Q9BPW0 (Q9BPW0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase RuleBase RU004273
EC=3.1.3.16 RuleBase RU004273

Gene names

Name:

PPP5C EMBL AAH00750.4

Organism

Homo sapiens (Human) EMBL AAH00750.4

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	484 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate. RuleBase RU004273
Sequence similarities	Belongs to the PPP phosphatase family. RuleBase RU004273

Ontologies

Keywords
Domain	Repeat RuleBase RU003537 TPR repeat RuleBase RU003339 SAAS SAAS001440
Ligand	Iron RuleBase RU004273 PIRSR PIRSR033096-2 Metal-binding PIRSR PIRSR033096-2
Molecular function	Hydrolase RuleBase RU004273
Gene Ontology (GO)
Biological_process	protein dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular_component	Golgi apparatus Inferred from direct assay. Source: HPA nucleus Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	302	1	Proton donor By similarity PIRSR PIRSR033096-1
	Metal binding	240	1	Iron By similarity
	Metal binding	242	1	Iron By similarity
	Metal binding	269	1	Iron By similarity
Experimental info
	Non-terminal residue	1	1	EMBL AAH00750.4

Sequences

	Sequence		Length	Mass (Da)
	Q9BPW0 [UniParc]. Last modified July 5, 2004. Version 2. Checksum: 152A9C374E3D4F69	FASTA	484	55,096
	10 20 30 40 50 60 MAEGERTECA EPPRDEPPAD GALKRAEELK TQANDYFKAK DYENAIKFYS QAIELNPSNA 70 80 90 100 110 120 IYYGNRSLAY LRTECYGYAL GDATRAIELD KKYIKGYYRR AASNMALGKF RAALRDYETV 130 140 150 160 170 180 VKVKPHDKDA KMKYQECNKI VKQKAFERAI AGDEHKRSVV DSLDIESMTI EDEYSGPKLE 190 200 210 220 230 240 DGKVTISFMK ELMQWYKDQK KLHRKCAYQI LVQVKEVLSK LSTLVETTLK ETEKITVCGD 250 260 270 280 290 300 THGQFYDLLN IFELNGLPSE TNPYIFNGDF VDRGSFSVEV ILTLFGFKLL YPDHFHLLRG 310 320 330 340 350 360 NHETDNMNQI YGFEGEVKAK YTAQMYELFS EVFEWLPLAQ CINGKVLIMH GGLFSEDGVT 370 380 390 400 410 420 LDDIRKIERN RQPPDSGPMC DLLWSDPQPQ NGRSISKRGV SCQFGPDVTK AFLEENNLDY 430 440 450 460 470 480 IIRSHEVKAE GYEVAHGGRC VTVFSAPNYC DQMGNKASYI HLQGSDLRPQ FHQFTAVGRP SSGS

References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle EMBL AAH00750.4.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC000750 mRNA. Translation: AAH00750.4. BC001831 mRNA. Translation: AAH01831.4.
IPI	IPI01014578.
UniGene	Hs.654604.
3D structure databases
HSSP	HSSP built from PDB template 1A17 based on UniProtKB P53041.
ProteinModelPortal	Q9BPW0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BPW0.
Proteomic databases
PRIDE	Q9BPW0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000216.
Gene expression databases
ArrayExpress	Q9BPW0.
Bgee	Q9BPW0.
Family and domain databases
Gene3D	1.25.40.10. 1 hit.
InterPro	IPR004843. Metallo_PEstase_dom. IPR013235. PPP_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. IPR011236. Ser/Thr_PPase_5. IPR001440. TPR-1. IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
PANTHER	PTHR11668:SF12. PTHR11668:SF12. 1 hit.
Pfam	PF00149. Metallophos. 1 hit. PF08321. PPP5. 1 hit. PF00515. TPR_1. 1 hit. [Graphical view]
PIRSF	PIRSF033096. PPPtase_5. 1 hit.
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. SM00028. TPR. 3 hits. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. PS50005. TPR. 3 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1293265.

Entry information

Entry name

Q9BPW0_HUMAN

Accession

Primary (citable) accession number: Q9BPW0

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	July 5, 2004
Last modified:	March 6, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.