Q9BPC4 (O266B_CONVE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Conotoxin VnMEKL-0111
Organism	Conus ventricosus (Mediterranean cone)
Taxonomic identifier	117992 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Hypsogastropoda › Neogastropoda › Conoidea › Conidae › Conus

Protein attributes

Sequence length	76 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted By similarity.
Tissue specificity	Expressed by the venom duct.
Domain	The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity. The cysteine framework is VI/VII (C-C-CC-C-C).
Sequence similarities	Belongs to the conotoxin O2 superfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Knottin Signal
Molecular function	Neurotoxin Toxin
PTM	Disulfide bond
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ion channel inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 45	27	By similarity		PRO_0000404820
	Peptide	46 – 76	31	Conotoxin VnMEKL-0111		PRO_0000404821
Amino acid modifications
	Disulfide bond	49 ↔ 65		By similarity
	Disulfide bond	56 ↔ 70		By similarity
	Disulfide bond	64 ↔ 74		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9BPC4 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: CBD1381A05B64D82	FASTA	76	8,534
	10 20 30 40 50 60 MKLTILFLVA AVLMSTQALI QHDGEKSQKA KMKFLTARTL SAKTRGVDCV GLSSYCGPWN 70 NPPCCSWYTC DYYCKF

References

[1]	"Mechanisms for evolving hypervariability: the case of conopeptides." Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M. Mol. Biol. Evol. 18:120-131(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Venom duct.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF215010 mRNA. Translation: AAG60438.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
ConoServer	697. Vn6.6 precursor.
Family and domain databases
InterPro	IPR004214. Conotoxin. [Graphical view]
Pfam	PF02950. Conotoxin. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O266B_CONVE

Accession

Primary (citable) accession number: Q9BPC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 8, 2011
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program