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Q9BPU6 (DPYL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydropyrimidinase-related protein 5

Short name=DRP-5
Alternative name(s):
CRMP3-associated molecule
Short name=CRAM
Collapsin response mediator protein 5
Short name=CRMP-5
UNC33-like phosphoprotein 6
Short name=ULIP-6
Gene names
Name:DPYSL5
Synonyms:CRMP5, ULIP6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length564 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May have a function in neuronal differentiation and/or axon growth.

Subunit structure

Homotetramer, and heterotetramer with other DPYS-like proteins. Interacts with DPYSL2, DPYSL3 and DPYSL4 By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.

Caution

Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 564564Dihydropyrimidinase-related protein 5
PRO_0000165924

Experimental info

Sequence conflict3801N → S in CAB95124. Ref.2
Sequence conflict3821A → S in AAF80348. Ref.3
Sequence conflict3991D → H in AAF80348. Ref.3

Secondary structure

...................................................................................... 564
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9BPU6 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: FF9DD1D44C599928

FASTA56461,421
        10         20         30         40         50         60 
MLANSASVRI LIKGGKVVND DCTHEADVYI ENGIIQQVGR ELMIPGGAKV IDATGKLVIP 

        70         80         90        100        110        120 
GGIDTSTHFH QTFMNATCVD DFYHGTKAAL VGGTTMIIGH VLPDKETSLV DAYEKCRGLA 

       130        140        150        160        170        180 
DPKVCCDYAL HVGITWWAPK VKAEMETLVR EKGVNSFQMF MTYKDLYMLR DSELYQVLHA 

       190        200        210        220        230        240 
CKDIGAIARV HAENGELVAE GAKEALDLGI TGPEGIEISR PEELEAEATH RVITIANRTH 

       250        260        270        280        290        300 
CPIYLVNVSS ISAGDVIAAA KMQGKVVLAE TTTAHATLTG LHYYHQDWSH AAAYVTVPPL 

       310        320        330        340        350        360 
RLDTNTSTYL MSLLANDTLN IVASDHRPFT TKQKAMGKED FTKIPHGVSG VQDRMSVIWE 

       370        380        390        400        410        420 
RGVVGGKMDE NRFVAVTSSN AAKLLNLYPR KGRIIPGADA DVVVWDPEAT KTISASTQVQ 

       430        440        450        460        470        480 
GGDFNLYENM RCHGVPLVTI SRGRVVYENG VFMCAEGTGK FCPLRSFPDT VYKKLVQREK 

       490        500        510        520        530        540 
TLKVRGVDRT PYLGDVAVVV HPGKKEMGTP LADTPTRPVT RHGGMRDLHE SSFSLSGSQI 

       550        560 
DDHVPKRASA RILAPPGGRS SGIW 

« Hide

References

« Hide 'large scale' references
[1]"Ulip6, a new human Unc-33-like phosphoprotein."
Aguera M., Antoine J.-C., Belin M.-F., Charrier E., Honnorat J., Rogemond V.
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spinal cord.
[2]"Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain."
Horiuchi M., El Far O., Betz H.
FEBS Lett. 480:283-286(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spinal cord.
[3]"CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity."
Yu Z., Kryzer T.J., Griesmann G.E., Kim K., Benarroch E.E., Lennon V.A.
Ann. Neurol. 49:146-154(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[6]Lubec G., Afjehi-Sadat L., Chen W.-Q., Sun Y.
Submitted (DEC-2008) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 17-40; 204-231; 239-261; 373-383; 394-431; 490-504 AND 527-546, MASS SPECTROMETRY.
Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
[7]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 101-564.
Tissue: Amygdala.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF264015 mRNA. Translation: AAK16830.1.
AJ251275 mRNA. Translation: CAB95124.1.
AF157634 mRNA. Translation: AAF80348.1.
BT006871 mRNA. Translation: AAP35517.1.
BC002874 mRNA. Translation: AAH02874.1.
AL713706 mRNA. Translation: CAD28503.1.
RefSeqNP_001240652.1. NM_001253723.1.
NP_001240653.1. NM_001253724.1.
NP_064519.2. NM_020134.3.
UniGeneHs.299315.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4B90X-ray2.20A/B1-564[»]
4B91X-ray1.70A/B1-483[»]
4B92X-ray2.90A/B1-483[»]
ProteinModelPortalQ9BPU6.
SMRQ9BPU6. Positions 8-492.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121226. 5 interactions.
IntActQ9BPU6. 3 interactions.
MINTMINT-1401135.
STRING9606.ENSP00000288699.

Protein family/group databases

MEROPSM38.978.

PTM databases

PhosphoSiteQ9BPU6.

Polymorphism databases

DMDM20137929.

2D gel databases

UCD-2DPAGEQ9BPU6.

Proteomic databases

PaxDbQ9BPU6.
PRIDEQ9BPU6.

Protocols and materials databases

DNASU56896.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000288699; ENSP00000288699; ENSG00000157851.
ENST00000401478; ENSP00000385549; ENSG00000157851.
GeneID56896.
KEGGhsa:56896.
UCSCuc002rhu.4. human.

Organism-specific databases

CTD56896.
GeneCardsGC02P027070.
HGNCHGNC:20637. DPYSL5.
HPAHPA034544.
MIM608383. gene.
neXtProtNX_Q9BPU6.
PharmGKBPA134927413.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0044.
HOGENOMHOG000219145.
HOVERGENHBG000806.
InParanoidQ9BPU6.
KOK07529.
OMAAIMLTHV.
OrthoDBEOG7SJD48.
PhylomeDBQ9BPU6.
TreeFamTF314706.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.

Gene expression databases

ArrayExpressQ9BPU6.
BgeeQ9BPU6.
CleanExHS_DPYSL5.
GenevestigatorQ9BPU6.

Family and domain databases

InterProIPR006680. Amidohydro_1.
IPR011778. Hydantoinase/dihydroPyrase.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMSSF51338. SSF51338. 2 hits.
TIGRFAMsTIGR02033. D-hydantoinase. 1 hit.
ProtoNetSearch...

Other

ChiTaRSDPYSL5. human.
GeneWikiDPYSL5.
GenomeRNAi56896.
NextBio62329.
PROQ9BPU6.
SOURCESearch...

Entry information

Entry nameDPYL5_HUMAN
AccessionPrimary (citable) accession number: Q9BPU6
Secondary accession number(s): Q8TCL6, Q9NQC4, Q9NRY9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM