Reviewed, UniProtKB/Swiss-Prot Q9BGW0 (THTPA_MACFA)

Names and origin

Protein names

Recommended name:
    Thiamine-triphosphatase
      Short name=ThTPase
    EC=3.6.1.28

Gene names

Name:	THTPA
ORF Names:	QflA-12514

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Hydrolase highly specific for thiamine triphosphate (ThTP) By similarity.
Catalytic activity	Thiamine triphosphate + H2O = thiamine diphosphate + phosphate.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ThTPase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
PTM	Acetylation
Gene Ontology (GO)
Biological process	cAMP biosynthetic process Inferred from electronic annotation. Source: InterPro thiamin metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenylate cyclase activity Inferred from electronic annotation. Source: InterPro thiamin-triphosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 230	229	Thiamine-triphosphatase		PRO_0000221491
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9BGW0-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 99F683E6475705C3	FASTA	230	25,342
	10 20 30 40 50 60 MAQGLIEVER KFLPGPGTEE RLQELGGTLE HRVTFRDTYY DTPELSLMQA DHWLRRREDS 70 80 90 100 110 120 GWELKCPGAA GVLGHHTEYK ELTAEPTIVA QLCKVLGADG LGAGDVAAVL DPLGLQEVAS 130 140 150 160 170 180 FVTKRSAWKL VLLGTDEEEP QLKVDLGTAD FGYAVGEVEA LVHEEAEVPA ALEKIHRLSS 190 200 210 220 230 MLGVPAQETA PAKLIVYLQR FRPQNYQRLL EVNSSKQRPQ ATEDPDNCLG

References

[1]

"Isolation of full-length cDNA clones from macaque brain cDNA libraries." Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Frontal cortex.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB055296 mRNA. Translation: BAB21921.1.
3D structure databases
SMR	Q9BGW0. Positions 2-217.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q9BGW0.
Enzyme and pathway databases
BRENDA	3.6.1.28. 3438.
Family and domain databases
InterPro	IPR008172. Adenylate_cyclase. IPR012177. ThTPase. [Graphical view]
PANTHER	PTHR14586. ThTPase. 1 hit.
Pfam	PF01928. CYTH. 1 hit. [Graphical view]
PIRSF	PIRSF036561. ThTPase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

THTPA_MACFA

Accession

Primary (citable) accession number: Q9BGW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 41 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)