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Protein

Major heat shock 70 kDa protein Bb

Gene

Hsp70Bb

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

Most strains have three copies of the gene coding for this protein at chromosome locus 87C1; two tandemly repeated Hsp70 genes (Hsp70Bb and Hsp70Bc) and one in reverse orientation (Hsp70Ba). Some strains, including that sequenced in the Drosophila genome project have three tandemly repeated Hsp70 genes (Hsp70Bb, Hsp70Bbb and Hsp70Bc).

GO - Molecular functioni

GO - Biological processi

  • heat shock-mediated polytene chromosome puffing Source: FlyBase
  • response to heat Source: FlyBase
  • response to hypoxia Source: FlyBase
  • response to unfolded protein Source: UniProtKB

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Major heat shock 70 kDa protein Bb
Short name:
Heat shock protein 70Bb
Alternative name(s):
HSP70-87C1
Gene namesi
Name:Hsp70Bb
ORF Names:CG31359
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0013278. Hsp70Bb.

Subcellular locationi

GO - Cellular componenti

  • microtubule associated complex Source: FlyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000783331 – 641Major heat shock 70 kDa protein BbAdd BLAST641

Proteomic databases

PaxDbiQ9BIS2.
PRIDEiQ9BIS2.

Expressioni

Inductioni

Heat shock induces the synthesis of seven proteins at five otherwise inactive sites in the polytene chromosomes of fruit fly larvae. Two separate sites, producing two and three copies, respectively, code for the 70 kDa protein.

Gene expression databases

BgeeiFBgn0013278.
ExpressionAtlasiQ9BIS2. differential.
GenevisibleiQ9BIS2. DM.

Interactioni

Protein-protein interaction databases

BioGridi71512. 40 interactors.
71513. 40 interactors.
IntActiQ9BIS2. 18 interactors.
STRINGi7227.FBpp0082107.

Structurei

3D structure databases

ProteinModelPortaliQ9BIS2.
SMRiQ9BIS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00880000138135.
InParanoidiQ9BIS2.
KOiK03283.
OrthoDBiEOG091G03SF.
PhylomeDBiQ9BIS2.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiView protein in InterPro
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
PfamiView protein in Pfam
PF00012. HSP70. 1 hit.
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiView protein in PROSITE
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BIS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAIGIDLGT TYSCVGVYQH GKVEIIANDQ GNRTTPSYVA FTDSERLIGD
60 70 80 90 100
PAKNQVAMNP RNTVFDAKRL IGRKYDDPKI AEDMKHWPFK VVSDGGKPKI
110 120 130 140 150
GVEYKGESKR FAPEEISSMV LTKMKETAEA YLGESITDAV ITVPAYFNDS
160 170 180 190 200
QRQATKDAGH IAGLNVLRII NEPTAAALAY GLDKNLKGER NVLIFDLGGG
210 220 230 240 250
TFDVSILTID EGSLFEVRST AGDTHLGGED FDNRLVTHLA EEFKRKYKKD
260 270 280 290 300
LRSNPRALRR LRTAAERAKR TLSSSTEATI EIDALFEGQD FYTKVSRARF
310 320 330 340 350
EELCADLFRN TLQPVEKALN DAKMDKGQIH DIVLVGGSTR IPKVQSLLQE
360 370 380 390 400
FFHGKNLNLS INPDEAVAYG AAVQAAILSG DQSGKIQDVL LVDVAPLSLG
410 420 430 440 450
IETAGGVMTK LIERNCRIPC KQTKTFSTYS DNQPGVSIQV YEGERAMTKD
460 470 480 490 500
NNALGTFDLS GIPPAPRGVP QIEVTFDLDA NGILNVSAKE MSTGKAKNIT
510 520 530 540 550
IKNDKGRLSQ AEIDRMVNEA EKYADEDEKH RQRITSRNAL ESYVFNVKQS
560 570 580 590 600
VEQAPAGKLD EADKNSVLDK CNETIRWLDS NTTAEKEEFD HKMEELTRHC
610 620 630 640
SPIMTKMHQQ GAGAAGGPGA NCGQQAGGFG GYSGPTVEEV D
Length:641
Mass (Da):70,195
Last modified:April 13, 2004 - v2
Checksum:iF2C9C204F67EBB59
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26 – 28IAN → NAY in AAD15226 (PubMed:6777045).Curated3
Sequence conflicti48 – 50IGD → NGE in AAD15226 (PubMed:6777045).Curated3
Sequence conflicti306D → N in AAD15226 (PubMed:6777045).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti43D → E in strain: 3CPA86. 1
Natural varianti60P → S in strain: FrV3-1. 1
Natural varianti67A → P in Z(S)29. 1
Natural varianti71I → T in Z(S)2. 1
Natural varianti187K → N in strain: IS2, IS3, IS4, IS5, IS25 and QD18. 1
Natural varianti195F → L in strain: ZZ30. 1
Natural varianti241E → D in strain: Z(H)1. 1
Natural varianti350E → D in strain: Z(H)1. 1
Natural varianti430S → A in strain: Z(H)1. 1
Natural varianti437S → P in strain: IS4 and IS5. 1
Natural varianti516M → I in strain: B28. 1
Natural varianti524A → V in strain: B28. 1
Natural varianti544V → I in strain: Z(S)24 and Z(S)49. 1
Natural varianti606K → T in strain: 3CPA126. 1
Natural varianti607M → V in strain: Z(S)30A. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01104 Genomic DNA. Translation: AAD15226.1.
AF295951 Genomic DNA. Translation: AAG26905.1.
AF295952 Genomic DNA. Translation: AAG26906.1.
AF295953 Genomic DNA. Translation: AAG26907.1.
AF295954 Genomic DNA. Translation: AAG26908.1.
AF295955 Genomic DNA. Translation: AAG26909.1.
AF295956 Genomic DNA. Translation: AAG26910.1.
AF295957 Genomic DNA. Translation: AAG26911.1.
AF350476 Genomic DNA. Translation: AAK30233.1.
AF350477 Genomic DNA. Translation: AAK30234.1.
AF350478 Genomic DNA. Translation: AAK30235.1.
AF350479 Genomic DNA. Translation: AAK30236.1.
AF350480 Genomic DNA. Translation: AAK30237.1.
AF350481 Genomic DNA. Translation: AAK30238.1.
AF350482 Genomic DNA. Translation: AAK30239.1.
AF350483 Genomic DNA. Translation: AAK30240.1.
AE014297 Genomic DNA. Translation: AAN13546.1.
BT011058 mRNA. Translation: AAR31129.1.
BT011379 mRNA. Translation: AAR96171.1.
BT031349 mRNA. Translation: ABY76186.1.
AY846848 Genomic DNA. Translation: AAW34339.1.
AY846849 Genomic DNA. Translation: AAW34340.1.
AY846850 Genomic DNA. Translation: AAW34341.1.
AY846851 Genomic DNA. Translation: AAW34342.1.
AY846852 Genomic DNA. Translation: AAW34343.1.
AY846853 Genomic DNA. Translation: AAW34344.1.
AY846854 Genomic DNA. Translation: AAW34345.1.
AY846855 Genomic DNA. Translation: AAW34346.1.
AY846856 Genomic DNA. Translation: AAW34347.1.
AY846857 Genomic DNA. Translation: AAW34348.1.
AY846858 Genomic DNA. Translation: AAW34349.1.
AY846859 Genomic DNA. Translation: AAW34350.1.
AY846860 Genomic DNA. Translation: AAW34351.1.
AY846861 Genomic DNA. Translation: AAW34352.1.
AY846862 Genomic DNA. Translation: AAW34353.1.
AY846863 Genomic DNA. Translation: AAW34354.1.
AY846864 Genomic DNA. Translation: AAW34355.1.
AY846865 Genomic DNA. Translation: AAW34356.1.
AY370940 Genomic DNA. Translation: AAQ75092.1.
RefSeqiNP_524927.2. NM_080188.3.
NP_650209.1. NM_141952.2.
UniGeneiDm.18947.
Dm.33336.

Genome annotation databases

EnsemblMetazoaiFBtr0082637; FBpp0082106; FBgn0013278.
FBtr0082638; FBpp0082107; FBgn0013279.
GeneIDi48582.
48583.
KEGGidme:Dmel_CG31359.
dme:Dmel_CG6489.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01104 Genomic DNA. Translation: AAD15226.1.
AF295951 Genomic DNA. Translation: AAG26905.1.
AF295952 Genomic DNA. Translation: AAG26906.1.
AF295953 Genomic DNA. Translation: AAG26907.1.
AF295954 Genomic DNA. Translation: AAG26908.1.
AF295955 Genomic DNA. Translation: AAG26909.1.
AF295956 Genomic DNA. Translation: AAG26910.1.
AF295957 Genomic DNA. Translation: AAG26911.1.
AF350476 Genomic DNA. Translation: AAK30233.1.
AF350477 Genomic DNA. Translation: AAK30234.1.
AF350478 Genomic DNA. Translation: AAK30235.1.
AF350479 Genomic DNA. Translation: AAK30236.1.
AF350480 Genomic DNA. Translation: AAK30237.1.
AF350481 Genomic DNA. Translation: AAK30238.1.
AF350482 Genomic DNA. Translation: AAK30239.1.
AF350483 Genomic DNA. Translation: AAK30240.1.
AE014297 Genomic DNA. Translation: AAN13546.1.
BT011058 mRNA. Translation: AAR31129.1.
BT011379 mRNA. Translation: AAR96171.1.
BT031349 mRNA. Translation: ABY76186.1.
AY846848 Genomic DNA. Translation: AAW34339.1.
AY846849 Genomic DNA. Translation: AAW34340.1.
AY846850 Genomic DNA. Translation: AAW34341.1.
AY846851 Genomic DNA. Translation: AAW34342.1.
AY846852 Genomic DNA. Translation: AAW34343.1.
AY846853 Genomic DNA. Translation: AAW34344.1.
AY846854 Genomic DNA. Translation: AAW34345.1.
AY846855 Genomic DNA. Translation: AAW34346.1.
AY846856 Genomic DNA. Translation: AAW34347.1.
AY846857 Genomic DNA. Translation: AAW34348.1.
AY846858 Genomic DNA. Translation: AAW34349.1.
AY846859 Genomic DNA. Translation: AAW34350.1.
AY846860 Genomic DNA. Translation: AAW34351.1.
AY846861 Genomic DNA. Translation: AAW34352.1.
AY846862 Genomic DNA. Translation: AAW34353.1.
AY846863 Genomic DNA. Translation: AAW34354.1.
AY846864 Genomic DNA. Translation: AAW34355.1.
AY846865 Genomic DNA. Translation: AAW34356.1.
AY370940 Genomic DNA. Translation: AAQ75092.1.
RefSeqiNP_524927.2. NM_080188.3.
NP_650209.1. NM_141952.2.
UniGeneiDm.18947.
Dm.33336.

3D structure databases

ProteinModelPortaliQ9BIS2.
SMRiQ9BIS2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi71512. 40 interactors.
71513. 40 interactors.
IntActiQ9BIS2. 18 interactors.
STRINGi7227.FBpp0082107.

Proteomic databases

PaxDbiQ9BIS2.
PRIDEiQ9BIS2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082637; FBpp0082106; FBgn0013278.
FBtr0082638; FBpp0082107; FBgn0013279.
GeneIDi48582.
48583.
KEGGidme:Dmel_CG31359.
dme:Dmel_CG6489.

Organism-specific databases

CTDi48582.
48583.
FlyBaseiFBgn0013278. Hsp70Bb.

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00880000138135.
InParanoidiQ9BIS2.
KOiK03283.
OrthoDBiEOG091G03SF.
PhylomeDBiQ9BIS2.

Miscellaneous databases

PROiPR:Q9BIS2.

Gene expression databases

BgeeiFBgn0013278.
ExpressionAtlasiQ9BIS2. differential.
GenevisibleiQ9BIS2. DM.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiView protein in InterPro
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
PfamiView protein in Pfam
PF00012. HSP70. 1 hit.
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiView protein in PROSITE
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHSP73_DROME
AccessioniPrimary (citable) accession number: Q9BIS2
Secondary accession number(s): B0BNN7
, P02824, Q53XF0, Q5I7H2, Q5I7H4, Q5I7H6, Q5I7H8, Q5I7I3, Q5I7I6, Q5I7I8, Q9BIS1, Q9I7J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 13, 2004
Last modified: June 7, 2017
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.