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Q9BPC4 (O266B_CONVE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Conotoxin VnMEKL-0111
OrganismConus ventricosus (Mediterranean cone)
Taxonomic identifier117992 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Protein attributes

Sequence length76 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted By similarity.

Tissue specificity

Expressed by the venom duct.

Domain

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity.

The cysteine framework is VI/VII (C-C-CC-C-C).

Sequence similarities

Belongs to the conotoxin O2 superfamily.

Ontologies

Keywords
   Cellular componentSecreted
   DomainKnottin
Signal
   Molecular functionNeurotoxin
Toxin
   PTMDisulfide bond
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionion channel inhibitor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 4527 By similarity
PRO_0000404820
Peptide46 – 7631Conotoxin VnMEKL-0111
PRO_0000404821

Amino acid modifications

Disulfide bond49 ↔ 65 By similarity
Disulfide bond56 ↔ 70 By similarity
Disulfide bond64 ↔ 74 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9BPC4 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: CBD1381A05B64D82

FASTA768,534
        10         20         30         40         50         60 
MKLTILFLVA AVLMSTQALI QHDGEKSQKA KMKFLTARTL SAKTRGVDCV GLSSYCGPWN 

        70 
NPPCCSWYTC DYYCKF 

« Hide

References

[1]"Mechanisms for evolving hypervariability: the case of conopeptides."
Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M.
Mol. Biol. Evol. 18:120-131(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Venom duct.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF215010 mRNA. Translation: AAG60438.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ConoServer697. Vn6.6 precursor.

Family and domain databases

InterProIPR004214. Conotoxin.
[Graphical view]
PfamPF02950. Conotoxin. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameO266B_CONVE
AccessionPrimary (citable) accession number: Q9BPC4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: June 1, 2001
Last modified: April 3, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families