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Q9BKB4

- KA144_MESMA

UniProt

Q9BKB4 - KA144_MESMA

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Protein
Potassium channel toxin alpha-KTx 14.4
Gene
N/A
Organism
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Selectively and reversibly inhibits small conductance calcium-activated potassium channels (KCNN, SK).1 Publication

GO - Molecular functioni

  1. ion channel inhibitor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. defense response Source: InterPro
  2. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 14.4
Alternative name(s):
BmSKTx1
Neurotoxin SKTx1
OrganismiMesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Taxonomic identifieri34649 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeMesobuthus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 Publication
Add
BLAST
Chaini24 – 5431Potassium channel toxin alpha-KTx 14.4
PRO_0000227815Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 46 By similarity
Disulfide bondi36 ↔ 51 By similarity
Disulfide bondi40 ↔ 53 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliQ9BKB4.
SMRiQ9BKB4. Positions 24-54.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamiPF00451. Toxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BKB4-1 [UniParc]FASTAAdd to Basket

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MKIFFAILLI LAVCSMAIWT VNGTPFAIKC ATNADCSRKC PGNPPCRNGF   50
CACT 54
Length:54
Mass (Da):5,785
Last modified:June 1, 2001 - v1
Checksum:iAF59694FDDD0A8A1
GO

Mass spectrometryi

Molecular mass is 3242.0 Da from positions 24 - 54. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF295594 Genomic DNA. Translation: AAK31986.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF295594 Genomic DNA. Translation: AAK31986.1 .

3D structure databases

ProteinModelPortali Q9BKB4.
SMRi Q9BKB4. Positions 24-54.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view ]
Pfami PF00451. Toxin_2. 1 hit.
[Graphical view ]
SUPFAMi SSF57095. SSF57095. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A novel scorpion toxin blocking small conductance Ca2+ activated K+ channel."
    Xu C.-Q., He L.-L., Brone B., Martin-Eauclaire M.-F., Van Kerkhove E., Zhou Z., Chi C.-W.
    Toxicon 43:961-971(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 24-45, FUNCTION, MASS SPECTROMETRY.
    Strain: Henan.
    Tissue: Venom.

Entry informationi

Entry nameiKA144_MESMA
AccessioniPrimary (citable) accession number: Q9BKB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

Has no effect on sodium, calcium, Kv nor BK currents. Does not affect apamin binding (1 Publication).

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi