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Protein

Serine/threonine-protein phosphatase

Gene

PPP5C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation)
Gene namesi
Name:PPP5CImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1293265.

Interactioni

Protein-protein interaction databases

IntActiQ9BPW0. 60 interactors.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 127TPR_REGIONInterPro annotationAdd BLAST102
Repeati26 – 59TPRPROSITE-ProRule annotationAdd BLAST34
Repeati60 – 93TPRPROSITE-ProRule annotationAdd BLAST34
Repeati94 – 127TPRPROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the PPP phosphatase family.UniRule annotation

Keywords - Domaini

RepeatSAAS annotation, TPR repeatPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0376. Eukaryota.
COG0639. LUCA.
HOVERGENiHBG000216.

Family and domain databases

Gene3Di1.20.120.420. 1 hit.
3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR027363. M1Pi_N.
IPR029052. Metallo-depent_PP-like.
IPR013235. PPP_dom.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR011236. Ser/Thr_PPase_5.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
PANTHERiPTHR11668:SF326. PTHR11668:SF326. 1 hit.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PF08321. PPP5. 1 hit.
PF00515. TPR_1. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SM00028. TPR. 3 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9BPW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGERTECA EPPRDEPPAD GALKRAEELK TQANDYFKAK DYENAIKFYS
60 70 80 90 100
QAIELNPSNA IYYGNRSLAY LRTECYGYAL GDATRAIELD KKYIKGYYRR
110 120 130 140 150
AASNMALGKF RAALRDYETV VKVKPHDKDA KMKYQECNKI VKQKAFERAI
160 170 180 190 200
AGDEHKRSVV DSLDIESMTI EDEYSGPKLE DGKVTISFMK ELMQWYKDQK
210 220 230 240 250
KLHRKCAYQI LVQVKEVLSK LSTLVETTLK ETEKITVCGD THGQFYDLLN
260 270 280 290 300
IFELNGLPSE TNPYIFNGDF VDRGSFSVEV ILTLFGFKLL YPDHFHLLRG
310 320 330 340 350
NHETDNMNQI YGFEGEVKAK YTAQMYELFS EVFEWLPLAQ CINGKVLIMH
360 370 380 390 400
GGLFSEDGVT LDDIRKIERN RQPPDSGPMC DLLWSDPQPQ NGRSISKRGV
410 420 430 440 450
SCQFGPDVTK AFLEENNLDY IIRSHEVKAE GYEVAHGGRC VTVFSAPNYC
460 470 480
DQMGNKASYI HLQGSDLRPQ FHQFTAVGRP SSGS
Length:484
Mass (Da):55,096
Last modified:July 5, 2004 - v2
Checksum:i152A9C374E3D4F69
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000750 mRNA. Translation: AAH00750.4.
BC001831 mRNA. Translation: AAH01831.4.
UniGeneiHs.654604.

Similar proteinsi

Entry informationi

Entry nameiQ9BPW0_HUMAN
AccessioniPrimary (citable) accession number: Q9BPW0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.