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Q9BPV8 (P2Y13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
P2Y purinoceptor 13

Short name=P2Y13
Alternative name(s):
G-protein coupled receptor 86
G-protein coupled receptor 94
Gene names
Name:P2RY13
Synonyms:GPR86, GPR94
ORF Names:FKSG77
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system. Ref.2

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Strong expression in spleen and adult brain. Lower expression in placenta, lung, liver, spinal cord, thymus, small intestine, uterus, stomach, testis, fetal brain, and adrenal gland. Not detected in pancreas, heart, kidney, skeletal muscle, ovary or fetal aorta. Clearly detected in lymph node and bone marrow, weakly detected in peripheral blood mononuclear cells (PBMC) and in peripheral blood leukocytes (PBL), but not detected in polymorphonuclear cells (PMN). In the brain, detected in all brain regions examined.

Miscellaneous

Stimulation by ADP in stably transfected CHO cells resulted in inhibition of adenylyl cyclase and the phosphorylation of the MAP kinases MAPK3 and MAPK1 in a pertussis toxin-sensitive way. Inhibition of adenylyl cyclase and phosphorylation of the MAP kinases are transduction mechanisms that involve G(i) proteins.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence AAH29363.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence AAH41116.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAG36024.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BPV8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BPV8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354P2Y purinoceptor 13
PRO_0000070040

Regions

Topological domain1 – 4949Extracellular Potential
Transmembrane50 – 7021Helical; Name=1; Potential
Topological domain71 – 777Cytoplasmic Potential
Transmembrane78 – 9821Helical; Name=2; Potential
Topological domain99 – 11719Extracellular Potential
Transmembrane118 – 13821Helical; Name=3; Potential
Topological domain139 – 16123Cytoplasmic Potential
Transmembrane162 – 18221Helical; Name=4; Potential
Topological domain183 – 21129Extracellular Potential
Transmembrane212 – 23221Helical; Name=5; Potential
Topological domain233 – 25220Cytoplasmic Potential
Transmembrane253 – 27321Helical; Name=6; Potential
Topological domain274 – 30027Extracellular Potential
Transmembrane301 – 32121Helical; Name=7; Potential
Topological domain322 – 33312Cytoplasmic Potential

Amino acid modifications

Glycosylation231N-linked (GlcNAc...) Potential
Glycosylation311N-linked (GlcNAc...) Potential
Glycosylation2851N-linked (GlcNAc...) Potential
Disulfide bond116 ↔ 194 By similarity

Natural variations

Alternative sequence1 – 2121Missing in isoform 2.
VSP_036226
Natural variant1791T → M. Ref.1 Ref.2 Ref.3 Ref.4 Ref.6 Ref.8 Ref.9 Ref.10
Corresponds to variant rs1466684 [ dbSNP | Ensembl ].
VAR_028299

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 8, 2011. Version 3.
Checksum: A2CE5F8ED84C4CAF

FASTA35440,789
        10         20         30         40         50         60 
MTAAIRRQRE LSILPKVTLE AMNTTVMQGF NRSERCPRDT RIVQLVFPAL YTVVFLTGIL 

        70         80         90        100        110        120 
LNTLALWVFV HIPSSSTFII YLKNTLVADL IMTLMLPFKI LSDSHLAPWQ LRAFVCRFSS 

       130        140        150        160        170        180 
VIFYETMYVG IVLLGLIAFD RFLKIIRPLR NIFLKKPVFA KTVSIFIWFF LFFISLPNTI 

       190        200        210        220        230        240 
LSNKEATPSS VKKCASLKGP LGLKWHQMVN NICQFIFWTV FILMLVFYVV IAKKVYDSYR 

       250        260        270        280        290        300 
KSKSKDRKNN KKLEGKVFVV VAVFFVCFAP FHFARVPYTH SQTNNKTDCR LQNQLFIAKE 

       310        320        330        340        350 
TTLFLAATNI CMDPLIYIFL CKKFTEKLPC MQGRKTTASS QENHSSQTDN ITLG 

« Hide

Isoform 2 [UniParc].

Checksum: 3F88E7EAC8F5428F
Show »

FASTA33338,410

References

« Hide 'large scale' references
[1]"Discovery and mapping of ten novel G protein-coupled receptor genes."
Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2), VARIANT MET-179.
[2]"Identification of a novel human ADP receptor coupled to Gi."
Communi D., Gonzalez N.S., Detheux M., Brezillon S., Lannoy V., Parmentier M., Boeynaems J.-M.
J. Biol. Chem. 276:41479-41485(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, VARIANT MET-179.
Tissue: Spleen.
[3]"An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors."
Wittenberger T., Schaller H.C., Hellebrand S.
J. Mol. Biol. 307:799-813(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT MET-179.
Tissue: Amygdala, Caudate nucleus, Fetal brain and Placenta.
[4]"Molecular cloning of FKSG77, a novel gene encoding a putative G-protein-coupled receptor."
Wang Y.-G., Gong L.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT MET-179.
Tissue: Heart.
[5]"Identification of G protein-coupled receptor genes from the human genome sequence."
Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-179.
[7]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-179.
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-179.
Tissue: Brain and Placenta.
[10]"Molecular cloning of a probable G protein-coupled receptor with three transmembrane domains."
Zhang W., Wan T., Cao X.
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 172-354, VARIANT MET-179.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF411113 Genomic DNA. Translation: AAL26484.1.
AF406692 mRNA. Translation: AAL01038.1.
AF295368 mRNA. Translation: AAK01864.1.
AF345565 mRNA. Translation: AAK29068.1.
AB083597 Genomic DNA. Translation: BAB89310.1.
AK313208 mRNA. Translation: BAG36024.1. Different initiation.
AC024886 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78805.1.
BC029363 mRNA. Translation: AAH29363.1. Sequence problems.
BC041116 mRNA. Translation: AAH41116.2. Different initiation.
BC066887 mRNA. Translation: AAH66887.1.
AF178982 mRNA. Translation: AAK18752.1.
CCDSCCDS3158.2. [Q9BPV8-1]
RefSeqNP_795713.2. NM_176894.2. [Q9BPV8-1]
UniGeneHs.546396.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2B6Umodel-A22-354[»]
ProteinModelPortalQ9BPV8.
SMRQ9BPV8. Positions 36-331.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000320376.

Chemistry

GuidetoPHARMACOLOGY329.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9BPV8.

Polymorphism databases

DMDM322510112.

Proteomic databases

PaxDbQ9BPV8.
PRIDEQ9BPV8.

Protocols and materials databases

DNASU53829.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000325602; ENSP00000320376; ENSG00000181631. [Q9BPV8-1]
GeneID53829.
KEGGhsa:53829.
UCSCuc003eyv.2. human. [Q9BPV8-1]

Organism-specific databases

CTD53829.
GeneCardsGC03M151044.
H-InvDBHIX0200553.
HGNCHGNC:4537. P2RY13.
HPAHPA049047.
MIM606380. gene.
neXtProtNX_Q9BPV8.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148143.
HOVERGENHBG108228.
InParanoidQ9BPV8.
KOK08388.
OMAFYVVIAK.
OrthoDBEOG7JQBNQ.
PhylomeDBQ9BPV8.
TreeFamTF330969.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ9BPV8.
CleanExHS_P2RY13.
GenevestigatorQ9BPV8.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
[Graphical view]
PANTHERPTHR24233:SF7. PTHR24233:SF7. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiP2RY13.
GenomeRNAi53829.
NextBio56152.
PROQ9BPV8.
SOURCESearch...

Entry information

Entry nameP2Y13_HUMAN
AccessionPrimary (citable) accession number: Q9BPV8
Secondary accession number(s): B2R827 expand/collapse secondary AC list , Q05C50, Q6DKN4, Q8IUT5, Q8TDU7, Q9BY61
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 8, 2011
Last modified: July 9, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries