Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable protein phosphatase methylesterase 1

Gene

B0464.9

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Demethylates proteins that have been reversibly carboxymethylated.By similarity

Catalytic activityi

[Phosphatase 2A protein]-leucine methyl ester + H2O = [phosphatase 2A protein]-leucine + methanol.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei164By similarity1
Active sitei190By similarity1
Active sitei316By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

ReactomeiR-CEL-69273 Cyclin A/B1/B2 associated events during G2/M transition

Protein family/group databases

ESTHERicaeel-ppme1 PPase_methylesterase_euk
MEROPSiS33.B12

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase methylesterase 1 (EC:3.1.1.89)
Short name:
PME-1
Gene namesi
ORF Names:B0464.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiB0464.9 ; CE26705 ; WBGene00007188

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000650851 – 364Probable protein phosphatase methylesterase 1Add BLAST364

Proteomic databases

EPDiQ9BIB3
PaxDbiQ9BIB3
PeptideAtlasiQ9BIB3
PRIDEiQ9BIB3

Expressioni

Gene expression databases

BgeeiWBGene00007188

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi46862, 1 interactor
STRINGi6239.B0464.9

Structurei

3D structure databases

ProteinModelPortaliQ9BIB3
SMRiQ9BIB3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiKOG2564 Eukaryota
COG0596 LUCA
GeneTreeiENSGT00390000004396
HOGENOMiHOG000212435
InParanoidiQ9BIB3
KOiK13617
OMAiRIQCRIV
OrthoDBiEOG091G0D0P
PhylomeDBiQ9BIB3

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR000639 Epox_hydrolase-like
IPR016812 PPase_methylesterase_euk
PANTHERiPTHR14189 PTHR14189, 1 hit
PfamiView protein in Pfam
PF12697 Abhydrolase_6, 1 hit
PIRSFiPIRSF022950 PPase_methylesterase_euk, 1 hit
PRINTSiPR00111 ABHYDROLASE
PR00412 EPOXHYDRLASE
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BIB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDDKLDTLP DLQSETSHVT TPHRQNDLLR QAVTHGRPPP VPSTSTSGKK
60 70 80 90 100
REMSELPWSD FFDEKKDANI DGDVFNVYIK GNEGPIFYLL HGGGYSGLTW
110 120 130 140 150
ACFAKELATL ISCRVVAPDL RGHGDTKCSD EHDLSKETQI KDIGAIFKNI
160 170 180 190 200
FGEDDSPVCI VGHSMGGALA IHTLNAKMIS SKVAALIVID VVEGSAMEAL
210 220 230 240 250
GGMVHFLHSR PSSFPSIEKA IHWCLSSGTA RNPTAARVSM PSQIREVSEH
260 270 280 290 300
EYTWRIDLTT TEQYWKGWFE GLSKEFLGCS VPKMLVLAGV DRLDRDLTIG
310 320 330 340 350
QMQGKFQTCV LPKVGHCVQE DSPQNLADEV GRFACRHRIA QPKFSALASP
360
PDPAILEYRK RHHQ
Length:364
Mass (Da):40,222
Last modified:June 1, 2001 - v1
Checksum:i03D419EA6DF4719B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19152 Genomic DNA Translation: CAC35809.1
RefSeqiNP_499084.1, NM_066683.3
UniGeneiCel.23572

Genome annotation databases

EnsemblMetazoaiB0464.9; B0464.9; WBGene00007188
GeneIDi181999
KEGGicel:CELE_B0464.9
UCSCiB0464.9 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPPME1_CAEEL
AccessioniPrimary (citable) accession number: Q9BIB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health