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Protein

Appetite-regulating hormone

Gene

GHRL

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity).By similarity
Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-CFA-416476. G alpha (q) signalling events.
R-CFA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Names & Taxonomyi

Protein namesi
Recommended name:
Appetite-regulating hormone
Alternative name(s):
Growth hormone secretagogue
Growth hormone-releasing peptide
Motilin-related peptide
Cleaved into the following 2 chains:
Gene namesi
Name:GHRL
Synonyms:MTLRP
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 20

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Peptidei24 – 5128GhrelinBy similarityPRO_0000019196Add
BLAST
Propeptidei52 – 7524Removed in mature formBy similarityPRO_0000019197Add
BLAST
Peptidei76 – 9823ObestatinBy similarityPRO_0000045134Add
BLAST
Propeptidei99 – 11719Removed in mature formBy similarityPRO_0000045135Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi26 – 261O-octanoyl serineBy similarity
Modified residuei98 – 981Leucine amideBy similarity

Post-translational modificationi

O-octanoylation is essential for ghrelin activity.By similarity
Amidation of Leu-98 is essential for obestatin activity.By similarity

Keywords - PTMi

Amidation, Lipoprotein

Proteomic databases

PaxDbiQ9BEF8.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000007641.

Family & Domainsi

Sequence similaritiesi

Belongs to the motilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZYV. Eukaryota.
ENOG410ZG1B. LUCA.
GeneTreeiENSGT00390000004064.
HOGENOMiHOG000236303.
HOVERGENiHBG018522.
InParanoidiQ9BEF8.
KOiK05254.
OMAiEIQFNAP.
OrthoDBiEOG741Z4K.
TreeFamiTF336219.

Family and domain databases

InterProiIPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
IPR005441. Preproghrelin.
[Graphical view]
PANTHERiPTHR14122. PTHR14122. 1 hit.
PfamiPF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
[Graphical view]
PRINTSiPR01624. GHRELIN.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BEF8-1) [UniParc]FASTAAdd to basket

Also known as: Ghrelin

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSLGTMCSL LLFSVLWVDL AMAGSSFLSP EHQKLQQRKE SKKPPAKLQP
60 70 80 90 100
RALEGSLGPE DTSQVEEAED ELEIRFNAPF DVGIKLSGPQ YHQHGQALGK
110
FLQEVLWEDT NEALADE
Length:117
Mass (Da):13,007
Last modified:June 1, 2001 - v1
Checksum:i3E57FED9D1847CF7
GO
Isoform 2 (identifier: Q9BEF8-2) [UniParc]FASTAAdd to basket

Also known as: des-Gln14-ghrelin

The sequence of this isoform differs from the canonical sequence as follows:
     37-37: Missing.

Show »
Length:116
Mass (Da):12,879
Checksum:i004BD7404B26974B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei37 – 371Missing in isoform 2. 1 PublicationVSP_003244

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ298295 mRNA. Translation: CAC29155.1.
AJ298296 mRNA. Translation: CAC29156.1.
AB060700 mRNA. Translation: BAC75929.1.
RefSeqiNP_001003052.1. NM_001003052.2. [Q9BEF8-1]
XP_005632067.1. XM_005632010.2. [Q9BEF8-2]
UniGeneiCfa.3451.

Genome annotation databases

EnsembliENSCAFT00000008248; ENSCAFP00000007641; ENSCAFG00000005129. [Q9BEF8-1]
GeneIDi403587.
KEGGicfa:403587.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Protein Spotlight

Gut feelings - Issue 66 of January 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ298295 mRNA. Translation: CAC29155.1.
AJ298296 mRNA. Translation: CAC29156.1.
AB060700 mRNA. Translation: BAC75929.1.
RefSeqiNP_001003052.1. NM_001003052.2. [Q9BEF8-1]
XP_005632067.1. XM_005632010.2. [Q9BEF8-2]
UniGeneiCfa.3451.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000007641.

Proteomic databases

PaxDbiQ9BEF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000008248; ENSCAFP00000007641; ENSCAFG00000005129. [Q9BEF8-1]
GeneIDi403587.
KEGGicfa:403587.

Organism-specific databases

CTDi51738.

Phylogenomic databases

eggNOGiENOG410IZYV. Eukaryota.
ENOG410ZG1B. LUCA.
GeneTreeiENSGT00390000004064.
HOGENOMiHOG000236303.
HOVERGENiHBG018522.
InParanoidiQ9BEF8.
KOiK05254.
OMAiEIQFNAP.
OrthoDBiEOG741Z4K.
TreeFamiTF336219.

Enzyme and pathway databases

ReactomeiR-CFA-416476. G alpha (q) signalling events.
R-CFA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Miscellaneous databases

NextBioi20817093.

Family and domain databases

InterProiIPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
IPR005441. Preproghrelin.
[Graphical view]
PANTHERiPTHR14122. PTHR14122. 1 hit.
PfamiPF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
[Graphical view]
PRINTSiPR01624. GHRELIN.
ProtoNetiSearch...

Publicationsi

  1. "Identification of cDNA encoding MTLRP/ghrelin precursor from dog fundus."
    Tomasetto C., Wendling C., Rio M.-C., Poitras P.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Gastric fundus.
  2. "Dog ghrelin."
    Doi K., Kojima M., Hosoda H., Kaiya H., Matsuo H., Kangawa K.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Stomach.

Entry informationi

Entry nameiGHRL_CANLF
AccessioniPrimary (citable) accession number: Q9BEF8
Secondary accession number(s): Q9BEF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.