Q9BG99 (TREX1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Three prime repair exonuclease 1
EC=3.1.11.2

Alternative name(s):
3'-5' exonuclease TREX1

Gene names

Name:

TREX1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA repair. Ref.1
Catalytic activity	Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
Cofactor	Magnesium. Required for activity. Substitution with Mn2+ results in partial activity By similarity.
Subunit structure	Homodimer. Ref.1
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the exonuclease superfamily. TREX family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Nucleus
Ligand	Magnesium
Molecular function	Exonuclease Hydrolase Nuclease
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'-5' exonuclease activity Inferred from sequence or structural similarity. Source: UniProtKB exodeoxyribonuclease III activity Inferred from electronic annotation. Source: EC nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Three prime repair exonuclease 1		PRO_0000109867
Amino acid modifications
	Modified residue	78	1	Phosphoserine By similarity
	Modified residue	167	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9BG99 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 90AD66D1513DFDE6	FASTA	315	33,132
	10 20 30 40 50 60 MGSRALPPGP VQTLIFLDLE ATGLPFSQPK ITELCLLAVH RYALEGLSAP QGPSPTAPVP 70 80 90 100 110 120 PRVLDKLSLC VAPGKVCSPA ASEITGLSTA VLAAHGRRAF DADLVNLIRT FLQRQPQPWC 130 140 150 160 170 180 LVAHNGDRYD FPLLRAELAL LGLASALDDA FCVDSIAALK ALEPTGSSSE HGPRKSYSLG 190 200 210 220 230 240 SVYTRLYGQA PPDSHTAEGD VLALLSVCQW RPRALLRWVD AHAKPFSTVK PMYVITTSTG 250 260 270 280 290 300 TNPRPSAVTA TVPLARASDT GPNLRGDRSP KPAPSPKMCP GAPPGEGLLA PLGLLAFLTL 310 AVAMLYGLSL AMPGQ

References

[1]

"Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases." Mazur D.J., Perrino F.W. J. Biol. Chem. 274:19655-19660(1999) [PubMed: 10391904] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 42-60; 99-109 AND 161-184, FUNCTION, HOMODIMERIZATION. Tissue: Thymus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF319575 mRNA. Translation: AAK07622.1.
IPI	IPI00696016.
UniGene	Bt.7472.
3D structure databases
ProteinModelPortal	Q9BG99.
SMR	Q9BG99. Positions 4-233.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BG99.
Proteomic databases
PRIDE	Q9BG99.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
GeneTree	ENSGT00390000012715.
HOVERGEN	HBG079278.
InParanoid	Q9BG99.
OrthoDB	EOG4D52ZG.
Family and domain databases
InterPro	IPR012337. RNaseH-like_dom. [Graphical view]
SUPFAM	SSF53098. RNaseH_fold. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TREX1_BOVIN

Accession

Primary (citable) accession number: Q9BG99

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	June 1, 2001
Last modified:	December 14, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program