ID P2Y13_HUMAN Reviewed; 354 AA. AC Q9BPV8; B2R827; Q05C50; Q6DKN4; Q8IUT5; Q8TDU7; Q9BY61; DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot. DT 08-FEB-2011, sequence version 3. DT 11-NOV-2015, entry version 136. DE RecName: Full=P2Y purinoceptor 13; DE Short=P2Y13; DE AltName: Full=G-protein coupled receptor 86; DE AltName: Full=G-protein coupled receptor 94; GN Name=P2RY13; Synonyms=GPR86, GPR94; ORFNames=FKSG77; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2), RP AND VARIANT MET-179. RX PubMed=11574155; DOI=10.1016/S0378-1119(01)00651-5; RA Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., RA Lewis T., Evans J.F., George S.R., O'Dowd B.F.; RT "Discovery and mapping of ten novel G protein-coupled receptor RT genes."; RL Gene 275:83-91(2001). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, AND VARIANT MET-179. RC TISSUE=Spleen; RX PubMed=11546776; DOI=10.1074/jbc.M105912200; RA Communi D., Gonzalez N.S., Detheux M., Brezillon S., Lannoy V., RA Parmentier M., Boeynaems J.-M.; RT "Identification of a novel human ADP receptor coupled to Gi."; RL J. Biol. Chem. 276:41479-41485(2001). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT MET-179. RC TISSUE=Amygdala, Caudate nucleus, Fetal brain, and Placenta; RX PubMed=11273702; DOI=10.1006/jmbi.2001.4520; RA Wittenberger T., Schaller H.C., Hellebrand S.; RT "An expressed sequence tag (EST) data mining strategy succeeding in RT the discovery of new G-protein coupled receptors."; RL J. Mol. Biol. 307:799-813(2001). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT MET-179. RC TISSUE=Heart; RA Wang Y.-G., Gong L.; RT "Molecular cloning of FKSG77, a novel gene encoding a putative G- RT protein-coupled receptor."; RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12044878; DOI=10.1016/S0014-5793(02)02775-8; RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.; RT "Identification of G protein-coupled receptor genes from the human RT genome sequence."; RL FEBS Lett. 520:97-101(2002). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT RP MET-179. RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., RA Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., RA Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., RA Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT MET-179. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT RP MET-179. RC TISSUE=Brain, and Placenta; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [10] RP NUCLEOTIDE SEQUENCE [MRNA] OF 172-354, AND VARIANT MET-179. RA Zhang W., Wan T., Cao X.; RT "Molecular cloning of a probable G protein-coupled receptor with three RT transmembrane domains."; RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for ADP. Coupled to G(i)-proteins. May play a CC role in hematopoiesis and the immune system. CC {ECO:0000269|PubMed:11546776}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9BPV8-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9BPV8-2; Sequence=VSP_036226; CC -!- TISSUE SPECIFICITY: Strong expression in spleen and adult brain. CC Lower expression in placenta, lung, liver, spinal cord, thymus, CC small intestine, uterus, stomach, testis, fetal brain, and adrenal CC gland. Not detected in pancreas, heart, kidney, skeletal muscle, CC ovary or fetal aorta. Clearly detected in lymph node and bone CC marrow, weakly detected in peripheral blood mononuclear cells CC (PBMC) and in peripheral blood leukocytes (PBL), but not detected CC in polymorphonuclear cells (PMN). In the brain, detected in all CC brain regions examined. CC -!- MISCELLANEOUS: Stimulation by ADP in stably transfected CHO cells CC resulted in inhibition of adenylyl cyclase and the phosphorylation CC of the MAP kinases MAPK3 and MAPK1 in a pertussis toxin-sensitive CC way. Inhibition of adenylyl cyclase and phosphorylation of the MAP CC kinases are transduction mechanisms that involve G(i) proteins. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- SEQUENCE CAUTION: CC Sequence=AAH29363.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; CC Sequence=AAH41116.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; CC Sequence=BAG36024.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF411113; AAL26484.1; -; Genomic_DNA. DR EMBL; AF406692; AAL01038.1; -; mRNA. DR EMBL; AF295368; AAK01864.1; -; mRNA. DR EMBL; AF345565; AAK29068.1; -; mRNA. DR EMBL; AB083597; BAB89310.1; -; Genomic_DNA. DR EMBL; AK313208; BAG36024.1; ALT_INIT; mRNA. DR EMBL; AC024886; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471052; EAW78805.1; -; Genomic_DNA. DR EMBL; BC029363; AAH29363.1; ALT_SEQ; mRNA. DR EMBL; BC041116; AAH41116.2; ALT_INIT; mRNA. DR EMBL; BC066887; AAH66887.1; -; mRNA. DR EMBL; AF178982; AAK18752.1; -; mRNA. DR CCDS; CCDS3158.2; -. [Q9BPV8-1] DR RefSeq; NP_795713.2; NM_176894.2. [Q9BPV8-1] DR UniGene; Hs.546396; -. DR PDB; 2B6U; Model; -; A=22-354. DR PDBsum; 2B6U; -. DR ProteinModelPortal; Q9BPV8; -. DR SMR; Q9BPV8; 33-324. DR STRING; 9606.ENSP00000320376; -. DR GuidetoPHARMACOLOGY; 329; -. DR PhosphoSite; Q9BPV8; -. DR BioMuta; P2RY13; -. DR DMDM; 322510112; -. DR PaxDb; Q9BPV8; -. DR PRIDE; Q9BPV8; -. DR DNASU; 53829; -. DR Ensembl; ENST00000325602; ENSP00000320376; ENSG00000181631. [Q9BPV8-1] DR GeneID; 53829; -. DR KEGG; hsa:53829; -. DR UCSC; uc003eyv.2; human. [Q9BPV8-1] DR CTD; 53829; -. DR GeneCards; P2RY13; -. DR H-InvDB; HIX0200553; -. DR HGNC; HGNC:4537; P2RY13. DR HPA; HPA049047; -. DR MIM; 606380; gene. DR neXtProt; NX_Q9BPV8; -. DR eggNOG; ENOG410IFYD; Eukaryota. DR eggNOG; ENOG410ZJD1; LUCA. DR GeneTree; ENSGT00640000091213; -. DR HOVERGEN; HBG108228; -. DR InParanoid; Q9BPV8; -. DR KO; K08388; -. DR OMA; FYVVIAK; -. DR OrthoDB; EOG7JQBNQ; -. DR PhylomeDB; Q9BPV8; -. DR TreeFam; TF330969; -. DR Reactome; R-HSA-417957; P2Y receptors. DR Reactome; R-HSA-418594; G alpha (i) signalling events. DR GeneWiki; P2RY13; -. DR GenomeRNAi; 53829; -. DR NextBio; 56152; -. DR PRO; PR:Q9BPV8; -. DR Proteomes; UP000005640; Chromosome 3. DR Bgee; Q9BPV8; -. DR CleanEx; HS_P2RY13; -. DR Genevisible; Q9BPV8; HS. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0045028; F:G-protein coupled purinergic nucleotide receptor activity; IBA:GO_Central. DR GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl. DR GO; GO:0035589; P:G-protein coupled purinergic nucleotide receptor signaling pathway; IBA:GOC. DR GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central. DR GO; GO:0007194; P:negative regulation of adenylate cyclase activity; IEA:InterPro. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR008109; P2Y13_rcpt. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01735; P2Y13PRNCPTR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW 3D-structure; Alternative splicing; Cell membrane; Complete proteome; KW Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; KW Polymorphism; Receptor; Reference proteome; Transducer; Transmembrane; KW Transmembrane helix. FT CHAIN 1 354 P2Y purinoceptor 13. FT /FTId=PRO_0000070040. FT TOPO_DOM 1 49 Extracellular. {ECO:0000255}. FT TRANSMEM 50 70 Helical; Name=1. {ECO:0000255}. FT TOPO_DOM 71 77 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 78 98 Helical; Name=2. {ECO:0000255}. FT TOPO_DOM 99 117 Extracellular. {ECO:0000255}. FT TRANSMEM 118 138 Helical; Name=3. {ECO:0000255}. FT TOPO_DOM 139 161 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 162 182 Helical; Name=4. {ECO:0000255}. FT TOPO_DOM 183 211 Extracellular. {ECO:0000255}. FT TRANSMEM 212 232 Helical; Name=5. {ECO:0000255}. FT TOPO_DOM 233 252 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 253 273 Helical; Name=6. {ECO:0000255}. FT TOPO_DOM 274 300 Extracellular. {ECO:0000255}. FT TRANSMEM 301 321 Helical; Name=7. {ECO:0000255}. FT TOPO_DOM 322 333 Cytoplasmic. {ECO:0000255}. FT CARBOHYD 23 23 N-linked (GlcNAc...). {ECO:0000255}. FT CARBOHYD 31 31 N-linked (GlcNAc...). {ECO:0000255}. FT CARBOHYD 285 285 N-linked (GlcNAc...). {ECO:0000255}. FT DISULFID 116 194 {ECO:0000255|PROSITE-ProRule:PRU00521}. FT VAR_SEQ 1 21 Missing (in isoform 2). FT {ECO:0000303|PubMed:11273702, FT ECO:0000303|PubMed:11546776, FT ECO:0000303|Ref.4}. FT /FTId=VSP_036226. FT VARIANT 179 179 T -> M (in dbSNP:rs1466684). FT {ECO:0000269|PubMed:11273702, FT ECO:0000269|PubMed:11546776, FT ECO:0000269|PubMed:11574155, FT ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334, FT ECO:0000269|Ref.10, ECO:0000269|Ref.4, FT ECO:0000269|Ref.8}. FT /FTId=VAR_028299. SQ SEQUENCE 354 AA; 40789 MW; A2CE5F8ED84C4CAF CRC64; MTAAIRRQRE LSILPKVTLE AMNTTVMQGF NRSERCPRDT RIVQLVFPAL YTVVFLTGIL LNTLALWVFV HIPSSSTFII YLKNTLVADL IMTLMLPFKI LSDSHLAPWQ LRAFVCRFSS VIFYETMYVG IVLLGLIAFD RFLKIIRPLR NIFLKKPVFA KTVSIFIWFF LFFISLPNTI LSNKEATPSS VKKCASLKGP LGLKWHQMVN NICQFIFWTV FILMLVFYVV IAKKVYDSYR KSKSKDRKNN KKLEGKVFVV VAVFFVCFAP FHFARVPYTH SQTNNKTDCR LQNQLFIAKE TTLFLAATNI CMDPLIYIFL CKKFTEKLPC MQGRKTTASS QENHSSQTDN ITLG //