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Q9BEB0

- GSTM2_MACFU

UniProt

Q9BEB0 - GSTM2_MACFU

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Protein

Glutathione S-transferase Mu 2

Gene
GSTM2
Organism
Macaca fuscata fuscata (Japanese macaque)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has activity toward aflatoxin B(1)-8,9-epoxide (AFBO).

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161Substrate By similarity
Sitei210 – 2101Important for substrate specificity By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB

GO - Biological processi

  1. glutathione metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 2 (EC:2.5.1.18)
Alternative name(s):
GST class-mu 2
GSTM2-2
Gene namesi
Name:GSTM2
OrganismiMacaca fuscata fuscata (Japanese macaque)
Taxonomic identifieri9543 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 218217Glutathione S-transferase Mu 2PRO_0000185820Add
BLAST

Proteomic databases

PRIDEiQ9BEB0.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9BEB0.
SMRiQ9BEB0. Positions 2-218.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8887GST N-terminalAdd
BLAST
Domaini90 – 208119GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni7 – 82Glutathione binding By similarity
Regioni46 – 505Glutathione binding By similarity
Regioni59 – 602Glutathione binding By similarity
Regioni72 – 732Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.

Phylogenomic databases

HOVERGENiHBG106842.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BEB0-1 [UniParc]FASTAAdd to Basket

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MPMTLGYWNI RGLAHSIRLL LEYTGSSYEE KKYTMGDAPD YDRSQWLNEK    50
FKLGLDFPNL PYLIDGTHKI TQSNAILRYI ARKHNLCGET EKEKIREDIL 100
ENQLMDNRMQ LARLCYDPDF EKLKPEYLEG LPEMLKLYSQ FLGKQPWFLG 150
DKITFVDFIA YDVLERNQVF EPSCLDAFPN LKDFISRFEG LEKISAYMKS 200
SRFLPRPVFT KMAVWGNK 218
Length:218
Mass (Da):25,709
Last modified:January 23, 2007 - v3
Checksum:iF2E509C3949F9051
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB025799 mRNA. Translation: BAB40442.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB025799 mRNA. Translation: BAB40442.1 .

3D structure databases

ProteinModelPortali Q9BEB0.
SMRi Q9BEB0. Positions 2-218.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9BEB0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106842.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01267. GSTRNSFRASEM.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Macaca fuscata glutathione transferase M2."
    Beuckmann C.T., Fujimori K., Urade Y.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGSTM2_MACFU
AccessioniPrimary (citable) accession number: Q9BEB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: October 16, 2013
This is version 51 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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