Q9BPU9 (B9D2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
B9 domain-containing protein 2

Gene names

Name:

B9D2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May have a role in ciliogenesis By similarity.
Subunit structure	Interacts with TUBG1 By similarity.
Subcellular location	Cytoplasm › cytoskeleton › cilium basal body By similarity. Cytoplasm › cytoskeleton › cilium axoneme By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the B9D family. Contains 1 B9 domain.

Ontologies

Keywords
Biological process	Cilium biogenesis/degradation
Cellular component	Cell projection Cilium Cytoplasm Cytoskeleton Nucleus
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cilium assembly Inferred from sequence or structural similarity. Source: UniProtKB mitotic prometaphase Traceable author statement. Source: Reactome
Cellular component	centrosome Inferred from direct assay. Source: UniProtKB cilium axoneme Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Traceable author statement. Source: Reactome microtubule basal body Inferred from direct assay. Source: UniProtKB nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	gamma-tubulin binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 175	175	B9 domain-containing protein 2		PRO_0000307674
Regions
	Domain	2 – 118	117	B9
Natural variations
	Natural variant	11	1	I → M. Ref.2 Ref.3 Corresponds to variant rs2241714 [ dbSNP | Ensembl ].		VAR_036626

Sequences

	Sequence		Length	Mass (Da)
	Q9BPU9 [UniParc]. Last modified January 20, 2009. Version 2. Checksum: A8B8D1A637C3EF5D	FASTA	175	19,261
	10 20 30 40 50 60 MAEVHVIGQI IGASGFSESS LFCKWGIHTG AAWKLLSGVR EGQTQVDTPQ IGDMAYWSHP 70 80 90 100 110 120 IDLHFATKGL QGWPRLHFQV WSQDSFGRCQ LAGYGFCHVP SSPGTHQLAC PTWRPLGSWR 130 140 150 160 170 EQLARAFVGG GPQLLHGDTI YSGADRYRLH TAAGGTVHLE IGLLLRNFDR YGVEC

References

[1]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-11.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-11. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC011462 Genomic DNA. No translation available. CH471126 Genomic DNA. Translation: EAW57034.1. BC004157 mRNA. Translation: AAH04157.1. BC004444 mRNA. Translation: AAH04444.1.
IPI	IPI00012253.
RefSeq	NP_085055.2. NM_030578.3.
UniGene	Hs.567596.
3D structure databases
ProteinModelPortal	Q9BPU9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BPU9.
Polymorphism databases
DMDM	221222440.
Proteomic databases
PRIDE	Q9BPU9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000243578; ENSP00000243578; ENSG00000123810.
GeneID	80776.
KEGG	hsa:80776.
UCSC	uc002oqj.1. human.
Organism-specific databases
CTD	80776.
GeneCards	GC19M041860.
HGNC	HGNC:28636. B9D2.
HPA	HPA042229. HPA042618.
MIM	611951. gene.
neXtProt	NX_Q9BPU9.
PharmGKB	PA162377347.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19231.
GeneTree	ENSGT00530000063756.
HOGENOM	HBG526946.
HOVERGEN	HBG107102.
InParanoid	Q9BPU9.
OMA	GWPRLHL.
OrthoDB	EOG4W6NX1.
PhylomeDB	Q9BPU9.
Enzyme and pathway databases
Reactome	REACT_152. Cell Cycle, Mitotic. REACT_383. DNA Replication.
Gene expression databases
CleanEx	HS_B9D2.
Genevestigator	Q9BPU9.
Family and domain databases
InterPro	IPR010796. B9. [Graphical view]
Pfam	PF07162. B9. 1 hit. [Graphical view]
PROSITE	PS51381. B9. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	71175.
SOURCE	Search...

Entry information

Entry name

B9D2_HUMAN

Accession

Primary (citable) accession number: Q9BPU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	January 20, 2009
Last modified:	January 25, 2012
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.