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Q9BPC4

- O266B_CONVE

UniProt

Q9BPC4 - O266B_CONVE

Protein

Conotoxin VnMEKL-0111

Gene
N/A
Organism
Conus ventricosus (Mediterranean cone)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. ion channel inhibitor activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Neurotoxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Conotoxin VnMEKL-0111
    OrganismiConus ventricosus (Mediterranean cone)
    Taxonomic identifieri117992 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

    Organism-specific databases

    ConoServeri697. Vn6.6 precursor.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 4527By similarityPRO_0000404820Add
    BLAST
    Peptidei46 – 7631Conotoxin VnMEKL-0111PRO_0000404821Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 65By similarity
    Disulfide bondi56 ↔ 70By similarity
    Disulfide bondi64 ↔ 74By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom duct.

    Family & Domainsi

    Domaini

    The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
    The cysteine framework is VI/VII (C-C-CC-C-C).

    Sequence similaritiesi

    Belongs to the conotoxin O2 superfamily.Curated

    Keywords - Domaini

    Knottin, Signal

    Family and domain databases

    InterProiIPR004214. Conotoxin.
    [Graphical view]
    PfamiPF02950. Conotoxin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BPC4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLTILFLVA AVLMSTQALI QHDGEKSQKA KMKFLTARTL SAKTRGVDCV   50
    GLSSYCGPWN NPPCCSWYTC DYYCKF 76
    Length:76
    Mass (Da):8,534
    Last modified:June 1, 2001 - v1
    Checksum:iCBD1381A05B64D82
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF215010 mRNA. Translation: AAG60438.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF215010 mRNA. Translation: AAG60438.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ConoServeri 697. Vn6.6 precursor.

    Family and domain databases

    InterProi IPR004214. Conotoxin.
    [Graphical view ]
    Pfami PF02950. Conotoxin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mechanisms for evolving hypervariability: the case of conopeptides."
      Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M.
      Mol. Biol. Evol. 18:120-131(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Venom duct.

    Entry informationi

    Entry nameiO266B_CONVE
    AccessioniPrimary (citable) accession number: Q9BPC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 8, 2011
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3