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Q9BN21

- CLE1_HETGL

UniProt

Q9BN21 - CLE1_HETGL

Protein

CLAVATA3/ESR (CLE)-related protein 1

Gene

CLE1

Organism
Heterodera glycines (Soybean cyst nematode worm)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Mimics host plant CLE extracellular signal peptides that regulate cell fate. May play a role in the differentiation or division of feeding cells (syncytia) induced in plant roots during infection By similarity.By similarity

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW

    Keywords - Biological processi

    Differentiation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CLAVATA3/ESR (CLE)-related protein 1
    Short name:
    CLE-like peptide 1
    Short name:
    Hg-SYV46
    Alternative name(s):
    Esophageal gland cell secretory protein 1
    Gene namesi
    Name:CLE1
    Synonyms:2B10, HSP1, SYV46
    OrganismiHeterodera glycines (Soybean cyst nematode worm)
    Taxonomic identifieri51029 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaTylenchidaTylenchinaTylenchoideaHeteroderidaeHeteroderinaeHeterodera

    Subcellular locationi

    Secreted. Host cytoplasm. Host extracellular space. Secretedextracellular spaceapoplast
    Note: Present in secretory granules within the dorsal esophageal gland secretory cell and in the dorsal gland ampulla (collecting reservoir) at the base of the nematode stylet. Secreted into host root cells via the nematode stylet to transform the recipient cells into enlarged multinucleate feeding cells called giant-cells or syncytia. Secreted to the host apoplasm from its cytoplasm via a plant secretory pathway.

    GO - Cellular componenti

    1. apoplast Source: UniProtKB-KW
    2. extracellular space of host Source: UniProtKB-SubCell
    3. host cell cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Apoplast, Host cytoplasm, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 139117CLAVATA3/ESR (CLE)-related protein 1PRO_0000401215Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    Highly expressed exclusively within the dorsal esophageal gland cell during syncytium formation in host plants (at protein level).4 Publications

    Developmental stagei

    Strongly up-regulated during root colonization, from the onset of syncytium formation by parasitic second-stage juveniles (pJ2) through the J3?J4 molts of sedentary life stages that become adult females.1 Publication

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni23 – 9068Required for secretion from the host cytoplasm to the host apoplasmAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili100 – 12526Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi128 – 13912CLEAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi92 – 965Poly-Pro

    Sequence similaritiesi

    Belongs to the CLV3/ESR signal peptide family.Curated

    Keywords - Domaini

    Coiled coil, Signal

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BN21-1 [UniParc]FASTAAdd to Basket

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    MPNIFKILLI VLLAVVSFRL SASTGDKKTA NDGSGNNSSA GIGTKIKRIV    50
    TAGLLFTSLA TGGAEAIGRS NAQGGNAAGL VPSHLTNRSM APPPPPAQFE 100
    KGAATRVEKM RAQLRELAEK MTDKDPKRLS PSGPDPHHH 139
    Length:139
    Mass (Da):14,504
    Last modified:June 1, 2001 - v1
    Checksum:iB29F9676CA3A73BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF273728 mRNA. Translation: AAG21331.2.
    FJ503004 Genomic DNA. Translation: ACT32609.1.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    the root of the problem - Issue 151 of July 2013

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF273728 mRNA. Translation: AAG21331.2 .
    FJ503004 Genomic DNA. Translation: ACT32609.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Signal peptide-selection of cDNA cloned directly from the esophageal gland cells of the soybean cyst nematode Heterodera glycines."
      Wang X., Allen R., Ding X., Goellner M., Maier T., de Boer J.M., Baum T.J., Hussey R.S., Davis E.L.
      Mol. Plant Microbe Interact. 14:536-544(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Esophagus and Gland.
    2. "Dual roles for the variable domain in protein trafficking and host-specific recognition of Heterodera glycines CLE effector proteins."
      Wang J., Lee C., Replogle A., Joshi S., Korkin D., Hussey R., Baum T.J., Davis E.L., Wang X., Mitchum M.G.
      New Phytol. 187:1003-1017(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
    3. Cited for: TISSUE SPECIFICITY.
      Tissue: Gland.
    4. "A parasitism gene from a plant-parasitic nematode with function similar to CLAVATA3/ESR (CLE) of Arabidopsis thaliana."
      Wang X., Mitchum M.G., Gao B., Li C., Diab H., Baum T.J., Hussey R.S., Davis E.L.
      Mol. Plant Pathol. 6:187-191(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    5. Cited for: REVIEW.

    Entry informationi

    Entry nameiCLE1_HETGL
    AccessioniPrimary (citable) accession number: Q9BN21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 30, 2010
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    Failed to trigger CLE-like cell fate regulation in Arabidopsis thaliana, a non-host plant.

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3