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Protein

Serum paraoxonase/lactonase 3

Gene

PON3

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters (By similarity). Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.By similarity1 Publication

Catalytic activityi

A phenyl acetate + H2O = a phenol + acetate.
An aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol.
An N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine.

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Calcium 1; catalyticBy similarity
Metal bindingi54 – 541Calcium 2By similarity
Active sitei114 – 1141Proton acceptorBy similarity
Metal bindingi116 – 1161Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi167 – 1671Calcium 1; catalyticBy similarity
Metal bindingi168 – 1681Calcium 2
Metal bindingi223 – 2231Calcium 1; catalyticBy similarity
Metal bindingi268 – 2681Calcium 1; catalyticBy similarity
Metal bindingi269 – 2691Calcium 1; catalyticBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.2. 1749.
3.1.1.25. 1749.
3.1.8.1. 1749.

Names & Taxonomyi

Protein namesi
Recommended name:
Serum paraoxonase/lactonase 3 (EC:3.1.1.2, EC:3.1.1.81, EC:3.1.8.1)
Gene namesi
Name:PON3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 354353Serum paraoxonase/lactonase 3PRO_0000223293Add
BLAST
Signal peptidei2 – ?Not cleavedSequence analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 352By similarity
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence analysis
Modified residuei165 – 1651PhosphoserineBy similarity
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Glycosylated.By similarity
The signal sequence is not cleaved.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001737.

Structurei

3D structure databases

ProteinModelPortaliQ9BGN0.
SMRiQ9BGN0. Positions 23-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paraoxonase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHDV. Eukaryota.
ENOG4111QK7. LUCA.
HOGENOMiHOG000252960.
HOVERGENiHBG003604.
InParanoidiQ9BGN0.
KOiK01045.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR002640. Arylesterase.
IPR008364. Paraoxonase2.
[Graphical view]
PfamiPF01731. Arylesterase. 1 hit.
[Graphical view]
PRINTSiPR01785. PARAOXONASE.
PR01787. PARAOXONASE2.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BGN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLLLLTLL GASLAFVGER LLAFRNSFGA VQELEPVEPQ NCVLIEGLEN
60 70 80 90 100
GSEDIDILPS GLAFISSGLK YPGMPNFAPD EPGKIFLIDM NEKNPRAQEL
110 120 130 140 150
EISNGFEKES FNPHGISTFI DKDHTVYLYV VNHPHMKSTV EIFKFEEQQR
160 170 180 190 200
SLVHLKTIKH ELLKSVNNIV VLGPEQFYAT RDHYFTNYVL ALLEMFLDLH
210 220 230 240 250
WTSVLFYSPK EVKVVAKGFS SANGITVSLD KKYVYVADAT AKNVHVMEKH
260 270 280 290 300
DNWDLTELKV IHLDTLVDNL SVDPATGDIL AGCHPNGMKL LNYNPEDPPG
310 320 330 340 350
SEVLRIQNVL SEKPRVSTVY TNDGSVLQGS TVASVYQGKI LIGTIFHKTL

YCVL
Length:354
Mass (Da):39,507
Last modified:June 1, 2001 - v1
Checksum:iDE782A7F2DA16603
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220944 mRNA. Translation: AAK06401.1.
RefSeqiNP_001075547.1. NM_001082078.2.
UniGeneiOcu.2525.

Genome annotation databases

GeneIDi100008754.
KEGGiocu:100008754.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220944 mRNA. Translation: AAK06401.1.
RefSeqiNP_001075547.1. NM_001082078.2.
UniGeneiOcu.2525.

3D structure databases

ProteinModelPortaliQ9BGN0.
SMRiQ9BGN0. Positions 23-354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001737.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008754.
KEGGiocu:100008754.

Organism-specific databases

CTDi5446.

Phylogenomic databases

eggNOGiENOG410IHDV. Eukaryota.
ENOG4111QK7. LUCA.
HOGENOMiHOG000252960.
HOVERGENiHBG003604.
InParanoidiQ9BGN0.
KOiK01045.

Enzyme and pathway databases

BRENDAi3.1.1.2. 1749.
3.1.1.25. 1749.
3.1.8.1. 1749.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR002640. Arylesterase.
IPR008364. Paraoxonase2.
[Graphical view]
PfamiPF01731. Arylesterase. 1 hit.
[Graphical view]
PRINTSiPR01785. PARAOXONASE.
PR01787. PARAOXONASE2.
ProtoNetiSearch...

Entry informationi

Entry nameiPON3_RABIT
AccessioniPrimary (citable) accession number: Q9BGN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.