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Protein
Submitted name:

Protein EPN-1, isoform b

Gene

epn-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Enzyme and pathway databases

ReactomeiREACT_258320. EGFR downregulation.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein EPN-1, isoform bImported
Gene namesi
Name:epn-1Imported
ORF Names:CELE_T04C10.2Imported, T04C10.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiT04C10.2b; CE26821; WBGene00001329; epn-1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: WormBase
  2. cytoplasmic vesicle Source: WormBase
  3. early phagosome Source: WormBase
  4. phagocytic cup Source: WormBase
  5. plasma membrane Source: WormBase
  6. pseudopodium Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ9BI71.
PRIDEiQ9BI71.

Expressioni

Gene expression databases

ExpressionAtlasiQ9BI71. baseline.

Interactioni

Protein-protein interaction databases

IntActiQ9BI71. 4 interactions.
MINTiMINT-1124746.
STRINGi6239.T04C10.2b.

Structurei

3D structure databases

ProteinModelPortaliQ9BI71.
SMRiQ9BI71. Positions 1-143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains ENTH (epsin N-terminal homology) domain.SAAS annotation

Phylogenomic databases

eggNOGiNOG263730.
GeneTreeiENSGT00550000074611.
HOGENOMiHOG000008298.
InParanoidiQ9BI71.
KOiK12471.
OMAiENCKSHI.
PhylomeDBiQ9BI71.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR013809. ENTH.
IPR008942. ENTH_VHS.
IPR001026. Epsin_dom_N.
IPR003903. Ubiquitin-int_motif.
[Graphical view]
PfamiPF01417. ENTH. 1 hit.
[Graphical view]
SMARTiSM00273. ENTH. 1 hit.
SM00726. UIM. 2 hits.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50942. ENTH. 1 hit.
PS50330. UIM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BI71-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSISTIRRQV KNVAYNFSDA QVKVREATSN DPWGPSTALM SEIADLTHNP
60 70 80 90 100
MAFTEIMSIV WKRLNDSGKN WRHVYKSLVL LDFLIKCGHE KVAQQCRENV
110 120 130 140 150
FTIETLKDFQ HVEDNRDQGL NIREKAKQIT SLLSDDERLK NERTRFILTR
160 170 180 190 200
NKFKQNNPGP VGAESRRSNR HHVTDASLDP EYEDARPSTA TEEEMQLQIA
210 220 230 240 250
LALSREECEK ADEMRKSDDA RLQMALEESQ KLQDADRLAT TKQGTVSSGQ
260 270 280 290 300
LTQSALDDLL SLGVGELVSG NNDQPSSSSA WGMNDPWGAP QASASLNTND
310 320 330 340 350
QMFANSMSNN DPWATSTVAQ PVAATAPNSD PFASWDAPAP AATTPSTMPT
360 370 380 390 400
SSSFDLLGGD LLSPTNSLSA NINTNNSTNG TRKTPENFLG ENSNLVNLDN
410 420 430 440 450
LLGSGTPSTT GGNPFLTGAA PANANPFAAQ QRKSPTLNEM RAAQGQAPPI
460
PSMAPRGTLP QANPFANPF
Length:469
Mass (Da):51,018
Last modified:June 1, 2001 - v1
Checksum:i28A57E2C65DD9931
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69885 Genomic DNA. Translation: CAC35825.1.
RefSeqiNP_510458.1. NM_078057.4.
UniGeneiCel.5240.

Genome annotation databases

EnsemblMetazoaiT04C10.2b; T04C10.2b; WBGene00001329.
GeneIDi181577.
KEGGicel:CELE_T04C10.2.
UCSCiT04C10.2b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69885 Genomic DNA. Translation: CAC35825.1.
RefSeqiNP_510458.1. NM_078057.4.
UniGeneiCel.5240.

3D structure databases

ProteinModelPortaliQ9BI71.
SMRiQ9BI71. Positions 1-143.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9BI71. 4 interactions.
MINTiMINT-1124746.
STRINGi6239.T04C10.2b.

Proteomic databases

PaxDbiQ9BI71.
PRIDEiQ9BI71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT04C10.2b; T04C10.2b; WBGene00001329.
GeneIDi181577.
KEGGicel:CELE_T04C10.2.
UCSCiT04C10.2b. c. elegans.

Organism-specific databases

CTDi181577.
WormBaseiT04C10.2b; CE26821; WBGene00001329; epn-1.

Phylogenomic databases

eggNOGiNOG263730.
GeneTreeiENSGT00550000074611.
HOGENOMiHOG000008298.
InParanoidiQ9BI71.
KOiK12471.
OMAiENCKSHI.
PhylomeDBiQ9BI71.

Enzyme and pathway databases

ReactomeiREACT_258320. EGFR downregulation.

Miscellaneous databases

NextBioi914512.

Gene expression databases

ExpressionAtlasiQ9BI71. baseline.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR013809. ENTH.
IPR008942. ENTH_VHS.
IPR001026. Epsin_dom_N.
IPR003903. Ubiquitin-int_motif.
[Graphical view]
PfamiPF01417. ENTH. 1 hit.
[Graphical view]
SMARTiSM00273. ENTH. 1 hit.
SM00726. UIM. 2 hits.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50942. ENTH. 1 hit.
PS50330. UIM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ9BI71_CAEEL
AccessioniPrimary (citable) accession number: Q9BI71
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: January 7, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.