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Protein

P2Y purinoceptor 13

Gene

P2RY13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.1 Publication

GO - Molecular functioni

  1. G-protein coupled purinergic nucleotide receptor activity Source: GO_Central

GO - Biological processi

  1. G-protein coupled purinergic nucleotide receptor signaling pathway Source: GOC
  2. G-protein coupled receptor signaling pathway Source: GO_Central
  3. negative regulation of adenylate cyclase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18289. P2Y receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 13
Short name:
P2Y13
Alternative name(s):
G-protein coupled receptor 86
G-protein coupled receptor 94
Gene namesi
Name:P2RY13
Synonyms:GPR86, GPR94
ORF Names:FKSG77
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:4537. P2RY13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949ExtracellularSequence AnalysisAdd
BLAST
Transmembranei50 – 7021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini71 – 777CytoplasmicSequence Analysis
Transmembranei78 – 9821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini99 – 11719ExtracellularSequence AnalysisAdd
BLAST
Transmembranei118 – 13821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini139 – 16123CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei162 – 18221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini183 – 21129ExtracellularSequence AnalysisAdd
BLAST
Transmembranei212 – 23221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini233 – 25220CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini274 – 30027ExtracellularSequence AnalysisAdd
BLAST
Transmembranei301 – 32121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini322 – 33312CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. integral component of plasma membrane Source: GO_Central
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354P2Y purinoceptor 13PRO_0000070040Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi116 ↔ 194PROSITE-ProRule annotation
Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BPV8.
PRIDEiQ9BPV8.

PTM databases

PhosphoSiteiQ9BPV8.

Expressioni

Tissue specificityi

Strong expression in spleen and adult brain. Lower expression in placenta, lung, liver, spinal cord, thymus, small intestine, uterus, stomach, testis, fetal brain, and adrenal gland. Not detected in pancreas, heart, kidney, skeletal muscle, ovary or fetal aorta. Clearly detected in lymph node and bone marrow, weakly detected in peripheral blood mononuclear cells (PBMC) and in peripheral blood leukocytes (PBL), but not detected in polymorphonuclear cells (PMN). In the brain, detected in all brain regions examined.

Gene expression databases

BgeeiQ9BPV8.
CleanExiHS_P2RY13.
GenevestigatoriQ9BPV8.

Organism-specific databases

HPAiHPA049047.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000320376.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B6Umodel-A22-354[»]
ProteinModelPortaliQ9BPV8.
SMRiQ9BPV8. Positions 36-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148143.
GeneTreeiENSGT00640000091213.
HOVERGENiHBG108228.
InParanoidiQ9BPV8.
KOiK08388.
OMAiFYVVIAK.
OrthoDBiEOG7JQBNQ.
PhylomeDBiQ9BPV8.
TreeFamiTF330969.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
[Graphical view]
PANTHERiPTHR24233:SF7. PTHR24233:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BPV8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAAIRRQRE LSILPKVTLE AMNTTVMQGF NRSERCPRDT RIVQLVFPAL
60 70 80 90 100
YTVVFLTGIL LNTLALWVFV HIPSSSTFII YLKNTLVADL IMTLMLPFKI
110 120 130 140 150
LSDSHLAPWQ LRAFVCRFSS VIFYETMYVG IVLLGLIAFD RFLKIIRPLR
160 170 180 190 200
NIFLKKPVFA KTVSIFIWFF LFFISLPNTI LSNKEATPSS VKKCASLKGP
210 220 230 240 250
LGLKWHQMVN NICQFIFWTV FILMLVFYVV IAKKVYDSYR KSKSKDRKNN
260 270 280 290 300
KKLEGKVFVV VAVFFVCFAP FHFARVPYTH SQTNNKTDCR LQNQLFIAKE
310 320 330 340 350
TTLFLAATNI CMDPLIYIFL CKKFTEKLPC MQGRKTTASS QENHSSQTDN

ITLG
Length:354
Mass (Da):40,789
Last modified:February 8, 2011 - v3
Checksum:iA2CE5F8ED84C4CAF
GO
Isoform 2 (identifier: Q9BPV8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Show »
Length:333
Mass (Da):38,410
Checksum:i3F88E7EAC8F5428F
GO

Sequence cautioni

The sequence AAH29363.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH41116.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG36024.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti179 – 1791T → M.8 Publications
Corresponds to variant rs1466684 [ dbSNP | Ensembl ].
VAR_028299

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2121Missing in isoform 2. 3 PublicationsVSP_036226Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411113 Genomic DNA. Translation: AAL26484.1.
AF406692 mRNA. Translation: AAL01038.1.
AF295368 mRNA. Translation: AAK01864.1.
AF345565 mRNA. Translation: AAK29068.1.
AB083597 Genomic DNA. Translation: BAB89310.1.
AK313208 mRNA. Translation: BAG36024.1. Different initiation.
AC024886 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78805.1.
BC029363 mRNA. Translation: AAH29363.1. Sequence problems.
BC041116 mRNA. Translation: AAH41116.2. Different initiation.
BC066887 mRNA. Translation: AAH66887.1.
AF178982 mRNA. Translation: AAK18752.1.
CCDSiCCDS3158.2. [Q9BPV8-1]
RefSeqiNP_795713.2. NM_176894.2. [Q9BPV8-1]
UniGeneiHs.546396.

Genome annotation databases

EnsembliENST00000325602; ENSP00000320376; ENSG00000181631. [Q9BPV8-1]
GeneIDi53829.
KEGGihsa:53829.
UCSCiuc003eyv.2. human. [Q9BPV8-1]

Polymorphism databases

DMDMi322510112.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411113 Genomic DNA. Translation: AAL26484.1.
AF406692 mRNA. Translation: AAL01038.1.
AF295368 mRNA. Translation: AAK01864.1.
AF345565 mRNA. Translation: AAK29068.1.
AB083597 Genomic DNA. Translation: BAB89310.1.
AK313208 mRNA. Translation: BAG36024.1. Different initiation.
AC024886 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78805.1.
BC029363 mRNA. Translation: AAH29363.1. Sequence problems.
BC041116 mRNA. Translation: AAH41116.2. Different initiation.
BC066887 mRNA. Translation: AAH66887.1.
AF178982 mRNA. Translation: AAK18752.1.
CCDSiCCDS3158.2. [Q9BPV8-1]
RefSeqiNP_795713.2. NM_176894.2. [Q9BPV8-1]
UniGeneiHs.546396.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B6Umodel-A22-354[»]
ProteinModelPortaliQ9BPV8.
SMRiQ9BPV8. Positions 36-324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000320376.

Chemistry

GuidetoPHARMACOLOGYi329.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9BPV8.

Polymorphism databases

DMDMi322510112.

Proteomic databases

PaxDbiQ9BPV8.
PRIDEiQ9BPV8.

Protocols and materials databases

DNASUi53829.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325602; ENSP00000320376; ENSG00000181631. [Q9BPV8-1]
GeneIDi53829.
KEGGihsa:53829.
UCSCiuc003eyv.2. human. [Q9BPV8-1]

Organism-specific databases

CTDi53829.
GeneCardsiGC03M151044.
H-InvDBHIX0200553.
HGNCiHGNC:4537. P2RY13.
HPAiHPA049047.
MIMi606380. gene.
neXtProtiNX_Q9BPV8.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG148143.
GeneTreeiENSGT00640000091213.
HOVERGENiHBG108228.
InParanoidiQ9BPV8.
KOiK08388.
OMAiFYVVIAK.
OrthoDBiEOG7JQBNQ.
PhylomeDBiQ9BPV8.
TreeFamiTF330969.

Enzyme and pathway databases

ReactomeiREACT_18289. P2Y receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiP2RY13.
GenomeRNAii53829.
NextBioi56152.
PROiQ9BPV8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BPV8.
CleanExiHS_P2RY13.
GenevestigatoriQ9BPV8.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
[Graphical view]
PANTHERiPTHR24233:SF7. PTHR24233:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Discovery and mapping of ten novel G protein-coupled receptor genes."
    Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
    Gene 275:83-91(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2), VARIANT MET-179.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, VARIANT MET-179.
    Tissue: Spleen.
  3. "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors."
    Wittenberger T., Schaller H.C., Hellebrand S.
    J. Mol. Biol. 307:799-813(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT MET-179.
    Tissue: Amygdala, Caudate nucleus, Fetal brain and Placenta.
  4. "Molecular cloning of FKSG77, a novel gene encoding a putative G-protein-coupled receptor."
    Wang Y.-G., Gong L.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT MET-179.
    Tissue: Heart.
  5. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-179.
  7. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-179.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-179.
    Tissue: Brain and Placenta.
  10. "Molecular cloning of a probable G protein-coupled receptor with three transmembrane domains."
    Zhang W., Wan T., Cao X.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 172-354, VARIANT MET-179.

Entry informationi

Entry nameiP2Y13_HUMAN
AccessioniPrimary (citable) accession number: Q9BPV8
Secondary accession number(s): B2R827
, Q05C50, Q6DKN4, Q8IUT5, Q8TDU7, Q9BY61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 8, 2011
Last modified: February 4, 2015
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Stimulation by ADP in stably transfected CHO cells resulted in inhibition of adenylyl cyclase and the phosphorylation of the MAP kinases MAPK3 and MAPK1 in a pertussis toxin-sensitive way. Inhibition of adenylyl cyclase and phosphorylation of the MAP kinases are transduction mechanisms that involve G(i) proteins.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.