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Q9BPW4

- APOL4_HUMAN

UniProt

Q9BPW4 - APOL4_HUMAN

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Protein

Apolipoprotein L4

Gene

APOL4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity).By similarity

GO - Molecular functioni

  1. lipid binding Source: InterPro

GO - Biological processi

  1. lipid metabolic process Source: UniProtKB
  2. lipid transport Source: UniProtKB-KW
  3. lipoprotein metabolic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein L4
Alternative name(s):
Apolipoprotein L-IV
Short name:
ApoL-IV
Gene namesi
Name:APOL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:14867. APOL4.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 351330Apolipoprotein L4PRO_0000002041Add
BLAST

Proteomic databases

PaxDbiQ9BPW4.
PRIDEiQ9BPW4.

PTM databases

PhosphoSiteiQ9BPW4.

Expressioni

Tissue specificityi

Widely expressed; the highest levels are in spinal cord, placenta, adrenal gland; also detected in spleen, bone marrow, uterus, trachea, mammary gland and testis; levels are low in brain, heart and pancreas.

Gene expression databases

BgeeiQ9BPW4.
CleanExiHS_APOL4.
ExpressionAtlasiQ9BPW4. baseline and differential.
GenevestigatoriQ9BPW4.

Organism-specific databases

HPAiHPA049797.

Interactioni

Protein-protein interaction databases

IntActiQ9BPW4. 1 interaction.
STRINGi9606.ENSP00000338260.

Structurei

3D structure databases

ProteinModelPortaliQ9BPW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein L family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG69704.
GeneTreeiENSGT00510000046700.
HOGENOMiHOG000294132.
HOVERGENiHBG074468.
InParanoidiQ9BPW4.
KOiK14480.
PhylomeDBiQ9BPW4.

Family and domain databases

InterProiIPR008405. ApoL.
[Graphical view]
PANTHERiPTHR14096. PTHR14096. 1 hit.
PfamiPF05461. ApoL. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BPW4-1) [UniParc]FASTAAdd to Basket

Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGAALLKIF VVCIWVQQNH PGWTVAGQFQ EKKRFTEEVI EYFQKKVSPV
60 70 80 90 100
HLKILLTSDE AWKRFVRVAE LPREEADALY EALKNLTPYV AIEDKDMQQK
110 120 130 140 150
EQQFREWFLK EFPQIRWKIQ ESIERLRVIA NEIEKVHRGC VIANVVSGST
160 170 180 190 200
GILSVIGVML APFTAGLSLS ITAAGVGLGI ASATAGIASS IVENTYTRSA
210 220 230 240 250
ELTASRLTAT STDQLEALRD ILRDITPNVL SFALDFDEAT KMIANDVHTL
260 270 280 290 300
RRSKATVGRP LIAWRYVPIN VVETLRTRGA PTRIVRKVAR NLGKATSGVL
310 320 330 340 350
VVLDVVNLVQ DSLDLHKGAK SESAESLRQW AQELEENLNE LTHIHQSLKA

G
Length:351
Mass (Da):39,164
Last modified:April 3, 2007 - v3
Checksum:iE8EC440BA0292412
GO
Isoform 2 (identifier: Q9BPW4-2) [UniParc]FASTAAdd to Basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MEGAALLKIFVVCIW → MGSWVQLITSVG

Show »
Length:348
Mass (Da):38,748
Checksum:i9C2F9E9912C6F175
GO
Isoform 3 (identifier: Q9BPW4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MEGAALLKIFVVCIW → MGSWVQLITSVG
     111-111: Missing.

Show »
Length:347
Mass (Da):38,619
Checksum:i7BEB91F9A47A5B39
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91I → V.
Corresponds to variant rs132736 [ dbSNP | Ensembl ].
VAR_053008
Natural varianti12 – 121V → L.
Corresponds to variant rs80587 [ dbSNP | Ensembl ].
VAR_053009
Natural varianti159 – 1591M → V.
Corresponds to variant rs132700 [ dbSNP | Ensembl ].
VAR_053010
Natural varianti223 – 2231R → H.
Corresponds to variant rs2227168 [ dbSNP | Ensembl ].
VAR_059966
Natural varianti319 – 3191A → E.
Corresponds to variant rs6000173 [ dbSNP | Ensembl ].
VAR_059967
Natural varianti326 – 3261S → L.
Corresponds to variant rs6000172 [ dbSNP | Ensembl ].
VAR_059968

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1515MEGAA…VVCIW → MGSWVQLITSVG in isoform 2 and isoform 3. 2 PublicationsVSP_000295Add
BLAST
Alternative sequencei111 – 1111Missing in isoform 3. 1 PublicationVSP_024380

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY014915 mRNA. Translation: AAG50353.1.
AY014913
, AY014909, AY014911, AY014912 Genomic DNA. Translation: AAG50350.1.
AY014914 mRNA. Translation: AAG50352.1.
AY014913
, AY014910, AY014911, AY014912 Genomic DNA. Translation: AAG50351.1.
AF305226 mRNA. Translation: AAK20212.1.
CCDSiCCDS74851.1. [Q9BPW4-2]
CCDS74852.1. [Q9BPW4-1]
RefSeqiNP_085146.2. NM_030643.4. [Q9BPW4-2]
NP_663693.1. NM_145660.2. [Q9BPW4-1]
UniGeneiHs.115099.

Genome annotation databases

EnsembliENST00000332987; ENSP00000333229; ENSG00000100336. [Q9BPW4-2]
ENST00000352371; ENSP00000338260; ENSG00000100336. [Q9BPW4-1]
ENST00000616056; ENSP00000483497; ENSG00000100336. [Q9BPW4-2]
GeneIDi80832.
KEGGihsa:80832.
UCSCiuc003aow.3. human. [Q9BPW4-2]
uc003aox.3. human. [Q9BPW4-1]

Polymorphism databases

DMDMi143811364.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY014915 mRNA. Translation: AAG50353.1 .
AY014913
, AY014909 , AY014911 , AY014912 Genomic DNA. Translation: AAG50350.1 .
AY014914 mRNA. Translation: AAG50352.1 .
AY014913
, AY014910 , AY014911 , AY014912 Genomic DNA. Translation: AAG50351.1 .
AF305226 mRNA. Translation: AAK20212.1 .
CCDSi CCDS74851.1. [Q9BPW4-2 ]
CCDS74852.1. [Q9BPW4-1 ]
RefSeqi NP_085146.2. NM_030643.4. [Q9BPW4-2 ]
NP_663693.1. NM_145660.2. [Q9BPW4-1 ]
UniGenei Hs.115099.

3D structure databases

ProteinModelPortali Q9BPW4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9BPW4. 1 interaction.
STRINGi 9606.ENSP00000338260.

PTM databases

PhosphoSitei Q9BPW4.

Polymorphism databases

DMDMi 143811364.

Proteomic databases

PaxDbi Q9BPW4.
PRIDEi Q9BPW4.

Protocols and materials databases

DNASUi 80832.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332987 ; ENSP00000333229 ; ENSG00000100336 . [Q9BPW4-2 ]
ENST00000352371 ; ENSP00000338260 ; ENSG00000100336 . [Q9BPW4-1 ]
ENST00000616056 ; ENSP00000483497 ; ENSG00000100336 . [Q9BPW4-2 ]
GeneIDi 80832.
KEGGi hsa:80832.
UCSCi uc003aow.3. human. [Q9BPW4-2 ]
uc003aox.3. human. [Q9BPW4-1 ]

Organism-specific databases

CTDi 80832.
GeneCardsi GC22M036585.
HGNCi HGNC:14867. APOL4.
HPAi HPA049797.
MIMi 607254. gene.
neXtProti NX_Q9BPW4.
PharmGKBi PA24907.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG69704.
GeneTreei ENSGT00510000046700.
HOGENOMi HOG000294132.
HOVERGENi HBG074468.
InParanoidi Q9BPW4.
KOi K14480.
PhylomeDBi Q9BPW4.

Miscellaneous databases

GenomeRNAii 80832.
NextBioi 71250.
PROi Q9BPW4.
SOURCEi Search...

Gene expression databases

Bgeei Q9BPW4.
CleanExi HS_APOL4.
ExpressionAtlasi Q9BPW4. baseline and differential.
Genevestigatori Q9BPW4.

Family and domain databases

InterProi IPR008405. ApoL.
[Graphical view ]
PANTHERi PTHR14096. PTHR14096. 1 hit.
Pfami PF05461. ApoL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene."
    Duchateau P.N., Pullinger C.R., Cho M.H., Eng C., Kane J.P.
    J. Lipid Res. 42:620-630(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
    Tissue: Pancreas.
  2. "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution."
    Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J.
    Genomics 74:71-78(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Placenta.

Entry informationi

Entry nameiAPOL4_HUMAN
AccessioniPrimary (citable) accession number: Q9BPW4
Secondary accession number(s): Q9BQ37, Q9BXQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3