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Q9BPW4 (APOL4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apolipoprotein L4
Alternative name(s):
Apolipoprotein L-IV
Short name=ApoL-IV
Gene names
Name:APOL4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver By similarity.

Subcellular location

Secreted Potential.

Tissue specificity

Widely expressed; the highest levels are in spinal cord, placenta, adrenal gland; also detected in spleen, bone marrow, uterus, trachea, mammary gland and testis; levels are low in brain, heart and pancreas.

Sequence similarities

Belongs to the apolipoprotein L family.

Ontologies

Keywords
   Biological processLipid transport
Transport
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlipid metabolic process

Non-traceable author statement PubMed 11944986. Source: UniProtKB

lipid transport

Inferred from electronic annotation. Source: UniProtKB-KW

lipoprotein metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular space

Inferred from sequence or structural similarity PubMed 22261194. Source: BHF-UCL

   Molecular_functionlipid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BPW4-1)

Also known as: B;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BPW4-2)

Also known as: A;

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MEGAALLKIFVVCIW → MGSWVQLITSVG
Isoform 3 (identifier: Q9BPW4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MEGAALLKIFVVCIW → MGSWVQLITSVG
     111-111: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 351330Apolipoprotein L4
PRO_0000002041

Natural variations

Alternative sequence1 – 1515MEGAA…VVCIW → MGSWVQLITSVG in isoform 2 and isoform 3.
VSP_000295
Alternative sequence1111Missing in isoform 3.
VSP_024380
Natural variant91I → V.
Corresponds to variant rs132736 [ dbSNP | Ensembl ].
VAR_053008
Natural variant121V → L.
Corresponds to variant rs80587 [ dbSNP | Ensembl ].
VAR_053009
Natural variant1591M → V.
Corresponds to variant rs132700 [ dbSNP | Ensembl ].
VAR_053010
Natural variant2231R → H.
Corresponds to variant rs2227168 [ dbSNP | Ensembl ].
VAR_059966
Natural variant3191A → E.
Corresponds to variant rs6000173 [ dbSNP | Ensembl ].
VAR_059967
Natural variant3261S → L.
Corresponds to variant rs6000172 [ dbSNP | Ensembl ].
VAR_059968

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (B) [UniParc].

Last modified April 3, 2007. Version 3.
Checksum: E8EC440BA0292412

FASTA35139,164
        10         20         30         40         50         60 
MEGAALLKIF VVCIWVQQNH PGWTVAGQFQ EKKRFTEEVI EYFQKKVSPV HLKILLTSDE 

        70         80         90        100        110        120 
AWKRFVRVAE LPREEADALY EALKNLTPYV AIEDKDMQQK EQQFREWFLK EFPQIRWKIQ 

       130        140        150        160        170        180 
ESIERLRVIA NEIEKVHRGC VIANVVSGST GILSVIGVML APFTAGLSLS ITAAGVGLGI 

       190        200        210        220        230        240 
ASATAGIASS IVENTYTRSA ELTASRLTAT STDQLEALRD ILRDITPNVL SFALDFDEAT 

       250        260        270        280        290        300 
KMIANDVHTL RRSKATVGRP LIAWRYVPIN VVETLRTRGA PTRIVRKVAR NLGKATSGVL 

       310        320        330        340        350 
VVLDVVNLVQ DSLDLHKGAK SESAESLRQW AQELEENLNE LTHIHQSLKA G 

« Hide

Isoform 2 (A) [UniParc].

Checksum: 9C2F9E9912C6F175
Show »

FASTA34838,748
Isoform 3 [UniParc].

Checksum: 7BEB91F9A47A5B39
Show »

FASTA34738,619

References

[1]"Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene."
Duchateau P.N., Pullinger C.R., Cho M.H., Eng C., Kane J.P.
J. Lipid Res. 42:620-630(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
Tissue: Pancreas.
[2]"The human apolipoprotein L gene cluster: identification, classification, and sites of distribution."
Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J.
Genomics 74:71-78(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY014915 mRNA. Translation: AAG50353.1.
AY014913 expand/collapse EMBL AC list , AY014909, AY014911, AY014912 Genomic DNA. Translation: AAG50350.1.
AY014914 mRNA. Translation: AAG50352.1.
AY014913 expand/collapse EMBL AC list , AY014910, AY014911, AY014912 Genomic DNA. Translation: AAG50351.1.
AF305226 mRNA. Translation: AAK20212.1.
RefSeqNP_085146.2. NM_030643.4. [Q9BPW4-2]
NP_663693.1. NM_145660.2. [Q9BPW4-1]
UniGeneHs.115099.

3D structure databases

ProteinModelPortalQ9BPW4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000338260.

PTM databases

PhosphoSiteQ9BPW4.

Polymorphism databases

DMDM143811364.

Proteomic databases

PaxDbQ9BPW4.
PRIDEQ9BPW4.

Protocols and materials databases

DNASU80832.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332987; ENSP00000333229; ENSG00000100336. [Q9BPW4-3]
GeneID80832.
KEGGhsa:80832.
UCSCuc003aow.3. human. [Q9BPW4-2]
uc003aox.3. human. [Q9BPW4-1]

Organism-specific databases

CTD80832.
GeneCardsGC22M036585.
HGNCHGNC:14867. APOL4.
HPAHPA049797.
MIM607254. gene.
neXtProtNX_Q9BPW4.
PharmGKBPA24907.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG69704.
HOGENOMHOG000294132.
HOVERGENHBG074468.
InParanoidQ9BPW4.
KOK14480.
PhylomeDBQ9BPW4.

Gene expression databases

ArrayExpressQ9BPW4.
BgeeQ9BPW4.
CleanExHS_APOL4.
GenevestigatorQ9BPW4.

Family and domain databases

InterProIPR008405. ApoL.
[Graphical view]
PANTHERPTHR14096. PTHR14096. 1 hit.
PfamPF05461. ApoL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi80832.
NextBio71250.
PROQ9BPW4.
SOURCESearch...

Entry information

Entry nameAPOL4_HUMAN
AccessionPrimary (citable) accession number: Q9BPW4
Secondary accession number(s): Q9BQ37, Q9BXQ8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: April 3, 2007
Last modified: May 14, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM