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Protein

Probable protein phosphatase methylesterase 1

Gene

B0464.9

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Demethylates proteins that have been reversibly carboxymethylated.By similarity

Catalytic activityi

[Phosphatase 2A protein]-leucine methyl ester + H2O = [phosphatase 2A protein]-leucine + methanol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641By similarity
Active sitei190 – 1901By similarity
Active sitei316 – 3161By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

ESTHERicaeel-ppme1. PPase_methylesterase_euk.
MEROPSiS33.B12.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase methylesterase 1 (EC:3.1.1.89)
Short name:
PME-1
Gene namesi
ORF Names:B0464.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiB0464.9; CE26705; WBGene00007188.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Probable protein phosphatase methylesterase 1PRO_0000065085Add
BLAST

Proteomic databases

EPDiQ9BIB3.
PaxDbiQ9BIB3.
PRIDEiQ9BIB3.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi46862. 1 interaction.
MINTiMINT-1057597.
STRINGi6239.B0464.9.

Structurei

3D structure databases

ProteinModelPortaliQ9BIB3.
SMRiQ9BIB3. Positions 51-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiKOG2564. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00390000004396.
HOGENOMiHOG000212435.
InParanoidiQ9BIB3.
KOiK13617.
OMAiLYTWRIE.
OrthoDBiEOG741Z2K.
PhylomeDBiQ9BIB3.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR016812. PPase_methylesterase_euk.
[Graphical view]
PANTHERiPTHR14189. PTHR14189. 1 hit.
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
PIRSFiPIRSF022950. PPase_methylesterase_euk. 1 hit.
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BIB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDDKLDTLP DLQSETSHVT TPHRQNDLLR QAVTHGRPPP VPSTSTSGKK
60 70 80 90 100
REMSELPWSD FFDEKKDANI DGDVFNVYIK GNEGPIFYLL HGGGYSGLTW
110 120 130 140 150
ACFAKELATL ISCRVVAPDL RGHGDTKCSD EHDLSKETQI KDIGAIFKNI
160 170 180 190 200
FGEDDSPVCI VGHSMGGALA IHTLNAKMIS SKVAALIVID VVEGSAMEAL
210 220 230 240 250
GGMVHFLHSR PSSFPSIEKA IHWCLSSGTA RNPTAARVSM PSQIREVSEH
260 270 280 290 300
EYTWRIDLTT TEQYWKGWFE GLSKEFLGCS VPKMLVLAGV DRLDRDLTIG
310 320 330 340 350
QMQGKFQTCV LPKVGHCVQE DSPQNLADEV GRFACRHRIA QPKFSALASP
360
PDPAILEYRK RHHQ
Length:364
Mass (Da):40,222
Last modified:June 1, 2001 - v1
Checksum:i03D419EA6DF4719B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19152 Genomic DNA. Translation: CAC35809.1.
RefSeqiNP_499084.1. NM_066683.3.
UniGeneiCel.23572.

Genome annotation databases

EnsemblMetazoaiB0464.9; B0464.9; WBGene00007188.
GeneIDi181999.
KEGGicel:CELE_B0464.9.
UCSCiB0464.9. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19152 Genomic DNA. Translation: CAC35809.1.
RefSeqiNP_499084.1. NM_066683.3.
UniGeneiCel.23572.

3D structure databases

ProteinModelPortaliQ9BIB3.
SMRiQ9BIB3. Positions 51-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi46862. 1 interaction.
MINTiMINT-1057597.
STRINGi6239.B0464.9.

Protein family/group databases

ESTHERicaeel-ppme1. PPase_methylesterase_euk.
MEROPSiS33.B12.

Proteomic databases

EPDiQ9BIB3.
PaxDbiQ9BIB3.
PRIDEiQ9BIB3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0464.9; B0464.9; WBGene00007188.
GeneIDi181999.
KEGGicel:CELE_B0464.9.
UCSCiB0464.9. c. elegans.

Organism-specific databases

CTDi181999.
WormBaseiB0464.9; CE26705; WBGene00007188.

Phylogenomic databases

eggNOGiKOG2564. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00390000004396.
HOGENOMiHOG000212435.
InParanoidiQ9BIB3.
KOiK13617.
OMAiLYTWRIE.
OrthoDBiEOG741Z2K.
PhylomeDBiQ9BIB3.

Miscellaneous databases

NextBioi916008.
PROiQ9BIB3.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR016812. PPase_methylesterase_euk.
[Graphical view]
PANTHERiPTHR14189. PTHR14189. 1 hit.
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
PIRSFiPIRSF022950. PPase_methylesterase_euk. 1 hit.
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPPME1_CAEEL
AccessioniPrimary (citable) accession number: Q9BIB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.