Reviewed, UniProtKB/Swiss-Prot Q9BPW4 (APOL4_HUMAN)

Names and origin

Protein names

Recommended name:
    Apolipoprotein L4
Alternative name(s):
    Apolipoprotein L-IV
      Short name=ApoL-IV

Gene names

Name:

APOL4

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver By similarity.
Subcellular location	Secreted Potential.
Tissue specificity	Widely expressed; the highest levels are in spinal cord, placenta, adrenal gland; also detected in spleen, bone marrow, uterus, trachea, mammary gland and testis; levels are low in brain, heart and pancreas.
Sequence similarities	Belongs to the apolipoprotein L family.

Ontologies

Keywords
Biological process	Lipid transport Transport
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid metabolic process Non-traceable author statement. Source: UniProtKB lipid transport Inferred from electronic annotation. Source: UniProtKB-KW lipoprotein metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	lipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BPW4-1)

Also known as: B;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BPW4-2)

Also known as: A;

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MEGAALLKIFVVCIW → MGSWVQLITSVG

Isoform 3 (identifier: Q9BPW4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MEGAALLKIFVVCIW → MGSWVQLITSVG
     111-111: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 351	330	Apolipoprotein L4		PRO_0000002041
Natural variations
	Alternative sequence	1 – 15	15	MEGAA…VVCIW → MGSWVQLITSVG in isoform 2 and isoform 3.		VSP_000295
	Alternative sequence	111	1	Missing in isoform 3.		VSP_024380
	Natural variant	9	1	I → V: dbSNP rs132736.		VAR_053008
	Natural variant	12	1	V → L: dbSNP rs80587.		VAR_053009
	Natural variant	159	1	M → V: dbSNP rs132700.		VAR_053010
	Natural variant	223	1	R → H: dbSNP rs2227168.		VAR_059966
	Natural variant	319	1	A → E: dbSNP rs6000173.		VAR_059967
	Natural variant	326	1	S → L: dbSNP rs6000172.		VAR_059968

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (B) [UniParc]. Last modified April 3, 2007. Version 3. Checksum: E8EC440BA0292412	FASTA	351	39,164
	10 20 30 40 50 60 MEGAALLKIF VVCIWVQQNH PGWTVAGQFQ EKKRFTEEVI EYFQKKVSPV HLKILLTSDE 70 80 90 100 110 120 AWKRFVRVAE LPREEADALY EALKNLTPYV AIEDKDMQQK EQQFREWFLK EFPQIRWKIQ 130 140 150 160 170 180 ESIERLRVIA NEIEKVHRGC VIANVVSGST GILSVIGVML APFTAGLSLS ITAAGVGLGI 190 200 210 220 230 240 ASATAGIASS IVENTYTRSA ELTASRLTAT STDQLEALRD ILRDITPNVL SFALDFDEAT 250 260 270 280 290 300 KMIANDVHTL RRSKATVGRP LIAWRYVPIN VVETLRTRGA PTRIVRKVAR NLGKATSGVL 310 320 330 340 350 VVLDVVNLVQ DSLDLHKGAK SESAESLRQW AQELEENLNE LTHIHQSLKA G
	Isoform 2 (A). Checksum: 9C2F9E9912C6F175	FASTA	348	38,748
	10 20 30 40 50 60 MGSWVQLITS VGVQQNHPGW TVAGQFQEKK RFTEEVIEYF QKKVSPVHLK ILLTSDEAWK 70 80 90 100 110 120 RFVRVAELPR EEADALYEAL KNLTPYVAIE DKDMQQKEQQ FREWFLKEFP QIRWKIQESI 130 140 150 160 170 180 ERLRVIANEI EKVHRGCVIA NVVSGSTGIL SVIGVMLAPF TAGLSLSITA AGVGLGIASA 190 200 210 220 230 240 TAGIASSIVE NTYTRSAELT ASRLTATSTD QLEALRDILR DITPNVLSFA LDFDEATKMI 250 260 270 280 290 300 ANDVHTLRRS KATVGRPLIA WRYVPINVVE TLRTRGAPTR IVRKVARNLG KATSGVLVVL 310 320 330 340 DVVNLVQDSL DLHKGAKSES AESLRQWAQE LEENLNELTH IHQSLKAG
	Isoform 3. Checksum: 7BEB91F9A47A5B39	FASTA	347	38,619
	10 20 30 40 50 60 MGSWVQLITS VGVQQNHPGW TVAGQFQEKK RFTEEVIEYF QKKVSPVHLK ILLTSDEAWK 70 80 90 100 110 120 RFVRVAELPR EEADALYEAL KNLTPYVAIE DKDMQQKEQQ FREWFLKFPQ IRWKIQESIE 130 140 150 160 170 180 RLRVIANEIE KVHRGCVIAN VVSGSTGILS VIGVMLAPFT AGLSLSITAA GVGLGIASAT 190 200 210 220 230 240 AGIASSIVEN TYTRSAELTA SRLTATSTDQ LEALRDILRD ITPNVLSFAL DFDEATKMIA 250 260 270 280 290 300 NDVHTLRRSK ATVGRPLIAW RYVPINVVET LRTRGAPTRI VRKVARNLGK ATSGVLVVLD 310 320 330 340 VVNLVQDSLD LHKGAKSESA ESLRQWAQEL EENLNELTHI HQSLKAG

References

[1]	"Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene." Duchateau P.N., Pullinger C.R., Cho M.H., Eng C., Kane J.P. J. Lipid Res. 42:620-630(2001) [PubMed: 11290834] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2). Tissue: Pancreas.
[2]	"The human apolipoprotein L gene cluster: identification, classification, and sites of distribution." Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J. Genomics 74:71-78(2001) [PubMed: 11374903] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY014915 mRNA. Translation: AAG50353.1. AY014913 , AY014909, AY014911, AY014912 Genomic DNA. Translation: AAG50350.1. AY014914 mRNA. Translation: AAG50352.1. AY014913 , AY014910, AY014911, AY014912 Genomic DNA. Translation: AAG50351.1. AF305226 mRNA. Translation: AAK20212.1.
IPI	IPI00028171. IPI00218384. IPI00843938.
RefSeq	NP_085146.2. NP_663693.1.
UniGene	Hs.115099
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BPW4.
Genome annotation databases
Ensembl	ENST00000352371; ENSP00000338260; ENSG00000100336; Homo sapiens. [Genome view]
GeneID	80832.
KEGG	hsa:80832.
Organism-specific databases
CTD	80832.
GeneCards	GC22M034909.
HGNC	HGNC:14867. APOL4.
MIM	607254. gene.
PharmGKB	PA24907.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9BPW4.
HOVERGEN	Q9BPW4.
Gene expression databases
ArrayExpress	Q9BPW4.
Bgee	Q9BPW4.
CleanEx	HS_APOL4.
Genevestigator	Q9BPW4.
GermOnline	ENSG00000100336. Homo sapiens.
Family and domain databases
InterPro	IPR008405. ApoL. [Graphical view]
PANTHER	PTHR14096. ApoL. 1 hit.
Pfam	PF05461. ApoL. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	71250.
SOURCE	Search...

Entry information

Entry name

APOL4_HUMAN

Accession

Primary (citable) accession number: Q9BPW4
Secondary accession number(s): Q9BQ37, Q9BXQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	April 3, 2007
Last modified:	November 24, 2009
This is version 61 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.