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Protein
Submitted name:

Calmodulin-domain protein kinase 1

Gene

CDPK1

Organism
Toxoplasma gondii
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80ATP analogCombined sources1
Binding sitei112ATP analogCombined sources1
Binding sitei195ATP analogCombined sources1
Metal bindingi368Calcium 1Combined sources1
Metal bindingi370Calcium 1Combined sources1
Metal bindingi372Calcium 1Combined sources1
Metal bindingi374Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi379Calcium 1Combined sources1
Metal bindingi415Calcium 2Combined sources1
Metal bindingi417Calcium 2Combined sources1
Metal bindingi419Calcium 2Combined sources1
Metal bindingi421Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi423Calcium 2Combined sources1
Metal bindingi426Calcium 2Combined sources1
Metal bindingi451Calcium 3Combined sources1
Metal bindingi453Calcium 3Combined sources1
Metal bindingi455Calcium 3Combined sources1
Metal bindingi457Calcium 3; via carbonyl oxygenCombined sources1
Metal bindingi462Calcium 3Combined sources1
Metal bindingi485Calcium 4Combined sources1
Metal bindingi487Calcium 4Combined sources1
Metal bindingi489Calcium 4Combined sources1
Metal bindingi491Calcium 4; via carbonyl oxygenCombined sources1
Metal bindingi496Calcium 4Combined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi59 – 63ATP analogCombined sources5
Nucleotide bindingi129 – 131ATP analogCombined sources3

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Keywords - Ligandi

CalciumCombined sources, Metal-bindingCombined sources, Nucleotide-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Calmodulin-domain protein kinase 1Imported
Gene namesi
Name:CDPK1Imported
OrganismiToxoplasma gondiiImported
Taxonomic identifieri5811 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1781862.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi247 ↔ 505Combined sources
Disulfide bondi247InterchainCombined sources

Interactioni

Protein-protein interaction databases

STRINGi5811.TGME49_101440.

Chemistry databases

BindingDBiQ9BJF5.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HX4X-ray1.95A1-507[»]
3I79X-ray2.04A30-507[»]
3I7BX-ray1.99A30-507[»]
3I7CX-ray1.98A30-507[»]
3KU2X-ray2.30A1-507[»]
3MA6X-ray2.50A/B36-315[»]
3N51X-ray2.10A30-507[»]
3NYVX-ray1.88A30-507[»]
3SX9X-ray2.65A30-507[»]
3SXFX-ray2.04A30-507[»]
3T3UX-ray2.10A30-507[»]
3T3VX-ray2.04A30-507[»]
3UPXX-ray2.27A30-507[»]
3UPZX-ray2.20A30-507[»]
3V51X-ray1.95A30-507[»]
3V5PX-ray2.10A30-507[»]
3V5TX-ray2.13A30-507[»]
4IEBX-ray2.05A1-507[»]
4IFGX-ray2.11A1-507[»]
4IH8X-ray2.88A1-507[»]
4IHPX-ray2.27A1-507[»]
4JBVX-ray1.95A27-507[»]
4M84X-ray2.00A30-507[»]
4ONAX-ray2.40A30-507[»]
4TZRX-ray2.00A30-507[»]
4WG3X-ray2.20A30-507[»]
4WG4X-ray2.30A30-507[»]
4WG5X-ray2.30A30-507[»]
4YGAX-ray2.94A/C/E/G1-507[»]
4YJNX-ray2.60A30-507[»]
5DVRX-ray2.40A1-507[»]
5DVTX-ray2.05A1-507[»]
5DVUX-ray2.05A1-507[»]
5JMSX-ray2.30A1-507[»]
5JN2X-ray2.20A1-507[»]
ProteinModelPortaliQ9BJF5.
SMRiQ9BJF5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BJF5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 308Protein kinaseInterPro annotationAdd BLAST258
Domaini355 – 390EF-handInterPro annotationAdd BLAST36
Domaini402 – 437EF-handInterPro annotationAdd BLAST36
Domaini438 – 467EF-handInterPro annotationAdd BLAST30
Domaini472 – 507EF-handInterPro annotationAdd BLAST36

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG41124N9. LUCA.
InParanoidiQ9BJF5.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BJF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQQESTLGG AAGEPRSRGH AAGTSGGPGD HLHATPGMFV QHSTAIFSDR
60 70 80 90 100
YKGQRVLGKG SFGEVILCKD KITGQECAVK VISKRQVKQK TDKESLLREV
110 120 130 140 150
QLLKQLDHPN IMKLYEFFED KGYFYLVGEV YTGGELFDEI ISRKRFSEVD
160 170 180 190 200
AARIIRQVLS GITYMHKNKI VHRDLKPENL LLESKSKDAN IRIIDFGLST
210 220 230 240 250
HFEASKKMKD KIGTAYYIAP EVLHGTYDEK CDVWSTGVIL YILLSGCPPF
260 270 280 290 300
NGANEYDILK KVEKGKYTFE LPQWKKVSES AKDLIRKMLT YVPSMRISAR
310 320 330 340 350
DALDHEWIQT YTKEQISVDV PSLDNAILNI RQFQGTQKLA QAALLYMGSK
360 370 380 390 400
LTSQDETKEL TAIFHKMDKN GDGQLDRAEL IEGYKELMRM KGQDASMLDA
410 420 430 440 450
SAVEHEVDQV LDAVDFDKNG YIEYSEFVTV AMDRKTLLSR ERLERAFRMF
460 470 480 490 500
DSDNSGKISS TELATIFGVS DVDSETWKSV LSEVDKNNDG EVDFDEFQQM

LLKLCGN
Length:507
Mass (Da):57,253
Last modified:June 1, 2001 - v1
Checksum:i87008C2075A9CBA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333958 mRNA. Translation: AAG53993.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333958 mRNA. Translation: AAG53993.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HX4X-ray1.95A1-507[»]
3I79X-ray2.04A30-507[»]
3I7BX-ray1.99A30-507[»]
3I7CX-ray1.98A30-507[»]
3KU2X-ray2.30A1-507[»]
3MA6X-ray2.50A/B36-315[»]
3N51X-ray2.10A30-507[»]
3NYVX-ray1.88A30-507[»]
3SX9X-ray2.65A30-507[»]
3SXFX-ray2.04A30-507[»]
3T3UX-ray2.10A30-507[»]
3T3VX-ray2.04A30-507[»]
3UPXX-ray2.27A30-507[»]
3UPZX-ray2.20A30-507[»]
3V51X-ray1.95A30-507[»]
3V5PX-ray2.10A30-507[»]
3V5TX-ray2.13A30-507[»]
4IEBX-ray2.05A1-507[»]
4IFGX-ray2.11A1-507[»]
4IH8X-ray2.88A1-507[»]
4IHPX-ray2.27A1-507[»]
4JBVX-ray1.95A27-507[»]
4M84X-ray2.00A30-507[»]
4ONAX-ray2.40A30-507[»]
4TZRX-ray2.00A30-507[»]
4WG3X-ray2.20A30-507[»]
4WG4X-ray2.30A30-507[»]
4WG5X-ray2.30A30-507[»]
4YGAX-ray2.94A/C/E/G1-507[»]
4YJNX-ray2.60A30-507[»]
5DVRX-ray2.40A1-507[»]
5DVTX-ray2.05A1-507[»]
5DVUX-ray2.05A1-507[»]
5JMSX-ray2.30A1-507[»]
5JN2X-ray2.20A1-507[»]
ProteinModelPortaliQ9BJF5.
SMRiQ9BJF5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5811.TGME49_101440.

Chemistry databases

BindingDBiQ9BJF5.
ChEMBLiCHEMBL1781862.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG41124N9. LUCA.
InParanoidiQ9BJF5.

Miscellaneous databases

EvolutionaryTraceiQ9BJF5.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9BJF5_TOXGO
AccessioniPrimary (citable) accession number: Q9BJF5
Secondary accession number(s): B9Q301, B9QPZ6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.