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Q9BPU6

- DPYL5_HUMAN

UniProt

Q9BPU6 - DPYL5_HUMAN

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Protein

Dihydropyrimidinase-related protein 5

Gene

DPYSL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May have a function in neuronal differentiation and/or axon growth.

GO - Molecular functioni

  1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Source: InterPro

GO - Biological processi

  1. axon guidance Source: Reactome
  2. nervous system development Source: ProtInc
  3. pyrimidine nucleobase catabolic process Source: InterPro
  4. signal transduction Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_19199. CRMPs in Sema3A signaling.

Protein family/group databases

MEROPSiM38.978.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidinase-related protein 5
Short name:
DRP-5
Alternative name(s):
CRMP3-associated molecule
Short name:
CRAM
Collapsin response mediator protein 5
Short name:
CRMP-5
UNC33-like phosphoprotein 6
Short name:
ULIP-6
Gene namesi
Name:DPYSL5
Synonyms:CRMP5, ULIP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:20637. DPYSL5.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. dendrite Source: Ensembl
  3. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134927413.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Dihydropyrimidinase-related protein 5PRO_0000165924Add
BLAST

Proteomic databases

MaxQBiQ9BPU6.
PaxDbiQ9BPU6.
PRIDEiQ9BPU6.

2D gel databases

UCD-2DPAGEQ9BPU6.

PTM databases

PhosphoSiteiQ9BPU6.

Expressioni

Gene expression databases

BgeeiQ9BPU6.
CleanExiHS_DPYSL5.
ExpressionAtlasiQ9BPU6. baseline and differential.
GenevestigatoriQ9BPU6.

Organism-specific databases

HPAiHPA034544.

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with other DPYS-like proteins. Interacts with DPYSL2, DPYSL3 and DPYSL4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi121226. 12 interactions.
IntActiQ9BPU6. 3 interactions.
MINTiMINT-1401135.
STRINGi9606.ENSP00000288699.

Structurei

Secondary structure

1
564
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 146
Beta strandi16 – 183
Beta strandi23 – 253
Beta strandi27 – 315
Beta strandi34 – 418
Beta strandi49 – 524
Beta strandi57 – 604
Beta strandi62 – 676
Helixi82 – 9110
Beta strandi94 – 1018
Helixi109 – 12012
Turni121 – 1233
Beta strandi125 – 1339
Helixi139 – 15113
Beta strandi156 – 1616
Turni164 – 1663
Helixi171 – 18313
Beta strandi187 – 1915
Helixi195 – 20713
Helixi215 – 2184
Helixi223 – 23917
Beta strandi243 – 2453
Helixi251 – 26212
Beta strandi267 – 2726
Helixi273 – 2775
Helixi280 – 2845
Helixi288 – 2925
Helixi306 – 31510
Beta strandi321 – 3233
Helixi331 – 3344
Helixi335 – 3373
Helixi341 – 3433
Turni351 – 3533
Helixi354 – 3629
Turni363 – 3664
Helixi370 – 3778
Helixi379 – 3846
Turni388 – 3903
Beta strandi402 – 4065
Helixi415 – 4173
Beta strandi420 – 4234
Turni426 – 4294
Beta strandi435 – 4417
Beta strandi444 – 4485
Helixi469 – 47810

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4B90X-ray2.20A/B1-564[»]
4B91X-ray1.70A/B1-483[»]
4B92X-ray2.90A/B1-483[»]
ProteinModelPortaliQ9BPU6.
SMRiQ9BPU6. Positions 8-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0044.
GeneTreeiENSGT00760000119241.
HOGENOMiHOG000219145.
HOVERGENiHBG000806.
InParanoidiQ9BPU6.
KOiK07529.
OMAiCRGLADP.
OrthoDBiEOG7SJD48.
PhylomeDBiQ9BPU6.
TreeFamiTF314706.

Family and domain databases

Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro_1.
IPR011778. Hydantoinase/dihydroPyrase.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR02033. D-hydantoinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BPU6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLANSASVRI LIKGGKVVND DCTHEADVYI ENGIIQQVGR ELMIPGGAKV
60 70 80 90 100
IDATGKLVIP GGIDTSTHFH QTFMNATCVD DFYHGTKAAL VGGTTMIIGH
110 120 130 140 150
VLPDKETSLV DAYEKCRGLA DPKVCCDYAL HVGITWWAPK VKAEMETLVR
160 170 180 190 200
EKGVNSFQMF MTYKDLYMLR DSELYQVLHA CKDIGAIARV HAENGELVAE
210 220 230 240 250
GAKEALDLGI TGPEGIEISR PEELEAEATH RVITIANRTH CPIYLVNVSS
260 270 280 290 300
ISAGDVIAAA KMQGKVVLAE TTTAHATLTG LHYYHQDWSH AAAYVTVPPL
310 320 330 340 350
RLDTNTSTYL MSLLANDTLN IVASDHRPFT TKQKAMGKED FTKIPHGVSG
360 370 380 390 400
VQDRMSVIWE RGVVGGKMDE NRFVAVTSSN AAKLLNLYPR KGRIIPGADA
410 420 430 440 450
DVVVWDPEAT KTISASTQVQ GGDFNLYENM RCHGVPLVTI SRGRVVYENG
460 470 480 490 500
VFMCAEGTGK FCPLRSFPDT VYKKLVQREK TLKVRGVDRT PYLGDVAVVV
510 520 530 540 550
HPGKKEMGTP LADTPTRPVT RHGGMRDLHE SSFSLSGSQI DDHVPKRASA
560
RILAPPGGRS SGIW
Length:564
Mass (Da):61,421
Last modified:June 1, 2001 - v1
Checksum:iFF9DD1D44C599928
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti380 – 3801N → S in CAB95124. (PubMed:11034345)Curated
Sequence conflicti382 – 3821A → S in AAF80348. (PubMed:11220734)Curated
Sequence conflicti399 – 3991D → H in AAF80348. (PubMed:11220734)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF264015 mRNA. Translation: AAK16830.1.
AJ251275 mRNA. Translation: CAB95124.1.
AF157634 mRNA. Translation: AAF80348.1.
BT006871 mRNA. Translation: AAP35517.1.
BC002874 mRNA. Translation: AAH02874.1.
AL713706 mRNA. Translation: CAD28503.1.
CCDSiCCDS1730.1.
RefSeqiNP_001240652.1. NM_001253723.1.
NP_001240653.1. NM_001253724.1.
NP_064519.2. NM_020134.3.
UniGeneiHs.299315.

Genome annotation databases

EnsembliENST00000288699; ENSP00000288699; ENSG00000157851.
ENST00000401478; ENSP00000385549; ENSG00000157851.
ENST00000614712; ENSP00000481305; ENSG00000157851.
GeneIDi56896.
KEGGihsa:56896.
UCSCiuc002rhu.4. human.

Polymorphism databases

DMDMi20137929.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF264015 mRNA. Translation: AAK16830.1 .
AJ251275 mRNA. Translation: CAB95124.1 .
AF157634 mRNA. Translation: AAF80348.1 .
BT006871 mRNA. Translation: AAP35517.1 .
BC002874 mRNA. Translation: AAH02874.1 .
AL713706 mRNA. Translation: CAD28503.1 .
CCDSi CCDS1730.1.
RefSeqi NP_001240652.1. NM_001253723.1.
NP_001240653.1. NM_001253724.1.
NP_064519.2. NM_020134.3.
UniGenei Hs.299315.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4B90 X-ray 2.20 A/B 1-564 [» ]
4B91 X-ray 1.70 A/B 1-483 [» ]
4B92 X-ray 2.90 A/B 1-483 [» ]
ProteinModelPortali Q9BPU6.
SMRi Q9BPU6. Positions 8-492.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121226. 12 interactions.
IntActi Q9BPU6. 3 interactions.
MINTi MINT-1401135.
STRINGi 9606.ENSP00000288699.

Protein family/group databases

MEROPSi M38.978.

PTM databases

PhosphoSitei Q9BPU6.

Polymorphism databases

DMDMi 20137929.

2D gel databases

UCD-2DPAGE Q9BPU6.

Proteomic databases

MaxQBi Q9BPU6.
PaxDbi Q9BPU6.
PRIDEi Q9BPU6.

Protocols and materials databases

DNASUi 56896.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000288699 ; ENSP00000288699 ; ENSG00000157851 .
ENST00000401478 ; ENSP00000385549 ; ENSG00000157851 .
ENST00000614712 ; ENSP00000481305 ; ENSG00000157851 .
GeneIDi 56896.
KEGGi hsa:56896.
UCSCi uc002rhu.4. human.

Organism-specific databases

CTDi 56896.
GeneCardsi GC02P027070.
HGNCi HGNC:20637. DPYSL5.
HPAi HPA034544.
MIMi 608383. gene.
neXtProti NX_Q9BPU6.
PharmGKBi PA134927413.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0044.
GeneTreei ENSGT00760000119241.
HOGENOMi HOG000219145.
HOVERGENi HBG000806.
InParanoidi Q9BPU6.
KOi K07529.
OMAi CRGLADP.
OrthoDBi EOG7SJD48.
PhylomeDBi Q9BPU6.
TreeFami TF314706.

Enzyme and pathway databases

Reactomei REACT_19199. CRMPs in Sema3A signaling.

Miscellaneous databases

ChiTaRSi DPYSL5. human.
GeneWikii DPYSL5.
GenomeRNAii 56896.
NextBioi 62329.
PROi Q9BPU6.
SOURCEi Search...

Gene expression databases

Bgeei Q9BPU6.
CleanExi HS_DPYSL5.
ExpressionAtlasi Q9BPU6. baseline and differential.
Genevestigatori Q9BPU6.

Family and domain databases

Gene3Di 2.30.40.10. 2 hits.
InterProi IPR006680. Amidohydro_1.
IPR011778. Hydantoinase/dihydroPyrase.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view ]
Pfami PF01979. Amidohydro_1. 1 hit.
[Graphical view ]
SUPFAMi SSF51338. SSF51338. 2 hits.
TIGRFAMsi TIGR02033. D-hydantoinase. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Ulip6, a new human Unc-33-like phosphoprotein."
    Aguera M., Antoine J.-C., Belin M.-F., Charrier E., Honnorat J., Rogemond V.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spinal cord.
  2. "Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain."
    Horiuchi M., El Far O., Betz H.
    FEBS Lett. 480:283-286(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spinal cord.
  3. "CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity."
    Yu Z., Kryzer T.J., Griesmann G.E., Kim K., Benarroch E.E., Lennon V.A.
    Ann. Neurol. 49:146-154(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. Lubec G., Afjehi-Sadat L., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 17-40; 204-231; 239-261; 373-383; 394-431; 490-504 AND 527-546, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 101-564.
    Tissue: Amygdala.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDPYL5_HUMAN
AccessioniPrimary (citable) accession number: Q9BPU6
Secondary accession number(s): Q8TCL6, Q9NQC4, Q9NRY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3