Q9BPF3 (CT121_CONPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Conotoxin Pn-B01121
Organism	Conus pennaceus (Feathered cone) (Conus episcopus)
Taxonomic identifier	37335 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Hypsogastropoda › Neogastropoda › Conoidea › Conidae › Conus

Protein attributes

Sequence length	64 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted By similarity.
Tissue specificity	Expressed by the venom duct.
Domain	The cysteine framework is V (CC-CC).
Sequence similarities	Belongs to the conotoxin T superfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Toxin
PTM	Amidation Cleavage on pair of basic residues Disulfide bond
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ion channel inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Propeptide	23 – 48	26	By similarity		PRO_0000274080
	Peptide	51 – 63	13	Conotoxin Pn-B01121		PRO_0000274081
Amino acid modifications
	Modified residue	63	1	Tryptophan amide By similarity
	Disulfide bond	52 ↔ 59		By similarity
	Disulfide bond	53 ↔ 60		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9BPF3 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 5E5A04C6B6ADDF88	FASTA	64	7,146
	10 20 30 40 50 60 MCCLPVFVIL LLLIASAPSV DALPKTKDDM SLASFHDNAK RTLQILSNKR YCCVYDYSCC LSWG

References

[1]	"Mechanisms for evolving hypervariability: the case of conopeptides." Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M. Mol. Biol. Evol. 18:120-131(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Venom duct.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF214976 mRNA. Translation: AAG60404.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
ConoServer	663. Pn-B01121 precursor.
Family and domain databases
InterPro	IPR004214. Conotoxin. [Graphical view]
Pfam	PF02950. Conotoxin. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CT121_CONPE

Accession

Primary (citable) accession number: Q9BPF3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program