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Protein

Prostaglandin E2 receptor EP1 subtype

Gene

PTGER1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP1 subtype
Short name:
PGE receptor EP1 subtype
Short name:
PGE2 receptor EP1 subtype
Alternative name(s):
Prostanoid EP1 receptor
Gene namesi
Name:PTGER1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 65Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini66 – 75CytoplasmicSequence analysis10
Transmembranei76 – 99Helical; Name=2Sequence analysisAdd BLAST24
Topological domaini100 – 114ExtracellularSequence analysisAdd BLAST15
Transmembranei115 – 136Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini137 – 158CytoplasmicSequence analysisAdd BLAST22
Transmembranei159 – 180Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini181 – 204ExtracellularSequence analysisAdd BLAST24
Transmembranei205 – 230Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini231 – 295CytoplasmicSequence analysisAdd BLAST65
Transmembranei296 – 322Helical; Name=6Sequence analysisAdd BLAST27
Topological domaini323 – 333ExtracellularSequence analysisAdd BLAST11
Transmembranei334 – 355Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini356 – 403CytoplasmicSequence analysisAdd BLAST48

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700491 – 403Prostaglandin E2 receptor EP1 subtypeAdd BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi113 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BGL8.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000024002.

Structurei

3D structure databases

ProteinModelPortaliQ9BGL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000015238.
HOVERGENiHBG003621.
InParanoidiQ9BGL8.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
IPR000708. Prostglndn_EP1_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 2 hits.
PTHR11866:SF3. PTHR11866:SF3. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00580. PRSTNOIDEP1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BGL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLCGPLNLS LAGEATPCAE PGAPNASAWP PSGRASASPA LPIFSMTLGA
60 70 80 90 100
VSNVLALALL AQAAGRLRRR RSAATFLLFV ASLLATDLAG HVIPGALVLR
110 120 130 140 150
LYAAGRSPAG GACHFLGGCM VFFGLCPLLL GCGMAVERCV GVTRPLLHAA
160 170 180 190 200
RVSAARARLA LAVLAALALA VALLPLARVG RYELQYPGTW CFIGLRPAGG
210 220 230 240 250
WRQALLAGLF AGLGLAALLA ALVCNTLSGL ALLRARWRRR RSRRRPQACG
260 270 280 290 300
PDGRRHWGAR APRSASASSS SSVASVPGGS PGRGSARRAR AHDVEMVGQL
310 320 330 340 350
VGIMVVSCIC WSPLLVLVVL AVGGWGSSSL QRPLFLAVRL ASWNQILDPW
360 370 380 390 400
VYILLRQAVL RQLLRLLPPR PGAKGSPAGL ALTRSAWEAS SLRSSRHSSL

SHL
Length:403
Mass (Da):42,063
Last modified:June 1, 2001 - v1
Checksum:iFE590C1EB04FD305
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF266477 Genomic DNA. Translation: AAK07512.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF266477 Genomic DNA. Translation: AAK07512.1.

3D structure databases

ProteinModelPortaliQ9BGL8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000024002.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9BGL8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000015238.
HOVERGENiHBG003621.
InParanoidiQ9BGL8.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
IPR000708. Prostglndn_EP1_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 2 hits.
PTHR11866:SF3. PTHR11866:SF3. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00580. PRSTNOIDEP1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPE2R1_CANLF
AccessioniPrimary (citable) accession number: Q9BGL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.