2; ENSG00000100336.18. [Q9BPW4-2]
DR   Ensembl; ENST00000352371.5; ENSP00000338260.3; ENSG00000100336.18. [Q9BPW4-1]
DR   Ensembl; ENST00000457630.7; ENSP00000409085.3; ENSG00000100336.18. [Q9BPW4-2]
DR   Ensembl; ENST00000616056.4; ENSP00000483497.1; ENSG00000100336.18. [Q9BPW4-2]
DR   Ensembl; ENST00000683024.1; ENSP00000507418.1; ENSG00000100336.18. [Q9BPW4-2]
DR   Ensembl; ENST00000684666.1; ENSP00000506782.1; ENSG00000100336.18. [Q9BPW4-2]
DR   GeneID; 80832; -.
DR   KEGG; hsa:80832; -.
DR   MANE-Select; ENST00000683024.1; ENSP00000507418.1; NM_001386885.1; NP_001373814.1. [Q9BPW4-2]
DR   UCSC; uc032qne.2; human. [Q9BPW4-1]
DR   AGR; HGNC:14867; -.
DR   CTD; 80832; -.
DR   DisGeNET; 80832; -.
DR   GeneCards; APOL4; -.
DR   HGNC; HGNC:14867; APOL4.
DR   HPA; ENSG00000100336; Low tissue specificity.
DR   MalaCards; APOL4; -.
DR   MIM; 607254; gene.
DR   neXtProt; NX_Q9BPW4; -.
DR   OpenTargets; ENSG00000100336; -.
DR   PharmGKB; PA24907; -.
DR   VEuPathDB; HostDB:ENSG00000100336; -.
DR   eggNOG; ENOG502RZGU; Eukaryota.
DR   GeneTree; ENSGT01030000234599; -.
DR   HOGENOM; CLU_046288_1_0_1; -.
DR   InParanoid; Q9BPW4; -.
DR   OMA; INIHAME; -.
DR   OrthoDB; 5323587at2759; -.
DR   PhylomeDB; Q9BPW4; -.
DR   PathwayCommons; Q9BPW4; -.
DR   SignaLink; Q9BPW4; -.
DR   BioGRID-ORCS; 80832; 14 hits in 356 CRISPR screens.
DR   ChiTaRS; APOL4; human.
DR   GenomeRNAi; 80832; -.
DR   Pharos; Q9BPW4; Tdark.
DR   PRO; PR:Q9BPW4; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   RNAct; Q9BPW4; Protein.
DR   Bgee; ENSG00000100336; Expressed in adenohypophysis and 141 other cell types or tissues.
DR   ExpressionAtlas; Q9BPW4; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; ISS:BHF-UCL.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0008289; F:lipid binding; IBA:GO_Central.
DR   GO; GO:0006629; P:lipid metabolic process; NAS:UniProtKB.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   InterPro; IPR008405; ApoL.
DR   PANTHER; PTHR14096; APOLIPOPROTEIN L; 1.
DR   PANTHER; PTHR14096:SF39; APOLIPOPROTEIN L4; 1.
DR   Pfam; PF05461; ApoL; 1.
DR   Genevisible; Q9BPW4; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Lipid transport; Reference proteome; Secreted;
KW   Signal; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..351
FT                   /note="Apolipoprotein L4"
FT                   /id="PRO_0000002041"
FT   VAR_SEQ         1..15
FT                   /note="MEGAALLKIFVVCIW -> MGSWVQLITSVG (in isoform 2 and
FT                   isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:11290834,
FT                   ECO:0000303|PubMed:11374903"
FT                   /id="VSP_000295"
FT   VAR_SEQ         111
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:11374903"
FT                   /id="VSP_024380"
FT   VARIANT         9
FT                   /note="I -> V (in dbSNP:rs132736)"
FT                   /id="VAR_053008"
FT   VARIANT         12
FT                   /note="V -> L (in dbSNP:rs80587)"
FT                   /id="VAR_053009"
FT   VARIANT         159
FT                   /note="M -> V (in dbSNP:rs132700)"
FT                   /id="VAR_053010"
FT   VARIANT         223
FT                   /note="R -> H (in dbSNP:rs2227168)"
FT                   /id="VAR_059966"
FT   VARIANT         319
FT                   /note="A -> E (in dbSNP:rs6000173)"
FT                   /id="VAR_059967"
FT   VARIANT         326
FT                   /note="S -> L (in dbSNP:rs6000172)"
FT                   /id="VAR_059968"
SQ   SEQUENCE   351 AA;  39164 MW;  E8EC440BA0292412 CRC64;
     MEGAALLKIF VVCIWVQQNH PGWTVAGQFQ EKKRFTEEVI EYFQKKVSPV HLKILLTSDE
     AWKRFVRVAE LPREEADALY EALKNLTPYV AIEDKDMQQK EQQFREWFLK EFPQIRWKIQ
     ESIERLRVIA NEIEKVHRGC VIANVVSGST GILSVIGVML APFTAGLSLS ITAAGVGLGI
     ASATAGIASS IVENTYTRSA ELTASRLTAT STDQLEALRD ILRDITPNVL SFALDFDEAT
     KMIANDVHTL RRSKATVGRP LIAWRYVPIN VVETLRTRGA PTRIVRKVAR NLGKATSGVL
     VVLDVVNLVQ DSLDLHKGAK SESAESLRQW AQELEENLNE LTHIHQSLKA G
//