Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CLAVATA3/ESR (CLE)-related protein 1

Gene

CLE1

Organism
Heterodera glycines (Soybean cyst nematode worm)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mimics host plant CLE extracellular signal peptides that regulate cell fate. May play a role in the differentiation or division of feeding cells (syncytia) induced in plant roots during infection (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
CLAVATA3/ESR (CLE)-related protein 1
Short name:
CLE-like peptide 1
Short name:
Hg-SYV46
Alternative name(s):
Esophageal gland cell secretory protein 1
Gene namesi
Name:CLE1
Synonyms:2B10, HSP1, SYV46
OrganismiHeterodera glycines (Soybean cyst nematode worm)
Taxonomic identifieri51029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaTylenchidaTylenchinaTylenchoideaHeteroderidaeHeteroderinaeHeterodera

Subcellular locationi

  • Secreted
  • Host cytoplasm
  • Host extracellular space
  • Secretedextracellular spaceapoplast

  • Note: Present in secretory granules within the dorsal esophageal gland secretory cell and in the dorsal gland ampulla (collecting reservoir) at the base of the nematode stylet. Secreted into host root cells via the nematode stylet to transform the recipient cells into enlarged multinucleate feeding cells called giant-cells or syncytia. Secreted to the host apoplasm from its cytoplasm via a plant secretory pathway.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Host cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 139117CLAVATA3/ESR (CLE)-related protein 1PRO_0000401215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Highly expressed exclusively within the dorsal esophageal gland cell during syncytium formation in host plants (at protein level).4 Publications

Developmental stagei

Strongly up-regulated during root colonization, from the onset of syncytium formation by parasitic second-stage juveniles (pJ2) through the J3?J4 molts of sedentary life stages that become adult females.1 Publication

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 9068Required for secretion from the host cytoplasm to the host apoplasmAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili100 – 12526Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi128 – 13912CLEAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi92 – 965Poly-Pro

Sequence similaritiesi

Belongs to the CLV3/ESR signal peptide family.Curated

Keywords - Domaini

Coiled coil, Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BN21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNIFKILLI VLLAVVSFRL SASTGDKKTA NDGSGNNSSA GIGTKIKRIV
60 70 80 90 100
TAGLLFTSLA TGGAEAIGRS NAQGGNAAGL VPSHLTNRSM APPPPPAQFE
110 120 130
KGAATRVEKM RAQLRELAEK MTDKDPKRLS PSGPDPHHH
Length:139
Mass (Da):14,504
Last modified:June 1, 2001 - v1
Checksum:iB29F9676CA3A73BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273728 mRNA. Translation: AAG21331.2.
FJ503004 Genomic DNA. Translation: ACT32609.1.

Cross-referencesi

Web resourcesi

Protein Spotlight

the root of the problem - Issue 151 of July 2013

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273728 mRNA. Translation: AAG21331.2.
FJ503004 Genomic DNA. Translation: ACT32609.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Signal peptide-selection of cDNA cloned directly from the esophageal gland cells of the soybean cyst nematode Heterodera glycines."
    Wang X., Allen R., Ding X., Goellner M., Maier T., de Boer J.M., Baum T.J., Hussey R.S., Davis E.L.
    Mol. Plant Microbe Interact. 14:536-544(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Esophagus and Gland.
  2. "Dual roles for the variable domain in protein trafficking and host-specific recognition of Heterodera glycines CLE effector proteins."
    Wang J., Lee C., Replogle A., Joshi S., Korkin D., Hussey R., Baum T.J., Davis E.L., Wang X., Mitchum M.G.
    New Phytol. 187:1003-1017(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
  3. Cited for: TISSUE SPECIFICITY.
    Tissue: Gland.
  4. "A parasitism gene from a plant-parasitic nematode with function similar to CLAVATA3/ESR (CLE) of Arabidopsis thaliana."
    Wang X., Mitchum M.G., Gao B., Li C., Diab H., Baum T.J., Hussey R.S., Davis E.L.
    Mol. Plant Pathol. 6:187-191(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. Cited for: REVIEW.

Entry informationi

Entry nameiCLE1_HETGL
AccessioniPrimary (citable) accession number: Q9BN21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: June 1, 2001
Last modified: April 29, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

Failed to trigger CLE-like cell fate regulation in Arabidopsis thaliana, a non-host plant.

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.