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Protein

Conotoxin VnMEKL-0111

Gene
N/A
Organism
Conus ventricosus (Mediterranean cone)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin VnMEKL-0111
OrganismiConus ventricosus (Mediterranean cone)
Taxonomic identifieri117992 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri697. Vn6.6 precursor.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 4527By similarityPRO_0000404820Add
BLAST
Peptidei46 – 7631Conotoxin VnMEKL-0111PRO_0000404821Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 65By similarity
Disulfide bondi56 ↔ 70By similarity
Disulfide bondi64 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
The cysteine framework is VI/VII (C-C-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin O2 superfamily.Curated

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiIPR004214. Conotoxin.
[Graphical view]
PfamiPF02950. Conotoxin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BPC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTILFLVA AVLMSTQALI QHDGEKSQKA KMKFLTARTL SAKTRGVDCV
60 70
GLSSYCGPWN NPPCCSWYTC DYYCKF
Length:76
Mass (Da):8,534
Last modified:June 1, 2001 - v1
Checksum:iCBD1381A05B64D82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215010 mRNA. Translation: AAG60438.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215010 mRNA. Translation: AAG60438.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri697. Vn6.6 precursor.

Family and domain databases

InterProiIPR004214. Conotoxin.
[Graphical view]
PfamiPF02950. Conotoxin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mechanisms for evolving hypervariability: the case of conopeptides."
    Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M.
    Mol. Biol. Evol. 18:120-131(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom duct.

Entry informationi

Entry nameiO266B_CONVE
AccessioniPrimary (citable) accession number: Q9BPC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: June 1, 2001
Last modified: January 7, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.