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Q9BGI0

- GABT_BOVIN

UniProt

Q9BGI0 - GABT_BOVIN

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Protein

4-aminobutyrate aminotransferase, mitochondrial

Gene

ABAT

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine (By similarity).By similarity

Catalytic activityi

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.

Cofactori

Pyridoxal phosphate.By similarity

GO - Molecular functioni

  1. (S)-3-amino-2-methylpropionate transaminase activity Source: UniProtKB-EC
  2. 4-aminobutyrate transaminase activity Source: UniProtKB-EC
  3. protein homodimerization activity Source: UniProtKB
  4. pyridoxal phosphate binding Source: UniProtKB

GO - Biological processi

  1. behavioral response to cocaine Source: UniProtKB
  2. gamma-aminobutyric acid catabolic process Source: UniProtKB
  3. neurotransmitter catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Neurotransmitter degradation

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
4-aminobutyrate aminotransferase, mitochondrial (EC:2.6.1.19)
Alternative name(s):
(S)-3-amino-2-methylpropionate transaminase (EC:2.6.1.22)
GABA aminotransferase
Short name:
GABA-AT
Gamma-amino-N-butyrate transaminase
Short name:
GABA transaminase
Short name:
GABA-T
L-AIBAT
Gene namesi
Name:ABAT
Synonyms:GABAT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. 4-aminobutyrate transaminase complex Source: UniProtKB
  2. mitochondrion Source: UniProtKB
  3. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2828MitochondrionBy similarityAdd
BLAST
Chaini29 – 5004724-aminobutyrate aminotransferase, mitochondrialPRO_0000001248Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi163 ↔ 166By similarity
Modified residuei231 – 2311N6-succinyllysineBy similarity
Modified residuei252 – 2521N6-acetyllysine; alternateBy similarity
Modified residuei252 – 2521N6-succinyllysine; alternateBy similarity
Modified residuei279 – 2791N6-acetyllysineBy similarity
Modified residuei318 – 3181N6-acetyllysineBy similarity
Disulfide bondi321 – 321InterchainBy similarity
Modified residuei357 – 3571N6-(pyridoxal phosphate)lysineBy similarity
Modified residuei413 – 4131N6-acetyllysine; alternateBy similarity
Modified residuei413 – 4131N6-succinyllysine; alternateBy similarity
Modified residuei452 – 4521N6-acetyllysineBy similarity
Modified residuei470 – 4701N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PRIDEiQ9BGI0.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9BGI0.
SMRiQ9BGI0. Positions 39-499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0160.
HOGENOMiHOG000020208.
HOVERGENiHBG000634.
InParanoidiQ9BGI0.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR004631. 4NH2But_aminotransferase_euk.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF6. PTHR11986:SF6. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 2 hits.
TIGRFAMsiTIGR00699. GABAtrns_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BGI0-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MASMLVAQRL ACSFQHSYRL LVPGSRHISQ AAAKVDVEFD YDGRLMKTEV
60 70 80 90 100
PGLRCQELMK QLNIIQNAEA VHFFCNYEES RGNYLVDVDG NRMLDLYSQI
110 120 130 140 150
SSVPIGYSHP GLLKLIQQPQ NASMFVNRPA LGILLPENFV EKLRQSLLSV
160 170 180 190 200
APKGMSQLIT MACGSCSNEN GLKTIFMWYR SKERGQRGFP QEELETCMIN
210 220 230 240 250
QAPWCPDYSI LSFMGAFHGR TMGCLATTHS KAIHKIDIPS FDWPIAPFPR
260 270 280 290 300
LKYPLEEFVK ENQQEEARCL EEVEDLIVKY RKKKKTVAGI IVEPIQSEGG
310 320 330 340 350
DNHASDDFFR KLRDIPRKQC CAFLVDVVQT GGGCTGKFWA HEHWARDDPE
360 370 380 390 400
DVMTSSKKMM TGGFFHKEEF RPNAPYRIFN TWLGDPSKNL LLAEVINIIK
410 420 430 440 450
REDLLNNAAH AGKALLTGLL DLQARYPQFI SRVRGRGTFC SFDTPDDSIR
460 470 480 490 500
NKLILIARNK GVVLGGCGDK SIRFRPTLVF RDHHAHLFLN IFSDILADFK
Length:500
Mass (Da):56,731
Last modified:June 1, 2001 - v1
Checksum:iDC622157B9326CBA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF305692 mRNA. Translation: AAG59861.1.
UniGeneiBt.104290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF305692 mRNA. Translation: AAG59861.1 .
UniGenei Bt.104290.

3D structure databases

ProteinModelPortali Q9BGI0.
SMRi Q9BGI0. Positions 39-499.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q9BGI0.

Proteomic databases

PRIDEi Q9BGI0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0160.
HOGENOMi HOG000020208.
HOVERGENi HBG000634.
InParanoidi Q9BGI0.

Miscellaneous databases

NextBioi 20805077.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProi IPR004631. 4NH2But_aminotransferase_euk.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
PTHR11986:SF6. PTHR11986:SF6. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 2 hits.
TIGRFAMsi TIGR00699. GABAtrns_euk. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and functional expression of bovine brain GABA transaminase."
    Jeon S.G., Bahn J.H., Jang J.S., Jang S.H., Lee B.R., Lee K.S., Park J., Kang T.C., Won M.H., Kim H.B., Kwo O.S., Cho S.W., Choi S.Y.
    Mol. Cells 12:91-96(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGABT_BOVIN
AccessioniPrimary (citable) accession number: Q9BGI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3