Q9BPU6 (DPYL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydropyrimidinase-related protein 5
Short name=DRP-5

Alternative name(s):
CRMP3-associated molecule
Short name=CRAM
Collapsin response mediator protein 5
Short name=CRMP-5
UNC33-like phosphoprotein 6
Short name=ULIP-6

Gene names

Name:	DPYSL5
Synonyms:	CRMP5, ULIP6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	564 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have a function in neuronal differentiation and/or axon growth.
Subunit structure	Homotetramer, and heterotetramer with other DPYS-like proteins. Interacts with DPYSL2, DPYSL3 and DPYSL4 By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
Caution	Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement. Source: Reactome pyrimidine nucleobase catabolic process Inferred from electronic annotation. Source: InterPro signal transduction Traceable author statement PubMed 10851247. Source: ProtInc
Cellular_component	cytosol Traceable author statement. Source: Reactome dendrite Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara protein complex Inferred from electronic annotation. Source: Compara
Molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 564

564

Dihydropyrimidinase-related protein 5

PRO_0000165924

Experimental info

Sequence conflict

380

1

N → S in CAB95124. Ref.2

Sequence conflict

382

1

A → S in AAF80348. Ref.3

Sequence conflict

399

1

D → H in AAF80348. Ref.3

Secondary structure

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564

Helix Strand Turn

Details...

Beta strand

9 – 14

6

Beta strand

16 – 18

3

Beta strand

23 – 25

3

Beta strand

27 – 31

5

Beta strand

34 – 41

8

Beta strand

49 – 52

4

Beta strand

57 – 60

4

Beta strand

62 – 67

6

Helix

82 – 91

10

Beta strand

94 – 101

8

Helix

109 – 120

12

Turn

121 – 123

3

Beta strand

125 – 133

9

Helix

139 – 151

13

Beta strand

156 – 161

6

Turn

164 – 166

3

Helix

171 – 183

13

Beta strand

187 – 191

5

Helix

195 – 207

13

Helix

215 – 218

4

Helix

223 – 239

17

Beta strand

243 – 245

3

Helix

251 – 262

12

Beta strand

267 – 272

6

Helix

273 – 277

5

Helix

280 – 284

5

Helix

288 – 292

5

Helix

306 – 315

10

Beta strand

321 – 323

3

Helix

331 – 334

4

Helix

335 – 337

3

Helix

341 – 343

3

Turn

351 – 353

3

Helix

354 – 362

9

Turn

363 – 366

4

Helix

370 – 377

8

Helix

379 – 384

6

Turn

388 – 390

3

Beta strand

402 – 406

5

Helix

415 – 417

3

Beta strand

420 – 423

4

Turn

426 – 429

4

Beta strand

435 – 441

7

Beta strand

444 – 448

5

Helix

469 – 478

10

Sequences

	Sequence		Length	Mass (Da)
	Q9BPU6 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: FF9DD1D44C599928	FASTA	564	61,421
	10 20 30 40 50 60 MLANSASVRI LIKGGKVVND DCTHEADVYI ENGIIQQVGR ELMIPGGAKV IDATGKLVIP 70 80 90 100 110 120 GGIDTSTHFH QTFMNATCVD DFYHGTKAAL VGGTTMIIGH VLPDKETSLV DAYEKCRGLA 130 140 150 160 170 180 DPKVCCDYAL HVGITWWAPK VKAEMETLVR EKGVNSFQMF MTYKDLYMLR DSELYQVLHA 190 200 210 220 230 240 CKDIGAIARV HAENGELVAE GAKEALDLGI TGPEGIEISR PEELEAEATH RVITIANRTH 250 260 270 280 290 300 CPIYLVNVSS ISAGDVIAAA KMQGKVVLAE TTTAHATLTG LHYYHQDWSH AAAYVTVPPL 310 320 330 340 350 360 RLDTNTSTYL MSLLANDTLN IVASDHRPFT TKQKAMGKED FTKIPHGVSG VQDRMSVIWE 370 380 390 400 410 420 RGVVGGKMDE NRFVAVTSSN AAKLLNLYPR KGRIIPGADA DVVVWDPEAT KTISASTQVQ 430 440 450 460 470 480 GGDFNLYENM RCHGVPLVTI SRGRVVYENG VFMCAEGTGK FCPLRSFPDT VYKKLVQREK 490 500 510 520 530 540 TLKVRGVDRT PYLGDVAVVV HPGKKEMGTP LADTPTRPVT RHGGMRDLHE SSFSLSGSQI 550 560 DDHVPKRASA RILAPPGGRS SGIW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ulip6, a new human Unc-33-like phosphoprotein." Aguera M., Antoine J.-C., Belin M.-F., Charrier E., Honnorat J., Rogemond V. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Spinal cord.
[2]	"Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain." Horiuchi M., El Far O., Betz H. FEBS Lett. 480:283-286(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Spinal cord.
[3]	"CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity." Yu Z., Kryzer T.J., Griesmann G.E., Kim K., Benarroch E.E., Lennon V.A. Ann. Neurol. 49:146-154(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[6]	Lubec G., Afjehi-Sadat L., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 17-40; 204-231; 239-261; 373-383; 394-431; 490-504 AND 527-546, MASS SPECTROMETRY. Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 101-564. Tissue: Amygdala.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF264015 mRNA. Translation: AAK16830.1.
AJ251275 mRNA. Translation: CAB95124.1.
AF157634 mRNA. Translation: AAF80348.1.
BT006871 mRNA. Translation: AAP35517.1.
BC002874 mRNA. Translation: AAH02874.1.
AL713706 mRNA. Translation: CAD28503.1.

IPI

IPI00335509.

RefSeq

NP_001240652.1. NM_001253723.1.
NP_001240653.1. NM_001253724.1.
NP_064519.2. NM_020134.3.

UniGene

Hs.299315.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4B90	X-ray	2.20	A/B	1-564	[»]
4B91	X-ray	1.70	A/B	1-483	[»]
4B92	X-ray	2.90	A/B	1-483	[»]

ProteinModelPortal

Q9BPU6.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9BPU6. 3 interactions.

MINT

MINT-1401135.

STRING

9606.ENSP00000288699.

Protein family/group databases

MEROPS

M38.978.

PTM databases

PhosphoSite

Q9BPU6.

Polymorphism databases

DMDM

20137929.

2D gel databases

UCD-2DPAGE

Q9BPU6.

Proteomic databases

PaxDb

Q9BPU6.

PRIDE

Q9BPU6.

Protocols and materials databases

DNASU

56896.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000288699; ENSP00000288699; ENSG00000157851.
ENST00000401478; ENSP00000385549; ENSG00000157851.

GeneID

56896.

KEGG

hsa:56896.

UCSC

uc002rhu.4. human.

Organism-specific databases

CTD

56896.

GeneCards

GC02P027070.

HGNC

HGNC:20637. DPYSL5.

HPA

HPA034544.

MIM

608383. gene.

neXtProt

NX_Q9BPU6.

PharmGKB

PA134927413.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0044.

HOGENOM

HOG000219145.

HOVERGEN

HBG000806.

InParanoid

Q9BPU6.

KO

K07529.

OMA

FAMANTS.

OrthoDB

EOG4DNF42.

PhylomeDB

Q9BPU6.

Enzyme and pathway databases

Reactome

REACT_111045. Developmental Biology.

Gene expression databases

ArrayExpress

Q9BPU6.

Bgee

Q9BPU6.

CleanEx

HS_DPYSL5.

Genevestigator

Q9BPU6.

GermOnline

ENSG00000157851. Homo sapiens.

Family and domain databases

InterPro

IPR006680. Amidohydro_1.
IPR011778. Hydantoinase/dihydroPyrase.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]

Pfam

PF01979. Amidohydro_1. 1 hit.
[Graphical view]

SUPFAM

SSF51338. Metalo_hydrolase. 2 hits.

TIGRFAMs

TIGR02033. D-hydantoinase. 1 hit.

ProtoNet

Search...

Other

ChiTaRS

DPYSL5. human.

GenomeRNAi

56896.

NextBio

62329.

SOURCE

Search...

Entry information

Entry name

DPYL5_HUMAN

Accession

Primary (citable) accession number: Q9BPU6
Secondary accession number(s): Q8TCL6, Q9NQC4, Q9NRY9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.