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Protein

Major heat shock 70 kDa protein Bc

Gene

Hsp70Bc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

Most strains have three copies of the gene coding for this protein at chromosome locus 87C1; two tandemly repeated Hsp70 genes (Hsp70Bb and Hsp70Bc) and one in reverse orientation (Hsp70Ba). Some strains, including that sequenced in the Drosophila genome project have three tandemly repeated Hsp70 genes (Hsp70Bb, Hsp70Bbb and Hsp70Bc).

GO - Molecular functioni

GO - Biological processi

  • heat shock-mediated polytene chromosome puffing Source: FlyBase
  • response to heat Source: FlyBase
  • response to hypoxia Source: FlyBase
  • response to toxic substance Source: FlyBase
  • response to unfolded protein Source: UniProtKB

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Major heat shock 70 kDa protein Bc
Short name:
Heat shock protein 70Bc
Alternative name(s):
HSP70-87C1
Gene namesi
Name:Hsp70Bc
ORF Names:CG6489
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0013279. Hsp70Bc.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000783351 – 641Major heat shock 70 kDa protein BcAdd BLAST641

Proteomic databases

PaxDbiQ9BIR7.
PRIDEiQ9BIR7.

Expressioni

Inductioni

Heat shock induces the synthesis of seven proteins at five otherwise inactive sites in the polytene chromosomes of fruit fly larvae. Two separate sites, producing two and three copies, respectively, code for the 70 kDa protein.

Gene expression databases

BgeeiFBgn0013278.
ExpressionAtlasiQ9BIR7. differential.
GenevisibleiQ9BIR7. DM.

Interactioni

Protein-protein interaction databases

BioGridi71512. 40 interactors.
71513. 40 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9BIR7.
SMRiQ9BIR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
InParanoidiQ9BIR7.
KOiK03283.
OrthoDBiEOG091G03SF.
PhylomeDBiQ9BIR7.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiView protein in InterPro
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
PfamiView protein in Pfam
PF00012. HSP70. 1 hit.
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiView protein in PROSITE
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BIR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAIGIDLGT TYSCVGVYQH GKVEIIANDQ GNRTTPSYVA FTDSERLIGD
60 70 80 90 100
PAKNQVAMNP RNTVFDAKRL IGRKYDDPKI AEDMKHWPFK VVSDGGKPKI
110 120 130 140 150
GVEYKGESKR FAPEEISSMV LTKMKETAEA YLGESITDAV ITVPAYFNDS
160 170 180 190 200
QRQATKDAGH IAGLNVLRII NEPTAAALAY GLDKNLKGER NVLIFDLGGG
210 220 230 240 250
TFDVSILTID EGSLFEVRST AGDTHLGGED FDNRLVTHLA EEFKRKYKKD
260 270 280 290 300
LRSNPRALRR LRTAAERAKR TLSSSTEATI EIDALFEGQD FYTKVSRARF
310 320 330 340 350
EELCADLFRN TLQPVEKALN DAKMDKGQIH DIVLVGGSTR IPKVQSLLQE
360 370 380 390 400
FFHGKNLNLS INPDEAVAYG AAVQAAILSG DQSGKIQDVL LVDVAPLSLG
410 420 430 440 450
IETAGGVMTK LIERNCRIPC KQTKTFSTYS DNQPGVSIQV YEGERAMTKD
460 470 480 490 500
NNALGTFDLS GIPPAPRGVP QIEVTFDLDA NGILNVSAKE MSTGKAKNIT
510 520 530 540 550
IKNDKGRLSQ AEIDRMVNEA EKYADEDEKH RQRITSRNAL ESYVFNVKQS
560 570 580 590 600
VEQAPAGKLD EADKNSVLDK CNETIRWLDS NTTAEKEEFD HKMEELTRHC
610 620 630 640
SPIMTKMHQQ GAGAAGGPGA NCGQQAGGFG GYSGPTVEEV D
Length:641
Mass (Da):70,195
Last modified:April 13, 2004 - v2
Checksum:iF2C9C204F67EBB59
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti45E → A in strain: 3CPA81. 1
Natural varianti74K → R in strain: 3CPA2. 1
Natural varianti93S → I in strain: FrV3-1. 1
Natural varianti135S → G in strain: 3CPA2. 1
Natural varianti187K → N in strain: 3CPA2. 1
Natural varianti210D → Y in strain: AUS. 1
Natural varianti330H → N in strain: 3CPA43 and 3CPA81. 1
Natural varianti342P → S in strain: 3CPA43. 1
Natural varianti458D → Y in strain: 3CPA43 and 3CPA81. 1
Natural varianti475T → I in strain: B28. 1
Natural varianti601S → P in strain: 3CPA126. 1
Natural varianti634G → R in strain: AUS. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295958 Genomic DNA. Translation: AAG26912.1.
AF295959 Genomic DNA. Translation: AAG26913.1.
AF295960 Genomic DNA. Translation: AAG26914.1.
AF295961 Genomic DNA. Translation: AAG26915.1.
AF295962 Genomic DNA. Translation: AAG26916.1.
AF350484 Genomic DNA. Translation: AAK30241.1.
AF350485 Genomic DNA. Translation: AAK30242.1.
AF350486 Genomic DNA. Translation: AAK30243.1.
AF350487 Genomic DNA. Translation: AAK30244.1.
AF350488 Genomic DNA. Translation: AAK30245.1.
AF350489 Genomic DNA. Translation: AAK30246.1.
AF350490 Genomic DNA. Translation: AAK30247.1.
AF350491 Genomic DNA. Translation: AAK30248.1.
AE014297 Genomic DNA. Translation: AAG22149.2.
BT011541 mRNA. Translation: AAS15677.1.
J01104 Genomic DNA. Translation: AAD15227.1.
PIRiA03307. HHFF72.
RefSeqiNP_524927.2. NM_080188.3.
NP_650209.1. NM_141952.2.
UniGeneiDm.18947.
Dm.33336.

Genome annotation databases

EnsemblMetazoaiFBtr0082637; FBpp0082106; FBgn0013278.
FBtr0082638; FBpp0082107; FBgn0013279.
GeneIDi48582.
48583.
KEGGidme:Dmel_CG31359.
dme:Dmel_CG6489.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHSP75_DROME
AccessioniPrimary (citable) accession number: Q9BIR7
Secondary accession number(s): P02824
, Q53XF0, Q9BIR8, Q9BIR9, Q9BIS0, Q9I7J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 13, 2004
Last modified: July 5, 2017
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families