Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9BGI0 (GABT_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-aminobutyrate aminotransferase, mitochondrial

EC=2.6.1.19
Alternative name(s):
(S)-3-amino-2-methylpropionate transaminase
EC=2.6.1.22
GABA aminotransferase
Short name=GABA-AT
Gamma-amino-N-butyrate transaminase
Short name=GABA transaminase
Short name=GABA-T
L-AIBAT
Gene names
Name:ABAT
Synonyms:GABAT
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine By similarity.

Catalytic activity

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.

(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.

Cofactor

Pyridoxal phosphate By similarity.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2828Mitochondrion By similarity
Chain29 – 5004724-aminobutyrate aminotransferase, mitochondrial
PRO_0000001248

Amino acid modifications

Modified residue2311N6-succinyllysine By similarity
Modified residue2521N6-acetyllysine; alternate By similarity
Modified residue2521N6-succinyllysine; alternate By similarity
Modified residue2791N6-acetyllysine By similarity
Modified residue3181N6-acetyllysine By similarity
Modified residue3571N6-(pyridoxal phosphate)lysine By similarity
Modified residue4131N6-acetyllysine; alternate By similarity
Modified residue4131N6-succinyllysine; alternate By similarity
Modified residue4521N6-acetyllysine By similarity
Modified residue4701N6-acetyllysine By similarity
Disulfide bond163 ↔ 166 By similarity
Disulfide bond321Interchain By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9BGI0 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: DC622157B9326CBA

FASTA50056,731
        10         20         30         40         50         60 
MASMLVAQRL ACSFQHSYRL LVPGSRHISQ AAAKVDVEFD YDGRLMKTEV PGLRCQELMK 

        70         80         90        100        110        120 
QLNIIQNAEA VHFFCNYEES RGNYLVDVDG NRMLDLYSQI SSVPIGYSHP GLLKLIQQPQ 

       130        140        150        160        170        180 
NASMFVNRPA LGILLPENFV EKLRQSLLSV APKGMSQLIT MACGSCSNEN GLKTIFMWYR 

       190        200        210        220        230        240 
SKERGQRGFP QEELETCMIN QAPWCPDYSI LSFMGAFHGR TMGCLATTHS KAIHKIDIPS 

       250        260        270        280        290        300 
FDWPIAPFPR LKYPLEEFVK ENQQEEARCL EEVEDLIVKY RKKKKTVAGI IVEPIQSEGG 

       310        320        330        340        350        360 
DNHASDDFFR KLRDIPRKQC CAFLVDVVQT GGGCTGKFWA HEHWARDDPE DVMTSSKKMM 

       370        380        390        400        410        420 
TGGFFHKEEF RPNAPYRIFN TWLGDPSKNL LLAEVINIIK REDLLNNAAH AGKALLTGLL 

       430        440        450        460        470        480 
DLQARYPQFI SRVRGRGTFC SFDTPDDSIR NKLILIARNK GVVLGGCGDK SIRFRPTLVF 

       490        500 
RDHHAHLFLN IFSDILADFK 

« Hide

References

[1]"Molecular cloning and functional expression of bovine brain GABA transaminase."
Jeon S.G., Bahn J.H., Jang J.S., Jang S.H., Lee B.R., Lee K.S., Park J., Kang T.C., Won M.H., Kim H.B., Kwo O.S., Cho S.W., Choi S.Y.
Mol. Cells 12:91-96(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF305692 mRNA. Translation: AAG59861.1.
UniGeneBt.104290.

3D structure databases

ProteinModelPortalQ9BGI0.
SMRQ9BGI0. Positions 39-499.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ9BGI0.

Proteomic databases

PRIDEQ9BGI0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0160.
HOGENOMHOG000020208.
HOVERGENHBG000634.
InParanoidQ9BGI0.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProIPR004631. 4NH2But_aminotransferase_euk.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF6. PTHR11986:SF6. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMSSF53383. SSF53383. 2 hits.
TIGRFAMsTIGR00699. GABAtrns_euk. 1 hit.
ProtoNetSearch...

Other

NextBio20805077.

Entry information

Entry nameGABT_BOVIN
AccessionPrimary (citable) accession number: Q9BGI0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families