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Q9BPW4

- APOL4_HUMAN

UniProt

Q9BPW4 - APOL4_HUMAN

Protein

Apolipoprotein L4

Gene

APOL4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 3 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver By similarity.By similarity

    GO - Molecular functioni

    1. lipid binding Source: InterPro

    GO - Biological processi

    1. lipid metabolic process Source: UniProtKB
    2. lipid transport Source: UniProtKB-KW
    3. lipoprotein metabolic process Source: InterPro

    Keywords - Biological processi

    Lipid transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein L4
    Alternative name(s):
    Apolipoprotein L-IV
    Short name:
    ApoL-IV
    Gene namesi
    Name:APOL4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:14867. APOL4.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24907.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 351330Apolipoprotein L4PRO_0000002041Add
    BLAST

    Proteomic databases

    PaxDbiQ9BPW4.
    PRIDEiQ9BPW4.

    PTM databases

    PhosphoSiteiQ9BPW4.

    Expressioni

    Tissue specificityi

    Widely expressed; the highest levels are in spinal cord, placenta, adrenal gland; also detected in spleen, bone marrow, uterus, trachea, mammary gland and testis; levels are low in brain, heart and pancreas.

    Gene expression databases

    ArrayExpressiQ9BPW4.
    BgeeiQ9BPW4.
    CleanExiHS_APOL4.
    GenevestigatoriQ9BPW4.

    Organism-specific databases

    HPAiHPA049797.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000338260.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BPW4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the apolipoprotein L family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG69704.
    HOGENOMiHOG000294132.
    HOVERGENiHBG074468.
    InParanoidiQ9BPW4.
    KOiK14480.
    PhylomeDBiQ9BPW4.

    Family and domain databases

    InterProiIPR008405. ApoL.
    [Graphical view]
    PANTHERiPTHR14096. PTHR14096. 1 hit.
    PfamiPF05461. ApoL. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BPW4-1) [UniParc]FASTAAdd to Basket

    Also known as: B

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEGAALLKIF VVCIWVQQNH PGWTVAGQFQ EKKRFTEEVI EYFQKKVSPV    50
    HLKILLTSDE AWKRFVRVAE LPREEADALY EALKNLTPYV AIEDKDMQQK 100
    EQQFREWFLK EFPQIRWKIQ ESIERLRVIA NEIEKVHRGC VIANVVSGST 150
    GILSVIGVML APFTAGLSLS ITAAGVGLGI ASATAGIASS IVENTYTRSA 200
    ELTASRLTAT STDQLEALRD ILRDITPNVL SFALDFDEAT KMIANDVHTL 250
    RRSKATVGRP LIAWRYVPIN VVETLRTRGA PTRIVRKVAR NLGKATSGVL 300
    VVLDVVNLVQ DSLDLHKGAK SESAESLRQW AQELEENLNE LTHIHQSLKA 350
    G 351
    Length:351
    Mass (Da):39,164
    Last modified:April 3, 2007 - v3
    Checksum:iE8EC440BA0292412
    GO
    Isoform 2 (identifier: Q9BPW4-2) [UniParc]FASTAAdd to Basket

    Also known as: A

    The sequence of this isoform differs from the canonical sequence as follows:
         1-15: MEGAALLKIFVVCIW → MGSWVQLITSVG

    Show »
    Length:348
    Mass (Da):38,748
    Checksum:i9C2F9E9912C6F175
    GO
    Isoform 3 (identifier: Q9BPW4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-15: MEGAALLKIFVVCIW → MGSWVQLITSVG
         111-111: Missing.

    Show »
    Length:347
    Mass (Da):38,619
    Checksum:i7BEB91F9A47A5B39
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91I → V.
    Corresponds to variant rs132736 [ dbSNP | Ensembl ].
    VAR_053008
    Natural varianti12 – 121V → L.
    Corresponds to variant rs80587 [ dbSNP | Ensembl ].
    VAR_053009
    Natural varianti159 – 1591M → V.
    Corresponds to variant rs132700 [ dbSNP | Ensembl ].
    VAR_053010
    Natural varianti223 – 2231R → H.
    Corresponds to variant rs2227168 [ dbSNP | Ensembl ].
    VAR_059966
    Natural varianti319 – 3191A → E.
    Corresponds to variant rs6000173 [ dbSNP | Ensembl ].
    VAR_059967
    Natural varianti326 – 3261S → L.
    Corresponds to variant rs6000172 [ dbSNP | Ensembl ].
    VAR_059968

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1515MEGAA…VVCIW → MGSWVQLITSVG in isoform 2 and isoform 3. 2 PublicationsVSP_000295Add
    BLAST
    Alternative sequencei111 – 1111Missing in isoform 3. 1 PublicationVSP_024380

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY014915 mRNA. Translation: AAG50353.1.
    AY014913
    , AY014909, AY014911, AY014912 Genomic DNA. Translation: AAG50350.1.
    AY014914 mRNA. Translation: AAG50352.1.
    AY014913
    , AY014910, AY014911, AY014912 Genomic DNA. Translation: AAG50351.1.
    AF305226 mRNA. Translation: AAK20212.1.
    RefSeqiNP_085146.2. NM_030643.4. [Q9BPW4-2]
    NP_663693.1. NM_145660.2. [Q9BPW4-1]
    UniGeneiHs.115099.

    Genome annotation databases

    EnsembliENST00000332987; ENSP00000333229; ENSG00000100336. [Q9BPW4-3]
    GeneIDi80832.
    KEGGihsa:80832.
    UCSCiuc003aow.3. human. [Q9BPW4-2]
    uc003aox.3. human. [Q9BPW4-1]

    Polymorphism databases

    DMDMi143811364.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY014915 mRNA. Translation: AAG50353.1 .
    AY014913
    , AY014909 , AY014911 , AY014912 Genomic DNA. Translation: AAG50350.1 .
    AY014914 mRNA. Translation: AAG50352.1 .
    AY014913
    , AY014910 , AY014911 , AY014912 Genomic DNA. Translation: AAG50351.1 .
    AF305226 mRNA. Translation: AAK20212.1 .
    RefSeqi NP_085146.2. NM_030643.4. [Q9BPW4-2 ]
    NP_663693.1. NM_145660.2. [Q9BPW4-1 ]
    UniGenei Hs.115099.

    3D structure databases

    ProteinModelPortali Q9BPW4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000338260.

    PTM databases

    PhosphoSitei Q9BPW4.

    Polymorphism databases

    DMDMi 143811364.

    Proteomic databases

    PaxDbi Q9BPW4.
    PRIDEi Q9BPW4.

    Protocols and materials databases

    DNASUi 80832.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332987 ; ENSP00000333229 ; ENSG00000100336 . [Q9BPW4-3 ]
    GeneIDi 80832.
    KEGGi hsa:80832.
    UCSCi uc003aow.3. human. [Q9BPW4-2 ]
    uc003aox.3. human. [Q9BPW4-1 ]

    Organism-specific databases

    CTDi 80832.
    GeneCardsi GC22M036585.
    HGNCi HGNC:14867. APOL4.
    HPAi HPA049797.
    MIMi 607254. gene.
    neXtProti NX_Q9BPW4.
    PharmGKBi PA24907.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG69704.
    HOGENOMi HOG000294132.
    HOVERGENi HBG074468.
    InParanoidi Q9BPW4.
    KOi K14480.
    PhylomeDBi Q9BPW4.

    Miscellaneous databases

    GenomeRNAii 80832.
    NextBioi 71250.
    PROi Q9BPW4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BPW4.
    Bgeei Q9BPW4.
    CleanExi HS_APOL4.
    Genevestigatori Q9BPW4.

    Family and domain databases

    InterProi IPR008405. ApoL.
    [Graphical view ]
    PANTHERi PTHR14096. PTHR14096. 1 hit.
    Pfami PF05461. ApoL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene."
      Duchateau P.N., Pullinger C.R., Cho M.H., Eng C., Kane J.P.
      J. Lipid Res. 42:620-630(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
      Tissue: Pancreas.
    2. "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution."
      Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J.
      Genomics 74:71-78(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Placenta.

    Entry informationi

    Entry nameiAPOL4_HUMAN
    AccessioniPrimary (citable) accession number: Q9BPW4
    Secondary accession number(s): Q9BQ37, Q9BXQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 92 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3