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Protein

Endothelin-1

Gene

EDN1

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

GO - Biological processi

Keywordsi

Molecular functionVasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Short name:
ET-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Cleaved into the following chain:
Gene namesi
Name:EDN1
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000807526 – 50By similarityAdd BLAST25
PeptideiPRO_000043640053 – 91Big endothelin-1By similarityAdd BLAST39
PeptideiPRO_000000807653 – 73Endothelin-1Add BLAST21
PropeptideiPRO_000000807774 – 202Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 67By similarity
Disulfide bondi55 ↔ 63By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei73 – 74Cleavage; by KELBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Structurei

3D structure databases

SMRiQ9BG76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 124Endothelin-likeAdd BLAST15

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG051441.
KOiK16366.

Family and domain databases

InterProiView protein in InterPro
IPR020475. Endothelin.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
PfamiView protein in Pfam
PF00322. Endothelin. 1 hit.
PRINTSiPR00365. ENDOTHELIN.
SMARTiView protein in SMART
SM00272. END. 2 hits.
PROSITEiView protein in PROSITE
PS00270. ENDOTHELIN. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BG76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYFPMIFAL LFVAFQGAPE AAVLGTELST GAESGGERPV PTTPWRPRRS
60 70 80 90 100
KRCSCSSLMD KECVYFCHLD IIWVNTPEHV VPYGLGSPSR SKRSLKDFFP
110 120 130 140 150
TKATVHRKRC QCASQTDKKC QNFCQAGKEL KDQDSMEKAW DNRKRGKDCP
160 170 180 190 200
KLGEKCLQQQ LVVGRKTRRL ETISNSIKTS FRVAKLKAQL YRDKKVIYSR

AH
Length:202
Mass (Da):23,040
Last modified:June 1, 2001 - v1
Checksum:i9E69BBB1CE9E1D11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329468 mRNA. Translation: AAG49531.1.
RefSeqiNP_001009810.1. NM_001009810.1.
UniGeneiOar.807.

Genome annotation databases

GeneIDi443498.
KEGGioas:443498.

Similar proteinsi

Entry informationi

Entry nameiEDN1_SHEEP
AccessioniPrimary (citable) accession number: Q9BG76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: December 20, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families