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Q9BKB4

- KA144_MESMA

UniProt

Q9BKB4 - KA144_MESMA

Protein

Potassium channel toxin alpha-KTx 14.4

Gene
N/A
Organism
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Selectively and reversibly inhibits small conductance calcium-activated potassium channels (KCNN, SK).1 Publication

    GO - Molecular functioni

    1. ion channel inhibitor activity Source: InterPro

    GO - Biological processi

    1. defense response Source: InterPro
    2. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin alpha-KTx 14.4
    Alternative name(s):
    BmSKTx1
    Neurotoxin SKTx1
    OrganismiMesobuthus martensii (Manchurian scorpion) (Buthus martensii)
    Taxonomic identifieri34649 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeMesobuthus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 5431Potassium channel toxin alpha-KTx 14.4PRO_0000227815Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 46By similarity
    Disulfide bondi36 ↔ 51By similarity
    Disulfide bondi40 ↔ 53By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BKB4.
    SMRiQ9BKB4. Positions 24-54.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR003614. Scorpion_toxin-like.
    IPR001947. Scorpion_toxinS_K_inh.
    [Graphical view]
    PfamiPF00451. Toxin_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF57095. SSF57095. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BKB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIFFAILLI LAVCSMAIWT VNGTPFAIKC ATNADCSRKC PGNPPCRNGF   50
    CACT 54
    Length:54
    Mass (Da):5,785
    Last modified:June 1, 2001 - v1
    Checksum:iAF59694FDDD0A8A1
    GO

    Mass spectrometryi

    Molecular mass is 3242.0 Da from positions 24 - 54. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF295594 Genomic DNA. Translation: AAK31986.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF295594 Genomic DNA. Translation: AAK31986.1 .

    3D structure databases

    ProteinModelPortali Q9BKB4.
    SMRi Q9BKB4. Positions 24-54.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR003614. Scorpion_toxin-like.
    IPR001947. Scorpion_toxinS_K_inh.
    [Graphical view ]
    Pfami PF00451. Toxin_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57095. SSF57095. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel scorpion toxin blocking small conductance Ca2+ activated K+ channel."
      Xu C.-Q., He L.-L., Brone B., Martin-Eauclaire M.-F., Van Kerkhove E., Zhou Z., Chi C.-W.
      Toxicon 43:961-971(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 24-45, FUNCTION, MASS SPECTROMETRY.
      Strain: Henan.
      Tissue: Venom.

    Entry informationi

    Entry nameiKA144_MESMA
    AccessioniPrimary (citable) accession number: Q9BKB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Miscellaneous

    Has no effect on sodium, calcium, Kv nor BK currents. Does not affect apamin binding (PubMed:15208029).1 Publication

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3