Q9BP62 (O3619_CONVE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Conotoxin VnMSGL-0121
Organism	Conus ventricosus (Mediterranean cone)
Taxonomic identifier	117992 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Hypsogastropoda › Neogastropoda › Conoidea › Conidae › Conus

Protein attributes

Sequence length	80 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted By similarity.
Tissue specificity	Expressed by the venom duct.
Domain	The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity. The cysteine framework is VI/VII (C-C-CC-C-C).
Sequence similarities	Belongs to the conotoxin O3 superfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Knottin Signal
Molecular function	Neurotoxin Toxin
PTM	Amidation Cleavage on pair of basic residues Disulfide bond
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ion channel inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Propeptide	21 – 44	24	By similarity		PRO_0000404838
	Peptide	47 – 79	33	Conotoxin VnMSGL-0121		PRO_0000404839
Amino acid modifications
	Modified residue	79	1	Phenylalanine amide By similarity
	Disulfide bond	52 ↔ 65		By similarity
	Disulfide bond	56 ↔ 74		By similarity
	Disulfide bond	64 ↔ 78		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9BP62 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 7B88E6C830121BEB	FASTA	80	8,812
	10 20 30 40 50 60 MSGLGIMVLT LLLLVSMATS HQDGGGKQAT QRDAINVRRR RSITRRVVTE ACEEYCEDRD 70 80 KKTCCGLENG EPFCATLCFG

References

[1]	"Mechanisms for evolving hypervariability: the case of conopeptides." Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M. Mol. Biol. Evol. 18:120-131(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Venom duct.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF215076 mRNA. Translation: AAG60504.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
ConoServer	763. Vn6.19 precursor.
Family and domain databases
InterPro	IPR004214. Conotoxin. [Graphical view]
Pfam	PF02950. Conotoxin. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O3619_CONVE

Accession

Primary (citable) accession number: Q9BP62

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 8, 2011
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program