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Q9BKB4 (KA144_MESMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 14.4
Alternative name(s):
BmSKTx1
Neurotoxin SKTx1
OrganismMesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Taxonomic identifier34649 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeMesobuthus

Protein attributes

Sequence length54 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Selectively and reversibly inhibits small conductance calcium-activated potassium channels (KCNN, SK). Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Miscellaneous

Has no effect on sodium, calcium, Kv nor BK currents. Does not affect apamin binding (Ref.1).

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 14 subfamily.

Mass spectrometry

Molecular mass is 3242.0 Da from positions 24 - 54. Ref.1

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionIon channel impairing toxin
Neurotoxin
Potassium channel impairing toxin
Toxin
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processdefense response

Inferred from electronic annotation. Source: InterPro

pathogenesis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionion channel inhibitor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.1
Chain24 – 5431Potassium channel toxin alpha-KTx 14.4
PRO_0000227815

Amino acid modifications

Disulfide bond30 ↔ 46 By similarity
Disulfide bond36 ↔ 51 By similarity
Disulfide bond40 ↔ 53 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9BKB4 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: AF59694FDDD0A8A1

FASTA545,785
        10         20         30         40         50 
MKIFFAILLI LAVCSMAIWT VNGTPFAIKC ATNADCSRKC PGNPPCRNGF CACT 

« Hide

References

[1]"A novel scorpion toxin blocking small conductance Ca2+ activated K+ channel."
Xu C.-Q., He L.-L., Brone B., Martin-Eauclaire M.-F., Van Kerkhove E., Zhou Z., Chi C.-W.
Toxicon 43:961-971(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 24-45, FUNCTION, MASS SPECTROMETRY.
Strain: Henan.
Tissue: Venom.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF295594 Genomic DNA. Translation: AAK31986.1.

3D structure databases

ProteinModelPortalQ9BKB4.
SMRQ9BKB4. Positions 24-54.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamPF00451. Toxin_2. 1 hit.
[Graphical view]
SUPFAMSSF57095. SSF57095. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKA144_MESMA
AccessionPrimary (citable) accession number: Q9BKB4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries